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The map label for this gene is lktB [H]

Identifier: 21242279

GI number: 21242279

Start: 1764321

End: 1766087

Strand: Reverse

Name: lktB [H]

Synonym: XAC1528

Alternate gene names: 21242279

Gene position: 1766087-1764321 (Counterclockwise)

Preceding gene: 21242280

Following gene: 21242278

Centisome position: 34.12

GC content: 65.48

Gene sequence:

>1767_bases
GTGCCGAATAAGCGCCATGGCCTTGTTTGCGGGCCGGCAACTCGTCAATGCTTCACTGAACTCATCAACGGATATCGAAT
GGCGGCCAAGCGGATTGGATGGCGGGAAGCGGCGAGCTGGCTGACGGAAATTGTCGGACCGGACATGCCGTATGTGCGCC
TGACCCTGGTGTACGGCGTTGCGATCAGCCTGCTCTCGCTGGCCACGCCGATCTCGGTGCAGTTGCTGATCAACAGCGTT
GCCAACACCGCGCTGCCCACGCCGCTGTGGACGTTGTCCGGCCTGCTGCTGGGCCTGCTGTTGCTGGTGGCGGCACTCAG
CGCGATGCGGGTGTGGGTGATGGCGCTGTTCGAACGTCGCCTGTTCGCACGCGTGGTGGCGGAGATCACCGTGCGCGCGG
TACATGCACAGAACCCGTTCTTCGCCGACCAGAACCGCGGCGATGTCTTCAACCGCTACTTCGATCTGGTGGTGGTGCAA
AAGGCAGTGCCCAGCCTGGCGGTCGGTGCGTTCACCATCGTGCTGCAGTCGGCGGTCGGCTTGATCGTCACCAGCTTCTA
TCACCCGTTTTTCCTCGGCTTCAACGCGCTGCTGCTGCTGACCATCTTCTCGATCTGGATGATCTGGTCGCGCGGCTCGA
TCCGCTCGGCGGTCGAACTGAGCCAGGCCAAGCACAATGCCGCGCATTGGCTGGAAAGCGTCGGCGGCTCCAACGGGTTC
TATAAATCCAGCCGCCATCTCAACTTTGCGATGGATCGCTCGGAAAAGGTGACCGCCGACTATGTCGACCGGCATCGGCG
CCATTTCCGCTACACCTTCACCCAGACGCTGGCGTTCCTGCTCACCTATGCGGTCGCCAGCGCGGCGCTGCTGGCACTGG
GCGGCAGCCTGATCCTGCGCGGCGAGCTGTCGATCGGCCAGCTGGTGGCAGCCGAGCTGATCCTGAGCGCGGTGTTCTAC
GGCATCGCACAGTTGGGCAGCTACCTGGACATGTTCTACGACCTGGTGGCCAGTGCGGAGGAGTTGTCGCTGCTGTACGC
CATCCCCCAGGAGCGCCCGGTGCTTGCCGCCGGCGAGGCGCCGCGCAACAGCGGGGTACGCCTGGATGGCGTGGTGATCG
AGGGCGCGCGTTTCGATTTCGCGCTGGAAGCCGGCGAGCAGTTGGTCACGCTGGCCGATGGCGGCGCCGAGCGCCTGCTG
GCCATGGTGCTCAAGCGCCACGTGGTCCCCGACCGCGGGCTGGTGATGGTGGGCGGCGCGGACATGGCCACCTTCGATAT
GTACCTGCTGCGTTCGGAAGTCACCGTGCTCGACCGCCCGACCATCGTGGAGGTCACCATTCGCGAATACCTGGCGATGG
CCTCGGCCGATGTGACGTCCGAAGCGATGCTGCAAGCCATCGACGCGGTGGGCTTGCGCGCGCGCATCGCCGCGTTGCCG
CAAGGCCTGGACACCCGGCTTGCCGCGTCCGGGTTCCCGTTGTGGATCGGCGAGGTCATGGCGCTGAAGCTGGCCAATGC
ACTGTTGGTGCGCCCGCGCGTGCTGATGCTGTCGCAGCTGTACGACCTGATCCCGGCCGAGCGCCTGACCCGGGTTCTGC
GACGGTTGAAGGATGCAGGAACCACCGTGCTGCTGTGCACCGGGCGGCCGGAGGACATCACCCTGGATGGCTGGTTCCGG
CTGGAGCCGCAGCGCCAGCAACGCTACGCCACACGCGCCGAGTTGATCGCATCCACGCAGGAGGTGCCGCATGCCGCACG
CCCCTGA

Upstream 100 bases:

>100_bases
GGGAGATCGGTCTGCTCTGGCGCCAGGGTGCCGGTCGCGCACCGGCCTTCGGTTTGATCGCCAATCTGCTGCGCGCGGTG
GCTGCATAGGAAAATCCTAT

Downstream 100 bases:

>100_bases
TCGCATGGCGCATTTCCCGACCCTGGCGGCAATGCGACCGCCCAGCATCGCCAAGGCGGTCGCCTGGATGCTGTTGATCG
GCATCGGCATCGCTGCGGCG

Product: toxin secretion ABC transporter ATP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MPNKRHGLVCGPATRQCFTELINGYRMAAKRIGWREAASWLTEIVGPDMPYVRLTLVYGVAISLLSLATPISVQLLINSV
ANTALPTPLWTLSGLLLGLLLLVAALSAMRVWVMALFERRLFARVVAEITVRAVHAQNPFFADQNRGDVFNRYFDLVVVQ
KAVPSLAVGAFTIVLQSAVGLIVTSFYHPFFLGFNALLLLTIFSIWMIWSRGSIRSAVELSQAKHNAAHWLESVGGSNGF
YKSSRHLNFAMDRSEKVTADYVDRHRRHFRYTFTQTLAFLLTYAVASAALLALGGSLILRGELSIGQLVAAELILSAVFY
GIAQLGSYLDMFYDLVASAEELSLLYAIPQERPVLAAGEAPRNSGVRLDGVVIEGARFDFALEAGEQLVTLADGGAERLL
AMVLKRHVVPDRGLVMVGGADMATFDMYLLRSEVTVLDRPTIVEVTIREYLAMASADVTSEAMLQAIDAVGLRARIAALP
QGLDTRLAASGFPLWIGEVMALKLANALLVRPRVLMLSQLYDLIPAERLTRVLRRLKDAGTTVLLCTGRPEDITLDGWFR
LEPQRQQRYATRAELIASTQEVPHAARP

Sequences:

>Translated_588_residues
MPNKRHGLVCGPATRQCFTELINGYRMAAKRIGWREAASWLTEIVGPDMPYVRLTLVYGVAISLLSLATPISVQLLINSV
ANTALPTPLWTLSGLLLGLLLLVAALSAMRVWVMALFERRLFARVVAEITVRAVHAQNPFFADQNRGDVFNRYFDLVVVQ
KAVPSLAVGAFTIVLQSAVGLIVTSFYHPFFLGFNALLLLTIFSIWMIWSRGSIRSAVELSQAKHNAAHWLESVGGSNGF
YKSSRHLNFAMDRSEKVTADYVDRHRRHFRYTFTQTLAFLLTYAVASAALLALGGSLILRGELSIGQLVAAELILSAVFY
GIAQLGSYLDMFYDLVASAEELSLLYAIPQERPVLAAGEAPRNSGVRLDGVVIEGARFDFALEAGEQLVTLADGGAERLL
AMVLKRHVVPDRGLVMVGGADMATFDMYLLRSEVTVLDRPTIVEVTIREYLAMASADVTSEAMLQAIDAVGLRARIAALP
QGLDTRLAASGFPLWIGEVMALKLANALLVRPRVLMLSQLYDLIPAERLTRVLRRLKDAGTTVLLCTGRPEDITLDGWFR
LEPQRQQRYATRAELIASTQEVPHAARP
>Mature_587_residues
PNKRHGLVCGPATRQCFTELINGYRMAAKRIGWREAASWLTEIVGPDMPYVRLTLVYGVAISLLSLATPISVQLLINSVA
NTALPTPLWTLSGLLLGLLLLVAALSAMRVWVMALFERRLFARVVAEITVRAVHAQNPFFADQNRGDVFNRYFDLVVVQK
AVPSLAVGAFTIVLQSAVGLIVTSFYHPFFLGFNALLLLTIFSIWMIWSRGSIRSAVELSQAKHNAAHWLESVGGSNGFY
KSSRHLNFAMDRSEKVTADYVDRHRRHFRYTFTQTLAFLLTYAVASAALLALGGSLILRGELSIGQLVAAELILSAVFYG
IAQLGSYLDMFYDLVASAEELSLLYAIPQERPVLAAGEAPRNSGVRLDGVVIEGARFDFALEAGEQLVTLADGGAERLLA
MVLKRHVVPDRGLVMVGGADMATFDMYLLRSEVTVLDRPTIVEVTIREYLAMASADVTSEAMLQAIDAVGLRARIAALPQ
GLDTRLAASGFPLWIGEVMALKLANALLVRPRVLMLSQLYDLIPAERLTRVLRRLKDAGTTVLLCTGRPEDITLDGWFRL
EPQRQQRYATRAELIASTQEVPHAARP

Specific function: Part of the ABC transporter complex LktBD involved in leukotoxin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable) [H]

COG id: COG2274

COG function: function code V; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 peptidase C39 domain [H]

Homologues:

Organism=Homo sapiens, GI171184400, Length=527, Percent_Identity=23.1499051233397, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI42741659, Length=302, Percent_Identity=23.1788079470199, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786653, Length=525, Percent_Identity=21.9047619047619, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI193202349, Length=320, Percent_Identity=20.9375, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323959, Length=376, Percent_Identity=23.936170212766, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593
- InterPro:   IPR010132
- InterPro:   IPR005074 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran; PF03412 Peptidase_C39 [H]

EC number: =3.6.3.43 [H]

Molecular weight: Translated: 64683; Mature: 64552

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CEEEEEECCCCCEEECCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PNKRHGLVCGPATRQCFTELINGYRMAAKRIGWREAASWLTEIVGPDMPYVRLTLVYGV
CCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
AISLLSLATPISVQLLINSVANTALPTPLWTLSGLLLGLLLLVAALSAMRVWVMALFERR
HHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFARVVAEITVRAVHAQNPFFADQNRGDVFNRYFDLVVVQKAVPSLAVGAFTIVLQSAVG
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIVTSFYHPFFLGFNALLLLTIFSIWMIWSRGSIRSAVELSQAKHNAAHWLESVGGSNGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
YKSSRHLNFAMDRSEKVTADYVDRHRRHFRYTFTQTLAFLLTYAVASAALLALGGSLILR
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
GELSIGQLVAAELILSAVFYGIAQLGSYLDMFYDLVASAEELSLLYAIPQERPVLAAGEA
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHEEEECCCCCCEEECCCC
PRNSGVRLDGVVIEGARFDFALEAGEQLVTLADGGAERLLAMVLKRHVVPDRGLVMVGGA
CCCCCCEEEEEEEECCCCCEEECCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCC
DMATFDMYLLRSEVTVLDRPTIVEVTIREYLAMASADVTSEAMLQAIDAVGLRARIAALP
CHHHHHHHHHHHHHHEECCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
QGLDTRLAASGFPLWIGEVMALKLANALLVRPRVLMLSQLYDLIPAERLTRVLRRLKDAG
CCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
TTVLLCTGRPEDITLDGWFRLEPQRQQRYATRAELIASTQEVPHAARP
CEEEEEECCCCCEEECCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11741868 [H]