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The map label for this gene is czcD [H]

Identifier: 57238035

GI number: 57238035

Start: 1214830

End: 1215780

Strand: Reverse

Name: czcD [H]

Synonym: CJE1297

Alternate gene names: 57238035

Gene position: 1215780-1214830 (Counterclockwise)

Preceding gene: 57238036

Following gene: 57238034

Centisome position: 68.39

GC content: 31.55

Gene sequence:

>951_bases
ATGTATAAATTTTTATCGCACGAGCCTTTAGCTAACAAATCTTGTCATCATAATCACGAAGAACATTCTCATGAACATCA
TCATTCCCATGCTGATGCAAGGAGTGTGGATAAAAAGATTTTAAAAATTTCTCTTTTAATGACTTTTTCTATGATGCTTG
TGCAATTTATTTATTCAATCCTTTCAAATTCTTTAGCACTTTTAAGCGATACTTTGCATATGTTTTCTGATGTTTTTGCC
TTAGCTCTTAGTTTTTTAGCCATTATAGCTGTAGAAAAATGGCAAGATCATCAAAAGACCTTTGGGTATTTTCGTCTTGA
AGTTTTAGTGGCTTTTATCAATGCTTTAACCATTATTTTATCGGCTTTATTTATCATTTATGAGGCTATAGAAAAATTTA
TCAATCCAAAAGAAATTGACGCTAAAACCATGATAATTGTAGCTATTTTGGGCTTTTTGGTAAATGGGATTAATGCTTTG
ATGATGTTTAAGGGTGCAAATTTAGAAAATGTCAATATGAAGTCCGCTTTTTTGCATATGATGAGCGATTTATTGGGTTC
TTTAGCGGTTATTATAGGTGGGATCGTGGTGTATTTTAGCGGTATTGTTTATATAGATACGATTTTAGCTATTGTATTAT
CAATCTTGCTTTTAAGATGGGCGATTATCTTGCTTAAACAAAGCGCTAATGTCTTGCTTGAAAGTTCTCCTGTGGATATA
GAAAAAGTAAGACAAGTTTTGCTTTTAAATCCTAGTGTGGATGAGGTAGTGGATTTGCATATTACTCAAATCACTAATAA
AATGCTAGTAGCCTCTATGCATTTAAAAGTAAGAGTTTGCAATCTAAAGGAATTTGAAAAACTATCTCAGGATTTATCTC
ATAAGTTATTGCATGAATTTGAAATCGGGCACATTACCATACAACCTATAAGGAGTGAAAATGAAATTTAA

Upstream 100 bases:

>100_bases
GCTAGGCGAGCTTTTTGACTTTTAATTTTTATAAAAATAACAAATATTTATATCCTTTTTAGCTTAATATCTTAAAATGT
CAAGCAAAAAAGGATATAAG

Downstream 100 bases:

>100_bases
AGTAAAAAATGTTAATTGCATGAATTGTGTAAATTTGATCAAAAATTCTCTTGAAGATGAATTTGGAAATATAGAAGTGG
ATTTGGAGCAAAAAATTTTA

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MYKFLSHEPLANKSCHHNHEEHSHEHHHSHADARSVDKKILKISLLMTFSMMLVQFIYSILSNSLALLSDTLHMFSDVFA
LALSFLAIIAVEKWQDHQKTFGYFRLEVLVAFINALTIILSALFIIYEAIEKFINPKEIDAKTMIIVAILGFLVNGINAL
MMFKGANLENVNMKSAFLHMMSDLLGSLAVIIGGIVVYFSGIVYIDTILAIVLSILLLRWAIILLKQSANVLLESSPVDI
EKVRQVLLLNPSVDEVVDLHITQITNKMLVASMHLKVRVCNLKEFEKLSQDLSHKLLHEFEIGHITIQPIRSENEI

Sequences:

>Translated_316_residues
MYKFLSHEPLANKSCHHNHEEHSHEHHHSHADARSVDKKILKISLLMTFSMMLVQFIYSILSNSLALLSDTLHMFSDVFA
LALSFLAIIAVEKWQDHQKTFGYFRLEVLVAFINALTIILSALFIIYEAIEKFINPKEIDAKTMIIVAILGFLVNGINAL
MMFKGANLENVNMKSAFLHMMSDLLGSLAVIIGGIVVYFSGIVYIDTILAIVLSILLLRWAIILLKQSANVLLESSPVDI
EKVRQVLLLNPSVDEVVDLHITQITNKMLVASMHLKVRVCNLKEFEKLSQDLSHKLLHEFEIGHITIQPIRSENEI
>Mature_316_residues
MYKFLSHEPLANKSCHHNHEEHSHEHHHSHADARSVDKKILKISLLMTFSMMLVQFIYSILSNSLALLSDTLHMFSDVFA
LALSFLAIIAVEKWQDHQKTFGYFRLEVLVAFINALTIILSALFIIYEAIEKFINPKEIDAKTMIIVAILGFLVNGINAL
MMFKGANLENVNMKSAFLHMMSDLLGSLAVIIGGIVVYFSGIVYIDTILAIVLSILLLRWAIILLKQSANVLLESSPVDI
EKVRQVLLLNPSVDEVVDLHITQITNKMLVASMHLKVRVCNLKEFEKLSQDLSHKLLHEFEIGHITIQPIRSENEI

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=314, Percent_Identity=26.7515923566879, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI21359890, Length=299, Percent_Identity=26.7558528428094, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI20070323, Length=321, Percent_Identity=26.4797507788162, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI64762489, Length=337, Percent_Identity=25.5192878338279, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI222080086, Length=121, Percent_Identity=39.6694214876033, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI40255009, Length=121, Percent_Identity=39.6694214876033, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI289803013, Length=303, Percent_Identity=25.7425742574257, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI289803009, Length=303, Percent_Identity=25.7425742574257, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI289803007, Length=303, Percent_Identity=25.7425742574257, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI289803003, Length=303, Percent_Identity=25.7425742574257, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI21361112, Length=318, Percent_Identity=24.2138364779874, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI14210520, Length=217, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI52351208, Length=122, Percent_Identity=33.6065573770492, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI52352803, Length=113, Percent_Identity=38.9380530973451, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1786966, Length=265, Percent_Identity=35.0943396226415, Blast_Score=136, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI193210990, Length=316, Percent_Identity=26.8987341772152, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI32564488, Length=269, Percent_Identity=29.7397769516729, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17555794, Length=307, Percent_Identity=25.7328990228013, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17555796, Length=336, Percent_Identity=24.4047619047619, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17550442, Length=147, Percent_Identity=29.9319727891156, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320411, Length=158, Percent_Identity=36.7088607594937, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323899, Length=131, Percent_Identity=29.7709923664122, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324892, Length=146, Percent_Identity=25.3424657534247, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24656728, Length=348, Percent_Identity=29.3103448275862, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24656724, Length=348, Percent_Identity=29.3103448275862, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24656720, Length=348, Percent_Identity=29.3103448275862, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24656715, Length=348, Percent_Identity=29.3103448275862, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI21357035, Length=348, Percent_Identity=29.3103448275862, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24645863, Length=114, Percent_Identity=41.2280701754386, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583858, Length=306, Percent_Identity=24.5098039215686, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24584409, Length=141, Percent_Identity=28.3687943262411, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574430, Length=146, Percent_Identity=28.0821917808219, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 35791; Mature: 35791

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKFLSHEPLANKSCHHNHEEHSHEHHHSHADARSVDKKILKISLLMTFSMMLVQFIYSI
CCCCCCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSNSLALLSDTLHMFSDVFALALSFLAIIAVEKWQDHQKTFGYFRLEVLVAFINALTIIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALFIIYEAIEKFINPKEIDAKTMIIVAILGFLVNGINALMMFKGANLENVNMKSAFLHM
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
MSDLLGSLAVIIGGIVVYFSGIVYIDTILAIVLSILLLRWAIILLKQSANVLLESSPVDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCH
EKVRQVLLLNPSVDEVVDLHITQITNKMLVASMHLKVRVCNLKEFEKLSQDLSHKLLHEF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHH
EIGHITIQPIRSENEI
CCCCEEEEECCCCCCC
>Mature Secondary Structure
MYKFLSHEPLANKSCHHNHEEHSHEHHHSHADARSVDKKILKISLLMTFSMMLVQFIYSI
CCCCCCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSNSLALLSDTLHMFSDVFALALSFLAIIAVEKWQDHQKTFGYFRLEVLVAFINALTIIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALFIIYEAIEKFINPKEIDAKTMIIVAILGFLVNGINALMMFKGANLENVNMKSAFLHM
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
MSDLLGSLAVIIGGIVVYFSGIVYIDTILAIVLSILLLRWAIILLKQSANVLLESSPVDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCH
EKVRQVLLLNPSVDEVVDLHITQITNKMLVASMHLKVRVCNLKEFEKLSQDLSHKLLHEF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHH
EIGHITIQPIRSENEI
CCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]