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The map label for this gene is gcp

Identifier: 21672348

GI number: 21672348

Start: 63281

End: 64294

Strand: Direct

Name: gcp

Synonym: BUsg055

Alternate gene names: 21672348

Gene position: 63281-64294 (Clockwise)

Preceding gene: 30410811

Following gene: 21672351

Centisome position: 9.87

GC content: 29.09

Gene sequence:

>1014_bases
ATGAAAGTTTTAGGTATTGAAACATCCTGTGATGATACTGGTATAGCTATTTATGATGTTTCTAAAGGTTTGTTAATTAA
TGAATTACATAGTCAAAAAAAAATACATGCTAATTATGGAGGTATTATTCCAGAATTAGCATCTCGTGAACATACAAGGA
AAATAATTTTTTTATTAGATAAAATTTTTAAAGAAAAAAATATTATGAAGGAAATTGATCTTATTGCATATACTGCGGGA
CCTGGTTTAGCTGGTTCTTTATTAGTTGGTGCTACATTTGCATGTTCTTTAGGTTTTTCTTTAAATATTCCTGTTTTACC
TGTTAATCATATGGAAGCGCATTTATTATCACCAATGTTAGAGTATAAGTCAATGCAATTTCCATTTATCGCATTGTTAG
TTTCCGGAAAACATACACAAATAATCGCTGCTTATGAATTAGGAAAATATGAAATATTAGGAAATTCTTTAGATGATGCA
GCAGGTGAAGCTTTTGATAAAGTATCAAAAATGTTAGGATTGAAATATCCGAGTGGACGTGAACTATCTAGTTTAGCTGC
TCAGGGAATAAAAAATTATTTTTATTTTCCTCGACCTATGATACATCATTCAAGCTTAAATTTTAGTTTTTCAGGTTTAA
AAACTTTTACTTCTAAAGTTATTAGTAATAATACTTTAAATATTCAACAAAAAGCTAATATTGCAAGAGCTTTTGAAGAT
GCAGTAATTGATGTACTATTAATTAAAACTAAAAAAGCGTTATACAAGAAAGGATGGAAACGTTTAGTTATAGCAGGCGG
TGTCAGTGCAAATACTGTATTACGCAAAAGATCGAAAGACATGATGGAAAACGTTTTTCATGGAAAAGTTTTTTATTCTT
CATTAAAATTTTGTACAGATAATGGTGCCATGATTGCCTATCTTGGATCTCTACGTTATAAAGAAGCAAGCGTTTCTCAA
TTGGAGATAATTGTGAAACCAAAATGGTCTATAGATAAGTTATCTTATATTTAA

Upstream 100 bases:

>100_bases
TAATTTTTCTTAAAAACTTAGTAAATAAATGATTTTTAATAGTATCTAACTTCAGCAGTGTTAATGATTTTAAATTAATT
TTATAGGTGTATGAAAAAAA

Downstream 100 bases:

>100_bases
TAAATATTAGTGTTTAACAATTTCTTTTTTTTATAAAATTTTTTATTTTTTATTTTGAACATAGAGAATTAAGTCTTTAA
TAGTTAATATTTTCATTTTT

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKVLGIETSCDDTGIAIYDVSKGLLINELHSQKKIHANYGGIIPELASREHTRKIIFLLDKIFKEKNIMKEIDLIAYTAG
PGLAGSLLVGATFACSLGFSLNIPVLPVNHMEAHLLSPMLEYKSMQFPFIALLVSGKHTQIIAAYELGKYEILGNSLDDA
AGEAFDKVSKMLGLKYPSGRELSSLAAQGIKNYFYFPRPMIHHSSLNFSFSGLKTFTSKVISNNTLNIQQKANIARAFED
AVIDVLLIKTKKALYKKGWKRLVIAGGVSANTVLRKRSKDMMENVFHGKVFYSSLKFCTDNGAMIAYLGSLRYKEASVSQ
LEIIVKPKWSIDKLSYI

Sequences:

>Translated_337_residues
MKVLGIETSCDDTGIAIYDVSKGLLINELHSQKKIHANYGGIIPELASREHTRKIIFLLDKIFKEKNIMKEIDLIAYTAG
PGLAGSLLVGATFACSLGFSLNIPVLPVNHMEAHLLSPMLEYKSMQFPFIALLVSGKHTQIIAAYELGKYEILGNSLDDA
AGEAFDKVSKMLGLKYPSGRELSSLAAQGIKNYFYFPRPMIHHSSLNFSFSGLKTFTSKVISNNTLNIQQKANIARAFED
AVIDVLLIKTKKALYKKGWKRLVIAGGVSANTVLRKRSKDMMENVFHGKVFYSSLKFCTDNGAMIAYLGSLRYKEASVSQ
LEIIVKPKWSIDKLSYI
>Mature_337_residues
MKVLGIETSCDDTGIAIYDVSKGLLINELHSQKKIHANYGGIIPELASREHTRKIIFLLDKIFKEKNIMKEIDLIAYTAG
PGLAGSLLVGATFACSLGFSLNIPVLPVNHMEAHLLSPMLEYKSMQFPFIALLVSGKHTQIIAAYELGKYEILGNSLDDA
AGEAFDKVSKMLGLKYPSGRELSSLAAQGIKNYFYFPRPMIHHSSLNFSFSGLKTFTSKVISNNTLNIQQKANIARAFED
AVIDVLLIKTKKALYKKGWKRLVIAGGVSANTVLRKRSKDMMENVFHGKVFYSSLKFCTDNGAMIAYLGSLRYKEASVSQ
LEIIVKPKWSIDKLSYI

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=336, Percent_Identity=33.6309523809524, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI8923380, Length=312, Percent_Identity=29.1666666666667, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1789445, Length=335, Percent_Identity=57.910447761194, Blast_Score=417, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17557464, Length=332, Percent_Identity=31.9277108433735, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71995670, Length=320, Percent_Identity=31.25, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320099, Length=367, Percent_Identity=33.5149863760218, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6322891, Length=320, Percent_Identity=27.5, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20129063, Length=354, Percent_Identity=35.0282485875706, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI21357207, Length=334, Percent_Identity=29.3413173652695, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_BUCAP (Q8KA56)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660415.1
- ProteinModelPortal:   Q8KA56
- SMR:   Q8KA56
- MEROPS:   M22.001
- EnsemblBacteria:   EBBUCT00000000529
- GeneID:   1005871
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg055
- GeneTree:   EBGT00050000008147
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   BAPH198804:BUSG055-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 37383; Mature: 37383

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLGIETSCDDTGIAIYDVSKGLLINELHSQKKIHANYGGIIPELASREHTRKIIFLLD
CEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHEEECCCCCCCHHHHCHHHHHHHHHHHH
KIFKEKNIMKEIDLIAYTAGPGLAGSLLVGATFACSLGFSLNIPVLPVNHMEAHLLSPML
HHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHH
EYKSMQFPFIALLVSGKHTQIIAAYELGKYEILGNSLDDAAGEAFDKVSKMLGLKYPSGR
HHHCCCCCEEEEEECCCCEEEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCC
ELSSLAAQGIKNYFYFPRPMIHHSSLNFSFSGLKTFTSKVISNNTLNIQQKANIARAFED
CHHHHHHHHHHHCCCCCCCEEECCCCCEEHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHH
AVIDVLLIKTKKALYKKGWKRLVIAGGVSANTVLRKRSKDMMENVFHGKVFYSSLKFCTD
HHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
NGAMIAYLGSLRYKEASVSQLEIIVKPKWSIDKLSYI
CCCEEEEECCCCCCCCCCCEEEEEECCCCCCHHHCCC
>Mature Secondary Structure
MKVLGIETSCDDTGIAIYDVSKGLLINELHSQKKIHANYGGIIPELASREHTRKIIFLLD
CEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHEEECCCCCCCHHHHCHHHHHHHHHHHH
KIFKEKNIMKEIDLIAYTAGPGLAGSLLVGATFACSLGFSLNIPVLPVNHMEAHLLSPML
HHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHH
EYKSMQFPFIALLVSGKHTQIIAAYELGKYEILGNSLDDAAGEAFDKVSKMLGLKYPSGR
HHHCCCCCEEEEEECCCCEEEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCC
ELSSLAAQGIKNYFYFPRPMIHHSSLNFSFSGLKTFTSKVISNNTLNIQQKANIARAFED
CHHHHHHHHHHHCCCCCCCEEECCCCCEEHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHH
AVIDVLLIKTKKALYKKGWKRLVIAGGVSANTVLRKRSKDMMENVFHGKVFYSSLKFCTD
HHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
NGAMIAYLGSLRYKEASVSQLEIIVKPKWSIDKLSYI
CCCEEEEECCCCCCCCCCCEEEEEECCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438