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The map label for this gene is hemN [H]

Identifier: 57237817

GI number: 57237817

Start: 1000910

End: 1002265

Strand: Reverse

Name: hemN [H]

Synonym: CJE1072

Alternate gene names: 57237817

Gene position: 1002265-1000910 (Counterclockwise)

Preceding gene: 57237818

Following gene: 57237816

Centisome position: 56.38

GC content: 30.6

Gene sequence:

>1356_bases
ATGAGAGATTATAAAGCTTTTGTAAAATACTCTAAAGCAGGACCACGCTACACTTCTTATCCTACAGCAGTAGAGTTTAA
TGCAAATTTCAAATACGAAGAATATATAGAAATTTTAAAAAAGCAAGATAGATCTTTATCGCTTTATTTTCATTTACCAT
TTTGTAGGAGTGCTTGTTATTTTTGTGGTTGCAATGTTATTTATACAGCCAAAGAAGAGAGTAAAGAAAGGTATTTAACT
TATATTTTTAAAGAGCTTGATATTTTAAGTACTATTTTAGATACTAAAAGAGAAGTGGTGCAAATGCACTTTGGGGGCGG
AACTCCAACTTTTTTTAGTGCTAAACAACTTCAAAATTTGATTTTAAAAATCAGATCTGTTTTTGGAAATTTTTCTAAAG
ATGTAGAGATTAGCTGTGAGATCGATCCGCGTTTTTTAAATGAGGAACAAGCCACAGTTTTAACGCAAAATGGCTTTAAT
CGTATCAGCTTTGGAGTGCAGGATTTTGATGAAAAAGTTCAAAAAGAAATTCATCGCATCCAGCCTTTTGAATTAACACA
AAATGCTTTAAATCTTGTAAGAAATAAAGGCATAAAGTCTGTAAATATGGATTTAATTTATGGCTTGCCTTATCAAAATT
TACAAAGCTTTACACAAACTTTAGAAAAAGTTATGCTTTTAAACCCTGATCGTTTGGCGATTTTTAATTACGCTCATGTG
CCTTGGCTTAAGAAAAATATGAGAAAATTTGATGAAAATACCTTGCCAAGTCCTGATGTTAAGCTTGAAATTTTAGAATT
TTGTGAGAAATTTTTAAGCAAAAATGGTTATAAAATGATAGGAATGGATCATTTTGCAAAAGAAAATGATGAGCTTTTTA
AAGCTTTAGAAAATGGAACTTTGCATAGAAATTTCCAAGGTTATACTACCAAAGGCGGTGCTGATTTAGTCGGTATTGGG
CTTACAAGTATAGGCGAAGGGCAAAGACATTATGCGCAAAATTTTAAAGATATGTCAAGTTATGAAGCTGCATTAGATAG
AGGAGTTTTGCCTTTTGAAAGAGGCGTAGCTTTAAGCGATGATGATGAGCTTAGAAAAGCAGTGATTATGGAGTTAATGG
CAAATTTTAAGCTTGATATCAAGTCAATAGAAAAAGAATTTTGCATTGATTTTCAGGAGTATTTTAAAGAGGATTTAAAA
GCTTTAGAAGAATACAAAGATTTTATTAATTTTGATGAAAATTTTATCAAAGTCAATGAAACAGGCGTTTTGCTTATAAG
AAATATTGCCATGTGTTTTGATGCTTATATGAAAAACATTAGTGAAGATAAAAAAGTATTCTCAAAAACGGTGTAA

Upstream 100 bases:

>100_bases
GAAGTTAGTATTGATCTTGAAAAATTAATTTCTAAAATCAAACAAGAGCATCCAAATTTATTTGTAGATATGCAAGCGAT
GATAGAAAGGGTAAACCAAA

Downstream 100 bases:

>100_bases
GATGAAATTTAGTCAAATAAGTGATGCTTGTGTTAAATGTGGCAAATGTATACCTGTTTGTACTATACACGAAGAAAATC
GCGATGAAATTACTAGTCCA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MRDYKAFVKYSKAGPRYTSYPTAVEFNANFKYEEYIEILKKQDRSLSLYFHLPFCRSACYFCGCNVIYTAKEESKERYLT
YIFKELDILSTILDTKREVVQMHFGGGTPTFFSAKQLQNLILKIRSVFGNFSKDVEISCEIDPRFLNEEQATVLTQNGFN
RISFGVQDFDEKVQKEIHRIQPFELTQNALNLVRNKGIKSVNMDLIYGLPYQNLQSFTQTLEKVMLLNPDRLAIFNYAHV
PWLKKNMRKFDENTLPSPDVKLEILEFCEKFLSKNGYKMIGMDHFAKENDELFKALENGTLHRNFQGYTTKGGADLVGIG
LTSIGEGQRHYAQNFKDMSSYEAALDRGVLPFERGVALSDDDELRKAVIMELMANFKLDIKSIEKEFCIDFQEYFKEDLK
ALEEYKDFINFDENFIKVNETGVLLIRNIAMCFDAYMKNISEDKKVFSKTV

Sequences:

>Translated_451_residues
MRDYKAFVKYSKAGPRYTSYPTAVEFNANFKYEEYIEILKKQDRSLSLYFHLPFCRSACYFCGCNVIYTAKEESKERYLT
YIFKELDILSTILDTKREVVQMHFGGGTPTFFSAKQLQNLILKIRSVFGNFSKDVEISCEIDPRFLNEEQATVLTQNGFN
RISFGVQDFDEKVQKEIHRIQPFELTQNALNLVRNKGIKSVNMDLIYGLPYQNLQSFTQTLEKVMLLNPDRLAIFNYAHV
PWLKKNMRKFDENTLPSPDVKLEILEFCEKFLSKNGYKMIGMDHFAKENDELFKALENGTLHRNFQGYTTKGGADLVGIG
LTSIGEGQRHYAQNFKDMSSYEAALDRGVLPFERGVALSDDDELRKAVIMELMANFKLDIKSIEKEFCIDFQEYFKEDLK
ALEEYKDFINFDENFIKVNETGVLLIRNIAMCFDAYMKNISEDKKVFSKTV
>Mature_451_residues
MRDYKAFVKYSKAGPRYTSYPTAVEFNANFKYEEYIEILKKQDRSLSLYFHLPFCRSACYFCGCNVIYTAKEESKERYLT
YIFKELDILSTILDTKREVVQMHFGGGTPTFFSAKQLQNLILKIRSVFGNFSKDVEISCEIDPRFLNEEQATVLTQNGFN
RISFGVQDFDEKVQKEIHRIQPFELTQNALNLVRNKGIKSVNMDLIYGLPYQNLQSFTQTLEKVMLLNPDRLAIFNYAHV
PWLKKNMRKFDENTLPSPDVKLEILEFCEKFLSKNGYKMIGMDHFAKENDELFKALENGTLHRNFQGYTTKGGADLVGIG
LTSIGEGQRHYAQNFKDMSSYEAALDRGVLPFERGVALSDDDELRKAVIMELMANFKLDIKSIEKEFCIDFQEYFKEDLK
ALEEYKDFINFDENFIKVNETGVLLIRNIAMCFDAYMKNISEDKKVFSKTV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=251, Percent_Identity=23.5059760956175, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI87082341, Length=452, Percent_Identity=44.6902654867257, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1789325, Length=245, Percent_Identity=29.3877551020408, Blast_Score=119, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52464; Mature: 52464

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDYKAFVKYSKAGPRYTSYPTAVEFNANFKYEEYIEILKKQDRSLSLYFHLPFCRSACY
CCCHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEEECHHHHHHHH
FCGCNVIYTAKEESKERYLTYIFKELDILSTILDTKREVVQMHFGGGTPTFFSAKQLQNL
HHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHH
ILKIRSVFGNFSKDVEISCEIDPRFLNEEQATVLTQNGFNRISFGVQDFDEKVQKEIHRI
HHHHHHHHCCCCCCEEEEEECCCHHCCCCHHEEEECCCCCHHHCCHHHHHHHHHHHHHHC
QPFELTQNALNLVRNKGIKSVNMDLIYGLPYQNLQSFTQTLEKVMLLNPDRLAIFNYAHV
CCHHHHHHHHHHHHHCCCCEECCEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
PWLKKNMRKFDENTLPSPDVKLEILEFCEKFLSKNGYKMIGMDHFAKENDELFKALENGT
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCHHHHCCHHHHHHHHHCCC
LHRNFQGYTTKGGADLVGIGLTSIGEGQRHYAQNFKDMSSYEAALDRGVLPFERGVALSD
EECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCC
DDELRKAVIMELMANFKLDIKSIEKEFCIDFQEYFKEDLKALEEYKDFINFDENFIKVNE
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
TGVLLIRNIAMCFDAYMKNISEDKKVFSKTV
CCCHHHHHHHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure
MRDYKAFVKYSKAGPRYTSYPTAVEFNANFKYEEYIEILKKQDRSLSLYFHLPFCRSACY
CCCHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEEECHHHHHHHH
FCGCNVIYTAKEESKERYLTYIFKELDILSTILDTKREVVQMHFGGGTPTFFSAKQLQNL
HHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHH
ILKIRSVFGNFSKDVEISCEIDPRFLNEEQATVLTQNGFNRISFGVQDFDEKVQKEIHRI
HHHHHHHHCCCCCCEEEEEECCCHHCCCCHHEEEECCCCCHHHCCHHHHHHHHHHHHHHC
QPFELTQNALNLVRNKGIKSVNMDLIYGLPYQNLQSFTQTLEKVMLLNPDRLAIFNYAHV
CCHHHHHHHHHHHHHCCCCEECCEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
PWLKKNMRKFDENTLPSPDVKLEILEFCEKFLSKNGYKMIGMDHFAKENDELFKALENGT
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCHHHHCCHHHHHHHHHCCC
LHRNFQGYTTKGGADLVGIGLTSIGEGQRHYAQNFKDMSSYEAALDRGVLPFERGVALSD
EECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCC
DDELRKAVIMELMANFKLDIKSIEKEFCIDFQEYFKEDLKALEEYKDFINFDENFIKVNE
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
TGVLLIRNIAMCFDAYMKNISEDKKVFSKTV
CCCHHHHHHHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]