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The map label for this gene is alsR [H]

Identifier: 30263615

GI number: 30263615

Start: 3431168

End: 3432073

Strand: Reverse

Name: alsR [H]

Synonym: BA_3729

Alternate gene names: 30263615

Gene position: 3432073-3431168 (Counterclockwise)

Preceding gene: 30263618

Following gene: 30263614

Centisome position: 65.66

GC content: 35.76

Gene sequence:

>906_bases
ATGGAATTACGGCATTTGCAATATTTTGTTGTAGTGGCAGAGGAGTTACACTTTGGACGAGCAGCTGCTCGTTTACAAAT
GACACAACCACCGCTTAGTCAACAAATTCAGCAATTAGAAAAAGAAATGGGAGTTATGTTATTTTCAAGAACGAAGAGAA
AGGTTGAATTAACAGAAGCTGGAGAAATGTTTTTGAAAGAAGTAAAAAAAGCGTTTGAACAAATTGAAAAAGCTGTAGAG
ATTGCACAAAGTGCCCAAAGGGGAGAAGTGGGCTCACTTTCAATTGGTTTTGTAGGTGCGGCGATATATGATATTTTACC
ATCTATCGTAAGAGAGTATAGAAAGAAATTTCCGAGGGTATCTGTTGCGTTACATGAATTATCTACTCCAGATCAAGTGC
ATGCACTTCATGATAATCGTATTGATATTGGATTTTTGCGTCCACCAATCCCAACACAATTATTAGAATTAGAGCCAATT
CAAAAACTATCTTGTACTTTATGTTTACCGAAGGCTCATCCACTTGCAGAGAAAGATGAAATACATATAGAAGATTTACG
GGATGAACCGTTTGTATTTATTACGAGACCAGTATGGCCAGCTTTGTATGATACGATTTTATCCCTTTGTAGAGAAGTTG
GATTTAGCCCGCGTATTGTGCAAGAAGCAACGGAATATCAAACAGTTATGGGACTTGTAGCAGCAGGGATTGGAATTACA
GTAATACCGGTATCGGCAAATAAATTATATAAAACAGAAGTTGTATATAAAGAGCTATATGATTCTAATTTTGTTGCAGA
AATGTCAGTCGCTTACAAAAAAATGAATAGCAATCCAGAGCTTTTAGAGTTTTTAAAAATTGCAAGAGAGAAGAAAAGAA
TAGAAGTTGAGGATGAGATTAATTAA

Upstream 100 bases:

>100_bases
AATTTCTACTATACGTTCATTCGAAAAATTTGTCTAATATATAAATTATATGTTATTAATATATTAGACGTATTAATTGA
AATGGAAAAGGGTGTCCAAA

Downstream 100 bases:

>100_bases
GTTATTAAAAAGTACACCTCATTAAACACTAAAGCGGAAATGTAATTATATTGCATTTCCGCTTTAGTGTTCTTTTTTTA
GTTCTATACGAAAGAGATAA

Product: als operon regulatory protein AlsR, putative

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MELRHLQYFVVVAEELHFGRAAARLQMTQPPLSQQIQQLEKEMGVMLFSRTKRKVELTEAGEMFLKEVKKAFEQIEKAVE
IAQSAQRGEVGSLSIGFVGAAIYDILPSIVREYRKKFPRVSVALHELSTPDQVHALHDNRIDIGFLRPPIPTQLLELEPI
QKLSCTLCLPKAHPLAEKDEIHIEDLRDEPFVFITRPVWPALYDTILSLCREVGFSPRIVQEATEYQTVMGLVAAGIGIT
VIPVSANKLYKTEVVYKELYDSNFVAEMSVAYKKMNSNPELLEFLKIAREKKRIEVEDEIN

Sequences:

>Translated_301_residues
MELRHLQYFVVVAEELHFGRAAARLQMTQPPLSQQIQQLEKEMGVMLFSRTKRKVELTEAGEMFLKEVKKAFEQIEKAVE
IAQSAQRGEVGSLSIGFVGAAIYDILPSIVREYRKKFPRVSVALHELSTPDQVHALHDNRIDIGFLRPPIPTQLLELEPI
QKLSCTLCLPKAHPLAEKDEIHIEDLRDEPFVFITRPVWPALYDTILSLCREVGFSPRIVQEATEYQTVMGLVAAGIGIT
VIPVSANKLYKTEVVYKELYDSNFVAEMSVAYKKMNSNPELLEFLKIAREKKRIEVEDEIN
>Mature_301_residues
MELRHLQYFVVVAEELHFGRAAARLQMTQPPLSQQIQQLEKEMGVMLFSRTKRKVELTEAGEMFLKEVKKAFEQIEKAVE
IAQSAQRGEVGSLSIGFVGAAIYDILPSIVREYRKKFPRVSVALHELSTPDQVHALHDNRIDIGFLRPPIPTQLLELEPI
QKLSCTLCLPKAHPLAEKDEIHIEDLRDEPFVFITRPVWPALYDTILSLCREVGFSPRIVQEATEYQTVMGLVAAGIGIT
VIPVSANKLYKTEVVYKELYDSNFVAEMSVAYKKMNSNPELLEFLKIAREKKRIEVEDEIN

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=275, Percent_Identity=38.9090909090909, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI2367136, Length=286, Percent_Identity=33.5664335664336, Blast_Score=167, Evalue=8e-43,
Organism=Escherichia coli, GI1788887, Length=292, Percent_Identity=35.6164383561644, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1790399, Length=248, Percent_Identity=31.8548387096774, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI157672245, Length=242, Percent_Identity=29.3388429752066, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI145693105, Length=245, Percent_Identity=24.8979591836735, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=29.0836653386454, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789204, Length=251, Percent_Identity=27.0916334661355, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788748, Length=264, Percent_Identity=26.5151515151515, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788297, Length=256, Percent_Identity=26.953125, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI87081904, Length=184, Percent_Identity=31.5217391304348, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790208, Length=298, Percent_Identity=26.510067114094, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787806, Length=248, Percent_Identity=23.3870967741935, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1790262, Length=243, Percent_Identity=26.3374485596708, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1787589, Length=123, Percent_Identity=38.2113821138211, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789506, Length=242, Percent_Identity=25.2066115702479, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788481, Length=197, Percent_Identity=27.4111675126904, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787601, Length=177, Percent_Identity=25.4237288135593, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789639, Length=248, Percent_Identity=23.7903225806452, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1787949, Length=302, Percent_Identity=23.841059602649, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789173, Length=257, Percent_Identity=25.6809338521401, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786401, Length=155, Percent_Identity=24.5161290322581, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787128, Length=144, Percent_Identity=27.0833333333333, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34320; Mature: 34320

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHLQYFVVVAEELHFGRAAARLQMTQPPLSQQIQQLEKEMGVMLFSRTKRKVELTEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHH
GEMFLKEVKKAFEQIEKAVEIAQSAQRGEVGSLSIGFVGAAIYDILPSIVREYRKKFPRV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCHH
SVALHELSTPDQVHALHDNRIDIGFLRPPIPTQLLELEPIQKLSCTLCLPKAHPLAEKDE
HHHHHHCCCCHHHHHHCCCCEEEEECCCCCCHHHHCCCCHHHHHHEEECCCCCCCCCCCC
IHIEDLRDEPFVFITRPVWPALYDTILSLCREVGFSPRIVQEATEYQTVMGLVAAGIGIT
EEHCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEE
VIPVSANKLYKTEVVYKELYDSNFVAEMSVAYKKMNSNPELLEFLKIAREKKRIEVEDEI
EEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCC
N
C
>Mature Secondary Structure
MELRHLQYFVVVAEELHFGRAAARLQMTQPPLSQQIQQLEKEMGVMLFSRTKRKVELTEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHH
GEMFLKEVKKAFEQIEKAVEIAQSAQRGEVGSLSIGFVGAAIYDILPSIVREYRKKFPRV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCHH
SVALHELSTPDQVHALHDNRIDIGFLRPPIPTQLLELEPIQKLSCTLCLPKAHPLAEKDE
HHHHHHCCCCHHHHHHCCCCEEEEECCCCCCHHHHCCCCHHHHHHEEECCCCCCCCCCCC
IHIEDLRDEPFVFITRPVWPALYDTILSLCREVGFSPRIVQEATEYQTVMGLVAAGIGIT
EEHCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEE
VIPVSANKLYKTEVVYKELYDSNFVAEMSVAYKKMNSNPELLEFLKIAREKKRIEVEDEI
EEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]