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The map label for this gene is ribA [H]

Identifier: 57237821

GI number: 57237821

Start: 1004698

End: 1005258

Strand: Direct

Name: ribA [H]

Synonym: CJE1076

Alternate gene names: 57237821

Gene position: 1004698-1005258 (Clockwise)

Preceding gene: 57237814

Following gene: 57237822

Centisome position: 56.51

GC content: 30.84

Gene sequence:

>561_bases
ATGGAAATAAAAATTTCAGAAATTGCGAATTTACCTAGCAAATGGGGAAATTTCCAAATGCAAAGTTTCAAAGAAAACGA
TAAAGAACATTTATGCATATTTAAAAACACTCCAAAAGATACACTCAATCTAAGAATTCATTCAGAGTGCTTAACAGGAG
ATGCTTTAGGAAGTTTAAAATGCGACTGCGGAGAACAGCTTGAATTTTCGCTAAAATATATAGAAAAGAATGGCGGAATG
GTGATTTATCTTAGACAAGAAGGAAGGGGTATAGGGCTTTTTAACAAGGTTAATGCTTATGCTTTACAAGATAAAGGTTT
TGATACGATTAAAGCAAATCATCAGCTTGGCTTTAAAGCCGATGAGAGAACTTATGAAATTGTAGAATTTATACTCAAAC
ACTATGAAATTTCTAAGGTTAATTTACTCACAAATAACCCTGAAAAGCTAGATTCTATCAAAGAAAAAATCATCATACGC
ATACCGATTTTAATAGAACCTAATCGTTTTAATGTAGAGTATTTAAACATAAAACAAACTCAAATGGGACATCTTAAATA
A

Upstream 100 bases:

>100_bases
TTAAGTTTTCATTAAGCCTTAATCTTCTAAATCTTTTAAACATTTTTTTGTCCTTTTTTTGCTAAAATCTTAACATAAAT
TTGATTATAGAGAGTAGTAA

Downstream 100 bases:

>100_bases
ATGATTTTTAAAGATTATGATTTTTTGCAAAACTACGATTTAAAAAACTTTGAAGAAAAGGTAAAAATTTATAAAGAATT
ATTATCTAAATTTAACCGCA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MEIKISEIANLPSKWGNFQMQSFKENDKEHLCIFKNTPKDTLNLRIHSECLTGDALGSLKCDCGEQLEFSLKYIEKNGGM
VIYLRQEGRGIGLFNKVNAYALQDKGFDTIKANHQLGFKADERTYEIVEFILKHYEISKVNLLTNNPEKLDSIKEKIIIR
IPILIEPNRFNVEYLNIKQTQMGHLK

Sequences:

>Translated_186_residues
MEIKISEIANLPSKWGNFQMQSFKENDKEHLCIFKNTPKDTLNLRIHSECLTGDALGSLKCDCGEQLEFSLKYIEKNGGM
VIYLRQEGRGIGLFNKVNAYALQDKGFDTIKANHQLGFKADERTYEIVEFILKHYEISKVNLLTNNPEKLDSIKEKIIIR
IPILIEPNRFNVEYLNIKQTQMGHLK
>Mature_186_residues
MEIKISEIANLPSKWGNFQMQSFKENDKEHLCIFKNTPKDTLNLRIHSECLTGDALGSLKCDCGEQLEFSLKYIEKNGGM
VIYLRQEGRGIGLFNKVNAYALQDKGFDTIKANHQLGFKADERTYEIVEFILKHYEISKVNLLTNNPEKLDSIKEKIIIR
IPILIEPNRFNVEYLNIKQTQMGHLK

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=47.1502590673575, Blast_Score=173, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=40.9356725146199, Blast_Score=108, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 21507; Mature: 21507

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKISEIANLPSKWGNFQMQSFKENDKEHLCIFKNTPKDTLNLRIHSECLTGDALGSLK
CEEEHHHHHCCCCCCCCEEEEHHCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCEE
CDCGEQLEFSLKYIEKNGGMVIYLRQEGRGIGLFNKVNAYALQDKGFDTIKANHQLGFKA
CCCCCCCEEEEEEEECCCCEEEEEECCCCEECEEECCCEEEECCCCCCEEECCCCCCCCC
DERTYEIVEFILKHYEISKVNLLTNNPEKLDSIKEKIIIRIPILIEPNRFNVEYLNIKQT
CCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHEEEEEEEEEECCCCCCEEEEEEECC
QMGHLK
CCCCCC
>Mature Secondary Structure
MEIKISEIANLPSKWGNFQMQSFKENDKEHLCIFKNTPKDTLNLRIHSECLTGDALGSLK
CEEEHHHHHCCCCCCCCEEEEHHCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCEE
CDCGEQLEFSLKYIEKNGGMVIYLRQEGRGIGLFNKVNAYALQDKGFDTIKANHQLGFKA
CCCCCCCEEEEEEEECCCCEEEEEECCCCEECEEECCCEEEECCCCCCEEECCCCCCCCC
DERTYEIVEFILKHYEISKVNLLTNNPEKLDSIKEKIIIRIPILIEPNRFNVEYLNIKQT
CCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHEEEEEEEEEECCCCCCEEEEEEECC
QMGHLK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA