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The map label for this gene is hisC [H]

Identifier: 21244148

GI number: 21244148

Start: 4030024

End: 4031226

Strand: Reverse

Name: hisC [H]

Synonym: XAC3423

Alternate gene names: 21244148

Gene position: 4031226-4030024 (Counterclockwise)

Preceding gene: 21244149

Following gene: 21244147

Centisome position: 77.89

GC content: 64.75

Gene sequence:

>1203_bases
ATGAACACTGCTCTTTCGCGCCGCACGTTTCTACGCGACTCCGCGCTGTTTGCCGGCGCCGCCGGTGCCGCCAGCTTGCC
GCTGCTGGCCAGCGCCATCGAACGCTCCACTGCCATTGCGCCCACGCCGGCAACGGCGCTGACACCGGTAATGATCGACT
CCAATGAATTTCCGGAGGGACCGTCGGCTGCCGCAGTAAGGGCCATCGCGCAGATCGCACCGCAAGGCGGGAGGTATCTG
CGCCAGGTACAGATGGAATTGATGACCACCCTGGCTGCCGAGCTCAAGCTGCCGGTGGATCATCTGATGGCGTACGCCGG
GTCCACCGAACCGCTCGACTACACGATGCTGGCATTCACTTCGCCCAGCGCCGCGTTGGTCACTGCCGACCCCACCTACG
AATCCGGCTGGCGTGCGGCAACCCGCAATGGCGCGCGCTTGATCAAGGTGCCGCTGCGCAAGGATTTTTCGCACGATGTA
CAGGCCATGTGCGCGGCCGATGCCAACGCGGGCGTCATCTACATCTGCAACCCCAACAATCCCACCGGCTCGGTCACCGC
ACGCAAGGACTTGGACTACGCATTGGCGCACAAGCCCAAAGGCAGCGTGTTGGTGGTGGATGAGGCGTATATCCACTTCG
CGCAAAGCACGCGCAGCATGGTCGACATGGTTGCCGCAGGCGAAGACGTGGTGGTGTTGCGCACGTTTTCCAAACTCTAT
GGCATGGCCGGCATCCGCCTGGGCTATGCGGCCGCGCGCCCGGACCTGCTGGCCAAGCTGAAGTTCTACAGCGTCAACAG
CTTGCCGGTCACCGCCGCCGCTGCCGGGCTGGCCAGCCTGCGCGATCCTGCACTGGTGCCGCAACGGCGCGCGCGTACCG
CCGCTACCCGCACGGATGTGATGGACTTTCTCGCGCGTCAGGGCTATGCGTGCACTGCCTCGGAGAGCAATTGCTTTATG
GTCGATGTGAAGCGCCCCGCGGCTGGCTTCAAGGACGATATGGCCACCCATGGCGTGTTCATCGGTCGCAGCTGGCCGGT
GTGGCCCACCTGGTCGCGCATTACCGTGGGCACCGACGCGGAGATGGCGCGCTTCAAACACGCGTTCGTGCAGGTGGTTG
CCGGTAACCGCGGCCCGCTGCCGGCGCCGGGCGTGGCGACTGCAGCGGCCGATCCGATGGATGCATTTTTCCGTTACGCC
TAG

Upstream 100 bases:

>100_bases
ATTCCAGATCGCGGCATTGGGTAACCCGCTGTACCGGGTCGAGATCGAAGTTGTTGCCGTGCGTCCCTGAGTCCGCGTCT
TCATCCTGCTGGAGTTTGTC

Downstream 100 bases:

>100_bases
AGCGTGTTATGCACTTGGAGGTGAGAGTGTTGGCCGCTGACGGCCAACCCTCCGGGAAGCGCCCTGTGGCGCGCCGAGGC
AAGGCGCGCAACGCGGTATC

Product: aminotransferase

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MNTALSRRTFLRDSALFAGAAGAASLPLLASAIERSTAIAPTPATALTPVMIDSNEFPEGPSAAAVRAIAQIAPQGGRYL
RQVQMELMTTLAAELKLPVDHLMAYAGSTEPLDYTMLAFTSPSAALVTADPTYESGWRAATRNGARLIKVPLRKDFSHDV
QAMCAADANAGVIYICNPNNPTGSVTARKDLDYALAHKPKGSVLVVDEAYIHFAQSTRSMVDMVAAGEDVVVLRTFSKLY
GMAGIRLGYAAARPDLLAKLKFYSVNSLPVTAAAAGLASLRDPALVPQRRARTAATRTDVMDFLARQGYACTASESNCFM
VDVKRPAAGFKDDMATHGVFIGRSWPVWPTWSRITVGTDAEMARFKHAFVQVVAGNRGPLPAPGVATAAADPMDAFFRYA

Sequences:

>Translated_400_residues
MNTALSRRTFLRDSALFAGAAGAASLPLLASAIERSTAIAPTPATALTPVMIDSNEFPEGPSAAAVRAIAQIAPQGGRYL
RQVQMELMTTLAAELKLPVDHLMAYAGSTEPLDYTMLAFTSPSAALVTADPTYESGWRAATRNGARLIKVPLRKDFSHDV
QAMCAADANAGVIYICNPNNPTGSVTARKDLDYALAHKPKGSVLVVDEAYIHFAQSTRSMVDMVAAGEDVVVLRTFSKLY
GMAGIRLGYAAARPDLLAKLKFYSVNSLPVTAAAAGLASLRDPALVPQRRARTAATRTDVMDFLARQGYACTASESNCFM
VDVKRPAAGFKDDMATHGVFIGRSWPVWPTWSRITVGTDAEMARFKHAFVQVVAGNRGPLPAPGVATAAADPMDAFFRYA
>Mature_400_residues
MNTALSRRTFLRDSALFAGAAGAASLPLLASAIERSTAIAPTPATALTPVMIDSNEFPEGPSAAAVRAIAQIAPQGGRYL
RQVQMELMTTLAAELKLPVDHLMAYAGSTEPLDYTMLAFTSPSAALVTADPTYESGWRAATRNGARLIKVPLRKDFSHDV
QAMCAADANAGVIYICNPNNPTGSVTARKDLDYALAHKPKGSVLVVDEAYIHFAQSTRSMVDMVAAGEDVVVLRTFSKLY
GMAGIRLGYAAARPDLLAKLKFYSVNSLPVTAAAAGLASLRDPALVPQRRARTAATRTDVMDFLARQGYACTASESNCFM
VDVKRPAAGFKDDMATHGVFIGRSWPVWPTWSRITVGTDAEMARFKHAFVQVVAGNRGPLPAPGVATAAADPMDAFFRYA

Specific function: May catalyze the transamination reaction in phenylalanine biosynthesis [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=286, Percent_Identity=27.6223776223776, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322075, Length=260, Percent_Identity=28.0769230769231, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9

Molecular weight: Translated: 42622; Mature: 42622

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTALSRRTFLRDSALFAGAAGAASLPLLASAIERSTAIAPTPATALTPVMIDSNEFPEG
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCEEEECCCCCCCC
PSAAAVRAIAQIAPQGGRYLRQVQMELMTTLAAELKLPVDHLMAYAGSTEPLDYTMLAFT
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEC
SPSAALVTADPTYESGWRAATRNGARLIKVPLRKDFSHDVQAMCAADANAGVIYICNPNN
CCCCEEEECCCCCCCCCCHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCC
PTGSVTARKDLDYALAHKPKGSVLVVDEAYIHFAQSTRSMVDMVAAGEDVVVLRTFSKLY
CCCCEEECCCCCHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHH
GMAGIRLGYAAARPDLLAKLKFYSVNSLPVTAAAAGLASLRDPALVPQRRARTAATRTDV
CCCCCEECHHHCCCHHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
MDFLARQGYACTASESNCFMVDVKRPAAGFKDDMATHGVFIGRSWPVWPTWSRITVGTDA
HHHHHHCCCEEECCCCCEEEEEECCCCCCCCHHHHHCCEEECCCCCCCCCCCEEEECCCH
EMARFKHAFVQVVAGNRGPLPAPGVATAAADPMDAFFRYA
HHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MNTALSRRTFLRDSALFAGAAGAASLPLLASAIERSTAIAPTPATALTPVMIDSNEFPEG
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCEEEECCCCCCCC
PSAAAVRAIAQIAPQGGRYLRQVQMELMTTLAAELKLPVDHLMAYAGSTEPLDYTMLAFT
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEC
SPSAALVTADPTYESGWRAATRNGARLIKVPLRKDFSHDVQAMCAADANAGVIYICNPNN
CCCCEEEECCCCCCCCCCHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCC
PTGSVTARKDLDYALAHKPKGSVLVVDEAYIHFAQSTRSMVDMVAAGEDVVVLRTFSKLY
CCCCEEECCCCCHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHH
GMAGIRLGYAAARPDLLAKLKFYSVNSLPVTAAAAGLASLRDPALVPQRRARTAATRTDV
CCCCCEECHHHCCCHHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
MDFLARQGYACTASESNCFMVDVKRPAAGFKDDMATHGVFIGRSWPVWPTWSRITVGTDA
HHHHHHCCCEEECCCCCEEEEEECCCCCCCCHHHHHCCEEECCCCCCCCCCCEEEECCCH
EMARFKHAFVQVVAGNRGPLPAPGVATAAADPMDAFFRYA
HHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA