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The map label for this gene is hppA [H]

Identifier: 21226802

GI number: 21226802

Start: 840962

End: 842992

Strand: Reverse

Name: hppA [H]

Synonym: MM_0700

Alternate gene names: 21226802

Gene position: 842992-840962 (Counterclockwise)

Preceding gene: 21226811

Following gene: 21226798

Centisome position: 20.58

GC content: 47.22

Gene sequence:

>2031_bases
ATGGATATGTTAATCTACCTTACACCAATATGTGCCCTTATTGGTTTAATTTTTGCAGGTATATCCTACAAAAATGTCCG
AAATGAAGGCGAGGGTAACGAACTTATTAAGAAAATTACGGCGGCAATTCATGGTGGAGCTATGGTCTACCTTAACAGGC
AATACCGTGCTATCGCTGTCTTTGTCGTTTTTATTGCAATTGTACTTGCGTTAGTTCTGCCGAACGGAGTTCTTACCGCC
GCATGTTTCGTGTTTGGTGCAGTGCTTTCCGCAACAGCCGGATACGCAGGGATGCTTACGGCCACTATTGCAAATGGAAG
GACCACAAATGCTGCCACAAGAGGCATCGGCCCTGCTTTTAAAGTTTCATTTGCATCAGGCACCGTCATGGGAATGAGTG
TCGTGGGCCTTGGTCTCTTTGGATTATCTCTTTCATTTATAATTCTTGGTAATATCTACACAGATATGGATCTGTTCACC
CTCCTGAACATTATTGCGGGCTTTTCATTCGGAGCTTCGTCTATAGCTCTCTTTGCCCGTGTAGGCGGCGGAATATTCAC
CAAAGCTGCTGATGTCGGAGCTGACCTTGTAGGTAAGGTTGAAGCCGGGATCCCTGAAGATGACCCCAGGAACCCTGCTG
TTATTGCTGACAATGTAGGAGACAATGTAGGAGACATTGCGGGAATGGGTGCTGACCTCTATGAGTCCTATGTGGGTTCA
ATCATTGCAACCATGCTTCTTGCAGCATCAACCGCAGCAGCAACTTTCCCCGGGATTCCTGTTATGAACGTTGTTATGGT
CCCACTTGTTATCGCAGCTGTTGGTATTCTGGCATCTGTTATAGGGACTTTTTTTGTACGCACCAACAAGACAGAATCTT
CAGCAATCCATATGGCATTTAATATGGGACTGATTGCCGCGATCGTTCTTACTGTCATTGCTTCATACGTCGTTACAGGC
CATCTCCTTGGAGGATACGGGCTTAACGTCTTCTTCTCAACGGTTGCAGGACTGGTTGCAGGCTTCCTTATCGGACAAAT
CACCGAGCACTATACATCATATGACAAAAAGCCAACTCTCACTGTTGCCCATTCCTGCCAGACAGGTTCTGCTACAAATG
TTATTACAGGATTTGCAAAAGGGATGGAGTCAACTCTCTGGCCCGCTGTCATCATCAGCATTGCAATTTATATCGCATTC
CAGCTCGCAGGTCTTTACGGCATAGCTATTGCAGCAGTCGGAATGCTCGCAACACTCGGGATTTCCCTCTCAGTCGATGC
TTACGGTCCTGTAGCTGACAATGCAGGTGGCATTGCAGAGATGTCCCACCAGAAGAAAGAGGTGCGCCAGATTACCGATA
CCCTTGATGCAGTAGGAAACACCACGGCAGCTATGGGTAAGGGATTTGCAATCGGTTCGGCAGCTCTTACTGCACTTTCA
CTCTTTGCTTCATATGCTATTGCAGTAGGCCTCACTTCTATTGACGTTATGAACCCTAACGTATTCATAGGGCTTATAAT
AGGCGCAATGCTTCCTTTCCTCTTTTCGTCCATGACCATTCTGGCTGTCGGAAATGCAGCAGGTGAAGTGGTGGTCGAAG
TGAGGAGGCAGTTTAAAGAGATCAAAGGCCTTATGGAAGGCAAAGCTGACCCCGACTACAGTAAATGTATTACAATCTCC
ACGCATTCTGCTCTTAAAGAGATGATCCCGCCCGGAATTCTTGCTGTTATTGCACCTATTCTGGTAGGACTTGTACTCGG
CGCAGGGGCTCTCGGTGGGCTGCTTGCAGGCTCCGTGGTTTCAGGTTTCATGCTTGCAATTACAATGTCCAATGCAGGAG
GTTCCTGGGACAATGCAAAGAAATTCATTGAACTTGGAAACTTCGGCGGAAAGGGTTCTGATGCCCACAAAGCGGGTGTA
ACCGGCGATACGGTAGGTGACCCTTTCAAAGACACCGCAGGACCTGCAATCAACATCCTCATTAAGCTCATGAGTATTGT
GGCTCTTGTGTTTGCACCGCTGTTTATTTGA

Upstream 100 bases:

>100_bases
TCAATTTATATACAAAGACTCATTTATTATCGCAAAAATTACTACGGAGATTAATACTTTAAAGTGCTTTTGATGTGTTT
TCTGGTAGGATGGTTTAAAT

Downstream 100 bases:

>100_bases
TTTCCTTAAATTTTTCCCTTTTTTTCCCTTTTTTTCTTTTTAATTTAGTCTGGATCTTTGCCTGTTTTGTTCTGGTCTTC
CTTTCCAGGTTTTCTTTTGC

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound sodium-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; Na(+)-PPase [H]

Number of amino acids: Translated: 676; Mature: 676

Protein sequence:

>676_residues
MDMLIYLTPICALIGLIFAGISYKNVRNEGEGNELIKKITAAIHGGAMVYLNRQYRAIAVFVVFIAIVLALVLPNGVLTA
ACFVFGAVLSATAGYAGMLTATIANGRTTNAATRGIGPAFKVSFASGTVMGMSVVGLGLFGLSLSFIILGNIYTDMDLFT
LLNIIAGFSFGASSIALFARVGGGIFTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDIAGMGADLYESYVGS
IIATMLLAASTAAATFPGIPVMNVVMVPLVIAAVGILASVIGTFFVRTNKTESSAIHMAFNMGLIAAIVLTVIASYVVTG
HLLGGYGLNVFFSTVAGLVAGFLIGQITEHYTSYDKKPTLTVAHSCQTGSATNVITGFAKGMESTLWPAVIISIAIYIAF
QLAGLYGIAIAAVGMLATLGISLSVDAYGPVADNAGGIAEMSHQKKEVRQITDTLDAVGNTTAAMGKGFAIGSAALTALS
LFASYAIAVGLTSIDVMNPNVFIGLIIGAMLPFLFSSMTILAVGNAAGEVVVEVRRQFKEIKGLMEGKADPDYSKCITIS
THSALKEMIPPGILAVIAPILVGLVLGAGALGGLLAGSVVSGFMLAITMSNAGGSWDNAKKFIELGNFGGKGSDAHKAGV
TGDTVGDPFKDTAGPAINILIKLMSIVALVFAPLFI

Sequences:

>Translated_676_residues
MDMLIYLTPICALIGLIFAGISYKNVRNEGEGNELIKKITAAIHGGAMVYLNRQYRAIAVFVVFIAIVLALVLPNGVLTA
ACFVFGAVLSATAGYAGMLTATIANGRTTNAATRGIGPAFKVSFASGTVMGMSVVGLGLFGLSLSFIILGNIYTDMDLFT
LLNIIAGFSFGASSIALFARVGGGIFTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDIAGMGADLYESYVGS
IIATMLLAASTAAATFPGIPVMNVVMVPLVIAAVGILASVIGTFFVRTNKTESSAIHMAFNMGLIAAIVLTVIASYVVTG
HLLGGYGLNVFFSTVAGLVAGFLIGQITEHYTSYDKKPTLTVAHSCQTGSATNVITGFAKGMESTLWPAVIISIAIYIAF
QLAGLYGIAIAAVGMLATLGISLSVDAYGPVADNAGGIAEMSHQKKEVRQITDTLDAVGNTTAAMGKGFAIGSAALTALS
LFASYAIAVGLTSIDVMNPNVFIGLIIGAMLPFLFSSMTILAVGNAAGEVVVEVRRQFKEIKGLMEGKADPDYSKCITIS
THSALKEMIPPGILAVIAPILVGLVLGAGALGGLLAGSVVSGFMLAITMSNAGGSWDNAKKFIELGNFGGKGSDAHKAGV
TGDTVGDPFKDTAGPAINILIKLMSIVALVFAPLFI
>Mature_676_residues
MDMLIYLTPICALIGLIFAGISYKNVRNEGEGNELIKKITAAIHGGAMVYLNRQYRAIAVFVVFIAIVLALVLPNGVLTA
ACFVFGAVLSATAGYAGMLTATIANGRTTNAATRGIGPAFKVSFASGTVMGMSVVGLGLFGLSLSFIILGNIYTDMDLFT
LLNIIAGFSFGASSIALFARVGGGIFTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDIAGMGADLYESYVGS
IIATMLLAASTAAATFPGIPVMNVVMVPLVIAAVGILASVIGTFFVRTNKTESSAIHMAFNMGLIAAIVLTVIASYVVTG
HLLGGYGLNVFFSTVAGLVAGFLIGQITEHYTSYDKKPTLTVAHSCQTGSATNVITGFAKGMESTLWPAVIISIAIYIAF
QLAGLYGIAIAAVGMLATLGISLSVDAYGPVADNAGGIAEMSHQKKEVRQITDTLDAVGNTTAAMGKGFAIGSAALTALS
LFASYAIAVGLTSIDVMNPNVFIGLIIGAMLPFLFSSMTILAVGNAAGEVVVEVRRQFKEIKGLMEGKADPDYSKCITIS
THSALKEMIPPGILAVIAPILVGLVLGAGALGGLLAGSVVSGFMLAITMSNAGGSWDNAKKFIELGNFGGKGSDAHKAGV
TGDTVGDPFKDTAGPAINILIKLMSIVALVFAPLFI

Specific function: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 69222; Mature: 69222

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMLIYLTPICALIGLIFAGISYKNVRNEGEGNELIKKITAAIHGGAMVYLNRQYRAIAV
CCEEEHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHH
FVVFIAIVLALVLPNGVLTAACFVFGAVLSATAGYAGMLTATIANGRTTNAATRGIGPAF
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHEEECCCCCCCCHHCCCCCCE
KVSFASGTVMGMSVVGLGLFGLSLSFIILGNIYTDMDLFTLLNIIAGFSFGASSIALFAR
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VGGGIFTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDIAGMGADLYESYVGS
HCCCHHHHHHHHCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHCCCHHHHHHHHHH
IIATMLLAASTAAATFPGIPVMNVVMVPLVIAAVGILASVIGTFFVRTNKTESSAIHMAF
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
NMGLIAAIVLTVIASYVVTGHLLGGYGLNVFFSTVAGLVAGFLIGQITEHYTSYDKKPTL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
TVAHSCQTGSATNVITGFAKGMESTLWPAVIISIAIYIAFQLAGLYGIAIAAVGMLATLG
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ISLSVDAYGPVADNAGGIAEMSHQKKEVRQITDTLDAVGNTTAAMGKGFAIGSAALTALS
CEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHH
LFASYAIAVGLTSIDVMNPNVFIGLIIGAMLPFLFSSMTILAVGNAAGEVVVEVRRQFKE
HHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHHHHHHH
IKGLMEGKADPDYSKCITISTHSALKEMIPPGILAVIAPILVGLVLGAGALGGLLAGSVV
HHHHHCCCCCCCHHHEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGFMLAITMSNAGGSWDNAKKFIELGNFGGKGSDAHKAGVTGDTVGDPFKDTAGPAINIL
HHHHHEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
IKLMSIVALVFAPLFI
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDMLIYLTPICALIGLIFAGISYKNVRNEGEGNELIKKITAAIHGGAMVYLNRQYRAIAV
CCEEEHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHH
FVVFIAIVLALVLPNGVLTAACFVFGAVLSATAGYAGMLTATIANGRTTNAATRGIGPAF
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHEEECCCCCCCCHHCCCCCCE
KVSFASGTVMGMSVVGLGLFGLSLSFIILGNIYTDMDLFTLLNIIAGFSFGASSIALFAR
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VGGGIFTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDIAGMGADLYESYVGS
HCCCHHHHHHHHCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHCCCHHHHHHHHHH
IIATMLLAASTAAATFPGIPVMNVVMVPLVIAAVGILASVIGTFFVRTNKTESSAIHMAF
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
NMGLIAAIVLTVIASYVVTGHLLGGYGLNVFFSTVAGLVAGFLIGQITEHYTSYDKKPTL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
TVAHSCQTGSATNVITGFAKGMESTLWPAVIISIAIYIAFQLAGLYGIAIAAVGMLATLG
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ISLSVDAYGPVADNAGGIAEMSHQKKEVRQITDTLDAVGNTTAAMGKGFAIGSAALTALS
CEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHH
LFASYAIAVGLTSIDVMNPNVFIGLIIGAMLPFLFSSMTILAVGNAAGEVVVEVRRQFKE
HHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHHHHHHH
IKGLMEGKADPDYSKCITISTHSALKEMIPPGILAVIAPILVGLVLGAGALGGLLAGSVV
HHHHHCCCCCCCHHHEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGFMLAITMSNAGGSWDNAKKFIELGNFGGKGSDAHKAGVTGDTVGDPFKDTAGPAINIL
HHHHHEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
IKLMSIVALVFAPLFI
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]