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The map label for this gene is mraW

Identifier: 21241542

GI number: 21241542

Start: 915221

End: 916249

Strand: Direct

Name: mraW

Synonym: XAC0772

Alternate gene names: 21241542

Gene position: 915221-916249 (Clockwise)

Preceding gene: 21241541

Following gene: 21241543

Centisome position: 17.68

GC content: 68.42

Gene sequence:

>1029_bases
GTGTCGCAGTCCCCGGCGGCCCATGTGCCGGTGCTGTACACGCAGGTGCTGGATGGCCTGCAAGTGACCGAAAACGGAAC
GTATCTGGATGGCACGTTCGGGCGTGGCGGGCACGCGCGCGGCGTGCTGGAACACCTTGGCCCGGGAGGTCGACTGCTGG
TGATGGACAAGGACCCCGAAGCGATCGCGGTGGCCGAACACAGCTTCGGTGGCGATGCGCGCGTGTCCATCCATCGCGGC
AGTTTTGCCGGGCTCGGCCAGGTGGTTGCCGCCGCCACCGTCGACGGCATCCTGCTGGATCTGGGCGTGTCTTCGCCGCA
GCTGGACGTGGCCGGGCGCGGTTTCAGTTTCGGCAAGGACGGCCCGCTGGACATGCGCATGGACCCGGACAGCGGCCAGA
GCGCAGCCGAGTGGCTGGCGCAGGCCAGCGACCGCGAGATCGCCGATGTGCTGTGGACCTATGGCGAAGAACGCCAGAGC
CGCCGTATCGCGCGCGCCATCGTGGCGCGGCGCGCCGAACAGCCGCTGCTGCGCACCGCGCAACTGGCCGACCTGATCGC
GTCGGTGATGCCGCGCGGCGACAGCAAGACCCACCCGGCCACACGCAGCTTCCAGGCCATCCGCATCCACATCAACCGCG
AGCTGGCCGATCTGGAAGCCGGGCTGGATGCCGCCCTGGGCGCGCTCAAGCCGGGCGGCCGGCTGGCGGTGATCAGCTTC
CATTCGCTGGAAGATCGCATCGTCAAACAATTCATGGCCCGCTACGCCAAGGCGCCGCCGAGCAACCGCCGCTTGCCCGA
AGCACAGCCGTTCGTGGCCACGCTGCAACTGGTGAGCGGCGCGATCAAGGCCGACGACGCCGAATTGCACGTCAACCCGC
GCGCACGCAGCGCGGTGTTGCGGGTGGCCGAGAAGCTGGGATTGGGGAATGGGGAATCGGGAATGGGCAAAGGCAACAGC
GCCGCTGCTTCCCGATTCCCGACTGCCGATTCCCCATTCCCGGCGTCAGCGAACGGTGACGCCGCATGA

Upstream 100 bases:

>100_bases
AGCAGACATTGTCTGACGGGGATCTGGGCGATGAATTGCTCGATCTCAGGTTGTGAGCCGGGGTGCCCGGATGCGCGGTG
AAGCGCAGCCCGGTCACCCG

Downstream 100 bases:

>100_bases
GCCGCTTGCTGCTCGTCGTGCTGCTTGCCTGCAGCATCGCCTCGGCGATCGGTGTGGTGTATATGCGCCATATGCATCGC
AAGCTGTTCGTGCAGTTGTC

Product: S-adenosyl-methyltransferase MraW

Products: NA

Alternate protein names: 16S rRNA m(4)C1402 methyltransferase; rRNA (cytosine-N(4)-)-methyltransferase RsmH

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MSQSPAAHVPVLYTQVLDGLQVTENGTYLDGTFGRGGHARGVLEHLGPGGRLLVMDKDPEAIAVAEHSFGGDARVSIHRG
SFAGLGQVVAAATVDGILLDLGVSSPQLDVAGRGFSFGKDGPLDMRMDPDSGQSAAEWLAQASDREIADVLWTYGEERQS
RRIARAIVARRAEQPLLRTAQLADLIASVMPRGDSKTHPATRSFQAIRIHINRELADLEAGLDAALGALKPGGRLAVISF
HSLEDRIVKQFMARYAKAPPSNRRLPEAQPFVATLQLVSGAIKADDAELHVNPRARSAVLRVAEKLGLGNGESGMGKGNS
AAASRFPTADSPFPASANGDAA

Sequences:

>Translated_342_residues
MSQSPAAHVPVLYTQVLDGLQVTENGTYLDGTFGRGGHARGVLEHLGPGGRLLVMDKDPEAIAVAEHSFGGDARVSIHRG
SFAGLGQVVAAATVDGILLDLGVSSPQLDVAGRGFSFGKDGPLDMRMDPDSGQSAAEWLAQASDREIADVLWTYGEERQS
RRIARAIVARRAEQPLLRTAQLADLIASVMPRGDSKTHPATRSFQAIRIHINRELADLEAGLDAALGALKPGGRLAVISF
HSLEDRIVKQFMARYAKAPPSNRRLPEAQPFVATLQLVSGAIKADDAELHVNPRARSAVLRVAEKLGLGNGESGMGKGNS
AAASRFPTADSPFPASANGDAA
>Mature_341_residues
SQSPAAHVPVLYTQVLDGLQVTENGTYLDGTFGRGGHARGVLEHLGPGGRLLVMDKDPEAIAVAEHSFGGDARVSIHRGS
FAGLGQVVAAATVDGILLDLGVSSPQLDVAGRGFSFGKDGPLDMRMDPDSGQSAAEWLAQASDREIADVLWTYGEERQSR
RIARAIVARRAEQPLLRTAQLADLIASVMPRGDSKTHPATRSFQAIRIHINRELADLEAGLDAALGALKPGGRLAVISFH
SLEDRIVKQFMARYAKAPPSNRRLPEAQPFVATLQLVSGAIKADDAELHVNPRARSAVLRVAEKLGLGNGESGMGKGNSA
AASRFPTADSPFPASANGDAA

Specific function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA

COG id: COG0275

COG function: function code M; Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmH family

Homologues:

Organism=Homo sapiens, GI165377209, Length=340, Percent_Identity=39.1176470588235, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI165377202, Length=190, Percent_Identity=40.5263157894737, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI1786270, Length=306, Percent_Identity=53.921568627451, Blast_Score=309, Evalue=2e-85,
Organism=Drosophila melanogaster, GI62472493, Length=338, Percent_Identity=38.4615384615385, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI28571637, Length=338, Percent_Identity=38.4615384615385, Blast_Score=183, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RSMH_XANAC (Q8PPB5)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641124.1
- ProteinModelPortal:   Q8PPB5
- SMR:   Q8PPB5
- GeneID:   1154843
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0772
- NMPDR:   fig|190486.1.peg.768
- HOGENOM:   HBG302779
- OMA:   PQLDDPE
- ProtClustDB:   PRK00050
- BioCyc:   XAXO190486:XAC0772-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01007
- InterPro:   IPR002903
- PANTHER:   PTHR11265
- PIRSF:   PIRSF004486
- TIGRFAMs:   TIGR00006

Pfam domain/function: PF01795 Methyltransf_5

EC number: NA

Molecular weight: Translated: 36059; Mature: 35928

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: BINDING 56-56 BINDING 82-82 BINDING 100-100 BINDING 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSPAAHVPVLYTQVLDGLQVTENGTYLDGTFGRGGHARGVLEHLGPGGRLLVMDKDPE
CCCCCCCCCHHHHHHHHCCCEEECCCCEEECCCCCCCCHHHHHHHCCCCCEEEEEECCCC
AIAVAEHSFGGDARVSIHRGSFAGLGQVVAAATVDGILLDLGVSSPQLDVAGRGFSFGKD
EEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEECCCCCCCEEECCCCCCCCCC
GPLDMRMDPDSGQSAAEWLAQASDREIADVLWTYGEERQSRRIARAIVARRAEQPLLRTA
CCCCEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHH
QLADLIASVMPRGDSKTHPATRSFQAIRIHINRELADLEAGLDAALGALKPGGRLAVISF
HHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEEE
HSLEDRIVKQFMARYAKAPPSNRRLPEAQPFVATLQLVSGAIKADDAELHVNPRARSAVL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHH
RVAEKLGLGNGESGMGKGNSAAASRFPTADSPFPASANGDAA
HHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQSPAAHVPVLYTQVLDGLQVTENGTYLDGTFGRGGHARGVLEHLGPGGRLLVMDKDPE
CCCCCCCCHHHHHHHHCCCEEECCCCEEECCCCCCCCHHHHHHHCCCCCEEEEEECCCC
AIAVAEHSFGGDARVSIHRGSFAGLGQVVAAATVDGILLDLGVSSPQLDVAGRGFSFGKD
EEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEECCCCCCCEEECCCCCCCCCC
GPLDMRMDPDSGQSAAEWLAQASDREIADVLWTYGEERQSRRIARAIVARRAEQPLLRTA
CCCCEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHH
QLADLIASVMPRGDSKTHPATRSFQAIRIHINRELADLEAGLDAALGALKPGGRLAVISF
HHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEEE
HSLEDRIVKQFMARYAKAPPSNRRLPEAQPFVATLQLVSGAIKADDAELHVNPRARSAVL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHH
RVAEKLGLGNGESGMGKGNSAAASRFPTADSPFPASANGDAA
HHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217