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The map label for this gene is parE [H]

Identifier: 30263545

GI number: 30263545

Start: 3365003

End: 3366967

Strand: Reverse

Name: parE [H]

Synonym: BA_3657

Alternate gene names: 30263545

Gene position: 3366967-3365003 (Counterclockwise)

Preceding gene: 30263546

Following gene: 30263544

Centisome position: 64.41

GC content: 38.93

Gene sequence:

>1965_bases
TTGGCGAAGCATCAGTTCCAATATAATGAAGATGCGATTCAAGTGTTAGAAGGACTTGAAGCCGTTCGAAAACGCCCGGG
TATGTATATCGGGAGCACGGACAGCCGTGGATTGCATCATTTAGTATACGAAATAGTAGATAACTCCGTTGATGAAGCGT
TAGCGGGATTTGGCGACGAAATTTCTGTCGTAATACATAAAGATAATAGTATTAGCGTTATAGATAAAGGGCGAGGAATG
CCTACGGGAATGCATAAGCTTGGAAAACCTACACCAGAAGTTATTTTAACTGTACTTCATGCCGGTGGTAAGTTTGGTCA
AGGTGGTTACAAAACGAGTGGTGGTTTACACGGTGTTGGGGCATCAGTTGTAAACGCCTTATCTGAATGGTTAGTCGTAA
CGATTAAGCGTGACGGAAATATTTATGAACAACGCTTTGAAAATGGCGGTGTTCCTGTAACGACGCTTGAGAAAATCGGA
AAGACGAAAGAATCTGGTACAACAATGCATTTCAAACCAGATACAACGATTTTCAGTACAACAAATTACAATTATGAAAC
ATTATGTGAGAGATTACGCGAATCTGCATTCTTATTAAAAGGGATGAAAATCTCAATAAAAGATGAAAGAAATGATTTAG
AAGATGTCTTTCATTATGAAACAGGAATTGAAGCTTTCGTTTCCTATTTAAACGAAGAAAAAGATTCAATTCACCCAGTT
GTATACTTCACTGGTGAACAAAATGGGATTGAAGCAGAATTAGCATTTCAATTTAACGATGGCTACTCAGAAAATATTCT
TTCGTTTGTAAATAATGTACGTACAAAAGATGGTGGAACACATGAAGCTGGATTTAAAACGGCGATGACACGTGTGTTTA
ATGAGTATGCTCGCAAAGTAGCACTATTAAAAGAAAAAGATAAAAACTTAGAAGGTACAGATATTCGTGAAGGTGTAGCA
GCTATCGTTTCTGTACGTGTACCAGAAGAAGTACTTCAGTTTGAAGGACAAACGAAGGGGAAACTAGGTACAAGTGAAGC
TCGTTCTTCAATTGATGCCATTGTATCAGAGCATTTAGCTTACTTTTTAGAAGAAAACCCGGACGTAGCTACACTTCTTG
TGAGAAAAGCAATTAAAGCAGCGCAAGCACGTGAAGCCGCTCGTAAAGCGAGAGAGGAAGCGCGTACTGGTAAAAAGAAA
AAGAAATCAGAAGGTACATTAAGTGGTAAGTTAACACCCGCACAATCACGTAACCCGCAGAAAAATGAACTGTACCTAGT
AGAGGGTGACTCTGCCGGTGGTTCTGCGAAACAAGGGCGAGATCGACGTTTCCAAGCGGTATTACCGTTACGTGGTAAAG
TAATTAATACAGAAAAAGCAAAGCTTGCTGATATTTTCAAAAATGAAGAGATTAATACAATCATTTATGCAATTGGCGGC
GGCGTAGGCAATGAATTTGATGTGGAAGACATTAACTACGATAAAGTTGTAATCATGACCGATGCCGATACAGACGGAGC
GCATATTCAAGTATTGTTATTAACATTCTTCTACAGATATATGAAACCACTTATCGAAGCTGGTAAAGTGTTTATCGCAC
TTCCACCTTTATACAAAGTAAGTAAAGGAAAAGGGAAAAGTGAAGTAATTGAATATGCATGGTCAGATGAAGAGTTAGAT
AGTGTAACGAAAAAAGTTGGAAAAGGTTACATGTTACAGCGTTACAAAGGACTTGGCGAAATGAATGCGGATCAATTATG
GGAAACAACGATGAATCCTGAAACACGTACATTAATTCGCGTGAAAATTGATGATGCAGCAAGAGCAGAGCGCCGCGTAA
CAACATTAATGGGCGATAAAGTAGAACCGCGCCGTAAATGGATTGAGCGTAATGTACAGTTCGGTATGCAAGAAGAAGGA
AATATTTTAGAAAATGAAATGATTATGGAGACGGAGGTGGAATAA

Upstream 100 bases:

>100_bases
ATATAAAAGAGATAAGATAACTTGCCAAAACTATAGTCGAGGCGTTATTCTATAATAGAAACATATGTTCTGATTTTGGA
TTAGGAAAGGGGCAAGGAGT

Downstream 100 bases:

>100_bases
CATGCAAGCAGAGAAGTTTCATGACCTCCCGCTTGAAGACGTGTTAGGTGACCGCTTTGCACGTTATAGTAAATATATTA
TTCAAGATCGCGCACTTCCA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 654; Mature: 653

Protein sequence:

>654_residues
MAKHQFQYNEDAIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGFGDEISVVIHKDNSISVIDKGRGM
PTGMHKLGKPTPEVILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVTIKRDGNIYEQRFENGGVPVTTLEKIG
KTKESGTTMHFKPDTTIFSTTNYNYETLCERLRESAFLLKGMKISIKDERNDLEDVFHYETGIEAFVSYLNEEKDSIHPV
VYFTGEQNGIEAELAFQFNDGYSENILSFVNNVRTKDGGTHEAGFKTAMTRVFNEYARKVALLKEKDKNLEGTDIREGVA
AIVSVRVPEEVLQFEGQTKGKLGTSEARSSIDAIVSEHLAYFLEENPDVATLLVRKAIKAAQAREAARKAREEARTGKKK
KKSEGTLSGKLTPAQSRNPQKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIYAIGG
GVGNEFDVEDINYDKVVIMTDADTDGAHIQVLLLTFFYRYMKPLIEAGKVFIALPPLYKVSKGKGKSEVIEYAWSDEELD
SVTKKVGKGYMLQRYKGLGEMNADQLWETTMNPETRTLIRVKIDDAARAERRVTTLMGDKVEPRRKWIERNVQFGMQEEG
NILENEMIMETEVE

Sequences:

>Translated_654_residues
MAKHQFQYNEDAIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGFGDEISVVIHKDNSISVIDKGRGM
PTGMHKLGKPTPEVILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVTIKRDGNIYEQRFENGGVPVTTLEKIG
KTKESGTTMHFKPDTTIFSTTNYNYETLCERLRESAFLLKGMKISIKDERNDLEDVFHYETGIEAFVSYLNEEKDSIHPV
VYFTGEQNGIEAELAFQFNDGYSENILSFVNNVRTKDGGTHEAGFKTAMTRVFNEYARKVALLKEKDKNLEGTDIREGVA
AIVSVRVPEEVLQFEGQTKGKLGTSEARSSIDAIVSEHLAYFLEENPDVATLLVRKAIKAAQAREAARKAREEARTGKKK
KKSEGTLSGKLTPAQSRNPQKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIYAIGG
GVGNEFDVEDINYDKVVIMTDADTDGAHIQVLLLTFFYRYMKPLIEAGKVFIALPPLYKVSKGKGKSEVIEYAWSDEELD
SVTKKVGKGYMLQRYKGLGEMNADQLWETTMNPETRTLIRVKIDDAARAERRVTTLMGDKVEPRRKWIERNVQFGMQEEG
NILENEMIMETEVE
>Mature_653_residues
AKHQFQYNEDAIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGFGDEISVVIHKDNSISVIDKGRGMP
TGMHKLGKPTPEVILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVTIKRDGNIYEQRFENGGVPVTTLEKIGK
TKESGTTMHFKPDTTIFSTTNYNYETLCERLRESAFLLKGMKISIKDERNDLEDVFHYETGIEAFVSYLNEEKDSIHPVV
YFTGEQNGIEAELAFQFNDGYSENILSFVNNVRTKDGGTHEAGFKTAMTRVFNEYARKVALLKEKDKNLEGTDIREGVAA
IVSVRVPEEVLQFEGQTKGKLGTSEARSSIDAIVSEHLAYFLEENPDVATLLVRKAIKAAQAREAARKAREEARTGKKKK
KSEGTLSGKLTPAQSRNPQKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIYAIGGG
VGNEFDVEDINYDKVVIMTDADTDGAHIQVLLLTFFYRYMKPLIEAGKVFIALPPLYKVSKGKGKSEVIEYAWSDEELDS
VTKKVGKGYMLQRYKGLGEMNADQLWETTMNPETRTLIRVKIDDAARAERRVTTLMGDKVEPRRKWIERNVQFGMQEEGN
ILENEMIMETEVE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=639, Percent_Identity=26.1345852895149, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI19913408, Length=661, Percent_Identity=24.0544629349471, Blast_Score=112, Evalue=8e-25,
Organism=Escherichia coli, GI48994957, Length=558, Percent_Identity=52.3297491039427, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1789408, Length=656, Percent_Identity=38.8719512195122, Blast_Score=426, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17535065, Length=679, Percent_Identity=24.8895434462445, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI212645845, Length=600, Percent_Identity=25, Blast_Score=106, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI212645657, Length=248, Percent_Identity=27.4193548387097, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=650, Percent_Identity=27.0769230769231, Blast_Score=116, Evalue=9e-27,
Organism=Drosophila melanogaster, GI17136538, Length=675, Percent_Identity=24.7407407407407, Blast_Score=117, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72968; Mature: 72836

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKHQFQYNEDAIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGFGDE
CCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHCCCCC
ISVVIHKDNSISVIDKGRGMPTGMHKLGKPTPEVILTVLHAGGKFGQGGYKTSGGLHGVG
EEEEEECCCCEEEEECCCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
ASVVNALSEWLVVTIKRDGNIYEQRFENGGVPVTTLEKIGKTKESGTTMHFKPDTTIFST
HHHHHHHHHHEEEEEECCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEECCCCEEEEC
TNYNYETLCERLRESAFLLKGMKISIKDERNDLEDVFHYETGIEAFVSYLNEEKDSIHPV
CCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
VYFTGEQNGIEAELAFQFNDGYSENILSFVNNVRTKDGGTHEAGFKTAMTRVFNEYARKV
EEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
ALLKEKDKNLEGTDIREGVAAIVSVRVPEEVLQFEGQTKGKLGTSEARSSIDAIVSEHLA
HHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
YFLEENPDVATLLVRKAIKAAQAREAARKAREEARTGKKKKKSEGTLSGKLTPAQSRNPQ
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCC
KNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIYAIGG
CCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECCCHHHHHHHHCCCCCCEEEEEECC
GVGNEFDVEDINYDKVVIMTDADTDGAHIQVLLLTFFYRYMKPLIEAGKVFIALPPLYKV
CCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
SKGKGKSEVIEYAWSDEELDSVTKKVGKGYMLQRYKGLGEMNADQLWETTMNPETRTLIR
CCCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEE
VKIDDAARAERRVTTLMGDKVEPRRKWIERNVQFGMQEEGNILENEMIMETEVE
EEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHCCEEEEECCC
>Mature Secondary Structure 
AKHQFQYNEDAIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGFGDE
CCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHCCCCC
ISVVIHKDNSISVIDKGRGMPTGMHKLGKPTPEVILTVLHAGGKFGQGGYKTSGGLHGVG
EEEEEECCCCEEEEECCCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
ASVVNALSEWLVVTIKRDGNIYEQRFENGGVPVTTLEKIGKTKESGTTMHFKPDTTIFST
HHHHHHHHHHEEEEEECCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEECCCCEEEEC
TNYNYETLCERLRESAFLLKGMKISIKDERNDLEDVFHYETGIEAFVSYLNEEKDSIHPV
CCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
VYFTGEQNGIEAELAFQFNDGYSENILSFVNNVRTKDGGTHEAGFKTAMTRVFNEYARKV
EEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
ALLKEKDKNLEGTDIREGVAAIVSVRVPEEVLQFEGQTKGKLGTSEARSSIDAIVSEHLA
HHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
YFLEENPDVATLLVRKAIKAAQAREAARKAREEARTGKKKKKSEGTLSGKLTPAQSRNPQ
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCC
KNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIYAIGG
CCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECCCHHHHHHHHCCCCCCEEEEEECC
GVGNEFDVEDINYDKVVIMTDADTDGAHIQVLLLTFFYRYMKPLIEAGKVFIALPPLYKV
CCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
SKGKGKSEVIEYAWSDEELDSVTKKVGKGYMLQRYKGLGEMNADQLWETTMNPETRTLIR
CCCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEE
VKIDDAARAERRVTTLMGDKVEPRRKWIERNVQFGMQEEGNILENEMIMETEVE
EEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]