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The map label for this gene is cjaB [H]

Identifier: 57237808

GI number: 57237808

Start: 992375

End: 993622

Strand: Reverse

Name: cjaB [H]

Synonym: CJE1063

Alternate gene names: 57237808

Gene position: 993622-992375 (Counterclockwise)

Preceding gene: 57237809

Following gene: 57237806

Centisome position: 55.89

GC content: 30.85

Gene sequence:

>1248_bases
ATGCAAAAAAAATACAAAAATATTATTTATGCTTCTTTGGGTGGAATTTTAGAATTTTATGATTTTGTGCTTTTTGCCTT
TTTTTTGGATATTTTTGCTAAGGTATTCTTTTCGCAAAATGATGCTTTTTGGATGCAGATAAATGCTTATATAGCCTTTG
GTGCTGCTTATTTAGCGCGTCCTTTTGGTTCTATTGTGATGGCACATTTTGCTGATAGATATGGAAGAAAGAATATTTTT
TATATTTCTATGCTTTTGATGGTTTTGCCTAGTTTTGCTTTAGCTTTTTTGCCAAGTTATGAAAGTATAGGTATATTTGC
TACTTTGATTTTATTTACTATACGCATTTTGCAAGGTTTAGCCGTTGGAACTGAGGTGAGCGGAGCTTGGATTTATGTGA
GCGAATTTGTCAAAGGGCGTCAAATTCCTTTAGCTCTTGGTTTTATTTCAGCGACTTTAACCATAGGTTTATTGCTAGGA
AATATTGCCACTTTAGGCATAAGATCTTATTTTACCCCAGAAGAAGTTCAAAGCTATGCTTGGAGAATTCCTTTTATCAT
AGGAGGATTTTTTGGAATTTTAGCTTTGTTTTTAAGAAATAAACTCAGCGAAACTCCAGAATTTATAAAAGTTCAAAATG
AAAAGAAAATTTTAAGTTTTCCATTGTTCGAAGCTTTAAAAACTCATAAAATGAGTATGCTTGTTTGTTTTTTAATGACC
ATGGTTTTAACAAGCGGTGTGGCAACTTTGATGATTTTACCTAAGTATTTTGAAAGTCTTTTAGCTATGAGTAAAACTTC
TGCTTTATGGGTGCAAAATTTTGCTATTTTAGCGGTGATTTTTGGAGCTTTATTTCAAGGTTTTTTAGCAAGCAAATGGG
GAAGCTATAGGATTTGTTTTATTTTTAGTATAGCTTTTATTATTTTTGGTGTGCTTTTTAGTTTTTATGATGAGAATTTT
TTATTTTATTTTTTACTGGCTTGTTTTGCACAAGGTATTATTACTTTCGCGCCTGTTTTTATGACGCAAATTTTTAAAAG
TGAACTGAAATTTAGCGGGCTTAGTTTTGCTTATAATATTTCTTATGCGATTTTAGGTTTTTTAACCCCTTTTATAGTTA
ATGCTTTTTATAAAGAGTATTTGGGTATTTATCTTGCTATAGTGGGATCTTGTTCCTTGCTTTGCGTGTTTTTGTTAAAA
CGCGTTTTTGCAAGAAGCAAGATTAAAGAATTAAGCATTGTCTTTTAA

Upstream 100 bases:

>100_bases
GCTCATTTTGGAGATGATGTTAAGGCTGATGATGTAGTGATTGAAGGTGGAAAAATTTAATAAAGGGCTTTTTGCCCTTT
ATATTGATTTAGGATAAAAT

Downstream 100 bases:

>100_bases
AACTTCAAAAACAACCTTAGATATTTTTTCAACTGAAGCGATTTCACAATGCTCATCAGTTGAATGAGGATTATGGATAT
TTGGGCCTATAGAAGCGCAT

Product: transport protein CjaB

Products: betaine [Cytoplasm]; Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MQKKYKNIIYASLGGILEFYDFVLFAFFLDIFAKVFFSQNDAFWMQINAYIAFGAAYLARPFGSIVMAHFADRYGRKNIF
YISMLLMVLPSFALAFLPSYESIGIFATLILFTIRILQGLAVGTEVSGAWIYVSEFVKGRQIPLALGFISATLTIGLLLG
NIATLGIRSYFTPEEVQSYAWRIPFIIGGFFGILALFLRNKLSETPEFIKVQNEKKILSFPLFEALKTHKMSMLVCFLMT
MVLTSGVATLMILPKYFESLLAMSKTSALWVQNFAILAVIFGALFQGFLASKWGSYRICFIFSIAFIIFGVLFSFYDENF
LFYFLLACFAQGIITFAPVFMTQIFKSELKFSGLSFAYNISYAILGFLTPFIVNAFYKEYLGIYLAIVGSCSLLCVFLLK
RVFARSKIKELSIVF

Sequences:

>Translated_415_residues
MQKKYKNIIYASLGGILEFYDFVLFAFFLDIFAKVFFSQNDAFWMQINAYIAFGAAYLARPFGSIVMAHFADRYGRKNIF
YISMLLMVLPSFALAFLPSYESIGIFATLILFTIRILQGLAVGTEVSGAWIYVSEFVKGRQIPLALGFISATLTIGLLLG
NIATLGIRSYFTPEEVQSYAWRIPFIIGGFFGILALFLRNKLSETPEFIKVQNEKKILSFPLFEALKTHKMSMLVCFLMT
MVLTSGVATLMILPKYFESLLAMSKTSALWVQNFAILAVIFGALFQGFLASKWGSYRICFIFSIAFIIFGVLFSFYDENF
LFYFLLACFAQGIITFAPVFMTQIFKSELKFSGLSFAYNISYAILGFLTPFIVNAFYKEYLGIYLAIVGSCSLLCVFLLK
RVFARSKIKELSIVF
>Mature_415_residues
MQKKYKNIIYASLGGILEFYDFVLFAFFLDIFAKVFFSQNDAFWMQINAYIAFGAAYLARPFGSIVMAHFADRYGRKNIF
YISMLLMVLPSFALAFLPSYESIGIFATLILFTIRILQGLAVGTEVSGAWIYVSEFVKGRQIPLALGFISATLTIGLLLG
NIATLGIRSYFTPEEVQSYAWRIPFIIGGFFGILALFLRNKLSETPEFIKVQNEKKILSFPLFEALKTHKMSMLVCFLMT
MVLTSGVATLMILPKYFESLLAMSKTSALWVQNFAILAVIFGALFQGFLASKWGSYRICFIFSIAFIIFGVLFSFYDENF
LFYFLLACFAQGIITFAPVFMTQIFKSELKFSGLSFAYNISYAILGFLTPFIVNAFYKEYLGIYLAIVGSCSLLCVFLLK
RVFARSKIKELSIVF

Specific function: May be a proton symporter invoved in the uptake of osmolytes such as proline and glycine betaine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790550, Length=398, Percent_Identity=28.1407035175879, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1789941, Length=426, Percent_Identity=29.1079812206573, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788292, Length=396, Percent_Identity=27.7777777777778, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1788942, Length=222, Percent_Identity=31.981981981982, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87082231, Length=446, Percent_Identity=22.6457399103139, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47009; Mature: 47009

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKYKNIIYASLGGILEFYDFVLFAFFLDIFAKVFFSQNDAFWMQINAYIAFGAAYLAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHH
PFGSIVMAHFADRYGRKNIFYISMLLMVLPSFALAFLPSYESIGIFATLILFTIRILQGL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
AVGTEVSGAWIYVSEFVKGRQIPLALGFISATLTIGLLLGNIATLGIRSYFTPEEVQSYA
HCCCCCCCHHEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
WRIPFIIGGFFGILALFLRNKLSETPEFIKVQNEKKILSFPLFEALKTHKMSMLVCFLMT
HHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MVLTSGVATLMILPKYFESLLAMSKTSALWVQNFAILAVIFGALFQGFLASKWGSYRICF
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
IFSIAFIIFGVLFSFYDENFLFYFLLACFAQGIITFAPVFMTQIFKSELKFSGLSFAYNI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SYAILGFLTPFIVNAFYKEYLGIYLAIVGSCSLLCVFLLKRVFARSKIKELSIVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQKKYKNIIYASLGGILEFYDFVLFAFFLDIFAKVFFSQNDAFWMQINAYIAFGAAYLAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHH
PFGSIVMAHFADRYGRKNIFYISMLLMVLPSFALAFLPSYESIGIFATLILFTIRILQGL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
AVGTEVSGAWIYVSEFVKGRQIPLALGFISATLTIGLLLGNIATLGIRSYFTPEEVQSYA
HCCCCCCCHHEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
WRIPFIIGGFFGILALFLRNKLSETPEFIKVQNEKKILSFPLFEALKTHKMSMLVCFLMT
HHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MVLTSGVATLMILPKYFESLLAMSKTSALWVQNFAILAVIFGALFQGFLASKWGSYRICF
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
IFSIAFIIFGVLFSFYDENFLFYFLLACFAQGIITFAPVFMTQIFKSELKFSGLSFAYNI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SYAILGFLTPFIVNAFYKEYLGIYLAIVGSCSLLCVFLLKRVFARSKIKELSIVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: betaine [Periplasm]; Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + betaine [Periplasm] = Proton [Cytoplasm] + betaine [Cytoplasm] Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA