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The map label for this gene is hemH [H]

Identifier: 21244937

GI number: 21244937

Start: 4978623

End: 4979585

Strand: Direct

Name: hemH [H]

Synonym: XAC4220

Alternate gene names: 21244937

Gene position: 4978623-4979585 (Clockwise)

Preceding gene: 77748764

Following gene: 21244938

Centisome position: 96.19

GC content: 68.33

Gene sequence:

>963_bases
GTGCGCATGAACACGACACCCGATACCGCCCTGCTGGTCGTCAACCTGGGCACCCCCGAATCGCCGACCGCCCCGGCCGT
GCGCCGCTACCTGGCCGAGTTCCTGAGCGACCGCCGCGTGGTCGCGATTCCGCCGTTGTTCTGGAAGCCGCTGCTGTATG
GGGTGATCCTGCCGATCCGCGGGCCGAAATCGGCCGAAAAATACGCCAAGGTGTGGTTGCCGGAGGGCTCGCCGCTGGCG
GTCTACACGCGCCGCCTAGCCGGCGGCCTGCAAGCGGTCATGCCCGACTGGCATGTGGAATGGGCCATGCGCTACGGCGA
GCCGGCGTTGCGCAAGACGCTGGACCGGCTGCGCGCACGCGGCATCAAGCGCATCGTGGTGCTGCCGCTGTATCCGCAGT
ACTCGACCACCACTACCGCCTCGATCCAGGACGTGGTGGATGCATGGCGCACCAGCGCGCCGGAGATTGCGGTGGAGGTG
ATCCAGGACTACTGCGAGGACACCGGCTGGGTGGCCGCGATCGCCGAGTCGATCCGCGCGCACTGGCAGGTGCATGGGCG
CAGCGAAAAGTTGATGTTCTCCTTCCACGGCCTGCCGCAGCGCGTGGCCGATGCCGGCGACCCGTATCCGCAGCAGTGCG
AACGCAGCGCGCAGGCGATTGTGGCAGCGCTGGGGCTGGGCGCGGACGAGTGGCAGATGGGCTACCAGTCGCGCTTCGGC
GCCGAGCGCTGGCTGCAGCCGTACGCCGAACCCACGCTGTGGAAACTGGCTGAAGGCGGCGTGCGCAGTTTCGACCTGGT
CTGCCCCGGCTTTGCCACCGACTGTCTGGAAACGCTGGAAGAAGTAGCGCTGGGCTTTTCCGAAACGCTGGCCGAACGTG
GCGCCACCCTCAGCTACATCCCCTGCCTCAACGCCAGCGATGCGCATGCGCACGCGCTGGCCGCCATGGCGCGCCGCGCG
TGA

Upstream 100 bases:

>100_bases
CGCAATGAATCGGTGGTGAGCGCAACCGGCATGGAAGAGACGGCCGATCGCAGCGATCGTTGCGCTGTTGTCGGCAGCGG
TGCCCGGCTCTGCCAGAATG

Downstream 100 bases:

>100_bases
AGTTGGAGCCGTTTGCATGCGACCTGGCCATCGGCCGGGTCACCGGATTGCGCAACCAAAATCGCGGCCCGCGCCGGGTG
CTGGCCTTGCATGGCTGGCT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRMNTTPDTALLVVNLGTPESPTAPAVRRYLAEFLSDRRVVAIPPLFWKPLLYGVILPIRGPKSAEKYAKVWLPEGSPLA
VYTRRLAGGLQAVMPDWHVEWAMRYGEPALRKTLDRLRARGIKRIVVLPLYPQYSTTTTASIQDVVDAWRTSAPEIAVEV
IQDYCEDTGWVAAIAESIRAHWQVHGRSEKLMFSFHGLPQRVADAGDPYPQQCERSAQAIVAALGLGADEWQMGYQSRFG
AERWLQPYAEPTLWKLAEGGVRSFDLVCPGFATDCLETLEEVALGFSETLAERGATLSYIPCLNASDAHAHALAAMARRA

Sequences:

>Translated_320_residues
MRMNTTPDTALLVVNLGTPESPTAPAVRRYLAEFLSDRRVVAIPPLFWKPLLYGVILPIRGPKSAEKYAKVWLPEGSPLA
VYTRRLAGGLQAVMPDWHVEWAMRYGEPALRKTLDRLRARGIKRIVVLPLYPQYSTTTTASIQDVVDAWRTSAPEIAVEV
IQDYCEDTGWVAAIAESIRAHWQVHGRSEKLMFSFHGLPQRVADAGDPYPQQCERSAQAIVAALGLGADEWQMGYQSRFG
AERWLQPYAEPTLWKLAEGGVRSFDLVCPGFATDCLETLEEVALGFSETLAERGATLSYIPCLNASDAHAHALAAMARRA
>Mature_320_residues
MRMNTTPDTALLVVNLGTPESPTAPAVRRYLAEFLSDRRVVAIPPLFWKPLLYGVILPIRGPKSAEKYAKVWLPEGSPLA
VYTRRLAGGLQAVMPDWHVEWAMRYGEPALRKTLDRLRARGIKRIVVLPLYPQYSTTTTASIQDVVDAWRTSAPEIAVEV
IQDYCEDTGWVAAIAESIRAHWQVHGRSEKLMFSFHGLPQRVADAGDPYPQQCERSAQAIVAALGLGADEWQMGYQSRFG
AERWLQPYAEPTLWKLAEGGVRSFDLVCPGFATDCLETLEEVALGFSETLAERGATLSYIPCLNASDAHAHALAAMARRA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=327, Percent_Identity=26.2996941896024, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI60499021, Length=327, Percent_Identity=26.2996941896024, Blast_Score=101, Evalue=9e-22,
Organism=Escherichia coli, GI1786681, Length=312, Percent_Identity=45.8333333333333, Blast_Score=273, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6324750, Length=328, Percent_Identity=22.8658536585366, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17864156, Length=300, Percent_Identity=24.6666666666667, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35479; Mature: 35479

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMNTTPDTALLVVNLGTPESPTAPAVRRYLAEFLSDRRVVAIPPLFWKPLLYGVILPIR
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHEECCC
GPKSAEKYAKVWLPEGSPLAVYTRRLAGGLQAVMPDWHVEWAMRYGEPALRKTLDRLRAR
CCCCHHHHHEEECCCCCCHHHHHHHHHCCHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHC
GIKRIVVLPLYPQYSTTTTASIQDVVDAWRTSAPEIAVEVIQDYCEDTGWVAAIAESIRA
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
HWQVHGRSEKLMFSFHGLPQRVADAGDPYPQQCERSAQAIVAALGLGADEWQMGYQSRFG
HHHCCCCCCEEEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
AERWLQPYAEPTLWKLAEGGVRSFDLVCPGFATDCLETLEEVALGFSETLAERGATLSYI
HHHHHHHCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCHHHHHHHCCCEEEEE
PCLNASDAHAHALAAMARRA
CCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRMNTTPDTALLVVNLGTPESPTAPAVRRYLAEFLSDRRVVAIPPLFWKPLLYGVILPIR
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHEECCC
GPKSAEKYAKVWLPEGSPLAVYTRRLAGGLQAVMPDWHVEWAMRYGEPALRKTLDRLRAR
CCCCHHHHHEEECCCCCCHHHHHHHHHCCHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHC
GIKRIVVLPLYPQYSTTTTASIQDVVDAWRTSAPEIAVEVIQDYCEDTGWVAAIAESIRA
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
HWQVHGRSEKLMFSFHGLPQRVADAGDPYPQQCERSAQAIVAALGLGADEWQMGYQSRFG
HHHCCCCCCEEEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
AERWLQPYAEPTLWKLAEGGVRSFDLVCPGFATDCLETLEEVALGFSETLAERGATLSYI
HHHHHHHCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCHHHHHHHCCCEEEEE
PCLNASDAHAHALAAMARRA
CCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]