Click here to switch to the map view.

The map label for this gene is coaBC [H]

Identifier: 57237663

GI number: 57237663

Start: 848041

End: 849195

Strand: Direct

Name: coaBC [H]

Synonym: CJE0909

Alternate gene names: 57237663

Gene position: 848041-849195 (Clockwise)

Preceding gene: 57237662

Following gene: 57237664

Centisome position: 47.7

GC content: 31.34

Gene sequence:

>1155_bases
ATGAAAACCATACTTTTAGCCATTAGCGGTAGTATAGCTTTTTATAAATCTTATGAGCTTATTTCTTTGTTTAAAAAAGA
AGGCTTTAGGGTAAAAGTTTTGCTTTCTAATGGTTTGTTAAAATTTGCTAGCAAAATGAGTTTTGAAGCCTTGGTTGATG
AAGTTTTATGTGAGGAAAATGAAAGTTGGCAAAATTCAAACAATCACATAGCTTTTAGCAAGGATGTAGACCTTGTTTTG
TTTGCCCCTGCAAGTGTTAATTCTATCAATAAACTTGCTTTTGGTATAGCGGATAATCTTTTTATCCAAACCTTAATCGC
AGCAAATAAACCTCTTATCATAGCTCCTGCGGCAAATACAAATATGTTTCATCATTTTAGCACGCGAAATTCTTTAAAGA
TACTTAAAGAAAATAAAGCTTTGATTATAGAGCCTATTTGTAAAGTTTTAGCTTGTAAAGATGAAGGCGTAGGAGCCTTA
GCTGAAGTTAAGGATATTTTTAATATCACCAAAAGAGAGCTTTTAAAAGAAAAGTTTTGGTGCGATAAAAGTGTAGTTAT
CACAGGTGGCGGCACAAAAGAAAAGATCGATGATGTGCGTTGTGTGAGTAATTTTTCAAGTGGAAAAATGGCAAAGGCCA
TAGCTGACGCTTTTTATTTTTTAGGAGCTAGGGTAAAACTTTTAAGCTCTGTGGAATTTGATACGCCTTATGAGCTTTGC
AAATTTGAAAGTTCTAAGGATCTAAAGGAGCTTTTGGATAAAAATTTAAATCATGACTTTTTGATTATGACGGCTGCGGT
GAGTGATTTTATCCCTCAAAGTGTAAAAGGGAAAATTAAAAAAAATGAGCATTTGCAGGGTTTAAATTTGCATCTATCTT
TAAATGAAGATTTGCTTAAAACTTGCAAATTTCAAGGCAAAAAGATAGGTTTTAAGATGGAATTTGATTCTCAAAATGCC
TTAGAAAATGCGAAAAAATCTTTAAAAGATAAGCAACTTGATATGGTTTGTCTTAATATCATTGATCAAAAAAATTATTT
TGGAAGCGATCAAAATGAGCTTTATTTTATCACTTTAAACAATGAAAATAAAAGCACTTTGCAAAGCAAAGAAAAATTGG
CATTTGAATTAGTAAAATGGTGTGAAAAATTATGA

Upstream 100 bases:

>100_bases
CAGGAAGCACAGTAAGTGTCAATGTAGAAAAGGGTGCTTTGTTTATCAATAGAGCAGGGCATAAAATGATAAAAGATTAT
TATTATAAGAAATTTCAAAA

Downstream 100 bases:

>100_bases
GTATGATTAATTCTACCTTACCTATACAAATGAAAGTTTTAGCTAAATCAGGTTATGGACATTATACGCTTTTATTAAAT
CATAAAAAGATTCAAACCAA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MKTILLAISGSIAFYKSYELISLFKKEGFRVKVLLSNGLLKFASKMSFEALVDEVLCEENESWQNSNNHIAFSKDVDLVL
FAPASVNSINKLAFGIADNLFIQTLIAANKPLIIAPAANTNMFHHFSTRNSLKILKENKALIIEPICKVLACKDEGVGAL
AEVKDIFNITKRELLKEKFWCDKSVVITGGGTKEKIDDVRCVSNFSSGKMAKAIADAFYFLGARVKLLSSVEFDTPYELC
KFESSKDLKELLDKNLNHDFLIMTAAVSDFIPQSVKGKIKKNEHLQGLNLHLSLNEDLLKTCKFQGKKIGFKMEFDSQNA
LENAKKSLKDKQLDMVCLNIIDQKNYFGSDQNELYFITLNNENKSTLQSKEKLAFELVKWCEKL

Sequences:

>Translated_384_residues
MKTILLAISGSIAFYKSYELISLFKKEGFRVKVLLSNGLLKFASKMSFEALVDEVLCEENESWQNSNNHIAFSKDVDLVL
FAPASVNSINKLAFGIADNLFIQTLIAANKPLIIAPAANTNMFHHFSTRNSLKILKENKALIIEPICKVLACKDEGVGAL
AEVKDIFNITKRELLKEKFWCDKSVVITGGGTKEKIDDVRCVSNFSSGKMAKAIADAFYFLGARVKLLSSVEFDTPYELC
KFESSKDLKELLDKNLNHDFLIMTAAVSDFIPQSVKGKIKKNEHLQGLNLHLSLNEDLLKTCKFQGKKIGFKMEFDSQNA
LENAKKSLKDKQLDMVCLNIIDQKNYFGSDQNELYFITLNNENKSTLQSKEKLAFELVKWCEKL
>Mature_384_residues
MKTILLAISGSIAFYKSYELISLFKKEGFRVKVLLSNGLLKFASKMSFEALVDEVLCEENESWQNSNNHIAFSKDVDLVL
FAPASVNSINKLAFGIADNLFIQTLIAANKPLIIAPAANTNMFHHFSTRNSLKILKENKALIIEPICKVLACKDEGVGAL
AEVKDIFNITKRELLKEKFWCDKSVVITGGGTKEKIDDVRCVSNFSSGKMAKAIADAFYFLGARVKLLSSVEFDTPYELC
KFESSKDLKELLDKNLNHDFLIMTAAVSDFIPQSVKGKIKKNEHLQGLNLHLSLNEDLLKTCKFQGKKIGFKMEFDSQNA
LENAKKSLKDKQLDMVCLNIIDQKNYFGSDQNELYFITLNNENKSTLQSKEKLAFELVKWCEKL

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=180, Percent_Identity=32.7777777777778, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87082301, Length=386, Percent_Identity=28.2383419689119, Blast_Score=137, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17560194, Length=179, Percent_Identity=34.0782122905028, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=192, Percent_Identity=28.125, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24657262, Length=178, Percent_Identity=33.7078651685393, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43259; Mature: 43259

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTILLAISGSIAFYKSYELISLFKKEGFRVKVLLSNGLLKFASKMSFEALVDEVLCEEN
CCEEEEEEECCEEEEHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCC
ESWQNSNNHIAFSKDVDLVLFAPASVNSINKLAFGIADNLFIQTLIAANKPLIIAPAANT
CCCCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
NMFHHFSTRNSLKILKENKALIIEPICKVLACKDEGVGALAEVKDIFNITKRELLKEKFW
CEEEEECCCCCEEEEECCCCEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
CDKSVVITGGGTKEKIDDVRCVSNFSSGKMAKAIADAFYFLGARVKLLSSVEFDTPYELC
CCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
KFESSKDLKELLDKNLNHDFLIMTAAVSDFIPQSVKGKIKKNEHLQGLNLHLSLNEDLLK
CCCCCHHHHHHHHCCCCCCEEEEEHHHHHHCCHHHCCCCCCCCCCCCEEEEEECCHHHHH
TCKFQGKKIGFKMEFDSQNALENAKKSLKDKQLDMVCLNIIDQKNYFGSDQNELYFITLN
HHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEC
NENKSTLQSKEKLAFELVKWCEKL
CCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTILLAISGSIAFYKSYELISLFKKEGFRVKVLLSNGLLKFASKMSFEALVDEVLCEEN
CCEEEEEEECCEEEEHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCC
ESWQNSNNHIAFSKDVDLVLFAPASVNSINKLAFGIADNLFIQTLIAANKPLIIAPAANT
CCCCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
NMFHHFSTRNSLKILKENKALIIEPICKVLACKDEGVGALAEVKDIFNITKRELLKEKFW
CEEEEECCCCCEEEEECCCCEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
CDKSVVITGGGTKEKIDDVRCVSNFSSGKMAKAIADAFYFLGARVKLLSSVEFDTPYELC
CCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
KFESSKDLKELLDKNLNHDFLIMTAAVSDFIPQSVKGKIKKNEHLQGLNLHLSLNEDLLK
CCCCCHHHHHHHHCCCCCCEEEEEHHHHHHCCHHHCCCCCCCCCCCCEEEEEECCHHHHH
TCKFQGKKIGFKMEFDSQNALENAKKSLKDKQLDMVCLNIIDQKNYFGSDQNELYFITLN
HHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEC
NENKSTLQSKEKLAFELVKWCEKL
CCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]