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The map label for this gene is gloA [H]

Identifier: 21244357

GI number: 21244357

Start: 4307647

End: 4308171

Strand: Direct

Name: gloA [H]

Synonym: XAC3632

Alternate gene names: 21244357

Gene position: 4307647-4308171 (Clockwise)

Preceding gene: 21244356

Following gene: 21244358

Centisome position: 83.23

GC content: 59.62

Gene sequence:

>525_bases
ATGCCTTTGAACGATCTGCAACACGTGCCAGGCGCCAATGACGCGCCCGCCGAGACACACGGCTTCGTGTTCAACCACAC
CATGCTGCGCGTCAAGGATGCAACGCAGTCACTGGATTTCTATACGCGTGTCCTGGGCTTCCGCCTGCTCGACGCACGCG
ATTTTGCCGACGCAAAATTCAGCCTGTATTTTCTCGCGCTGCTACCCGAAGGCACCGCCATTCCCGATGACGACGCCCAG
CGTCGGCTGTGGATGGCAGGTATCCCCGGCGTGCTCGAACTCACCCATAACCATGGCACCGAAACCCAGGATGGCCCGGT
CTATCACGACGGCAACAGCGACCCGCGCGGCTTCGGCCATCTCTGTATCTCGGTGCCGGATATCCATGCCGCCTGCGCAC
GTTTCGACAGCCTCAACGTGCCATACCAAAAACGCCTGGAAGACGGCCGCATGAAGCACCTGGCCTTCATCAAGGACCCG
GATGGTTACTGGGTGGAGATCATTTCCAATACGCCGTTGGCGTAA

Upstream 100 bases:

>100_bases
CGCTGCCAGTCGGCCATGACACGCCGACAACCCTGCCCTGGCTAACATCGCCCATTCGCGCAACACGCCGCACCCCCACA
ATCCACACCAGGAGACCGCC

Downstream 100 bases:

>100_bases
GTCCAACGCTCAGCGGCAAGCTGGCGCGTCAGCGGGGACGGGATGGCAACCAGCCGATACCAATGCCGAACGCGACGCGT
CCCTTGCCTCGAAGCCCCGC

Product: lactoylglutathione lyase

Products: NA

Alternate protein names: Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MPLNDLQHVPGANDAPAETHGFVFNHTMLRVKDATQSLDFYTRVLGFRLLDARDFADAKFSLYFLALLPEGTAIPDDDAQ
RRLWMAGIPGVLELTHNHGTETQDGPVYHDGNSDPRGFGHLCISVPDIHAACARFDSLNVPYQKRLEDGRMKHLAFIKDP
DGYWVEIISNTPLA

Sequences:

>Translated_174_residues
MPLNDLQHVPGANDAPAETHGFVFNHTMLRVKDATQSLDFYTRVLGFRLLDARDFADAKFSLYFLALLPEGTAIPDDDAQ
RRLWMAGIPGVLELTHNHGTETQDGPVYHDGNSDPRGFGHLCISVPDIHAACARFDSLNVPYQKRLEDGRMKHLAFIKDP
DGYWVEIISNTPLA
>Mature_173_residues
PLNDLQHVPGANDAPAETHGFVFNHTMLRVKDATQSLDFYTRVLGFRLLDARDFADAKFSLYFLALLPEGTAIPDDDAQR
RLWMAGIPGVLELTHNHGTETQDGPVYHDGNSDPRGFGHLCISVPDIHAACARFDSLNVPYQKRLEDGRMKHLAFIKDPD
GYWVEIISNTPLA

Specific function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione [H]

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

Organism=Homo sapiens, GI118402586, Length=172, Percent_Identity=50, Blast_Score=176, Evalue=1e-44,
Organism=Escherichia coli, GI1787940, Length=146, Percent_Identity=34.2465753424658, Blast_Score=77, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6323639, Length=149, Percent_Identity=45.6375838926174, Blast_Score=135, Evalue=4e-33,
Organism=Drosophila melanogaster, GI20129743, Length=153, Percent_Identity=54.9019607843137, Blast_Score=169, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR004361
- InterPro:   IPR018146 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =4.4.1.5 [H]

Molecular weight: Translated: 19443; Mature: 19312

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00934 GLYOXALASE_I_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNDLQHVPGANDAPAETHGFVFNHTMLRVKDATQSLDFYTRVLGFRLLDARDFADAKF
CCCCCCCCCCCCCCCCCCCCCEEEECEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCEE
SLYFLALLPEGTAIPDDDAQRRLWMAGIPGVLELTHNHGTETQDGPVYHDGNSDPRGFGH
EEEEEEECCCCCCCCCCCHHHEEEECCCCCEEEEECCCCCCCCCCCEEECCCCCCCCCEE
LCISVPDIHAACARFDSLNVPYQKRLEDGRMKHLAFIKDPDGYWVEIISNTPLA
EEEECCCHHHHHHHHCCCCCCHHHHHCCCCEEEEEEEECCCCEEEEEECCCCCC
>Mature Secondary Structure 
PLNDLQHVPGANDAPAETHGFVFNHTMLRVKDATQSLDFYTRVLGFRLLDARDFADAKF
CCCCCCCCCCCCCCCCCCCCEEEECEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCEE
SLYFLALLPEGTAIPDDDAQRRLWMAGIPGVLELTHNHGTETQDGPVYHDGNSDPRGFGH
EEEEEEECCCCCCCCCCCHHHEEEECCCCCEEEEECCCCCCCCCCCEEECCCCCCCCCEE
LCISVPDIHAACARFDSLNVPYQKRLEDGRMKHLAFIKDPDGYWVEIISNTPLA
EEEECCCHHHHHHHHCCCCCCHHHHHCCCCEEEEEEEECCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7959071 [H]