| Definition | Streptococcus pyogenes MGAS315 chromosome, complete genome. |
|---|---|
| Accession | NC_004070 |
| Length | 1,900,521 |
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The map label for this gene is gyrA [H]
Identifier: 21910346
GI number: 21910346
Start: 862780
End: 865266
Strand: Direct
Name: gyrA [H]
Synonym: SpyM3_0810
Alternate gene names: 21910346
Gene position: 862780-865266 (Clockwise)
Preceding gene: 21910344
Following gene: 21910347
Centisome position: 45.4
GC content: 40.05
Gene sequence:
>2487_bases ATGCAAGATCGAAATTTAATTGACGTCAATCTGACAAGTGAAATGAAAACGAGTTTCATTGACTATGCCATGAGTGTCAT TGTGGCAAGAGCTTTGCCAGATGTGCGTGATGGTCTGAAACCTGTGCATCGTCGTATTCTCTATGGGATGAATGAACTCG GTGTGACACCTGATAAACCGCATAAAAAATCTGCTCGTATTACGGGTGATGTCATGGGTAAATATCACCCGCATGGGGAT TCTTCTATTTATGAAGCTATGGTTCGTATGGCTCAGTGGTGGAGTTATCGCCATATGCTTGTTGATGGGCATGGCAATTT TGGTTCTATGGATGGTGATGGTGCTGCCGCTCAACGTTATACTGAAGCGCGCATGAGTAAAATTGCGCTTGAATTATTAA GGGATATCAATAAAAATACCGTTAATTTTCAAGATAACTACGATGGAAGCGAAAGAGAACCAGTAGTATTACCAGCTCGC TTTCCTAATTTATTAGTCAATGGAGCGACAGGGATTGCCGTTGGGATGGCAACTAACATTCCGCCTCATAATTTGGCAGA ATCTATTGACGCTGTCAAGATGGTAATGGAACATCCAGACTGTACAACAAGAGAGTTGATGGAAGTGATCCCTGGACCTG ACTTTCCGACTGGTGCCCTTGTTATGGGGCGCTCAGGTATTCATAGGGCTTATGATACTGGTAAAGGTTCTATCGTTTTA CGCTCTCGAACAGAAATTGAAACAACTCAAACAGGTCGGGAACGTATTGTGGTTACTGAATTTCCCTATGGCGTCAATAA AACGAAAGTGCATGAACACATTGTTCGTTTAGCACAAGAAAAAAGACTAGAAGGTATTACAGCAGTTCGTGACGAATCTA GCCGTGAAGGAGTGCGTTTTGTTATCGAGATTCGTCGAGAAGCATCCGCGACAGTTATCTTAAATAACCTCTTTAAATTA ACAAGCCTTCAGACGAATTTCAGTTTTAATATGTTGGCTATTGAAAATGGTGTGCCTAAAATATTGTCACTCAGACAAAT CATTGATAATTACATTAGTCATCAAAAAGAAGTTATTATACGTCGCACCCGATTTGATAAAGATAAAGCTGAAGCCAGAG CTCATATTTTAGAAGGCTTACTGATTGCCCTTGATCATTTAGACGAAGTGATTGCTATTATTCGTAACAGCGAGACAGAT GTCATTGCTCAGACAGAATTGATGTCACGTTTCGACTTGTCTGAACGCCAAAGCCAAGCTATTTTGGATATGCGTTTGCG TCGTTTGACTGGTTTGGAACGTGATAAGATTCAATCAGAATATGATGATTTGTTGGCCTTGATTGCTGACTTATCTGATA TTTTAGCCAAACCAGAACGTATTATCACTATCATCAAAGAAGAAATGGATGAGATCAAGCGTAAATACGCTAACCCACGC CGTACAGAATTAATGGTCGGTGAAGTCCTTTCTCTAGAAGATGAAGACCTAATTGAAGAAGAAGATGTTTTGATTACCTT GTCAAATAAAGGTTATATCAAGCGTCTTGCTCAAGATGAATTTCGTGCCCAGAAGCGTGGTGGACGTGGCGTCCAAGGAA CTGGGGTCAACAATGACGACTTTGTACGTGAATTGGTATCAACAAGTACCCATGATACTTTGCTCTTCTTTACGAATTTT GGGCGTGTCTATCGGTTGAAAGCTTACGAAATTCCAGAATATGGTCGTACAGCAAAAGGTCTTCCAATTGTTAATCTATT GAAATTAGAAGATGGTGAAACCATTCAAACTATTATCAACGCACGTAAGGAAGAAACAGCAGGTAAATCCTTCTTCTTTA CAACGAAACAAGGCATTGTCAAACGTACAGAAGTTTCAGAATTTAATAATATCCGTCAAAACGGTCTCCGTGCTCTTAAG TTGAAAGAGGGAGATCAGCTGATTAACGTCCTTTTGACAAGCGGTCAGGATGACATTATCATTGGAACTCATTCCGGATA TTCTGTTCGTTTTAATGAAGCAAGCATCCGCAACATGGGCCGATCAGCTACGGGTGTTCGCGGGGTTAAGCTTCGTGAAG ATGATCGCGTTGTTGGAGCGTCACGTATTCAAGATAACCAAGAAGTTCTTGTAATTACCGAAAATGGCTTTGGTAAGAGA ACAAGTGCTACAGACTATCCTACAAAAGGTAGGGGGGGAAAAGGAATAAAAACAGCTAATATTACCCCTAAAAATGGTCA ATTAGCTGGATTGGTTACCGTAGATGGTACAGAAGATATCATGGTGATTACAAATAAAGGTGTCATTATTCGCACAAATG TTGCAAATATTTCGCAAACAGGTCGTGCTACTTTGGGTGTTAAAATTATGAAACTAGATGCTGATGCTAAGATTGTAACA TTTACCTTGGTTCAGCCTGAAGACAGTAGTATCGCTGAAATCAATACTGATCGTGAAAATAGTATTTCAAAAAATAAAGA TAATTAA
Upstream 100 bases:
>100_bases ATAATGAAAATAGTTTCCTGATAACGCTTCCAATAAGAAAAAATAAGGAATTTATGGTATAATGAAATCTAGTATTGACT AGAAAAGGAGCATTCCTTAA
Downstream 100 bases:
>100_bases TCATAACAAGGAGTAAAAAATGGTAAAAAAACAAAAGCGTCGAAAAATAAAATCCATGTCTTGGGCAAGAAAACTACTAA TAGCTGTACTTTTAATTCTA
Product: DNA gyrase subunit A
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 828; Mature: 828
Protein sequence:
>828_residues MQDRNLIDVNLTSEMKTSFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGD SSIYEAMVRMAQWWSYRHMLVDGHGNFGSMDGDGAAAQRYTEARMSKIALELLRDINKNTVNFQDNYDGSEREPVVLPAR FPNLLVNGATGIAVGMATNIPPHNLAESIDAVKMVMEHPDCTTRELMEVIPGPDFPTGALVMGRSGIHRAYDTGKGSIVL RSRTEIETTQTGRERIVVTEFPYGVNKTKVHEHIVRLAQEKRLEGITAVRDESSREGVRFVIEIRREASATVILNNLFKL TSLQTNFSFNMLAIENGVPKILSLRQIIDNYISHQKEVIIRRTRFDKDKAEARAHILEGLLIALDHLDEVIAIIRNSETD VIAQTELMSRFDLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLSDILAKPERIITIIKEEMDEIKRKYANPR RTELMVGEVLSLEDEDLIEEEDVLITLSNKGYIKRLAQDEFRAQKRGGRGVQGTGVNNDDFVRELVSTSTHDTLLFFTNF GRVYRLKAYEIPEYGRTAKGLPIVNLLKLEDGETIQTIINARKEETAGKSFFFTTKQGIVKRTEVSEFNNIRQNGLRALK LKEGDQLINVLLTSGQDDIIIGTHSGYSVRFNEASIRNMGRSATGVRGVKLREDDRVVGASRIQDNQEVLVITENGFGKR TSATDYPTKGRGGKGIKTANITPKNGQLAGLVTVDGTEDIMVITNKGVIIRTNVANISQTGRATLGVKIMKLDADAKIVT FTLVQPEDSSIAEINTDRENSISKNKDN
Sequences:
>Translated_828_residues MQDRNLIDVNLTSEMKTSFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGD SSIYEAMVRMAQWWSYRHMLVDGHGNFGSMDGDGAAAQRYTEARMSKIALELLRDINKNTVNFQDNYDGSEREPVVLPAR FPNLLVNGATGIAVGMATNIPPHNLAESIDAVKMVMEHPDCTTRELMEVIPGPDFPTGALVMGRSGIHRAYDTGKGSIVL RSRTEIETTQTGRERIVVTEFPYGVNKTKVHEHIVRLAQEKRLEGITAVRDESSREGVRFVIEIRREASATVILNNLFKL TSLQTNFSFNMLAIENGVPKILSLRQIIDNYISHQKEVIIRRTRFDKDKAEARAHILEGLLIALDHLDEVIAIIRNSETD VIAQTELMSRFDLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLSDILAKPERIITIIKEEMDEIKRKYANPR RTELMVGEVLSLEDEDLIEEEDVLITLSNKGYIKRLAQDEFRAQKRGGRGVQGTGVNNDDFVRELVSTSTHDTLLFFTNF GRVYRLKAYEIPEYGRTAKGLPIVNLLKLEDGETIQTIINARKEETAGKSFFFTTKQGIVKRTEVSEFNNIRQNGLRALK LKEGDQLINVLLTSGQDDIIIGTHSGYSVRFNEASIRNMGRSATGVRGVKLREDDRVVGASRIQDNQEVLVITENGFGKR TSATDYPTKGRGGKGIKTANITPKNGQLAGLVTVDGTEDIMVITNKGVIIRTNVANISQTGRATLGVKIMKLDADAKIVT FTLVQPEDSSIAEINTDRENSISKNKDN >Mature_828_residues MQDRNLIDVNLTSEMKTSFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGD SSIYEAMVRMAQWWSYRHMLVDGHGNFGSMDGDGAAAQRYTEARMSKIALELLRDINKNTVNFQDNYDGSEREPVVLPAR FPNLLVNGATGIAVGMATNIPPHNLAESIDAVKMVMEHPDCTTRELMEVIPGPDFPTGALVMGRSGIHRAYDTGKGSIVL RSRTEIETTQTGRERIVVTEFPYGVNKTKVHEHIVRLAQEKRLEGITAVRDESSREGVRFVIEIRREASATVILNNLFKL TSLQTNFSFNMLAIENGVPKILSLRQIIDNYISHQKEVIIRRTRFDKDKAEARAHILEGLLIALDHLDEVIAIIRNSETD VIAQTELMSRFDLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLSDILAKPERIITIIKEEMDEIKRKYANPR RTELMVGEVLSLEDEDLIEEEDVLITLSNKGYIKRLAQDEFRAQKRGGRGVQGTGVNNDDFVRELVSTSTHDTLLFFTNF GRVYRLKAYEIPEYGRTAKGLPIVNLLKLEDGETIQTIINARKEETAGKSFFFTTKQGIVKRTEVSEFNNIRQNGLRALK LKEGDQLINVLLTSGQDDIIIGTHSGYSVRFNEASIRNMGRSATGVRGVKLREDDRVVGASRIQDNQEVLVITENGFGKR TSATDYPTKGRGGKGIKTANITPKNGQLAGLVTVDGTEDIMVITNKGVIIRTNVANISQTGRATLGVKIMKLDADAKIVT FTLVQPEDSSIAEINTDRENSISKNKDN
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913406, Length=338, Percent_Identity=25.4437869822485, Blast_Score=78, Evalue=4e-14, Organism=Escherichia coli, GI1788562, Length=841, Percent_Identity=47.5624256837099, Blast_Score=792, Evalue=0.0, Organism=Escherichia coli, GI1789396, Length=593, Percent_Identity=37.4367622259696, Blast_Score=382, Evalue=1e-107, Organism=Caenorhabditis elegans, GI212645845, Length=477, Percent_Identity=22.8511530398323, Blast_Score=73, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17535065, Length=174, Percent_Identity=31.6091954022989, Blast_Score=71, Evalue=3e-12, Organism=Saccharomyces cerevisiae, GI6324241, Length=369, Percent_Identity=23.8482384823848, Blast_Score=76, Evalue=3e-14, Organism=Drosophila melanogaster, GI17136538, Length=413, Percent_Identity=23.2445520581114, Blast_Score=75, Evalue=2e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR005743 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013757 - InterPro: IPR013760 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 92691; Mature: 92691
Theoretical pI: Translated: 7.13; Mature: 7.13
Prosite motif: PS00572 GLYCOSYL_HYDROL_F1_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.1 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.1 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQDRNLIDVNLTSEMKTSFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKP CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHCCCCCCCC HKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRHMLVDGHGNFGSMDGDGAAAQRY CCCCCCEEHHHCCCCCCCCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCHHHHHH TEARMSKIALELLRDINKNTVNFQDNYDGSEREPVVLPARFPNLLVNGATGIAVGMATNI HHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCEEEECCCCCCEEECCCEEEEEEECCC PPHNLAESIDAVKMVMEHPDCTTRELMEVIPGPDFPTGALVMGRSGIHRAYDTGKGSIVL CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCHHHCCCCCCEEE RSRTEIETTQTGRERIVVTEFPYGVNKTKVHEHIVRLAQEKRLEGITAVRDESSREGVRF ECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEE VIEIRREASATVILNNLFKLTSLQTNFSFNMLAIENGVPKILSLRQIIDNYISHQKEVII EEEEHHCCCHHHHHHHHHHHHEEECCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHH RRTRFDKDKAEARAHILEGLLIALDHLDEVIAIIRNSETDVIAQTELMSRFDLSERQSQA HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHH ILDMRLRRLTGLERDKIQSEYDDLLALIADLSDILAKPERIITIIKEEMDEIKRKYANPR HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCC RTELMVGEVLSLEDEDLIEEEDVLITLSNKGYIKRLAQDEFRAQKRGGRGVQGTGVNNDD HHHHHHHHHHCCCCHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH FVRELVSTSTHDTLLFFTNFGRVYRLKAYEIPEYGRTAKGLPIVNLLKLEDGETIQTIIN HHHHHHHCCCCCEEEEEECCCEEEEEEEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHH ARKEETAGKSFFFTTKQGIVKRTEVSEFNNIRQNGLRALKLKEGDQLINVLLTSGQDDII HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCEE IGTHSGYSVRFNEASIRNMGRSATGVRGVKLREDDRVVGASRIQDNQEVLVITENGFGKR EECCCCCEEEECCHHHHHCCCCCCCCCCEEECCCCCEECHHHCCCCCEEEEEECCCCCCC TSATDYPTKGRGGKGIKTANITPKNGQLAGLVTVDGTEDIMVITNKGVIIRTNVANISQT CCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEEECCCCCEEEEECCCEEEEECCCCCCCC GRATLGVKIMKLDADAKIVTFTLVQPEDSSIAEINTDRENSISKNKDN CCEEEEEEEEEECCCCEEEEEEEECCCCCCCEEECCCCCCCCCCCCCC >Mature Secondary Structure MQDRNLIDVNLTSEMKTSFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKP CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHCCCCCCCC HKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRHMLVDGHGNFGSMDGDGAAAQRY CCCCCCEEHHHCCCCCCCCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCHHHHHH TEARMSKIALELLRDINKNTVNFQDNYDGSEREPVVLPARFPNLLVNGATGIAVGMATNI HHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCEEEECCCCCCEEECCCEEEEEEECCC PPHNLAESIDAVKMVMEHPDCTTRELMEVIPGPDFPTGALVMGRSGIHRAYDTGKGSIVL CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCHHHCCCCCCEEE RSRTEIETTQTGRERIVVTEFPYGVNKTKVHEHIVRLAQEKRLEGITAVRDESSREGVRF ECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEE VIEIRREASATVILNNLFKLTSLQTNFSFNMLAIENGVPKILSLRQIIDNYISHQKEVII EEEEHHCCCHHHHHHHHHHHHEEECCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHH RRTRFDKDKAEARAHILEGLLIALDHLDEVIAIIRNSETDVIAQTELMSRFDLSERQSQA HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHH ILDMRLRRLTGLERDKIQSEYDDLLALIADLSDILAKPERIITIIKEEMDEIKRKYANPR HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCC RTELMVGEVLSLEDEDLIEEEDVLITLSNKGYIKRLAQDEFRAQKRGGRGVQGTGVNNDD HHHHHHHHHHCCCCHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH FVRELVSTSTHDTLLFFTNFGRVYRLKAYEIPEYGRTAKGLPIVNLLKLEDGETIQTIIN HHHHHHHCCCCCEEEEEECCCEEEEEEEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHH ARKEETAGKSFFFTTKQGIVKRTEVSEFNNIRQNGLRALKLKEGDQLINVLLTSGQDDII HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCEE IGTHSGYSVRFNEASIRNMGRSATGVRGVKLREDDRVVGASRIQDNQEVLVITENGFGKR EECCCCCEEEECCHHHHHCCCCCCCCCCEEECCCCCEECHHHCCCCCEEEEEECCCCCCC TSATDYPTKGRGGKGIKTANITPKNGQLAGLVTVDGTEDIMVITNKGVIIRTNVANISQT CCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEEECCCCCEEEEECCCEEEEECCCCCCCC GRATLGVKIMKLDADAKIVTFTLVQPEDSSIAEINTDRENSISKNKDN CCEEEEEEEEEECCCCEEEEEEEECCCCCCCEEECCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11296296 [H]