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The map label for this gene is lon [H]

Identifier: 57237955

GI number: 57237955

Start: 1132770

End: 1135145

Strand: Reverse

Name: lon [H]

Synonym: CJE1216

Alternate gene names: 57237955

Gene position: 1135145-1132770 (Counterclockwise)

Preceding gene: 57237956

Following gene: 57237946

Centisome position: 63.85

GC content: 29.76

Gene sequence:

>2376_bases
ATGCAGATTGAAGAGATACAAAATTATCCAGCAAATTTACCAGTATTGGTTGAAGATGAATTATTTTTATATCCTTTTAT
GATAACTCCTATTTTTATTAACGATTCATCCAATATGAAAGCTTTAGATCTTGCGATTAAAAATGATAGCATGCTTTTTG
TTGCACCTTCAAAGTTGGAAAATGGAAGAAATTTTGATGAAATTTATAATTGCGGAGTGATTGGGACTATCATGCGAAAA
GTTCCTTTGCCTGATGGAAGAGTGAAAATACTTTTTCAAGGATATGCCAAGGGTAAAATTATAGAGCAAATTTCTAATAA
ACCTTTAGAAGCCAAGATAGAACTTATAAAAGAAGACTTTTTAGAAGGAACTAAAAAAGAAGCACTTCTTGAAGTTTTAA
AAGAGAAAGTAAAAAATTTGGCAAATATTAGTCATTATTTTTCTCCAGATCTTTTAAGAACAATTGAAGAAGGTTTTGAT
GCATCTAGGATTTGCGATTTGATTTTAAACACTGTGCGTATTAAAAAACAAGTTGCTTATGAGTTTTTTGTTTTAACAGA
TCTTGAGCAAAAATTAGTAAAATTAATAGATTTAATTGCTCAAGAAATAGAAGCTAATAAAATTCAAAAAGAAATTAAAA
ATAAAGTACATTCTCGTATTGATAAGGTAAATAAAGAATATTTTTTAAAAGAACAATTAAGACAAATTCAAAAAGAGCTT
GGTTCTGATACGCAAAAAGAAGATGAGGTTAGAGAGTATCAAAAGCGTCTGGAGTTAAAGAAGAAATTTATGCACGAAGA
CGCTTATAAAGAAATCAAAAAACAAATTGAAAAATTCGAACGCATTCATCAAGATAATTCCGAAGCATCGATGATTCAAA
CTTACATAGAAACAGCATTAGATGTTCCTTTTGAAAAAATTTCTAAGAAAAAACTTGATATTAAGGAAGTTTCAAAACAG
CTCAACCATGATCATTATGCATTAAATAAACCAAAAGAACGCATAGAAGAATATTTTGCAGTTAGGGAACTTTTAGAAAA
AAGAAAAATAGCAGAAAAAGATGGTGCTAAAGTTATACTTTGTCTTTATGGGCCTCCTGGCGTTGGTAAAACTTCACTGG
CAAATTCTGTTTCAAAAGCTTTAAAAAGAGAGCTTATTCGTATAGCCTTAGGTGGACTTGAAGATGTTAATGAGCTGCGT
GGTCATCGTAGAACTTATATAGGCGCTATGCCTGGACGTATTACTCAAGGACTCATAGAGGCAAAACAAATTAATCCTGT
AATTGTATTGGATGAAATTGATAAATTAAATCGCAGTTTTAGAGGCGATCCAAGTGCGGTGCTTTTAGAAATTTTAGATC
CAGAGCAAAATTCTAAATTTAGGGATTATTATTTAAATTTTAATATTGATTTAAGTAAAGTCATTTTTATAGCAACGGCA
AATGATATTAGCAATATTCCTGCACCTTTAAGAGATAGAATGGAATTTATAGAACTTAGCTCTTATACTCCAAGTGAAAA
ATTTCATATAATGAAAAAATATTTAATTCCAGATGAGCTTAAAAAACATGGCTTAAAATCCAATGAATTATTTATTGATG
ATGAAACTATAGAGCTAATCATTAGCGATTATACTCGTGAATCAGGAGTTAGAAATTTGCGTCGCAAAGTGGCAGAGTTG
TGTCGTAAGAGTGCTAAAAAACTACTTTTAGAAAATATTAAAAAAGTCATTATTAATACAAAAAATTTGAATGAATTTTT
AGATAAAAAAGTTTTTGAAATAGAAAAAAATAATGGAGAAAATCAAGTAGGTCAGGTCAATGGTTTGGCTTGGACAAGCG
TAGGTGGAGATGTTTTAAAAGTAGAGGCTGTAAAAATTAAAGGTAAAGGAGAATTAACGCTCACAGGAAGTTTGGGTGAT
GTAATGAAAGAATCAGCTAGAATTGCTTTTAGCATGATAAAAGTTTTAATCGATGAAGGAAAAATAAAAATACCTAAAAA
AATAATTATTGATCCTAAAGTTAATGTTTATGATAGTTATAATATTCATATACATGTGCCAGATGGAGCTACTCCAAAAG
ATGGCCCAAGTGCAGGTATTACGATAAGCACAGCTATTGCTTCTATTTTTAGTGATAAAAAGGTTAAAGCAGATGTTGCA
ATGACGGGTGAAATAGATTTAAAAGGAAAAGTTTTACCAATAGGCGGATTAAAAGAAAAATTAATTGCAGCTTATAAAGC
AGATATAAAAACAGCTTTAATTCCAAGAAAAAATTACGAAAGAGATTTAAAAGATATTCCTAGTGAGGTTAGAGACAATA
TGGAAATCATTGCTGTTGATACTTTCAGTGATGTTTTAGAATATACTTTGGTTTAA

Upstream 100 bases:

>100_bases
AGACTTCAAGAAAGTGAATTTTATCAGCAAAGTATTATCAAACCTGAGCTTCCTTGGTATAGAAGTATATTTGAAAGATT
TTAATAAACAAGGAAAATAA

Downstream 100 bases:

>100_bases
CTTTATTTTGAGAATAAATGTATAAGAAAGCAAACTTTTTACAAGTTTGCTTTAAAAGATTATAGTCCTTCAAAAGGATT
ATTGATTACTTCTTTTCTAT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 791; Mature: 791

Protein sequence:

>791_residues
MQIEEIQNYPANLPVLVEDELFLYPFMITPIFINDSSNMKALDLAIKNDSMLFVAPSKLENGRNFDEIYNCGVIGTIMRK
VPLPDGRVKILFQGYAKGKIIEQISNKPLEAKIELIKEDFLEGTKKEALLEVLKEKVKNLANISHYFSPDLLRTIEEGFD
ASRICDLILNTVRIKKQVAYEFFVLTDLEQKLVKLIDLIAQEIEANKIQKEIKNKVHSRIDKVNKEYFLKEQLRQIQKEL
GSDTQKEDEVREYQKRLELKKKFMHEDAYKEIKKQIEKFERIHQDNSEASMIQTYIETALDVPFEKISKKKLDIKEVSKQ
LNHDHYALNKPKERIEEYFAVRELLEKRKIAEKDGAKVILCLYGPPGVGKTSLANSVSKALKRELIRIALGGLEDVNELR
GHRRTYIGAMPGRITQGLIEAKQINPVIVLDEIDKLNRSFRGDPSAVLLEILDPEQNSKFRDYYLNFNIDLSKVIFIATA
NDISNIPAPLRDRMEFIELSSYTPSEKFHIMKKYLIPDELKKHGLKSNELFIDDETIELIISDYTRESGVRNLRRKVAEL
CRKSAKKLLLENIKKVIINTKNLNEFLDKKVFEIEKNNGENQVGQVNGLAWTSVGGDVLKVEAVKIKGKGELTLTGSLGD
VMKESARIAFSMIKVLIDEGKIKIPKKIIIDPKVNVYDSYNIHIHVPDGATPKDGPSAGITISTAIASIFSDKKVKADVA
MTGEIDLKGKVLPIGGLKEKLIAAYKADIKTALIPRKNYERDLKDIPSEVRDNMEIIAVDTFSDVLEYTLV

Sequences:

>Translated_791_residues
MQIEEIQNYPANLPVLVEDELFLYPFMITPIFINDSSNMKALDLAIKNDSMLFVAPSKLENGRNFDEIYNCGVIGTIMRK
VPLPDGRVKILFQGYAKGKIIEQISNKPLEAKIELIKEDFLEGTKKEALLEVLKEKVKNLANISHYFSPDLLRTIEEGFD
ASRICDLILNTVRIKKQVAYEFFVLTDLEQKLVKLIDLIAQEIEANKIQKEIKNKVHSRIDKVNKEYFLKEQLRQIQKEL
GSDTQKEDEVREYQKRLELKKKFMHEDAYKEIKKQIEKFERIHQDNSEASMIQTYIETALDVPFEKISKKKLDIKEVSKQ
LNHDHYALNKPKERIEEYFAVRELLEKRKIAEKDGAKVILCLYGPPGVGKTSLANSVSKALKRELIRIALGGLEDVNELR
GHRRTYIGAMPGRITQGLIEAKQINPVIVLDEIDKLNRSFRGDPSAVLLEILDPEQNSKFRDYYLNFNIDLSKVIFIATA
NDISNIPAPLRDRMEFIELSSYTPSEKFHIMKKYLIPDELKKHGLKSNELFIDDETIELIISDYTRESGVRNLRRKVAEL
CRKSAKKLLLENIKKVIINTKNLNEFLDKKVFEIEKNNGENQVGQVNGLAWTSVGGDVLKVEAVKIKGKGELTLTGSLGD
VMKESARIAFSMIKVLIDEGKIKIPKKIIIDPKVNVYDSYNIHIHVPDGATPKDGPSAGITISTAIASIFSDKKVKADVA
MTGEIDLKGKVLPIGGLKEKLIAAYKADIKTALIPRKNYERDLKDIPSEVRDNMEIIAVDTFSDVLEYTLV
>Mature_791_residues
MQIEEIQNYPANLPVLVEDELFLYPFMITPIFINDSSNMKALDLAIKNDSMLFVAPSKLENGRNFDEIYNCGVIGTIMRK
VPLPDGRVKILFQGYAKGKIIEQISNKPLEAKIELIKEDFLEGTKKEALLEVLKEKVKNLANISHYFSPDLLRTIEEGFD
ASRICDLILNTVRIKKQVAYEFFVLTDLEQKLVKLIDLIAQEIEANKIQKEIKNKVHSRIDKVNKEYFLKEQLRQIQKEL
GSDTQKEDEVREYQKRLELKKKFMHEDAYKEIKKQIEKFERIHQDNSEASMIQTYIETALDVPFEKISKKKLDIKEVSKQ
LNHDHYALNKPKERIEEYFAVRELLEKRKIAEKDGAKVILCLYGPPGVGKTSLANSVSKALKRELIRIALGGLEDVNELR
GHRRTYIGAMPGRITQGLIEAKQINPVIVLDEIDKLNRSFRGDPSAVLLEILDPEQNSKFRDYYLNFNIDLSKVIFIATA
NDISNIPAPLRDRMEFIELSSYTPSEKFHIMKKYLIPDELKKHGLKSNELFIDDETIELIISDYTRESGVRNLRRKVAEL
CRKSAKKLLLENIKKVIINTKNLNEFLDKKVFEIEKNNGENQVGQVNGLAWTSVGGDVLKVEAVKIKGKGELTLTGSLGD
VMKESARIAFSMIKVLIDEGKIKIPKKIIIDPKVNVYDSYNIHIHVPDGATPKDGPSAGITISTAIASIFSDKKVKADVA
MTGEIDLKGKVLPIGGLKEKLIAAYKADIKTALIPRKNYERDLKDIPSEVRDNMEIIAVDTFSDVLEYTLV

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=842, Percent_Identity=34.916864608076, Blast_Score=468, Evalue=1e-131,
Organism=Homo sapiens, GI21396489, Length=611, Percent_Identity=39.443535188216, Blast_Score=465, Evalue=1e-131,
Organism=Escherichia coli, GI1786643, Length=782, Percent_Identity=39.8976982097187, Blast_Score=590, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17505831, Length=670, Percent_Identity=36.5671641791045, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17556486, Length=531, Percent_Identity=36.346516007533, Blast_Score=353, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6319449, Length=661, Percent_Identity=37.2163388804841, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI221513036, Length=611, Percent_Identity=39.7708674304419, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24666867, Length=611, Percent_Identity=39.7708674304419, Blast_Score=466, Evalue=1e-131,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 90147; Mature: 90147

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIEEIQNYPANLPVLVEDELFLYPFMITPIFINDSSNMKALDLAIKNDSMLFVAPSKLE
CCCHHHHCCCCCCCEEECCCEEEEEEEEEEEEEECCCCCEEEEEEEECCCEEEEECHHCC
NGRNFDEIYNCGVIGTIMRKVPLPDGRVKILFQGYAKGKIIEQISNKPLEAKIELIKEDF
CCCCHHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHH
LEGTKKEALLEVLKEKVKNLANISHYFSPDLLRTIEEGFDASRICDLILNTVRIKKQVAY
HCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EFFVLTDLEQKLVKLIDLIAQEIEANKIQKEIKNKVHSRIDKVNKEYFLKEQLRQIQKEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSDTQKEDEVREYQKRLELKKKFMHEDAYKEIKKQIEKFERIHQDNSEASMIQTYIETAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DVPFEKISKKKLDIKEVSKQLNHDHYALNKPKERIEEYFAVRELLEKRKIAEKDGAKVIL
CCCHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
CLYGPPGVGKTSLANSVSKALKRELIRIALGGLEDVNELRGHRRTYIGAMPGRITQGLIE
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHEEEECCCCHHHHHHHH
AKQINPVIVLDEIDKLNRSFRGDPSAVLLEILDPEQNSKFRDYYLNFNIDLSKVIFIATA
HHHCCCEEEECCHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEEEEEEHHHEEEEEEC
NDISNIPAPLRDRMEFIELSSYTPSEKFHIMKKYLIPDELKKHGLKSNELFIDDETIELI
CCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCCCCCCCEEEECHHHHHH
ISDYTRESGVRNLRRKVAELCRKSAKKLLLENIKKVIINTKNLNEFLDKKVFEIEKNNGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCC
NQVGQVNGLAWTSVGGDVLKVEAVKIKGKGELTLTGSLGDVMKESARIAFSMIKVLIDEG
CCCCCCCCEEEECCCCCEEEEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCC
KIKIPKKIIIDPKVNVYDSYNIHIHVPDGATPKDGPSAGITISTAIASIFSDKKVKADVA
CEECCCEEEECCCCEEEECEEEEEECCCCCCCCCCCCCCEEHHHHHHHHHCCCCEEEEEE
MTGEIDLKGKVLPIGGLKEKLIAAYKADIKTALIPRKNYERDLKDIPSEVRDNMEIIAVD
EECCEECCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHCCCEEEEEE
TFSDVLEYTLV
CHHHHHHHHCC
>Mature Secondary Structure
MQIEEIQNYPANLPVLVEDELFLYPFMITPIFINDSSNMKALDLAIKNDSMLFVAPSKLE
CCCHHHHCCCCCCCEEECCCEEEEEEEEEEEEEECCCCCEEEEEEEECCCEEEEECHHCC
NGRNFDEIYNCGVIGTIMRKVPLPDGRVKILFQGYAKGKIIEQISNKPLEAKIELIKEDF
CCCCHHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHH
LEGTKKEALLEVLKEKVKNLANISHYFSPDLLRTIEEGFDASRICDLILNTVRIKKQVAY
HCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EFFVLTDLEQKLVKLIDLIAQEIEANKIQKEIKNKVHSRIDKVNKEYFLKEQLRQIQKEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSDTQKEDEVREYQKRLELKKKFMHEDAYKEIKKQIEKFERIHQDNSEASMIQTYIETAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DVPFEKISKKKLDIKEVSKQLNHDHYALNKPKERIEEYFAVRELLEKRKIAEKDGAKVIL
CCCHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
CLYGPPGVGKTSLANSVSKALKRELIRIALGGLEDVNELRGHRRTYIGAMPGRITQGLIE
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHEEEECCCCHHHHHHHH
AKQINPVIVLDEIDKLNRSFRGDPSAVLLEILDPEQNSKFRDYYLNFNIDLSKVIFIATA
HHHCCCEEEECCHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEEEEEEHHHEEEEEEC
NDISNIPAPLRDRMEFIELSSYTPSEKFHIMKKYLIPDELKKHGLKSNELFIDDETIELI
CCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCCCCCCCEEEECHHHHHH
ISDYTRESGVRNLRRKVAELCRKSAKKLLLENIKKVIINTKNLNEFLDKKVFEIEKNNGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCC
NQVGQVNGLAWTSVGGDVLKVEAVKIKGKGELTLTGSLGDVMKESARIAFSMIKVLIDEG
CCCCCCCCEEEECCCCCEEEEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCC
KIKIPKKIIIDPKVNVYDSYNIHIHVPDGATPKDGPSAGITISTAIASIFSDKKVKADVA
CEECCCEEEECCCCEEEECEEEEEECCCCCCCCCCCCCCEEHHHHHHHHHCCCCEEEEEE
MTGEIDLKGKVLPIGGLKEKLIAAYKADIKTALIPRKNYERDLKDIPSEVRDNMEIIAVD
EECCEECCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHCCCEEEEEE
TFSDVLEYTLV
CHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9742705; 10688204 [H]