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The map label for this gene is rpfC [H]

Identifier: 21244398

GI number: 21244398

Start: 4350149

End: 4351885

Strand: Direct

Name: rpfC [H]

Synonym: XAC3673

Alternate gene names: 21244398

Gene position: 4350149-4351885 (Clockwise)

Preceding gene: 21244397

Following gene: 21244399

Centisome position: 84.05

GC content: 64.25

Gene sequence:

>1737_bases
ATGCGTAGCACTCCCAATCGCGCAGCGCCCGGCCTGATCCTGGCCGCCAGGCAATTGCATAACGACAGACTGGTGCGGCT
GTTCGAGTCGTTCCTGGAATATCGCGCCTGCGTCGGCCGTGTGATCGTGCAGACCATCGTCACTGCGTGGTGCCTGGGCT
GGCTGTACGGGCCGCAACCGGTGCTGGTGGCCGACGCGCACCATGTCTTTCCCACTGCGCTGAGCCTGTGGGCGCTGTCG
GTGGTGTGGATGCTGCTGGTGCGCCGCCGTGTCATTGCGCCCAGCGAATGGCTCGATGCGATGGGGTTTGCGATGAACCT
GCTGTTCATCGGCATCCAGACCTACCTGGCCTTCATCCTGCTGATGTCGTTGAACGCATTTTTGCCGTTCATCACCATCG
CTGCGGTGGCGCGTTACGGGCAACGCGCGATATTTCCGGTGTTGCTCAGCACCTTCGTGCTGATGCTGTTGACCGCACCG
TCAGGCTACTGGCTGTCGCGTCCGGCATATTTCGTCTATGCCGTGGCGCTGATCATCGTGCTGCCGTTGCTGGTGGCGCG
GATCGTGCTTGCGATGCAGGAAGTGGCACTGCAGGCGCTGGCCTCGCGCGATGCGCAAAGCCATTTCATCAGCACCATGA
GCCACGAATTGCGCACCCCGCTGAATGCGGTGATCAACTGCGCCCAGTTGATCGAGACCGAACAAATGCCGGCGCAGCAA
CGCGAGTTGCTGCAATCGGTGACCGCCAATGCGACCGCACTGCGCCATCGTGTCAACGAGGTGCTGGACGTGGCCAGCAT
CGATGGCGGGCGCCTGCAGCTGCATCGCAAGCCCTTGAACCTGCTGGACGTGGTCACCACGGTGAAAGCGGTCTGCGCCA
CCGCGGCGTCCAGCAAGGGCGTCACGCTCGATGTGCGTGTCGATAGCCCGCAAGCACCGCATGTGATGGGCGACGAAGGC
CGCATCGAACAGGTGATCAGCAACCTGGTGATCAACGCGATCAAGTTCACCCCGGCCGGCGGCACGGTGGATCTGCTGAT
CGACGCGACCCAGGTGCAGGAGCGCTGGAGCATCGCAGTGACCGTCACCGACACCGGTATCGGCGTACCGGACGATCAGA
AGGCCTACATCTTCACCCCGTTCACTCAGCTCAGTACCGGCTTCAGTCGCGTCGAGGGCGGCGTGGGCCTGGGCCTGTAC
ATCGCGCTGTCCGTCTCCGATGCGATGGGCGGCAGCCTCACCGTGAGCGACAACCCCGCCGGTGGCAGCATCTTTCGCTG
GATCTTCGAACTGCCCGGCACCGCGGCCGGTAGCAATACGCTCGCACTGCGCGATGCGCTGGCCCAGCACGCACAAAACG
TACCCTCCCTGCATTGCCTGGTCTTTGAAGACATGGATACCAATCGTCTGGTGATCGGCAATCTGCTGACCCGCGCCGGG
CATCGGGTGAGCTTCCAGGTCGATGGCACCGATGCGGTGCAGCGCATCCGCGAGGCAGCGCCGGACCTGGTGTTCCTGGA
CCTGCACATGCCCGGTACGTCCGGCTGGGATGCGCTGCGCGAAGCGCGCGATGCGATGTCGGCGCTGCCGCCGATCATCG
TGCTGACCGCCGACACCCGGACCGATTCGATGCGCGACGCCAGCGCGGCGGGCGTGGCCGGCTACCTGCCCAAGCCGATC
AATGCGCACGAGTTGCTGGCATTGCTCGCCCAGCACGCCAGCCATGCACGCCCCTGA

Upstream 100 bases:

>100_bases
GGCGAAACGCTGGCGCAGCGCTTCACTGCGGTGGCGAACGCGGCTGGCCTGCTGGTCAAGCAGTACCGGCGTACCCTCCC
CTCAGACGACGCGGACCCTC

Downstream 100 bases:

>100_bases
GCTCAAGCCGGGCAACGCCGCACGCGTCTACTGGCACCATGCCGCACACGCCAGCACGCCGCTGGTGGTGCTGTACCTGC
ACGGCTTCAGCGCCAGCCCG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MRSTPNRAAPGLILAARQLHNDRLVRLFESFLEYRACVGRVIVQTIVTAWCLGWLYGPQPVLVADAHHVFPTALSLWALS
VVWMLLVRRRVIAPSEWLDAMGFAMNLLFIGIQTYLAFILLMSLNAFLPFITIAAVARYGQRAIFPVLLSTFVLMLLTAP
SGYWLSRPAYFVYAVALIIVLPLLVARIVLAMQEVALQALASRDAQSHFISTMSHELRTPLNAVINCAQLIETEQMPAQQ
RELLQSVTANATALRHRVNEVLDVASIDGGRLQLHRKPLNLLDVVTTVKAVCATAASSKGVTLDVRVDSPQAPHVMGDEG
RIEQVISNLVINAIKFTPAGGTVDLLIDATQVQERWSIAVTVTDTGIGVPDDQKAYIFTPFTQLSTGFSRVEGGVGLGLY
IALSVSDAMGGSLTVSDNPAGGSIFRWIFELPGTAAGSNTLALRDALAQHAQNVPSLHCLVFEDMDTNRLVIGNLLTRAG
HRVSFQVDGTDAVQRIREAAPDLVFLDLHMPGTSGWDALREARDAMSALPPIIVLTADTRTDSMRDASAAGVAGYLPKPI
NAHELLALLAQHASHARP

Sequences:

>Translated_578_residues
MRSTPNRAAPGLILAARQLHNDRLVRLFESFLEYRACVGRVIVQTIVTAWCLGWLYGPQPVLVADAHHVFPTALSLWALS
VVWMLLVRRRVIAPSEWLDAMGFAMNLLFIGIQTYLAFILLMSLNAFLPFITIAAVARYGQRAIFPVLLSTFVLMLLTAP
SGYWLSRPAYFVYAVALIIVLPLLVARIVLAMQEVALQALASRDAQSHFISTMSHELRTPLNAVINCAQLIETEQMPAQQ
RELLQSVTANATALRHRVNEVLDVASIDGGRLQLHRKPLNLLDVVTTVKAVCATAASSKGVTLDVRVDSPQAPHVMGDEG
RIEQVISNLVINAIKFTPAGGTVDLLIDATQVQERWSIAVTVTDTGIGVPDDQKAYIFTPFTQLSTGFSRVEGGVGLGLY
IALSVSDAMGGSLTVSDNPAGGSIFRWIFELPGTAAGSNTLALRDALAQHAQNVPSLHCLVFEDMDTNRLVIGNLLTRAG
HRVSFQVDGTDAVQRIREAAPDLVFLDLHMPGTSGWDALREARDAMSALPPIIVLTADTRTDSMRDASAAGVAGYLPKPI
NAHELLALLAQHASHARP
>Mature_578_residues
MRSTPNRAAPGLILAARQLHNDRLVRLFESFLEYRACVGRVIVQTIVTAWCLGWLYGPQPVLVADAHHVFPTALSLWALS
VVWMLLVRRRVIAPSEWLDAMGFAMNLLFIGIQTYLAFILLMSLNAFLPFITIAAVARYGQRAIFPVLLSTFVLMLLTAP
SGYWLSRPAYFVYAVALIIVLPLLVARIVLAMQEVALQALASRDAQSHFISTMSHELRTPLNAVINCAQLIETEQMPAQQ
RELLQSVTANATALRHRVNEVLDVASIDGGRLQLHRKPLNLLDVVTTVKAVCATAASSKGVTLDVRVDSPQAPHVMGDEG
RIEQVISNLVINAIKFTPAGGTVDLLIDATQVQERWSIAVTVTDTGIGVPDDQKAYIFTPFTQLSTGFSRVEGGVGLGLY
IALSVSDAMGGSLTVSDNPAGGSIFRWIFELPGTAAGSNTLALRDALAQHAQNVPSLHCLVFEDMDTNRLVIGNLLTRAG
HRVSFQVDGTDAVQRIREAAPDLVFLDLHMPGTSGWDALREARDAMSALPPIIVLTADTRTDSMRDASAAGVAGYLPKPI
NAHELLALLAQHASHARP

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=375, Percent_Identity=29.3333333333333, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789149, Length=243, Percent_Identity=35.8024691358025, Blast_Score=149, Evalue=7e-37,
Organism=Escherichia coli, GI1788713, Length=390, Percent_Identity=28.974358974359, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87081816, Length=394, Percent_Identity=26.1421319796954, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=31.8725099601594, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1788393, Length=214, Percent_Identity=28.9719626168224, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1786912, Length=261, Percent_Identity=30.6513409961686, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1787894, Length=241, Percent_Identity=26.9709543568465, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=27.8026905829596, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786783, Length=254, Percent_Identity=25.9842519685039, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1786600, Length=252, Percent_Identity=24.6031746031746, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790346, Length=229, Percent_Identity=27.0742358078603, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790861, Length=227, Percent_Identity=25.5506607929515, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI87082128, Length=235, Percent_Identity=25.1063829787234, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788191, Length=112, Percent_Identity=34.8214285714286, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI1790300, Length=231, Percent_Identity=28.1385281385281, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 62688; Mature: 62688

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSTPNRAAPGLILAARQLHNDRLVRLFESFLEYRACVGRVIVQTIVTAWCLGWLYGPQP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VLVADAHHVFPTALSLWALSVVWMLLVRRRVIAPSEWLDAMGFAMNLLFIGIQTYLAFIL
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LMSLNAFLPFITIAAVARYGQRAIFPVLLSTFVLMLLTAPSGYWLSRPAYFVYAVALIIV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
LPLLVARIVLAMQEVALQALASRDAQSHFISTMSHELRTPLNAVINCAQLIETEQMPAQQ
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHH
RELLQSVTANATALRHRVNEVLDVASIDGGRLQLHRKPLNLLDVVTTVKAVCATAASSKG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCC
VTLDVRVDSPQAPHVMGDEGRIEQVISNLVINAIKFTPAGGTVDLLIDATQVQERWSIAV
CEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCEEEEEEHHHHHCCEEEEE
TVTDTGIGVPDDQKAYIFTPFTQLSTGFSRVEGGVGLGLYIALSVSDAMGGSLTVSDNPA
EEEECCCCCCCCCCEEEEECHHHHHCCHHHHCCCCCEEEEEEEEECCCCCCEEEECCCCC
GGSIFRWIFELPGTAAGSNTLALRDALAQHAQNVPSLHCLVFEDMDTNRLVIGNLLTRAG
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHCC
HRVSFQVDGTDAVQRIREAAPDLVFLDLHMPGTSGWDALREARDAMSALPPIIVLTADTR
CEEEEEECCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCC
TDSMRDASAAGVAGYLPKPINAHELLALLAQHASHARP
CCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRSTPNRAAPGLILAARQLHNDRLVRLFESFLEYRACVGRVIVQTIVTAWCLGWLYGPQP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VLVADAHHVFPTALSLWALSVVWMLLVRRRVIAPSEWLDAMGFAMNLLFIGIQTYLAFIL
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LMSLNAFLPFITIAAVARYGQRAIFPVLLSTFVLMLLTAPSGYWLSRPAYFVYAVALIIV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
LPLLVARIVLAMQEVALQALASRDAQSHFISTMSHELRTPLNAVINCAQLIETEQMPAQQ
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHH
RELLQSVTANATALRHRVNEVLDVASIDGGRLQLHRKPLNLLDVVTTVKAVCATAASSKG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCC
VTLDVRVDSPQAPHVMGDEGRIEQVISNLVINAIKFTPAGGTVDLLIDATQVQERWSIAV
CEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCEEEEEEHHHHHCCEEEEE
TVTDTGIGVPDDQKAYIFTPFTQLSTGFSRVEGGVGLGLYIALSVSDAMGGSLTVSDNPA
EEEECCCCCCCCCCEEEEECHHHHHCCHHHHCCCCCEEEEEEEEECCCCCCEEEECCCCC
GGSIFRWIFELPGTAAGSNTLALRDALAQHAQNVPSLHCLVFEDMDTNRLVIGNLLTRAG
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHCC
HRVSFQVDGTDAVQRIREAAPDLVFLDLHMPGTSGWDALREARDAMSALPPIIVLTADTR
CEEEEEECCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCC
TDSMRDASAAGVAGYLPKPINAHELLALLAQHASHARP
CCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]