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The map label for this gene is gnd

Identifier: 21672392

GI number: 21672392

Start: 112092

End: 113513

Strand: Direct

Name: gnd

Synonym: BUsg100

Alternate gene names: 21672392

Gene position: 112092-113513 (Clockwise)

Preceding gene: 21672391

Following gene: 21672393

Centisome position: 17.47

GC content: 27.99

Gene sequence:

>1422_bases
ATGTTAAAGCAACAAGTTGGTGTTATAGGAATGGCAGTAATGGGAAGAAATTTAGCATTAAACATTGAAAGTAAGAAGTA
TACGGTATCTATTTTTAATAGAACTCAATCTGTAACCGAAGAAGTTATCAATAATAACAAAGAAAAAAAAATTTTTCCAT
ATTTTTCTATTAAAGATTTTGTAAATTCATTAAGAAAACCTAGATGTATTTTACTCATGGTAAAATCAGGGCAACCTACA
GATGAAACTATTCAATTTATTCTTCCTTATTTAAATAAAGGAGATATATTGATTGATGGTGGAAATACCTTTTATAAAGA
CTCTATTAGAAGAAGTAATGATTTAATGAAATGTGGCATTAATTTTATCGGAATGGGTGTATCTGGAGGCGAGTTAGGAG
CATTAAATGGTCCATCTATTATGCCAGGTGGATCCAGGGAAGCATATGATCTAGTTTCTTCTATGTTAAAGAAAATATCT
GCGAAATTTAAAAATGAACCATGTGTTAGTTATATTGGTCCAAATGGCGCTGGTCATTATGTTAAAATGATTCACAATGG
TATTGAATATGGTGATATGCAATTAATATCAGAATCATATTTTATATTAAAAAATGTATTGAATATGAAAAATGAGGAAT
TATCTAATACATTTTCTCAATGGAATAAAGGTGAGTTAAATAGTTATTTAATTGAAATAACAAAAAATATTTTTCTTAAA
AAAGAAAAAGATGGTATTCATTATTTAATAGATTCTATATTAGATCACGCAGAAGATAAAGGCACCGGTAAATGGATTAG
TCAAGATGCTTTAGAACTTCATGAACCGCTCTCACTCATTACTGAATCTGTTTTCGCAAGATATTTGTCTTCTCTTAAAG
ATCAACGTCTTATTGCATCAAAAATTTTAAAAGGTCCGATTTTAAAATGTATATCTTCTCAGAATAAAGAACTTTTTGTT
GAAGAAGTACGAAGAGCTTTATATTTAGGTAAAATAATTTCCTATGCACAAGGTTTCTCTCAATTAAAAAAAGCTTCAGA
AAAATATTCTTGGAATTTACAATATGGTAAAATTGCTAAGATTTTTAGAGCTGGTTGTATTATTCGCGCTGATTTTTTAG
AAAGAATAACTGATGCATTTAAAAGTAACAATGTAACTAACTTGTTATTGACACCTTATTTTTCAGAAATATCTAATAAA
TATGAAAAATCTTTACGTTATATTACCTCATATGCAATAAAATACGGTATTCCTGTTCCTACTTTTGCATCCGCTATATC
ATATTACGATAATTATCGAACAATGTCTTCGTCTGCAAATTTAATTCAAGCTCAAAGAGATTATTTTGGAGCACATACTT
ATAGAAGAACTGATAAAAAAGGATATTTTCATACGAATTGGTTAACTAAAAAAGAGCTTTAA

Upstream 100 bases:

>100_bases
TTGTAATATCATTTATTGTGTAAGAATATAGAATGAAACATAAATAGAATTTAAAAAATATTTTTTTTGTAAATTATAAG
ATGTAAAATTGGAGAAAAAA

Downstream 100 bases:

>100_bases
TTGTTAATTTAAAATTAATTGTAGAACTATTTTTTAGTTTTTTATTATAGAATAGCAGAAGATAATAAAATACATCTCTC
TGCTATTAATAAAAATTATT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MLKQQVGVIGMAVMGRNLALNIESKKYTVSIFNRTQSVTEEVINNNKEKKIFPYFSIKDFVNSLRKPRCILLMVKSGQPT
DETIQFILPYLNKGDILIDGGNTFYKDSIRRSNDLMKCGINFIGMGVSGGELGALNGPSIMPGGSREAYDLVSSMLKKIS
AKFKNEPCVSYIGPNGAGHYVKMIHNGIEYGDMQLISESYFILKNVLNMKNEELSNTFSQWNKGELNSYLIEITKNIFLK
KEKDGIHYLIDSILDHAEDKGTGKWISQDALELHEPLSLITESVFARYLSSLKDQRLIASKILKGPILKCISSQNKELFV
EEVRRALYLGKIISYAQGFSQLKKASEKYSWNLQYGKIAKIFRAGCIIRADFLERITDAFKSNNVTNLLLTPYFSEISNK
YEKSLRYITSYAIKYGIPVPTFASAISYYDNYRTMSSSANLIQAQRDYFGAHTYRRTDKKGYFHTNWLTKKEL

Sequences:

>Translated_473_residues
MLKQQVGVIGMAVMGRNLALNIESKKYTVSIFNRTQSVTEEVINNNKEKKIFPYFSIKDFVNSLRKPRCILLMVKSGQPT
DETIQFILPYLNKGDILIDGGNTFYKDSIRRSNDLMKCGINFIGMGVSGGELGALNGPSIMPGGSREAYDLVSSMLKKIS
AKFKNEPCVSYIGPNGAGHYVKMIHNGIEYGDMQLISESYFILKNVLNMKNEELSNTFSQWNKGELNSYLIEITKNIFLK
KEKDGIHYLIDSILDHAEDKGTGKWISQDALELHEPLSLITESVFARYLSSLKDQRLIASKILKGPILKCISSQNKELFV
EEVRRALYLGKIISYAQGFSQLKKASEKYSWNLQYGKIAKIFRAGCIIRADFLERITDAFKSNNVTNLLLTPYFSEISNK
YEKSLRYITSYAIKYGIPVPTFASAISYYDNYRTMSSSANLIQAQRDYFGAHTYRRTDKKGYFHTNWLTKKEL
>Mature_473_residues
MLKQQVGVIGMAVMGRNLALNIESKKYTVSIFNRTQSVTEEVINNNKEKKIFPYFSIKDFVNSLRKPRCILLMVKSGQPT
DETIQFILPYLNKGDILIDGGNTFYKDSIRRSNDLMKCGINFIGMGVSGGELGALNGPSIMPGGSREAYDLVSSMLKKIS
AKFKNEPCVSYIGPNGAGHYVKMIHNGIEYGDMQLISESYFILKNVLNMKNEELSNTFSQWNKGELNSYLIEITKNIFLK
KEKDGIHYLIDSILDHAEDKGTGKWISQDALELHEPLSLITESVFARYLSSLKDQRLIASKILKGPILKCISSQNKELFV
EEVRRALYLGKIISYAQGFSQLKKASEKYSWNLQYGKIAKIFRAGCIIRADFLERITDAFKSNNVTNLLLTPYFSEISNK
YEKSLRYITSYAIKYGIPVPTFASAISYYDNYRTMSSSANLIQAQRDYFGAHTYRRTDKKGYFHTNWLTKKEL

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI40068518, Length=471, Percent_Identity=50.1061571125265, Blast_Score=446, Evalue=1e-125,
Organism=Escherichia coli, GI1788341, Length=470, Percent_Identity=65.7446808510638, Blast_Score=659, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=46.7091295116773, Blast_Score=451, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6321695, Length=453, Percent_Identity=48.1236203090508, Blast_Score=449, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6321977, Length=456, Percent_Identity=48.6842105263158, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24639279, Length=468, Percent_Identity=47.008547008547, Blast_Score=436, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 6PGD_BUCAP (Q9ZHD9)

Other databases:

- EMBL:   AF067228
- EMBL:   AE013218
- RefSeq:   NP_660459.1
- ProteinModelPortal:   Q9ZHD9
- SMR:   Q9ZHD9
- EnsemblBacteria:   EBBUCT00000000015
- GeneID:   1005917
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg100
- GeneTree:   EBGT00050000007968
- HOGENOM:   HBG286913
- OMA:   CIIRAGF
- ProtClustDB:   PRK09287
- BioCyc:   BAPH198804:BUSG100-MONOMER
- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183
- Gene3D:   G3DSA:1.20.5.320
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PIRSF:   PIRSF000109
- PRINTS:   PR00076
- TIGRFAMs:   TIGR00873

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2; SSF48179 6DGDH_C_like

EC number: =1.1.1.44

Molecular weight: Translated: 53806; Mature: 53806

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS00461 6PGD

Important sites: ACT_SITE 182-182 ACT_SITE 189-189 BINDING 102-102 BINDING 102-102 BINDING 190-190 BINDING 260-260 BINDING 287-287 BINDING 446-446 BINDING 452-452

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKQQVGVIGMAVMGRNLALNIESKKYTVSIFNRTQSVTEEVINNNKEKKIFPYFSIKDF
CCCHHHHHHHHHHHCCCEEEEECCCEEEEEEHHHHHHHHHHHHCCCCCCEEECCCCHHHH
VNSLRKPRCILLMVKSGQPTDETIQFILPYLNKGDILIDGGNTFYKDSIRRSNDLMKCGI
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCHHHHHCC
NFIGMGVSGGELGALNGPSIMPGGSREAYDLVSSMLKKISAKFKNEPCVSYIGPNGAGHY
HHEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHH
VKMIHNGIEYGDMQLISESYFILKNVLNMKNEELSNTFSQWNKGELNSYLIEITKNIFLK
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEE
KEKDGIHYLIDSILDHAEDKGTGKWISQDALELHEPLSLITESVFARYLSSLKDQRLIAS
ECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KILKGPILKCISSQNKELFVEEVRRALYLGKIISYAQGFSQLKKASEKYSWNLQYGKIAK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCHHHHHH
IFRAGCIIRADFLERITDAFKSNNVTNLLLTPYFSEISNKYEKSLRYITSYAIKYGIPVP
HHHHCCHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
TFASAISYYDNYRTMSSSANLIQAQRDYFGAHTYRRTDKKGYFHTNWLTKKEL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCCCEEECCCCCCCC
>Mature Secondary Structure
MLKQQVGVIGMAVMGRNLALNIESKKYTVSIFNRTQSVTEEVINNNKEKKIFPYFSIKDF
CCCHHHHHHHHHHHCCCEEEEECCCEEEEEEHHHHHHHHHHHHCCCCCCEEECCCCHHHH
VNSLRKPRCILLMVKSGQPTDETIQFILPYLNKGDILIDGGNTFYKDSIRRSNDLMKCGI
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCHHHHHCC
NFIGMGVSGGELGALNGPSIMPGGSREAYDLVSSMLKKISAKFKNEPCVSYIGPNGAGHY
HHEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHH
VKMIHNGIEYGDMQLISESYFILKNVLNMKNEELSNTFSQWNKGELNSYLIEITKNIFLK
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEE
KEKDGIHYLIDSILDHAEDKGTGKWISQDALELHEPLSLITESVFARYLSSLKDQRLIAS
ECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KILKGPILKCISSQNKELFVEEVRRALYLGKIISYAQGFSQLKKASEKYSWNLQYGKIAK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCHHHHHH
IFRAGCIIRADFLERITDAFKSNNVTNLLLTPYFSEISNKYEKSLRYITSYAIKYGIPVP
HHHHCCHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
TFASAISYYDNYRTMSSSANLIQAQRDYFGAHTYRRTDKKGYFHTNWLTKKEL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9767718; 12089438