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The map label for this gene is sbcB [H]

Identifier: 21242349

GI number: 21242349

Start: 1845619

End: 1847064

Strand: Reverse

Name: sbcB [H]

Synonym: XAC1599

Alternate gene names: 21242349

Gene position: 1847064-1845619 (Counterclockwise)

Preceding gene: 21242350

Following gene: 21242348

Centisome position: 35.69

GC content: 65.35

Gene sequence:

>1446_bases
ATGCCTGACAGCTTTCTCTTCTACGACCTGGAAACCTTCGGCCAGGATCCACGCCGCACCCGCATTGCACAGTTCGCTGC
AGTGCGCACCGACGCGCAACTGCGCGTGATCGAAGAGCCCATCAGCTTTTTCGTGCAGCCGGCCGACGATCTGCTGCCCT
CGCCCTACGCCACCATGGTGACCGGCATCACCCCGCAGCACGCGCTGCGCGAAGGCGTCACCGAGGCCGAGGCGTTCGCA
CGCATCGCCGAACAGATGGGCCGACCGCAGACCTGCACGCTGGGCTACAACTCGATCCGCTTCGACGACGAATTCATCCG
CTGCGGCCTGTTCCGCAATTTCTACGACCCGTACGAGCGCGAGTGGCGTGGCGGCAATTCCCGCTGGGATTTGCTGGATG
TGCTGCGACTGGTACACGCGCTGCGCCCGGACGGCATCGTCTGGCCACAGCGCGAAGATGGCGCCACCTCGTTCAAGCTG
GAGCACCTGGCCGATGCCAACGATGTGCGCGAAGGCGATGCGCACGAAGCCTTGTCGGACGTGTACGCCACCATCGGCAT
GGCGCGCAAATTCCAGCAGCACCAGCCGAAGTTGTGGGACTACGCGCTGCGCCTGCGCGACAAGCGCTTTGCAGCCGCCT
TGCTGGATGTCATTGCGATGCAACCGGTGCTGCATGTTTCGCAGCGTTACCCCGCCTCGCGCCTTTGCGCTGCGGCGGTA
CTGCCGCTGACGCGCCACCCGCGCATCGACAGCCGCGTGATCGTATTCGATCTGGAGGGCGACCCGGAGGTGCTGTTGCG
GCTCAGCCCCGACGATATTGCAGACCGCCTGTATATCCGCGCCGCGGATTTGCCGGAAGGCGAACAGCGTATCCCGCTAA
AGGAAGTGCATCTGAACAAGTCGCCCGCGCTGGTAGCCTGGCAGCATCTGCGCGCTGCGGATTTCGAGCGCCTGGGTGTG
GATCACGACGCGGTAGTGGCCAAGGCGGCACGGTTGCGCGCATTGGGCCCTGAACTTGCCGAGAAGGTGCGCCAGGTCTA
CGGCAGCGAACGCGCCGCGGCCGCGGCGGTCAACGATGCCGACGCCTCGCTCTACGATGGCTTTCTGGCCGAAGGCGACA
AACGCCTGCTTGCGCAGGTCCGCGCCAGCGCGCCGGACGAACTGGGCGCGCTGGAAGCGCGCTTTCGCGATCCGCGCCTG
ATCGAGCTGCTGTTTCGCTACCGCGCGCGCAACTGGCCGCAGACACTCTCGTTCGAGGAACAGGAGCGCTGGAACGTGTA
TCGCCGCCAGCGCCTGCTCCAAGACCGCGGCCTGGGCGAAGTCACCCTGGAGCAATACCACGCGCAGATCGCGGATTTAC
GGGGTGCTCACCCCGACGATGCTACCAAGCAAGCCCTACTCGACCAGCTCGCCGCCTGGGGTTCGGACCTCCAACGCACG
CTATGA

Upstream 100 bases:

>100_bases
TTTGTTAGCTGCTCTTCGCGTGGCGTTGCCGCGATGGGGGATACTAGGCGACCCCGGCAGCGCATACGCCGTGCGCCGCG
CATCTGGATGTCGTACCCGC

Downstream 100 bases:

>100_bases
CCACCTACTTTTCCGACGCCAGCTTCAAGTTCCTGCGCGCCCTGGCCCGCCACAACGACAAGACCTGGTTCAACGACCAT
CGGCATCAGTATGAAGCGCA

Product: exonuclease I

Products: NA

Alternate protein names: Exonuclease I; DNA deoxyribophosphodiesterase; dRPase [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MPDSFLFYDLETFGQDPRRTRIAQFAAVRTDAQLRVIEEPISFFVQPADDLLPSPYATMVTGITPQHALREGVTEAEAFA
RIAEQMGRPQTCTLGYNSIRFDDEFIRCGLFRNFYDPYEREWRGGNSRWDLLDVLRLVHALRPDGIVWPQREDGATSFKL
EHLADANDVREGDAHEALSDVYATIGMARKFQQHQPKLWDYALRLRDKRFAAALLDVIAMQPVLHVSQRYPASRLCAAAV
LPLTRHPRIDSRVIVFDLEGDPEVLLRLSPDDIADRLYIRAADLPEGEQRIPLKEVHLNKSPALVAWQHLRAADFERLGV
DHDAVVAKAARLRALGPELAEKVRQVYGSERAAAAAVNDADASLYDGFLAEGDKRLLAQVRASAPDELGALEARFRDPRL
IELLFRYRARNWPQTLSFEEQERWNVYRRQRLLQDRGLGEVTLEQYHAQIADLRGAHPDDATKQALLDQLAAWGSDLQRT
L

Sequences:

>Translated_481_residues
MPDSFLFYDLETFGQDPRRTRIAQFAAVRTDAQLRVIEEPISFFVQPADDLLPSPYATMVTGITPQHALREGVTEAEAFA
RIAEQMGRPQTCTLGYNSIRFDDEFIRCGLFRNFYDPYEREWRGGNSRWDLLDVLRLVHALRPDGIVWPQREDGATSFKL
EHLADANDVREGDAHEALSDVYATIGMARKFQQHQPKLWDYALRLRDKRFAAALLDVIAMQPVLHVSQRYPASRLCAAAV
LPLTRHPRIDSRVIVFDLEGDPEVLLRLSPDDIADRLYIRAADLPEGEQRIPLKEVHLNKSPALVAWQHLRAADFERLGV
DHDAVVAKAARLRALGPELAEKVRQVYGSERAAAAAVNDADASLYDGFLAEGDKRLLAQVRASAPDELGALEARFRDPRL
IELLFRYRARNWPQTLSFEEQERWNVYRRQRLLQDRGLGEVTLEQYHAQIADLRGAHPDDATKQALLDQLAAWGSDLQRT
L
>Mature_480_residues
PDSFLFYDLETFGQDPRRTRIAQFAAVRTDAQLRVIEEPISFFVQPADDLLPSPYATMVTGITPQHALREGVTEAEAFAR
IAEQMGRPQTCTLGYNSIRFDDEFIRCGLFRNFYDPYEREWRGGNSRWDLLDVLRLVHALRPDGIVWPQREDGATSFKLE
HLADANDVREGDAHEALSDVYATIGMARKFQQHQPKLWDYALRLRDKRFAAALLDVIAMQPVLHVSQRYPASRLCAAAVL
PLTRHPRIDSRVIVFDLEGDPEVLLRLSPDDIADRLYIRAADLPEGEQRIPLKEVHLNKSPALVAWQHLRAADFERLGVD
HDAVVAKAARLRALGPELAEKVRQVYGSERAAAAAVNDADASLYDGFLAEGDKRLLAQVRASAPDELGALEARFRDPRLI
ELLFRYRARNWPQTLSFEEQERWNVYRRQRLLQDRGLGEVTLEQYHAQIADLRGAHPDDATKQALLDQLAAWGSDLQRTL

Specific function: Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase [H]

COG id: COG2925

COG function: function code L; Exonuclease I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788321, Length=474, Percent_Identity=43.4599156118143, Blast_Score=379, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013620
- InterPro:   IPR013520
- InterPro:   IPR012337 [H]

Pfam domain/function: PF00929 Exonuc_X-T; PF08411 Exonuc_X-T_C [H]

EC number: =3.1.11.1 [H]

Molecular weight: Translated: 54736; Mature: 54604

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSFLFYDLETFGQDPRRTRIAQFAAVRTDAQLRVIEEPISFFVQPADDLLPSPYATMV
CCCCEEEEEHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHH
TGITPQHALREGVTEAEAFARIAEQMGRPQTCTLGYNSIRFDDEFIRCGLFRNFYDPYER
CCCCHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCCCCEECCHHHHHHHHHHHHCCHHHH
EWRGGNSRWDLLDVLRLVHALRPDGIVWPQREDGATSFKLEHLADANDVREGDAHEALSD
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHCCCHHCCCCHHHHHHHH
VYATIGMARKFQQHQPKLWDYALRLRDKRFAAALLDVIAMQPVLHVSQRYPASRLCAAAV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LPLTRHPRIDSRVIVFDLEGDPEVLLRLSPDDIADRLYIRAADLPEGEQRIPLKEVHLNK
CCCCCCCCCCCEEEEEEECCCCEEEEEECCHHHHHHEEEEECCCCCCCCCCCHHHHCCCC
SPALVAWQHLRAADFERLGVDHDAVVAKAARLRALGPELAEKVRQVYGSERAAAAAVNDA
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHCCCC
DASLYDGFLAEGDKRLLAQVRASAPDELGALEARFRDPRLIELLFRYRARNWPQTLSFEE
CHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCH
QERWNVYRRQRLLQDRGLGEVTLEQYHAQIADLRGAHPDDATKQALLDQLAAWGSDLQRT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
L
C
>Mature Secondary Structure 
PDSFLFYDLETFGQDPRRTRIAQFAAVRTDAQLRVIEEPISFFVQPADDLLPSPYATMV
CCCEEEEEHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHH
TGITPQHALREGVTEAEAFARIAEQMGRPQTCTLGYNSIRFDDEFIRCGLFRNFYDPYER
CCCCHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCCCCEECCHHHHHHHHHHHHCCHHHH
EWRGGNSRWDLLDVLRLVHALRPDGIVWPQREDGATSFKLEHLADANDVREGDAHEALSD
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHCCCHHCCCCHHHHHHHH
VYATIGMARKFQQHQPKLWDYALRLRDKRFAAALLDVIAMQPVLHVSQRYPASRLCAAAV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LPLTRHPRIDSRVIVFDLEGDPEVLLRLSPDDIADRLYIRAADLPEGEQRIPLKEVHLNK
CCCCCCCCCCCEEEEEEECCCCEEEEEECCHHHHHHEEEEECCCCCCCCCCCHHHHCCCC
SPALVAWQHLRAADFERLGVDHDAVVAKAARLRALGPELAEKVRQVYGSERAAAAAVNDA
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHCCCC
DASLYDGFLAEGDKRLLAQVRASAPDELGALEARFRDPRLIELLFRYRARNWPQTLSFEE
CHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCH
QERWNVYRRQRLLQDRGLGEVTLEQYHAQIADLRGAHPDDATKQALLDQLAAWGSDLQRT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3539937; 9097040; 9278503; 1329027 [H]