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The map label for this gene is tpmT

Identifier: 21242192

GI number: 21242192

Start: 1660877

End: 1661533

Strand: Reverse

Name: tpmT

Synonym: XAC1439

Alternate gene names: 21242192

Gene position: 1661533-1660877 (Counterclockwise)

Preceding gene: 21242193

Following gene: 21242190

Centisome position: 32.1

GC content: 62.25

Gene sequence:

>657_bases
ATGGACACGAACTTCTGGTTGGAACGTTGGCAGCTGGGACACACCGGCTTTCATCAGCAAGAGGTGTTGCCGCTGCTGCA
AAAGCACTGGCACGCGCTTGATTTGCCGAAGGAATCGCGCGTGCTGGTGCCCCTGTGCGGCAAGACGCTGGACATGCACT
GGCTGGCGTCGCAAGGCCATCGCGTGCTTGGCGTGGAACTGTCGCCGCTGGCGGTGACGCAATTCTTCGATGAGGCAGGC
CTTCAACCGCAACGTCACACCAGCGCTGCTGGCGAGCATTTCATCGCCGGCCCGATCGAGATCATCTGCGGCGATGCATT
CGCGCTGGACGCCAGCGTGCTGGCCGACTGCACGGCCGTCTACGACCGTGCAGCACTGGTCGCGCTACCGGCCGAACTGC
GCCAGCGTTACCTGCAAACGGTCTATGTGCAGTTGCCCACACACTGCCGCGGCCTGCTGATCACCCTGGAATATCCGCAG
GCAGAAAAGGCCGGCCCGCCATTCTCGGTGGACGCAACGCACGTGCATGCACTTTTCGATGCTGCCTGGCAGGTAGACCA
GTTGGAACGGCGCGACATCCTCGATCAGGAACCACGCTTCCGCGATGAAGGTGTCACTGGGTTGTCGACTGCCGTCTATC
GCCTGCAACGCCGCTGA

Upstream 100 bases:

>100_bases
TGCCATCGCAACGGCCTGCCAACGCTGCGCACCGCTTCAGAACGCACCACGCCCCACTCTCACATGACCACAGTGGAGAC
AGCCACTGGCAAGGCAACGC

Downstream 100 bases:

>100_bases
AACGGCCGTCGGATGTTGCACGCCCATCACGTCGCAATTGCATGGCTTGCATGCGGCGAGCGCCGCCGGCTGATCAGGCC
AGCGCGGCATTGCCCCATGC

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MDTNFWLERWQLGHTGFHQQEVLPLLQKHWHALDLPKESRVLVPLCGKTLDMHWLASQGHRVLGVELSPLAVTQFFDEAG
LQPQRHTSAAGEHFIAGPIEIICGDAFALDASVLADCTAVYDRAALVALPAELRQRYLQTVYVQLPTHCRGLLITLEYPQ
AEKAGPPFSVDATHVHALFDAAWQVDQLERRDILDQEPRFRDEGVTGLSTAVYRLQRR

Sequences:

>Translated_218_residues
MDTNFWLERWQLGHTGFHQQEVLPLLQKHWHALDLPKESRVLVPLCGKTLDMHWLASQGHRVLGVELSPLAVTQFFDEAG
LQPQRHTSAAGEHFIAGPIEIICGDAFALDASVLADCTAVYDRAALVALPAELRQRYLQTVYVQLPTHCRGLLITLEYPQ
AEKAGPPFSVDATHVHALFDAAWQVDQLERRDILDQEPRFRDEGVTGLSTAVYRLQRR
>Mature_218_residues
MDTNFWLERWQLGHTGFHQQEVLPLLQKHWHALDLPKESRVLVPLCGKTLDMHWLASQGHRVLGVELSPLAVTQFFDEAG
LQPQRHTSAAGEHFIAGPIEIICGDAFALDASVLADCTAVYDRAALVALPAELRQRYLQTVYVQLPTHCRGLLITLEYPQ
AEKAGPPFSVDATHVHALFDAAWQVDQLERRDILDQEPRFRDEGVTGLSTAVYRLQRR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=219, Percent_Identity=32.4200913242009, Blast_Score=114, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_XANAC (Q8PMI8)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641774.1
- ProteinModelPortal:   Q8PMI8
- SMR:   Q8PMI8
- GeneID:   1155510
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1439
- NMPDR:   fig|190486.1.peg.1418
- HOGENOM:   HBG444929
- OMA:   PPFAVSP
- ProtClustDB:   PRK13255
- BioCyc:   XAXO190486:XAC1439-MONOMER
- BRENDA:   2.1.1.67
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 24607; Mature: 24607

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 45-45 BINDING 66-66 BINDING 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTNFWLERWQLGHTGFHQQEVLPLLQKHWHALDLPKESRVLVPLCGKTLDMHWLASQGH
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHCCCC
RVLGVELSPLAVTQFFDEAGLQPQRHTSAAGEHFIAGPIEIICGDAFALDASVLADCTAV
EEEEEEECHHHHHHHHHHHCCCCCHHHHCCCCCEECCCEEEEECCHHHHHHHHHHHHHHH
YDRAALVALPAELRQRYLQTVYVQLPTHCRGLLITLEYPQAEKAGPPFSVDATHVHALFD
HHHHHHEECCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
AAWQVDQLERRDILDQEPRFRDEGVTGLSTAVYRLQRR
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MDTNFWLERWQLGHTGFHQQEVLPLLQKHWHALDLPKESRVLVPLCGKTLDMHWLASQGH
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHCCCC
RVLGVELSPLAVTQFFDEAGLQPQRHTSAAGEHFIAGPIEIICGDAFALDASVLADCTAV
EEEEEEECHHHHHHHHHHHCCCCCHHHHCCCCCEECCCEEEEECCHHHHHHHHHHHHHHH
YDRAALVALPAELRQRYLQTVYVQLPTHCRGLLITLEYPQAEKAGPPFSVDATHVHALFD
HHHHHHEECCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
AAWQVDQLERRDILDQEPRFRDEGVTGLSTAVYRLQRR
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217