Click here to switch to the map view.

The map label for this gene is pepQ [H]

Identifier: 21909897

GI number: 21909897

Start: 399251

End: 400336

Strand: Reverse

Name: pepQ [H]

Synonym: SpyM3_0361

Alternate gene names: 21909897

Gene position: 400336-399251 (Counterclockwise)

Preceding gene: 21909913

Following gene: 21909896

Centisome position: 21.06

GC content: 42.08

Gene sequence:

>1086_bases
ATGACAAAATTAGACCAAATACGTTTGTATCTTGACCAAAAGGGAGCTGAATTGGCGATTTTCTCAGATCCTGTTACGAT
TAACTATTTAACTGGATTCTTCTGTGACCCACATGAAAGACAACTGTTCTTGTTTGTCTACCATGATTTAGCTCCTGTGC
TTTTTGTACCTGCCCTTGAGGTGGCCAGAGCTAGCCAGGCCATATCATTTCCTGTGTTTGGTTATGTTGACTCTGAAAAT
CCTTGGGAAAAGATCAAGGCCGTTTTACCAAATACAGCAGCCAAAACCATTTATGCTGAATTTGACCACCTTAACGTCAA
TAAGTTCCATGGCTTGCAGACTATCTTTTCAGGGCAATTTAACAATCTAACCCCTTATGTCCAAGGCATGCGCCTCGTCA
AATCAGCTGATGAAATCAATAAAATGATGATTGCCGGGCAGTTCGCTGATAAGGCTGTTCAAGTTGGTTTTGACAATATT
TCCTTAGATGCTACCGAAACAGACGTCATCGCTCAAATTGAGTTTGAAATGAAAAAACAAGGCATTCATAAAATGAGCTT
TGACACTATGGTCTTAACTGGAAATAATGCAGCCAATCCCCATGGCATTCCTGGAACAAATAACATTGAAAACAATGCCC
TACTTCTTTTTGACTTAGGTGTTGAGACCTTAGGCTACACCAGTGATATGACCAGAACTGTGGCTGTTGGTCAGCCAGAC
CAATTTAAAATCGATATCTACAATCTCTGCCTAGAGGCACAACTAGCGGCTATTGACTTTATCAAACCAGGTGTAACAGC
TGCTCAAGTAGATGCTGCTGCTCGTCAAGTGATTGAAAAGGCTGGATATGGTCAGTACTTCAACCACCGCTTGGGACATG
GTATCGGCATGGATGTCCACGAATTTCCCTCCATTATGGCTGGCAATGACTTGGTCCTTGAAGAAGGTATGTGCTTCTCT
GTTGAACCTGGTATTTACATTCCAGGAAAGGTCGGTGTGCGCATCGAAGACTGTGGCCATGTCACTAAAAATGGCTTTGA
AGTCTTTACCCATACTCCAAAAGAGTTGCTTTATTTTGAAGGCTAA

Upstream 100 bases:

>100_bases
TGTTATAGGTTAATTTTTGAAAAAGTTTTCAAACATTAGCTCGAAGCTTGATTTTTTAAGCTTTTTTTGAAAAAATAGTA
AGTAGAAAGAAGGTTAGCCT

Downstream 100 bases:

>100_bases
GCCCCTACCATCTGGTTAAACAAACCCTCGCGAAAGGAAGGTATTCGTATGGATCAAACCATTCATCACCAAATACAGCA
AGCACTACACTTTAGAACAG

Product: putative Xaa-Pro dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTKLDQIRLYLDQKGAELAIFSDPVTINYLTGFFCDPHERQLFLFVYHDLAPVLFVPALEVARASQAISFPVFGYVDSEN
PWEKIKAVLPNTAAKTIYAEFDHLNVNKFHGLQTIFSGQFNNLTPYVQGMRLVKSADEINKMMIAGQFADKAVQVGFDNI
SLDATETDVIAQIEFEMKKQGIHKMSFDTMVLTGNNAANPHGIPGTNNIENNALLLFDLGVETLGYTSDMTRTVAVGQPD
QFKIDIYNLCLEAQLAAIDFIKPGVTAAQVDAAARQVIEKAGYGQYFNHRLGHGIGMDVHEFPSIMAGNDLVLEEGMCFS
VEPGIYIPGKVGVRIEDCGHVTKNGFEVFTHTPKELLYFEG

Sequences:

>Translated_361_residues
MTKLDQIRLYLDQKGAELAIFSDPVTINYLTGFFCDPHERQLFLFVYHDLAPVLFVPALEVARASQAISFPVFGYVDSEN
PWEKIKAVLPNTAAKTIYAEFDHLNVNKFHGLQTIFSGQFNNLTPYVQGMRLVKSADEINKMMIAGQFADKAVQVGFDNI
SLDATETDVIAQIEFEMKKQGIHKMSFDTMVLTGNNAANPHGIPGTNNIENNALLLFDLGVETLGYTSDMTRTVAVGQPD
QFKIDIYNLCLEAQLAAIDFIKPGVTAAQVDAAARQVIEKAGYGQYFNHRLGHGIGMDVHEFPSIMAGNDLVLEEGMCFS
VEPGIYIPGKVGVRIEDCGHVTKNGFEVFTHTPKELLYFEG
>Mature_360_residues
TKLDQIRLYLDQKGAELAIFSDPVTINYLTGFFCDPHERQLFLFVYHDLAPVLFVPALEVARASQAISFPVFGYVDSENP
WEKIKAVLPNTAAKTIYAEFDHLNVNKFHGLQTIFSGQFNNLTPYVQGMRLVKSADEINKMMIAGQFADKAVQVGFDNIS
LDATETDVIAQIEFEMKKQGIHKMSFDTMVLTGNNAANPHGIPGTNNIENNALLLFDLGVETLGYTSDMTRTVAVGQPDQ
FKIDIYNLCLEAQLAAIDFIKPGVTAAQVDAAARQVIEKAGYGQYFNHRLGHGIGMDVHEFPSIMAGNDLVLEEGMCFSV
EPGIYIPGKVGVRIEDCGHVTKNGFEVFTHTPKELLYFEG

Specific function: Strict dipeptidase active on Xaa-Pro dipeptides, except Gly-Pro and Pro-Pro [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=351, Percent_Identity=25.9259259259259, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI93141226, Length=193, Percent_Identity=33.160621761658, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI264681563, Length=173, Percent_Identity=31.7919075144509, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI40385867, Length=201, Percent_Identity=25.8706467661692, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1788728, Length=278, Percent_Identity=37.0503597122302, Blast_Score=188, Evalue=4e-49,
Organism=Escherichia coli, GI1789275, Length=289, Percent_Identity=27.3356401384083, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786364, Length=231, Percent_Identity=25.1082251082251, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17509539, Length=168, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322999, Length=161, Percent_Identity=36.6459627329193, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6321118, Length=279, Percent_Identity=24.3727598566308, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320922, Length=255, Percent_Identity=23.5294117647059, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19920384, Length=329, Percent_Identity=25.8358662613982, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137632, Length=201, Percent_Identity=30.3482587064677, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 39987; Mature: 39856

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLDQIRLYLDQKGAELAIFSDPVTINYLTGFFCDPHERQLFLFVYHDLAPVLFVPALE
CCCHHEEEEEEECCCCEEEEEECCEEEEEEEEEEECCCCCEEEEEEEHHHHHHHHHHHHH
VARASQAISFPVFGYVDSENPWEKIKAVLPNTAAKTIYAEFDHLNVNKFHGLQTIFSGQF
HHHHHCCEECCEEEEECCCCHHHHHHHHCCCCHHHEEEEECCCCCCHHHHCHHHHHCCCC
NNLTPYVQGMRLVKSADEINKMMIAGQFADKAVQVGFDNISLDATETDVIAQIEFEMKKQ
CCCCHHHHHHHHHHHHHHHHHEEEEEHHHCCEEEECCCCEEECCCCCCEEEEEEEHHHHC
GIHKMSFDTMVLTGNNAANPHGIPGTNNIENNALLLFDLGVETLGYTSDMTRTVAVGQPD
CCCEEECCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCC
QFKIDIYNLCLEAQLAAIDFIKPGVTAAQVDAAARQVIEKAGYGQYFNHRLGHGIGMDVH
CEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHH
EFPSIMAGNDLVLEEGMCFSVEPGIYIPGKVGVRIEDCGHVTKNGFEVFTHTPKELLYFE
HCCHHHCCCEEEEECCCEEEECCCEEECCCCCEEEECCCCCCCCCEEEEECCCHHEEEEC
G
C
>Mature Secondary Structure 
TKLDQIRLYLDQKGAELAIFSDPVTINYLTGFFCDPHERQLFLFVYHDLAPVLFVPALE
CCHHEEEEEEECCCCEEEEEECCEEEEEEEEEEECCCCCEEEEEEEHHHHHHHHHHHHH
VARASQAISFPVFGYVDSENPWEKIKAVLPNTAAKTIYAEFDHLNVNKFHGLQTIFSGQF
HHHHHCCEECCEEEEECCCCHHHHHHHHCCCCHHHEEEEECCCCCCHHHHCHHHHHCCCC
NNLTPYVQGMRLVKSADEINKMMIAGQFADKAVQVGFDNISLDATETDVIAQIEFEMKKQ
CCCCHHHHHHHHHHHHHHHHHEEEEEHHHCCEEEECCCCEEECCCCCCEEEEEEEHHHHC
GIHKMSFDTMVLTGNNAANPHGIPGTNNIENNALLLFDLGVETLGYTSDMTRTVAVGQPD
CCCEEECCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCC
QFKIDIYNLCLEAQLAAIDFIKPGVTAAQVDAAARQVIEKAGYGQYFNHRLGHGIGMDVH
CEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHH
EFPSIMAGNDLVLEEGMCFSVEPGIYIPGKVGVRIEDCGHVTKNGFEVFTHTPKELLYFE
HCCHHHCCCEEEEECCCEEEECCCEEECCCCCEEEECCCCCCCCCEEEEECCCHHEEEEC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075426 [H]