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The map label for this gene is hutH

Identifier: 21242387

GI number: 21242387

Start: 1888376

End: 1889917

Strand: Reverse

Name: hutH

Synonym: XAC1637

Alternate gene names: 21242387

Gene position: 1889917-1888376 (Counterclockwise)

Preceding gene: 77748598

Following gene: 21242386

Centisome position: 36.52

GC content: 67.9

Gene sequence:

>1542_bases
ATGAGTGTTTCTATTGTCTTGCAACCCGGCCAGGTCACGCTGGCGCAATGGCGTGCGCTGTATCGCGGTGCCGAAGTCGC
GTTGGACGATGCATGTGCTGCTGCGGTGCTGCGCAGCGCGCAAACGGTGGAGGCCATCGTGGCGCGTGGCGAGCCGGTGT
ATGGCGTCAACACCGGCTTCGGCAAGCTGGCCAGCGTGCGTATCGAGCGCGAGGATCTGCAGGCCCTGCAGCGCAATATC
GTGCTCTCGCATGCGGCAGGCGTGGGCGAGCCCACGCCGGTGCCGGTGGTACGGCTGATGATGGCACTCAAGCTCACCAG
CCTGGCCCAGGGCGCGTCCGGCGTGCAGCCGGACACGCTGGCACTGCTGGACGCGATGCTGCGCGCCGGCATCACGCCGG
TGGTGCCGTGCCAGGGCTCGGTGGGCGCTTCCGGCGATCTGGCACCGCTGTCGCATCTGGCTGCGGCGATGATCGGCGTT
GGCGAGGCCTTCGTCGGCGCGCAGCGTCTGCCTGCTGCCGACGCGCTTGCACATGCGCAGCTGCAGCCGCGCGTGCTGGG
CGCAAAGGAAGGGTTGGCCCTGCTCAACGGCACCCAGTTTTCCACCGCCTGCGCCCTGGCCGGTCTGTTCGAGATCGAAA
CCGTCCTGCAGGCCGCGCTGGTCACCGGTGCATTGTCGGTGGAAGCGGCCAAGGGCTCGGATACGCCCTTCGATGCGCGA
ATCCATGCGCTGCGCGGGCAGCCTGGACAGATCGCCACTGCCGCAGCGCTGCGCGCCCTGATGGCCGATTCGGCCATCCG
CGAATCGCATCGGCTTGGCGATGTGCGCGTGCAGGACCCGTACTGCCTGCGCTGCCAGCCGCAGGTGATGGGTGCGGCGC
TGGATGTGATGCGTCAGGCCGCGCGCACCCTGGAGATCGAGGCCAATGGCGTGTCCGATAACCCGCTGGTCTTCAGCGAT
ACCGGCGAAGCGCTGTCTGGCGGCAACTTCCACGCCGAGCCGGTCGCCTTTGCCGCGGACATGCTGGCGATGGCGGTCTG
CGAAATCGGCTCGATCAGCGAACGCCGCACCGCGATGCTGGTCGACCCGGCGCTGTCCGGCCTGCCCGCCTTTCTCACAC
CGCGCCCGGGCTTGAACTCCGGCTTCATGATTCCGCAGGTGACGGCCGCCGCGCTGGTGTCGGAAAACAAACAGCGCGCG
TATCCGGCCAGTGTCGATTCGATCCCGACCTCGGCCAATCAGGAAGATCACGTCTCGATGGCTGCGCACGGTGCGCGCCG
GTTGCTGGCGATGGCCGAGAACGCCGCGCACGTGATCGGCATCGAGCTGCTGGCTGCCGTGCAAGGCTGCGACTTCCATG
CGCCACTGCGCTCCAGCACTGCGCTGGAAGCGGCACGTGCCCTGTTGCGCGCACAGGTGCCCACGTTGCAGGACGACCGC
TATTTCCATCCGGATATGCTGGCTGCCAGCGCGTTGGTGCGCTCGGGCGCGCTGGCGCAGACAGTGGCGATCCCGTTGCC
GGGTGTGGAGCAGGACGTATGA

Upstream 100 bases:

>100_bases
TGGAACATCGATGCGCCGGCCGATCTGGTCTATCGCATGGGCTTCAATCCTCTTCATGCCCGCGTGTGGCGCGGGCATCC
GTGCTGAATCCGGAGTCGTC

Downstream 100 bases:

>100_bases
GTGGGCAGCGCTTATGCAGCGAATCGATACCTGCATCGTCACGGTCGCAACTGCGGTCTTTCGCTGTCTCCCCAAGCACA
CGCACTTGCGATGACGCCGC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MSVSIVLQPGQVTLAQWRALYRGAEVALDDACAAAVLRSAQTVEAIVARGEPVYGVNTGFGKLASVRIEREDLQALQRNI
VLSHAAGVGEPTPVPVVRLMMALKLTSLAQGASGVQPDTLALLDAMLRAGITPVVPCQGSVGASGDLAPLSHLAAAMIGV
GEAFVGAQRLPAADALAHAQLQPRVLGAKEGLALLNGTQFSTACALAGLFEIETVLQAALVTGALSVEAAKGSDTPFDAR
IHALRGQPGQIATAAALRALMADSAIRESHRLGDVRVQDPYCLRCQPQVMGAALDVMRQAARTLEIEANGVSDNPLVFSD
TGEALSGGNFHAEPVAFAADMLAMAVCEIGSISERRTAMLVDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRA
YPASVDSIPTSANQEDHVSMAAHGARRLLAMAENAAHVIGIELLAAVQGCDFHAPLRSSTALEAARALLRAQVPTLQDDR
YFHPDMLAASALVRSGALAQTVAIPLPGVEQDV

Sequences:

>Translated_513_residues
MSVSIVLQPGQVTLAQWRALYRGAEVALDDACAAAVLRSAQTVEAIVARGEPVYGVNTGFGKLASVRIEREDLQALQRNI
VLSHAAGVGEPTPVPVVRLMMALKLTSLAQGASGVQPDTLALLDAMLRAGITPVVPCQGSVGASGDLAPLSHLAAAMIGV
GEAFVGAQRLPAADALAHAQLQPRVLGAKEGLALLNGTQFSTACALAGLFEIETVLQAALVTGALSVEAAKGSDTPFDAR
IHALRGQPGQIATAAALRALMADSAIRESHRLGDVRVQDPYCLRCQPQVMGAALDVMRQAARTLEIEANGVSDNPLVFSD
TGEALSGGNFHAEPVAFAADMLAMAVCEIGSISERRTAMLVDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRA
YPASVDSIPTSANQEDHVSMAAHGARRLLAMAENAAHVIGIELLAAVQGCDFHAPLRSSTALEAARALLRAQVPTLQDDR
YFHPDMLAASALVRSGALAQTVAIPLPGVEQDV
>Mature_512_residues
SVSIVLQPGQVTLAQWRALYRGAEVALDDACAAAVLRSAQTVEAIVARGEPVYGVNTGFGKLASVRIEREDLQALQRNIV
LSHAAGVGEPTPVPVVRLMMALKLTSLAQGASGVQPDTLALLDAMLRAGITPVVPCQGSVGASGDLAPLSHLAAAMIGVG
EAFVGAQRLPAADALAHAQLQPRVLGAKEGLALLNGTQFSTACALAGLFEIETVLQAALVTGALSVEAAKGSDTPFDARI
HALRGQPGQIATAAALRALMADSAIRESHRLGDVRVQDPYCLRCQPQVMGAALDVMRQAARTLEIEANGVSDNPLVFSDT
GEALSGGNFHAEPVAFAADMLAMAVCEIGSISERRTAMLVDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRAY
PASVDSIPTSANQEDHVSMAAHGARRLLAMAENAAHVIGIELLAAVQGCDFHAPLRSSTALEAARALLRAQVPTLQDDRY
FHPDMLAASALVRSGALAQTVAIPLPGVEQDV

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=492, Percent_Identity=43.2926829268293, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17567831, Length=482, Percent_Identity=44.8132780082988, Blast_Score=347, Evalue=6e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_XANAC (Q8PLZ8)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641969.1
- ProteinModelPortal:   Q8PLZ8
- SMR:   Q8PLZ8
- GeneID:   1155708
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1637
- NMPDR:   fig|190486.1.peg.1613
- HOGENOM:   HBG510887
- OMA:   QKGQIDS
- ProtClustDB:   PRK09367
- BioCyc:   XAXO190486:XAC1637-MONOMER
- BRENDA:   4.3.1.3
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 53162; Mature: 53030

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00488 PAL_HISTIDASE; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSIVLQPGQVTLAQWRALYRGAEVALDDACAAAVLRSAQTVEAIVARGEPVYGVNTGF
CCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
GKLASVRIEREDLQALQRNIVLSHAAGVGEPTPVPVVRLMMALKLTSLAQGASGVQPDTL
CCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
ALLDAMLRAGITPVVPCQGSVGASGDLAPLSHLAAAMIGVGEAFVGAQRLPAADALAHAQ
HHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHH
LQPRVLGAKEGLALLNGTQFSTACALAGLFEIETVLQAALVTGALSVEAAKGSDTPFDAR
CCCHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHH
IHALRGQPGQIATAAALRALMADSAIRESHRLGDVRVQDPYCLRCQPQVMGAALDVMRQA
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHHHHHHHHH
ARTLEIEANGVSDNPLVFSDTGEALSGGNFHAEPVAFAADMLAMAVCEIGSISERRTAML
HHEEEEEECCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEE
VDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRAYPASVDSIPTSANQEDHVSM
ECHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
AAHGARRLLAMAENAAHVIGIELLAAVQGCDFHAPLRSSTALEAARALLRAQVPTLQDDR
HHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
YFHPDMLAASALVRSGALAQTVAIPLPGVEQDV
CCCHHHHHHHHHHHCCCHHHEEEECCCCCCCCC
>Mature Secondary Structure 
SVSIVLQPGQVTLAQWRALYRGAEVALDDACAAAVLRSAQTVEAIVARGEPVYGVNTGF
CEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
GKLASVRIEREDLQALQRNIVLSHAAGVGEPTPVPVVRLMMALKLTSLAQGASGVQPDTL
CCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
ALLDAMLRAGITPVVPCQGSVGASGDLAPLSHLAAAMIGVGEAFVGAQRLPAADALAHAQ
HHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHH
LQPRVLGAKEGLALLNGTQFSTACALAGLFEIETVLQAALVTGALSVEAAKGSDTPFDAR
CCCHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHH
IHALRGQPGQIATAAALRALMADSAIRESHRLGDVRVQDPYCLRCQPQVMGAALDVMRQA
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHHHHHHHHH
ARTLEIEANGVSDNPLVFSDTGEALSGGNFHAEPVAFAADMLAMAVCEIGSISERRTAML
HHEEEEEECCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEE
VDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRAYPASVDSIPTSANQEDHVSM
ECHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
AAHGARRLLAMAENAAHVIGIELLAAVQGCDFHAPLRSSTALEAARALLRAQVPTLQDDR
HHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
YFHPDMLAASALVRSGALAQTVAIPLPGVEQDV
CCCHHHHHHHHHHHCCCHHHEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217