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The map label for this gene is gpmA

Identifier: 21672571

GI number: 21672571

Start: 338021

End: 338713

Strand: Direct

Name: gpmA

Synonym: BUsg294

Alternate gene names: 21672571

Gene position: 338021-338713 (Clockwise)

Preceding gene: 21672570

Following gene: 21672572

Centisome position: 52.7

GC content: 26.12

Gene sequence:

>693_bases
ATGAAAACTAATAAATTAGTCTTAATTAGACATGGTCAAAGTAAATGGAATAAATTAAATAAATTTACTGGATGGCATGA
TATAGAATTAAGTGACAATGGTATAAATGAAGCTCTAAAAGCCGGTTCTCTCTTGAAAAAAGAAAAATTTTTTTTCGATT
ATGCACATACTTCTATGTTAAAAAGAGCAATACATACTTTAAGATATATTTTAGATACATTAGATCAATCTTGGTTACCA
GTTCAAAAATCTTGGCGTTTAAATGAAAGACATTATGGTGCATTGGAGGGATTAAATAAAGATGAAATGATTTCAAAATA
CGGTGAAGAACAAGTAAATTTATGGAGACGAAGTTTTGAAATTATACCACCTCAAATCAGATTAAATGATAAAAGATTTC
CAGGAAATGATATACGTTATTCGAATATAGATAACAATGAACTTCCGTTAGGTGAAAGTTTAGAATTGACTGCAAAAAGA
GTGATTCCTTATTGGAATAAATTTATTTTACCACAAATAAAAAAAAGAAATAGAGTTCTTATTGTAGCACATGGAAATTC
TCTACGTGCATTAATTCAATTTTTAAATAAAATAGATAATAAAAAAATTTTAGAATTAAACATTCCAACTGCAACGCCAA
TTATCCTAGAATTCAATGAAGAATATAATTCTATTAAATGGTATTATTTATAA

Upstream 100 bases:

>100_bases
TTGTACTTTTATATTCATAAAAATTAATTTTTTATTTAGTCAAAAACTAATTTTTAATCAAATAATGATACACTTATATA
TCAAAAATAGAAGATGAAAA

Downstream 100 bases:

>100_bases
TCAATTATTTAAAATAAAATATTTTTCTGTCAAAAATTACTATGTATAAAAAAAATTTTTTAATATTTTTAATAATTTTA
AAAAAAATTACATACAAAAA

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MKTNKLVLIRHGQSKWNKLNKFTGWHDIELSDNGINEALKAGSLLKKEKFFFDYAHTSMLKRAIHTLRYILDTLDQSWLP
VQKSWRLNERHYGALEGLNKDEMISKYGEEQVNLWRRSFEIIPPQIRLNDKRFPGNDIRYSNIDNNELPLGESLELTAKR
VIPYWNKFILPQIKKRNRVLIVAHGNSLRALIQFLNKIDNKKILELNIPTATPIILEFNEEYNSIKWYYL

Sequences:

>Translated_230_residues
MKTNKLVLIRHGQSKWNKLNKFTGWHDIELSDNGINEALKAGSLLKKEKFFFDYAHTSMLKRAIHTLRYILDTLDQSWLP
VQKSWRLNERHYGALEGLNKDEMISKYGEEQVNLWRRSFEIIPPQIRLNDKRFPGNDIRYSNIDNNELPLGESLELTAKR
VIPYWNKFILPQIKKRNRVLIVAHGNSLRALIQFLNKIDNKKILELNIPTATPIILEFNEEYNSIKWYYL
>Mature_230_residues
MKTNKLVLIRHGQSKWNKLNKFTGWHDIELSDNGINEALKAGSLLKKEKFFFDYAHTSMLKRAIHTLRYILDTLDQSWLP
VQKSWRLNERHYGALEGLNKDEMISKYGEEQVNLWRRSFEIIPPQIRLNDKRFPGNDIRYSNIDNNELPLGESLELTAKR
VIPYWNKFILPQIKKRNRVLIVAHGNSLRALIQFLNKIDNKKILELNIPTATPIILEFNEEYNSIKWYYL

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=231, Percent_Identity=50.2164502164502, Blast_Score=244, Evalue=6e-65,
Organism=Homo sapiens, GI4505753, Length=228, Percent_Identity=47.8070175438597, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI71274132, Length=228, Percent_Identity=45.6140350877193, Blast_Score=210, Evalue=8e-55,
Organism=Homo sapiens, GI4502445, Length=229, Percent_Identity=44.9781659388646, Blast_Score=207, Evalue=8e-54,
Organism=Homo sapiens, GI40353764, Length=229, Percent_Identity=44.9781659388646, Blast_Score=207, Evalue=8e-54,
Organism=Homo sapiens, GI310129614, Length=165, Percent_Identity=47.8787878787879, Blast_Score=158, Evalue=4e-39,
Organism=Escherichia coli, GI1786970, Length=230, Percent_Identity=59.1304347826087, Blast_Score=304, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6322697, Length=227, Percent_Identity=47.5770925110132, Blast_Score=214, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6324516, Length=280, Percent_Identity=30, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6320183, Length=279, Percent_Identity=27.9569892473118, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646216, Length=219, Percent_Identity=48.4018264840183, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI85725270, Length=224, Percent_Identity=46.4285714285714, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI85725272, Length=224, Percent_Identity=46.4285714285714, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24650981, Length=224, Percent_Identity=46.4285714285714, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI28571817, Length=222, Percent_Identity=40.0900900900901, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI28571815, Length=222, Percent_Identity=40.0900900900901, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24648979, Length=222, Percent_Identity=40.0900900900901, Blast_Score=178, Evalue=2e-45,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_BUCAP (Q8K9N1)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660638.1
- ProteinModelPortal:   Q8K9N1
- SMR:   Q8K9N1
- EnsemblBacteria:   EBBUCT00000000355
- GeneID:   1005498
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg294
- GeneTree:   EBGT00050000008044
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- ProtClustDB:   PRK14115
- BioCyc:   BAPH198804:BUSG294-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 27265; Mature: 27265

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 11-11 ACT_SITE 184-184

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTNKLVLIRHGQSKWNKLNKFTGWHDIELSDNGINEALKAGSLLKKEKFFFDYAHTSML
CCCCCEEEEECCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KRAIHTLRYILDTLDQSWLPVQKSWRLNERHYGALEGLNKDEMISKYGEEQVNLWRRSFE
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHCHHHHHHHHHHHH
IIPPQIRLNDKRFPGNDIRYSNIDNNELPLGESLELTAKRVIPYWNKFILPQIKKRNRVL
CCCCEEEECCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCCCCEE
IVAHGNSLRALIQFLNKIDNKKILELNIPTATPIILEFNEEYNSIKWYYL
EEECCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEC
>Mature Secondary Structure
MKTNKLVLIRHGQSKWNKLNKFTGWHDIELSDNGINEALKAGSLLKKEKFFFDYAHTSML
CCCCCEEEEECCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KRAIHTLRYILDTLDQSWLPVQKSWRLNERHYGALEGLNKDEMISKYGEEQVNLWRRSFE
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHCHHHHHHHHHHHH
IIPPQIRLNDKRFPGNDIRYSNIDNNELPLGESLELTAKRVIPYWNKFILPQIKKRNRVL
CCCCEEEECCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCCCCEE
IVAHGNSLRALIQFLNKIDNKKILELNIPTATPIILEFNEEYNSIKWYYL
EEECCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438