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The map label for this gene is pyrH

Identifier: 21242172

GI number: 21242172

Start: 1633881

End: 1634603

Strand: Reverse

Name: pyrH

Synonym: XAC1419

Alternate gene names: 21242172

Gene position: 1634603-1633881 (Counterclockwise)

Preceding gene: 21242173

Following gene: 21242171

Centisome position: 31.58

GC content: 64.18

Gene sequence:

>723_bases
ATGTCCGAACTTTCCTATCGCCGCATTCTTCTCAAACTTTCCGGGGAGGCGCTGATGGGAGACGGGGATTACGGCATCGA
CCCCAAAGTCATCAATCGTCTGGCGCATGAGGTGATCGAAGCCCAGCAGGCCGGCGCGCAGGTGGCGCTGGTGATCGGCG
GTGGCAACATCTTCCGCGGCGCCGGCCTGGCTGCCAGCGGCATGGACCGCGTCACCGGCGATCACATGGGCATGCTGGCC
ACGGTGATCAATGCATTGGCGATGCAGGATGCGCTGGAAAAGCTCGGCGCCAAGGTGCGCGTAATGAGCGCGATCAAGAT
CAACGACGTCTGCGAAGACTTCATCCGTCGCCGCGCGATCCGTCACCTGGAAAAGGGTCGCATCGCGATCTTCGCCGCCG
GCACCGGCAACCCGTTCTTCACCACCGACTCGGGCGCAGCGCTGCGCGCGATCGAGATCGGTGCCGACCTGCTGCTCAAG
GCGACCAAGGTCGACGGCGTGTACGACAAGGATCCGAAGAAGCACACCGATGCGGTGCGCTACGACAGCCTGACCTACGA
CCGGGTGATCCTGCAGGGCCTGGAAGTGATGGATACCGCCGCCTTCGCACTGGCGCGCGACAGTGACCTGCCGCTGCGCA
TCTTCGGCATGAGCGAACCGGGCGTGCTGCTGCGCATCCTGCATGGCGAGCAGATCGGCACGTTGGTGCAGGGCCGCAGC
TGA

Upstream 100 bases:

>100_bases
GGTCACGCCACTGCCAACAAAGGAATTTTTACCACGCCAGGTGACAGGCTTCCGCTAGAATTGCCGGCGTTTGCCGATCC
CCCACCCCCGAGGTCTCCCC

Downstream 100 bases:

>100_bases
GGCTGGGAATCGGGATTGGGGAATCGGGAATCGTTGAGCGCAGTGCTGACGCCTGCGTCGATGCCTGTCCGTCGAGCGCC
TCCAGCGGCAAGTGAACCGC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSELSYRRILLKLSGEALMGDGDYGIDPKVINRLAHEVIEAQQAGAQVALVIGGGNIFRGAGLAASGMDRVTGDHMGMLA
TVINALAMQDALEKLGAKVRVMSAIKINDVCEDFIRRRAIRHLEKGRIAIFAAGTGNPFFTTDSGAALRAIEIGADLLLK
ATKVDGVYDKDPKKHTDAVRYDSLTYDRVILQGLEVMDTAAFALARDSDLPLRIFGMSEPGVLLRILHGEQIGTLVQGRS

Sequences:

>Translated_240_residues
MSELSYRRILLKLSGEALMGDGDYGIDPKVINRLAHEVIEAQQAGAQVALVIGGGNIFRGAGLAASGMDRVTGDHMGMLA
TVINALAMQDALEKLGAKVRVMSAIKINDVCEDFIRRRAIRHLEKGRIAIFAAGTGNPFFTTDSGAALRAIEIGADLLLK
ATKVDGVYDKDPKKHTDAVRYDSLTYDRVILQGLEVMDTAAFALARDSDLPLRIFGMSEPGVLLRILHGEQIGTLVQGRS
>Mature_239_residues
SELSYRRILLKLSGEALMGDGDYGIDPKVINRLAHEVIEAQQAGAQVALVIGGGNIFRGAGLAASGMDRVTGDHMGMLAT
VINALAMQDALEKLGAKVRVMSAIKINDVCEDFIRRRAIRHLEKGRIAIFAAGTGNPFFTTDSGAALRAIEIGADLLLKA
TKVDGVYDKDPKKHTDAVRYDSLTYDRVILQGLEVMDTAAFALARDSDLPLRIFGMSEPGVLLRILHGEQIGTLVQGRS

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=57.5757575757576, Blast_Score=272, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_XANAC (P59008)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641754.1
- ProteinModelPortal:   P59008
- SMR:   P59008
- GeneID:   1155490
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1419
- NMPDR:   fig|190486.1.peg.1398
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   XAXO190486:XAC1419-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25833; Mature: 25702

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 162-162 BINDING 168-168 BINDING 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELSYRRILLKLSGEALMGDGDYGIDPKVINRLAHEVIEAQQAGAQVALVIGGGNIFRG
CCCCHHHHEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEECC
AGLAASGMDRVTGDHMGMLATVINALAMQDALEKLGAKVRVMSAIKINDVCEDFIRRRAI
CCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHH
RHLEKGRIAIFAAGTGNPFFTTDSGAALRAIEIGADLLLKATKVDGVYDKDPKKHTDAVR
HHHCCCCEEEEEECCCCCCEECCCCCEEEEEEECHHHHEEECCCCCCCCCCCCHHCCHHH
YDSLTYDRVILQGLEVMDTAAFALARDSDLPLRIFGMSEPGVLLRILHGEQIGTLVQGRS
HCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCHHHHHCCCCC
>Mature Secondary Structure 
SELSYRRILLKLSGEALMGDGDYGIDPKVINRLAHEVIEAQQAGAQVALVIGGGNIFRG
CCCHHHHEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEECC
AGLAASGMDRVTGDHMGMLATVINALAMQDALEKLGAKVRVMSAIKINDVCEDFIRRRAI
CCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHH
RHLEKGRIAIFAAGTGNPFFTTDSGAALRAIEIGADLLLKATKVDGVYDKDPKKHTDAVR
HHHCCCCEEEEEECCCCCCEECCCCCEEEEEEECHHHHEEECCCCCCCCCCCCHHCCHHH
YDSLTYDRVILQGLEVMDTAAFALARDSDLPLRIFGMSEPGVLLRILHGEQIGTLVQGRS
HCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217