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The map label for this gene is moeB [H]

Identifier: 21242767

GI number: 21242767

Start: 2366990

End: 2368132

Strand: Reverse

Name: moeB [H]

Synonym: XAC2023

Alternate gene names: 21242767

Gene position: 2368132-2366990 (Counterclockwise)

Preceding gene: 21242773

Following gene: 21242758

Centisome position: 45.76

GC content: 65.97

Gene sequence:

>1143_bases
ATGAGCAGCCACGACATCTCTCCCGCCGACGCCCGTGCTCGCGCCCTGCAGGGCGCCTTGCTGGTCGACATCCGGCAACT
GCATGAGCGCGCCAGCGGCCAGGCCGAAGGCGCGTTGGCGATCGCACAGAACTCCCTGGAAACGGAGCCTGCAGTCCATC
TGCCCGAGCAAACCCGCGCAATCGTATTGATCTGCCAGAGCGGCAAACGCTCGGCGCATACGGCCGCCATCTTGCGCACG
CACGGCTATGCGCACGTGGCATCGGTGGCCGGCGGCACCAGCGCATGGGCCAGCGCCGGCCTGCCCCTGGTACGCCCGAC
ATTGCCGGCGGACGAGCAGGATTTTCTTGAGCGTTATTCACGCCATCTGCGTCTGTCGCAGGTCGGCCTGGAAGGTCAGC
GGCGCCTGGCACGTGCACGGGTGTTGCTGATCGGCGCAGGCGGACTAGGCTCGCCTGCAGCGTTCTACCTCGCCGCAGCC
GGTGTGGGGTATCTACGCATAGCCGACGACGACGTGGTGGACCGCAGCAACCTGCAACGCCAGATTCTGCACACCGAAGA
CAGCGTCGGCACTGCAAAGGTCGACTCCGCCGCACGGCGCATCGCCGCGCTCAACCCGCGCGTGGACATCGAGGCGGTGC
AAACGCGCGTGGCGGCCGACAATGTCGAAGCGCTGCTGCAGGACGTGGATGTGGTGGTCGATGGCGCAGATAATTTTCCC
GCGCGGTATTTGCTCAACGATGCCTGCGTCAAGTTCGCTAAACCGCTGGTCTACGGCGCCGTGCAGCAGTTCGAAGGACA
GGTCAGCGTATTCGATGCCGGCCGCCACCGTGGTCATGCGCCTTGCTACCGCTGCCTGTTTCCCGAACCGCCGCCGCCGG
AATTCGCGCCCAGTTGTGCCGAAGCTGGAGTGCTCGGCGTACTGCCCGGGGTGATCGGACTCCTGCAGGCGACCGAAGCG
ATCAAGTTGCTGCTCGGCATCGGCGACGGCCTCACTGGCCGCCTGCTCAGTTTCGATGCGTTGGCGATGCGCTTCCGCGA
CATCCGCTTGCCGCCGGACCCGCACTGCCCGGTCTGTGCGCCTGGCGCTGTGTTTACCGGTTATGCGGATTACGCGGCGT
TCTGCGGTAGTGCGGTCGGTTGA

Upstream 100 bases:

>100_bases
GCGCCGCGATCATGACGCGCCTTTCATCGGCAGCGAGGTGCGTGCGTGTCGTGGGCAAGATTGCACATCGCAGCTGCTGC
GTTTGCGCGACAATGGCCGC

Downstream 100 bases:

>100_bases
GTTCAGCTCACAGCGGTGGCGTGGTGTCGGTCGGTTGGCCGATTGCCTTGCCACCGAAGCAACGAGGTGTATCGCTGCGT
TGAGTATTTGGCGAGGTGGG

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSSHDISPADARARALQGALLVDIRQLHERASGQAEGALAIAQNSLETEPAVHLPEQTRAIVLICQSGKRSAHTAAILRT
HGYAHVASVAGGTSAWASAGLPLVRPTLPADEQDFLERYSRHLRLSQVGLEGQRRLARARVLLIGAGGLGSPAAFYLAAA
GVGYLRIADDDVVDRSNLQRQILHTEDSVGTAKVDSAARRIAALNPRVDIEAVQTRVAADNVEALLQDVDVVVDGADNFP
ARYLLNDACVKFAKPLVYGAVQQFEGQVSVFDAGRHRGHAPCYRCLFPEPPPPEFAPSCAEAGVLGVLPGVIGLLQATEA
IKLLLGIGDGLTGRLLSFDALAMRFRDIRLPPDPHCPVCAPGAVFTGYADYAAFCGSAVG

Sequences:

>Translated_380_residues
MSSHDISPADARARALQGALLVDIRQLHERASGQAEGALAIAQNSLETEPAVHLPEQTRAIVLICQSGKRSAHTAAILRT
HGYAHVASVAGGTSAWASAGLPLVRPTLPADEQDFLERYSRHLRLSQVGLEGQRRLARARVLLIGAGGLGSPAAFYLAAA
GVGYLRIADDDVVDRSNLQRQILHTEDSVGTAKVDSAARRIAALNPRVDIEAVQTRVAADNVEALLQDVDVVVDGADNFP
ARYLLNDACVKFAKPLVYGAVQQFEGQVSVFDAGRHRGHAPCYRCLFPEPPPPEFAPSCAEAGVLGVLPGVIGLLQATEA
IKLLLGIGDGLTGRLLSFDALAMRFRDIRLPPDPHCPVCAPGAVFTGYADYAAFCGSAVG
>Mature_379_residues
SSHDISPADARARALQGALLVDIRQLHERASGQAEGALAIAQNSLETEPAVHLPEQTRAIVLICQSGKRSAHTAAILRTH
GYAHVASVAGGTSAWASAGLPLVRPTLPADEQDFLERYSRHLRLSQVGLEGQRRLARARVLLIGAGGLGSPAAFYLAAAG
VGYLRIADDDVVDRSNLQRQILHTEDSVGTAKVDSAARRIAALNPRVDIEAVQTRVAADNVEALLQDVDVVVDGADNFPA
RYLLNDACVKFAKPLVYGAVQQFEGQVSVFDAGRHRGHAPCYRCLFPEPPPPEFAPSCAEAGVLGVLPGVIGLLQATEAI
KLLLGIGDGLTGRLLSFDALAMRFRDIRLPPDPHCPVCAPGAVFTGYADYAAFCGSAVG

Specific function: Involved In The Biosynthesis Of A Demolybdo Cofactor (Molybdopterin), Necessary For Molybdoenzymes. Plays A Role In The Activation Of The Small Subunit Of The Molybdopterin Converting Factor (Moad). [C]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=274, Percent_Identity=45.6204379562044, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI23510338, Length=178, Percent_Identity=29.2134831460674, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI23510340, Length=178, Percent_Identity=29.2134831460674, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4885649, Length=173, Percent_Identity=31.7919075144509, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787048, Length=248, Percent_Identity=42.741935483871, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87082356, Length=249, Percent_Identity=42.9718875502008, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1789177, Length=144, Percent_Identity=32.6388888888889, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17540406, Length=261, Percent_Identity=41.7624521072797, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI193203301, Length=172, Percent_Identity=29.0697674418605, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI86565433, Length=197, Percent_Identity=29.9492385786802, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI86565431, Length=197, Percent_Identity=29.9492385786802, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71984476, Length=187, Percent_Identity=27.807486631016, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=272, Percent_Identity=34.1911764705882, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6322639, Length=164, Percent_Identity=29.2682926829268, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24582879, Length=265, Percent_Identity=46.0377358490566, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24660640, Length=154, Percent_Identity=31.1688311688312, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20129973, Length=181, Percent_Identity=29.2817679558011, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641311, Length=265, Percent_Identity=29.0566037735849, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28573937, Length=169, Percent_Identity=28.9940828402367, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357111, Length=147, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 40181; Mature: 40050

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHDISPADARARALQGALLVDIRQLHERASGQAEGALAIAQNSLETEPAVHLPEQTRA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCE
IVLICQSGKRSAHTAAILRTHGYAHVASVAGGTSAWASAGLPLVRPTLPADEQDFLERYS
EEEEECCCCCCHHHHHHHHHCCCHHHHHHCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHH
RHLRLSQVGLEGQRRLARARVLLIGAGGLGSPAAFYLAAAGVGYLRIADDDVVDRSNLQR
HHHHHHHHCCHHHHHHHHEEEEEEECCCCCCHHHHHHHHCCCCEEEECCCCHHCHHHHHH
QILHTEDSVGTAKVDSAARRIAALNPRVDIEAVQTRVAADNVEALLQDVDVVVDGADNFP
HHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
ARYLLNDACVKFAKPLVYGAVQQFEGQVSVFDAGRHRGHAPCYRCLFPEPPPPEFAPSCA
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCHH
EAGVLGVLPGVIGLLQATEAIKLLLGIGDGLTGRLLSFDALAMRFRDIRLPPDPHCPVCA
HCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PGAVFTGYADYAAFCGSAVG
CCCHHHCHHHHHHHHCCCCC
>Mature Secondary Structure 
SSHDISPADARARALQGALLVDIRQLHERASGQAEGALAIAQNSLETEPAVHLPEQTRA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCE
IVLICQSGKRSAHTAAILRTHGYAHVASVAGGTSAWASAGLPLVRPTLPADEQDFLERYS
EEEEECCCCCCHHHHHHHHHCCCHHHHHHCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHH
RHLRLSQVGLEGQRRLARARVLLIGAGGLGSPAAFYLAAAGVGYLRIADDDVVDRSNLQR
HHHHHHHHCCHHHHHHHHEEEEEEECCCCCCHHHHHHHHCCCCEEEECCCCHHCHHHHHH
QILHTEDSVGTAKVDSAARRIAALNPRVDIEAVQTRVAADNVEALLQDVDVVVDGADNFP
HHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
ARYLLNDACVKFAKPLVYGAVQQFEGQVSVFDAGRHRGHAPCYRCLFPEPPPPEFAPSCA
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCHH
EAGVLGVLPGVIGLLQATEAIKLLLGIGDGLTGRLLSFDALAMRFRDIRLPPDPHCPVCA
HCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PGAVFTGYADYAAFCGSAVG
CCCHHHCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA