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The map label for this gene is lpxB [H]

Identifier: 21242161

GI number: 21242161

Start: 1622525

End: 1623811

Strand: Reverse

Name: lpxB [H]

Synonym: XAC1408

Alternate gene names: 21242161

Gene position: 1623811-1622525 (Counterclockwise)

Preceding gene: 21242162

Following gene: 21242160

Centisome position: 31.37

GC content: 67.37

Gene sequence:

>1287_bases
GTGGACGGCCAGCGCAACGGCGCGTCGGTCGGCAGCGTTACGACTGCGCTACCGATTCCCGATTCCCCACTCCCGATTCC
CGGTGCGCGCAAGCGCGCACCTCGCATCGCGCTGATCGCCGGCGAGGCCTCTGGCGACATTCTCGGCGCGGGGCTGATCG
AGCAATTGCGGTTGCGCTATCCGAATGCCGAATTCGTGGGCATCGGTGGCGATGCGATGCGTGGCGTCGGTTGCCAGACC
TGGTTCGATGCCAGCGAGCTGGCGGTGATGGGCCTGACCGAGGTGCTGCGGCATTTGCCGCGCCTGCTCAAGCTGCGCAG
CGCGTTCCGCGAGCGGGTGCTGGCGTGGAAGCCGGACGTGTTCATCGGCATCGACGCGCCGGATTTCAATCTGCCGGTGG
AACGCTGGCTCAAGCAGCGCGGGATCAAGACCGTGCACTACGTCAGCCCGTCGGTGTGGGCGTGGCGCGAGAAGCGTGCC
GAAAAAATCGGCGTCAGCGCCGATCTGGTGCTGTGCCTGTTTCCGATGGAGCCGCCGATCTATGCCAAGCATGGCGTGGA
CGCCCGCTTTGTCGGCCACCCGATGGCCGACGATATCGCCTACCAGTCCGACCGCGCAGCGGCGCGCGCAACGCTGGGCC
TCTCCGCCTCCAGCACCGTCCTGGCAGTGTTGCCCGGCAGCCGGCACGGCGAAATCAGCCGGCTCGGCGACACCTTTTTC
CAGGCGGCCTGGCTGGTGTCCGAGCACCTGCCCAATCTGCATGTGCTGGTACCGGCCGCCAATCCGGGCTGCAAGCAACT
GCTGGCCGAGCAGCTGTCACGCTCGTCGCTGCCGGTGATGCGCTCGCATCTGCTCGACGGCCAGGCGCGCACCGCCATGC
TGGCCGCCGACGTGGTACTGCTGGCCTCCGGCACCGCCACGCTGGAAGCGATGCTGGTCAAGCGCCCGATGGTGGTGGGC
TACAAGGTCGCTCCGCTCACCTACCGTATCGTCAAGCTGCTGGGCCTGCTCAAGGTCAACCGCTACGCCCTGCCCAATAT
CCTGGCCAATGACGACTTGGCGCCGGAACTGATGCAGGACGACTGCACCCCCGAGCGACTGTGCGTGGCACTGCTGGACT
GGTTCAAACACCCCGACAAGGTCGCCGCCCTGCAGCCGCGCTACCTGGCCCTGCACGCAGAGTTGCGCCGCGATGCGTCG
GCGCGGGCAGCGGATGCGGTGGCTGGGCTGCTGTCGCAGCGCGAATCGGGAATGGAGAATCGGGAATCGGCAGGAGCCGG
CGCATGA

Upstream 100 bases:

>100_bases
CCAAGAGCAGCGACGATGTGCGCGGGATGCTCGAGTTCATCGAAGCAGCAGAACGGCCCTTGTTGCGATGAAGGGAATTG
GGAATCGGGAGTCGGGAATC

Downstream 100 bases:

>100_bases
GGCGCTCTACCTCCAATGGCGCGGTTGTCGTTCCGGCGACGCAGGACGGGCTTTTCCACGATTCCCCATTCCCCATTCCC
GATTCCCGCCTGATCGCCGG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MDGQRNGASVGSVTTALPIPDSPLPIPGARKRAPRIALIAGEASGDILGAGLIEQLRLRYPNAEFVGIGGDAMRGVGCQT
WFDASELAVMGLTEVLRHLPRLLKLRSAFRERVLAWKPDVFIGIDAPDFNLPVERWLKQRGIKTVHYVSPSVWAWREKRA
EKIGVSADLVLCLFPMEPPIYAKHGVDARFVGHPMADDIAYQSDRAAARATLGLSASSTVLAVLPGSRHGEISRLGDTFF
QAAWLVSEHLPNLHVLVPAANPGCKQLLAEQLSRSSLPVMRSHLLDGQARTAMLAADVVLLASGTATLEAMLVKRPMVVG
YKVAPLTYRIVKLLGLLKVNRYALPNILANDDLAPELMQDDCTPERLCVALLDWFKHPDKVAALQPRYLALHAELRRDAS
ARAADAVAGLLSQRESGMENRESAGAGA

Sequences:

>Translated_428_residues
MDGQRNGASVGSVTTALPIPDSPLPIPGARKRAPRIALIAGEASGDILGAGLIEQLRLRYPNAEFVGIGGDAMRGVGCQT
WFDASELAVMGLTEVLRHLPRLLKLRSAFRERVLAWKPDVFIGIDAPDFNLPVERWLKQRGIKTVHYVSPSVWAWREKRA
EKIGVSADLVLCLFPMEPPIYAKHGVDARFVGHPMADDIAYQSDRAAARATLGLSASSTVLAVLPGSRHGEISRLGDTFF
QAAWLVSEHLPNLHVLVPAANPGCKQLLAEQLSRSSLPVMRSHLLDGQARTAMLAADVVLLASGTATLEAMLVKRPMVVG
YKVAPLTYRIVKLLGLLKVNRYALPNILANDDLAPELMQDDCTPERLCVALLDWFKHPDKVAALQPRYLALHAELRRDAS
ARAADAVAGLLSQRESGMENRESAGAGA
>Mature_428_residues
MDGQRNGASVGSVTTALPIPDSPLPIPGARKRAPRIALIAGEASGDILGAGLIEQLRLRYPNAEFVGIGGDAMRGVGCQT
WFDASELAVMGLTEVLRHLPRLLKLRSAFRERVLAWKPDVFIGIDAPDFNLPVERWLKQRGIKTVHYVSPSVWAWREKRA
EKIGVSADLVLCLFPMEPPIYAKHGVDARFVGHPMADDIAYQSDRAAARATLGLSASSTVLAVLPGSRHGEISRLGDTFF
QAAWLVSEHLPNLHVLVPAANPGCKQLLAEQLSRSSLPVMRSHLLDGQARTAMLAADVVLLASGTATLEAMLVKRPMVVG
YKVAPLTYRIVKLLGLLKVNRYALPNILANDDLAPELMQDDCTPERLCVALLDWFKHPDKVAALQPRYLALHAELRRDAS
ARAADAVAGLLSQRESGMENRESAGAGA

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=380, Percent_Identity=47.1052631578947, Blast_Score=335, Evalue=4e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 46375; Mature: 46375

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGQRNGASVGSVTTALPIPDSPLPIPGARKRAPRIALIAGEASGDILGAGLIEQLRLRY
CCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCC
PNAEFVGIGGDAMRGVGCQTWFDASELAVMGLTEVLRHLPRLLKLRSAFRERVLAWKPDV
CCCCEEECCCHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCE
FIGIDAPDFNLPVERWLKQRGIKTVHYVSPSVWAWREKRAEKIGVSADLVLCLFPMEPPI
EEEECCCCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCC
YAKHGVDARFVGHPMADDIAYQSDRAAARATLGLSASSTVLAVLPGSRHGEISRLGDTFF
EECCCCCCEECCCCCHHHHHHCCCHHHHHHEECCCCCCCEEEEECCCCCCCHHHHHHHHH
QAAWLVSEHLPNLHVLVPAANPGCKQLLAEQLSRSSLPVMRSHLLDGQARTAMLAADVVL
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHH
LASGTATLEAMLVKRPMVVGYKVAPLTYRIVKLLGLLKVNRYALPNILANDDLAPELMQD
EECCHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHCHHHCCCHHCCCCCCHHHHHC
DCTPERLCVALLDWFKHPDKVAALQPRYLALHAELRRDASARAADAVAGLLSQRESGMEN
CCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCH
RESAGAGA
HCCCCCCC
>Mature Secondary Structure
MDGQRNGASVGSVTTALPIPDSPLPIPGARKRAPRIALIAGEASGDILGAGLIEQLRLRY
CCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCC
PNAEFVGIGGDAMRGVGCQTWFDASELAVMGLTEVLRHLPRLLKLRSAFRERVLAWKPDV
CCCCEEECCCHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCE
FIGIDAPDFNLPVERWLKQRGIKTVHYVSPSVWAWREKRAEKIGVSADLVLCLFPMEPPI
EEEECCCCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCC
YAKHGVDARFVGHPMADDIAYQSDRAAARATLGLSASSTVLAVLPGSRHGEISRLGDTFF
EECCCCCCEECCCCCHHHHHHCCCHHHHHHEECCCCCCCEEEEECCCCCCCHHHHHHHHH
QAAWLVSEHLPNLHVLVPAANPGCKQLLAEQLSRSSLPVMRSHLLDGQARTAMLAADVVL
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHH
LASGTATLEAMLVKRPMVVGYKVAPLTYRIVKLLGLLKVNRYALPNILANDDLAPELMQD
EECCHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHCHHHCCCHHCCCCCCHHHHHC
DCTPERLCVALLDWFKHPDKVAALQPRYLALHAELRRDASARAADAVAGLLSQRESGMEN
CCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCH
RESAGAGA
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]