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The map label for this gene is groEL [H]

Identifier: 21241313

GI number: 21241313

Start: 632705

End: 634345

Strand: Direct

Name: groEL [H]

Synonym: XAC0542

Alternate gene names: 21241313

Gene position: 632705-634345 (Clockwise)

Preceding gene: 21241312

Following gene: 77748535

Centisome position: 12.22

GC content: 64.29

Gene sequence:

>1641_bases
ATGGCTGCTAAAGACATTCGTTTCGGTGAAGACGCACGTACCCGCATGGTTCGTGGCGTCAACGTGCTTGCCAATGCCGT
GAAGGCAACCCTGGGCCCGAAGGGCCGCAACGTCGTGCTCGAGAAGAGCTTCGGCGCGCCGACCATCACCAAGGATGGCG
TCTCCGTCGCCAAGGAAATCGAACTGGCTGACAAGTTCGAGAACATGGGCGCGCAGATGGTCAAGGAAGTCGCTTCCAAG
ACCAACGACAACGCCGGCGACGGCACCACCACCGCCACCGTGCTGGCCCAGGCCCTGATCCGCGAAGGCGCCAAGGCTGT
GGCCGCCGGCATGAACCCGATGGACCTCAAGCGCGGTATCGACCAGGCCGTCAAGGCTGCGGTCGTCGAGCTGAAGAACA
TCTCCAAGCCCACCACCGACGACAAGGCGATCGCCCAGGTCGGCACCATCTCGGCCAACTCGGACGAGTCGATCGGCAAC
ATCATTGCCGAAGCGATGAAGAAGGTCGGCAAGGAAGGCGTGATCACCGTTGAAGAAGGCTCGGGCCTGGAAAACGAGCT
GGACGTGGTCGAGGGCATGCAGTTCGACCGCGGCTATCTCTCCCCGTACTTCATCAACAACCAGCAGAGCCAGTCGGCCG
ATCTGGACGACCCGTTCATCCTGCTGCACGACAAGAAGATCTCCAACGTGCGCGACCTGCTGCCCGTGCTGGAAGGCGTG
GCCAAGGCCGGCAAGCCGTTGCTGATCGTCGCCGAGGAAGTCGAAGGCGAAGCGCTGGCGACCCTGGTGGTCAACACCAT
CCGCGGCATCGTGAAGGTCGTGGCCGTCAAGGCGCCGGGCTTCGGCGACCGTCGCAAGGCGATGCTGGAAGACATGGCCG
TGCTGACCGGCGGTACCGTGATCTCCGAGGAAGTGGGTCTGGCGCTGGAGAAGGCGACCATCAAGGACCTGGGCCGCGCC
AAGAAGGTGCAGGTCTCCAAGGAAAACACCACGATCATCGACGGCGCTGGCGATTCGGCCGCGATCGAGTCGCGCGTGGG
CCAGATCAAGACCCAGATCGAAGACACCTCGTCCGATTACGACCGCGAGAAGCTGCAGGAGCGCGTGGCCAAGCTGGCCG
GTGGCGTTGCGGTGATCAAGGTGGGCGCCTCGACCGAAATCGAGATGAAGGAAAAGAAGGCACGCGTCGAAGACGCCCTG
CACGCCACCCGTGCAGCCGTCGAAGAAGGCGTGGTCCCGGGCGGCGGCGTGGCCCTGGTGCGTGCGCTGGTGGCCGTGGG
TGACCTGAAGGGCGCCAACGAAGACCAGACCCACGGCATCCAGATCGCCCTGCGCGCCATGGAAGCCCCGCTGCGCGAGA
TCGTGGCCAATGCCGGCGAAGAGCCCTCCGTGATCCTGAACAAGGTCAAGGAAGGCACCGGCAACTACGGCTACAACGCC
GCCAACGGCGAGTTCGGCGACATGGTCGAATTCGGCATCCTGGACCCGACCAAGGTGACCCGCTCTGCGCTGCAGAACGC
CGCCTCGATCGCCGGCCTGATGATCACCACCGAAGCCATGGTGGCCGATGCACCGAAGAAGGACGAGCCGGCACTGCCGG
CCGGCGGTGGCATGGGCGGCATGGGCGGCATGGATTTCTGA

Upstream 100 bases:

>100_bases
CAAAGCGGCTAGCGTCCTTCGCCATCCCACCCCACCCCGATTCACGCTGTTGATCTACCGATTCCCCATTTCCCATTCCC
AATTTCCGGAGTAACAACCA

Downstream 100 bases:

>100_bases
TCCAGGCCACTTAGGCTGTTGCAGTAAAAAAAAACCCGCCCAACGGCGGGGTTTTTTTATGCGCGTAACTTGCGCATGCA
CGCGGCAGTTGCCGATTACC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAAKDIRFGEDARTRMVRGVNVLANAVKATLGPKGRNVVLEKSFGAPTITKDGVSVAKEIELADKFENMGAQMVKEVASK
TNDNAGDGTTTATVLAQALIREGAKAVAAGMNPMDLKRGIDQAVKAAVVELKNISKPTTDDKAIAQVGTISANSDESIGN
IIAEAMKKVGKEGVITVEEGSGLENELDVVEGMQFDRGYLSPYFINNQQSQSADLDDPFILLHDKKISNVRDLLPVLEGV
AKAGKPLLIVAEEVEGEALATLVVNTIRGIVKVVAVKAPGFGDRRKAMLEDMAVLTGGTVISEEVGLALEKATIKDLGRA
KKVQVSKENTTIIDGAGDSAAIESRVGQIKTQIEDTSSDYDREKLQERVAKLAGGVAVIKVGASTEIEMKEKKARVEDAL
HATRAAVEEGVVPGGGVALVRALVAVGDLKGANEDQTHGIQIALRAMEAPLREIVANAGEEPSVILNKVKEGTGNYGYNA
ANGEFGDMVEFGILDPTKVTRSALQNAASIAGLMITTEAMVADAPKKDEPALPAGGGMGGMGGMDF

Sequences:

>Translated_546_residues
MAAKDIRFGEDARTRMVRGVNVLANAVKATLGPKGRNVVLEKSFGAPTITKDGVSVAKEIELADKFENMGAQMVKEVASK
TNDNAGDGTTTATVLAQALIREGAKAVAAGMNPMDLKRGIDQAVKAAVVELKNISKPTTDDKAIAQVGTISANSDESIGN
IIAEAMKKVGKEGVITVEEGSGLENELDVVEGMQFDRGYLSPYFINNQQSQSADLDDPFILLHDKKISNVRDLLPVLEGV
AKAGKPLLIVAEEVEGEALATLVVNTIRGIVKVVAVKAPGFGDRRKAMLEDMAVLTGGTVISEEVGLALEKATIKDLGRA
KKVQVSKENTTIIDGAGDSAAIESRVGQIKTQIEDTSSDYDREKLQERVAKLAGGVAVIKVGASTEIEMKEKKARVEDAL
HATRAAVEEGVVPGGGVALVRALVAVGDLKGANEDQTHGIQIALRAMEAPLREIVANAGEEPSVILNKVKEGTGNYGYNA
ANGEFGDMVEFGILDPTKVTRSALQNAASIAGLMITTEAMVADAPKKDEPALPAGGGMGGMGGMDF
>Mature_545_residues
AAKDIRFGEDARTRMVRGVNVLANAVKATLGPKGRNVVLEKSFGAPTITKDGVSVAKEIELADKFENMGAQMVKEVASKT
NDNAGDGTTTATVLAQALIREGAKAVAAGMNPMDLKRGIDQAVKAAVVELKNISKPTTDDKAIAQVGTISANSDESIGNI
IAEAMKKVGKEGVITVEEGSGLENELDVVEGMQFDRGYLSPYFINNQQSQSADLDDPFILLHDKKISNVRDLLPVLEGVA
KAGKPLLIVAEEVEGEALATLVVNTIRGIVKVVAVKAPGFGDRRKAMLEDMAVLTGGTVISEEVGLALEKATIKDLGRAK
KVQVSKENTTIIDGAGDSAAIESRVGQIKTQIEDTSSDYDREKLQERVAKLAGGVAVIKVGASTEIEMKEKKARVEDALH
ATRAAVEEGVVPGGGVALVRALVAVGDLKGANEDQTHGIQIALRAMEAPLREIVANAGEEPSVILNKVKEGTGNYGYNAA
NGEFGDMVEFGILDPTKVTRSALQNAASIAGLMITTEAMVADAPKKDEPALPAGGGMGGMGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=52.2727272727273, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=52.2727272727273, Blast_Score=553, Evalue=1e-157,
Organism=Escherichia coli, GI1790586, Length=528, Percent_Identity=78.030303030303, Blast_Score=831, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=52.165725047081, Blast_Score=554, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI193210679, Length=213, Percent_Identity=53.5211267605634, Blast_Score=224, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=53.041825095057, Blast_Score=545, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6322524, Length=161, Percent_Identity=29.8136645962733, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=51.8026565464896, Blast_Score=560, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=51.8026565464896, Blast_Score=560, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=50.9541984732824, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=50.9541984732824, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=50.9541984732824, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI17864606, Length=547, Percent_Identity=40.9506398537477, Blast_Score=444, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24584129, Length=534, Percent_Identity=37.8277153558052, Blast_Score=351, Evalue=6e-97,
Organism=Drosophila melanogaster, GI19921262, Length=534, Percent_Identity=37.8277153558052, Blast_Score=351, Evalue=6e-97,
Organism=Drosophila melanogaster, GI17647245, Length=505, Percent_Identity=23.3663366336634, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24652903, Length=491, Percent_Identity=23.4215885947047, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57167; Mature: 57036

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDIRFGEDARTRMVRGVNVLANAVKATLGPKGRNVVLEKSFGAPTITKDGVSVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHH
ELADKFENMGAQMVKEVASKTNDNAGDGTTTATVLAQALIREGAKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHH
DQAVKAAVVELKNISKPTTDDKAIAQVGTISANSDESIGNIIAEAMKKVGKEGVITVEEG
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC
SGLENELDVVEGMQFDRGYLSPYFINNQQSQSADLDDPFILLHDKKISNVRDLLPVLEGV
CCCCHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIVAEEVEGEALATLVVNTIRGIVKVVAVKAPGFGDRRKAMLEDMAVLTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEE
ISEEVGLALEKATIKDLGRAKKVQVSKENTTIIDGAGDSAAIESRVGQIKTQIEDTSSDY
EHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
DREKLQERVAKLAGGVAVIKVGASTEIEMKEKKARVEDALHATRAAVEEGVVPGGGVALV
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RALVAVGDLKGANEDQTHGIQIALRAMEAPLREIVANAGEEPSVILNKVKEGTGNYGYNA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
ANGEFGDMVEFGILDPTKVTRSALQNAASIAGLMITTEAMVADAPKKDEPALPAGGGMGG
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
MGGMDF
CCCCCC
>Mature Secondary Structure 
AAKDIRFGEDARTRMVRGVNVLANAVKATLGPKGRNVVLEKSFGAPTITKDGVSVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHH
ELADKFENMGAQMVKEVASKTNDNAGDGTTTATVLAQALIREGAKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHH
DQAVKAAVVELKNISKPTTDDKAIAQVGTISANSDESIGNIIAEAMKKVGKEGVITVEEG
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC
SGLENELDVVEGMQFDRGYLSPYFINNQQSQSADLDDPFILLHDKKISNVRDLLPVLEGV
CCCCHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIVAEEVEGEALATLVVNTIRGIVKVVAVKAPGFGDRRKAMLEDMAVLTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEE
ISEEVGLALEKATIKDLGRAKKVQVSKENTTIIDGAGDSAAIESRVGQIKTQIEDTSSDY
EHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
DREKLQERVAKLAGGVAVIKVGASTEIEMKEKKARVEDALHATRAAVEEGVVPGGGVALV
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RALVAVGDLKGANEDQTHGIQIALRAMEAPLREIVANAGEEPSVILNKVKEGTGNYGYNA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
ANGEFGDMVEFGILDPTKVTRSALQNAASIAGLMITTEAMVADAPKKDEPALPAGGGMGG
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
MGGMDF
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA