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The map label for this gene is cdhA2

Identifier: 21226786

GI number: 21226786

Start: 819935

End: 822358

Strand: Direct

Name: cdhA2

Synonym: MM_0684

Alternate gene names: 21226786

Gene position: 819935-822358 (Clockwise)

Preceding gene: 21226781

Following gene: 21226787

Centisome position: 20.02

GC content: 51.07

Gene sequence:

>2424_bases
ATGAGCAAACTAACTACCGGGAGTTTTTCAATAGAAGATCTTGAATCCGTTCAGATCACTATTAACAACATTGTAGGGGC
AGCAAAGGAGGCTGCTGAAGAAAAAGCAAAGGAGCTCGTTAAGGCTGGTCCCACTCTTTTCCCAGGACTTGAGTCCTACA
GAGATGACTGGAACTTCAAACTTCTTGACCGCTACGAGCCTGTTGTTACCCCAATGTGTGACCAGTGCTGCTACTGTACC
TATGGACCCTGTGACCTTTCAGGGAACAAAAGAGGTGCCTGTGGTATCGACATGATGGGCCACAACGGAAGGGAATTCTT
CCTCCGTGTAATTACAGGTACTGCCTGCCACGCAGCCCACGGCCGCCACCTGCTTGATCACCTGATCGAAACCTTCGGAG
AAGACTTACCCCTCAACCTTGGGCAGTCAAATGTCCTTACTCCGAACATCACAATCAGCACAGGGCTCAGCCCCAAGAAC
CTTGGCGAAGTCAAGCCAGCAATGGAATTCGTTGAAGAACAGCTGACTCAGCTGCTTGCAACCGTCCACGCAGGACAGGA
ATCCGCAGAGATCGATTACGACTCAAAAGCCCTCTTCAGCGGTAGCCTGGACCACGTAGGCATGGAAATTTCCGATGTTG
TACAGGTTGCAGCCTACGACTTCCCGAAAGCTGACCCCGAAGCCCCCCTGATCGAAATCGGCATGGGGACCATCGACAAG
TCCAAGCCCTTCCTCTGTGTTATAGGGCACAATGTAGGCGGTGTAACCTACATGATGGACTACATGGAAGAAAACAACCT
GACTGACAAGATGGAAATTGCCGGGCTCTGCTGTACCGCAATCGACCTTACAAGGTACAAGGAAGCTGACAGGAGACCAC
CATATGCCAAGGTCATCGGTTCCATGGCCAAGGAACTAAAGGTTATCCGCTCCGGAATGCCTGATGTCATTGTTGTGGAC
GAACAGTGTGTACGCGGTGACATCGTACCCGAAGCACAGAAACTCAAGATTCCGGTCATTGCATCAAATGCAAAGATTAT
GTTCGGGCTTCCAAACAGGACCGATGCAGATGTTAATGAGACTATCGAGGAACTCAAGTCCGGAGCAATTCCAGGCTGTG
TAATGCTGGACTACGAGAAACTCGGTGAACTCTGTATCAGGCTTACCATGGAAATGGCCCCGATCCGCGATGCATCCGGT
ATCACTGCGATTCCAACAGATGAGGAATTAGCAAACTGGGTCGCAAAGTGTGCAGATTGTGGAGCCTGCCTGATTGCCTG
CCCTGAAGAACTCGACATACCCGAAGCTATGGGATTTGCAAAGGAAGGAGATTACTCATACCTCGAAGGCCTGCATGACA
TATGTATCGGCTGCCGCCGCTGCGAACAGGTCTGTAAGAAGGAAATTCCAATTCTTAACATAATCGAAAAAGTTTCCCAG
AAGCAGATTGCAGAAGAGAAAGGCTGGATGAGAGCCGGCAGAGGACAGGTATCTGATGCCGAAATCCGTGCAGAAGGTCT
TAACCTCGTCATGGGTACAACCCCAGGTATCATCGCAATCATCGGATGCCCGAACTATGCAGAAGGCACAAAGGACGTCT
ACTACATTGCTGAAGAATTCCTGAAGAGGAACTTCATTGTGGTTACGACCGGCTGTGGAGCAATGGACATTGGTATGTTC
AAGGACGACGACGGCAAGACTCTCTATGAGAGGTACCCTGGCGGATTCCAGTGCGGTGGACTCGTTAACATAGGATCCTG
TGTTTCTAACGCCCATATTACCGGAGCAGCCGAGAAAGTCGCAGCTATCTTTGCCCAGAGGACCCTTGAAGGCAACCTCG
CCGAGATCGCAGACTACATCCTTAACCGTGTAGGTGCTTGCGGACTTGCATGGGGTGCATTCTCACAGAAAGCTTCCTCA
ATCGGTACCGGCTGTAACATTCTTGGTATCCCAGCAGTTCTTGGCCCACACTCCTCGAAGTACAGGAGAGCCCTGATTGC
CAAGACCTATGAAGAAGACAAGTGGAAAGTCTATGATGCAAGGAACGGACAGGAGATGCCAATCCCACCAGCACCAGAAT
TCCTCCTGACCACAGCAGAAACCTGGCAGGAAGCAATCCCGATGATGGCAAAGGCATGCATCCGCCCGTCTGACAACAGC
ATGGGAAGAGCCATAAAGCTGACCCACTGGATGGAGCTGCACAAGAAATACCTTGGTGGTTCAGAACCTGAAGACTGGTG
GAAGTTCGTCAGGAACGAAGCTGACCTCCCGCTGGCTAACCGTGAAGCGCTCCTCAAGAAGCTCGAGGCAGAACGCGGCT
GGGAGATTGACTGGAAGAAGAAGAAGATCATTTCCGGTCCGAAGATCAAATTCGATGTCTCGGCACAGCCCACCAACCTC
AAGAGACTTTGCAAGGAGGCCTGA

Upstream 100 bases:

>100_bases
GCAAAATATATAATTAATAATCATTAAGAATATGCCGAAGATAAGATTGCAATCGTCTTGGCGAAGTTGACTTTAAACAA
ATTTAGGAGGTAAAGCTCAA

Downstream 100 bases:

>100_bases
AAATGGTTGACACTACCAAGAACACAAAGCTCTTTACCAGCTACGGAGTGAGCACCTCAAAAACCGTTGCTCCTGAAATG
GCTGCAAAGCTTATCTCAAA

Product: acetyl-CoA decarbonylase/synthase complex subunit alpha

Products: NA

Alternate protein names: ACDS complex subunit alpha 2; ACDS complex carbon monoxide dehydrogenase 2; ACDS CODH 2

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MSKLTTGSFSIEDLESVQITINNIVGAAKEAAEEKAKELVKAGPTLFPGLESYRDDWNFKLLDRYEPVVTPMCDQCCYCT
YGPCDLSGNKRGACGIDMMGHNGREFFLRVITGTACHAAHGRHLLDHLIETFGEDLPLNLGQSNVLTPNITISTGLSPKN
LGEVKPAMEFVEEQLTQLLATVHAGQESAEIDYDSKALFSGSLDHVGMEISDVVQVAAYDFPKADPEAPLIEIGMGTIDK
SKPFLCVIGHNVGGVTYMMDYMEENNLTDKMEIAGLCCTAIDLTRYKEADRRPPYAKVIGSMAKELKVIRSGMPDVIVVD
EQCVRGDIVPEAQKLKIPVIASNAKIMFGLPNRTDADVNETIEELKSGAIPGCVMLDYEKLGELCIRLTMEMAPIRDASG
ITAIPTDEELANWVAKCADCGACLIACPEELDIPEAMGFAKEGDYSYLEGLHDICIGCRRCEQVCKKEIPILNIIEKVSQ
KQIAEEKGWMRAGRGQVSDAEIRAEGLNLVMGTTPGIIAIIGCPNYAEGTKDVYYIAEEFLKRNFIVVTTGCGAMDIGMF
KDDDGKTLYERYPGGFQCGGLVNIGSCVSNAHITGAAEKVAAIFAQRTLEGNLAEIADYILNRVGACGLAWGAFSQKASS
IGTGCNILGIPAVLGPHSSKYRRALIAKTYEEDKWKVYDARNGQEMPIPPAPEFLLTTAETWQEAIPMMAKACIRPSDNS
MGRAIKLTHWMELHKKYLGGSEPEDWWKFVRNEADLPLANREALLKKLEAERGWEIDWKKKKIISGPKIKFDVSAQPTNL
KRLCKEA

Sequences:

>Translated_807_residues
MSKLTTGSFSIEDLESVQITINNIVGAAKEAAEEKAKELVKAGPTLFPGLESYRDDWNFKLLDRYEPVVTPMCDQCCYCT
YGPCDLSGNKRGACGIDMMGHNGREFFLRVITGTACHAAHGRHLLDHLIETFGEDLPLNLGQSNVLTPNITISTGLSPKN
LGEVKPAMEFVEEQLTQLLATVHAGQESAEIDYDSKALFSGSLDHVGMEISDVVQVAAYDFPKADPEAPLIEIGMGTIDK
SKPFLCVIGHNVGGVTYMMDYMEENNLTDKMEIAGLCCTAIDLTRYKEADRRPPYAKVIGSMAKELKVIRSGMPDVIVVD
EQCVRGDIVPEAQKLKIPVIASNAKIMFGLPNRTDADVNETIEELKSGAIPGCVMLDYEKLGELCIRLTMEMAPIRDASG
ITAIPTDEELANWVAKCADCGACLIACPEELDIPEAMGFAKEGDYSYLEGLHDICIGCRRCEQVCKKEIPILNIIEKVSQ
KQIAEEKGWMRAGRGQVSDAEIRAEGLNLVMGTTPGIIAIIGCPNYAEGTKDVYYIAEEFLKRNFIVVTTGCGAMDIGMF
KDDDGKTLYERYPGGFQCGGLVNIGSCVSNAHITGAAEKVAAIFAQRTLEGNLAEIADYILNRVGACGLAWGAFSQKASS
IGTGCNILGIPAVLGPHSSKYRRALIAKTYEEDKWKVYDARNGQEMPIPPAPEFLLTTAETWQEAIPMMAKACIRPSDNS
MGRAIKLTHWMELHKKYLGGSEPEDWWKFVRNEADLPLANREALLKKLEAERGWEIDWKKKKIISGPKIKFDVSAQPTNL
KRLCKEA
>Mature_806_residues
SKLTTGSFSIEDLESVQITINNIVGAAKEAAEEKAKELVKAGPTLFPGLESYRDDWNFKLLDRYEPVVTPMCDQCCYCTY
GPCDLSGNKRGACGIDMMGHNGREFFLRVITGTACHAAHGRHLLDHLIETFGEDLPLNLGQSNVLTPNITISTGLSPKNL
GEVKPAMEFVEEQLTQLLATVHAGQESAEIDYDSKALFSGSLDHVGMEISDVVQVAAYDFPKADPEAPLIEIGMGTIDKS
KPFLCVIGHNVGGVTYMMDYMEENNLTDKMEIAGLCCTAIDLTRYKEADRRPPYAKVIGSMAKELKVIRSGMPDVIVVDE
QCVRGDIVPEAQKLKIPVIASNAKIMFGLPNRTDADVNETIEELKSGAIPGCVMLDYEKLGELCIRLTMEMAPIRDASGI
TAIPTDEELANWVAKCADCGACLIACPEELDIPEAMGFAKEGDYSYLEGLHDICIGCRRCEQVCKKEIPILNIIEKVSQK
QIAEEKGWMRAGRGQVSDAEIRAEGLNLVMGTTPGIIAIIGCPNYAEGTKDVYYIAEEFLKRNFIVVTTGCGAMDIGMFK
DDDGKTLYERYPGGFQCGGLVNIGSCVSNAHITGAAEKVAAIFAQRTLEGNLAEIADYILNRVGACGLAWGAFSQKASSI
GTGCNILGIPAVLGPHSSKYRRALIAKTYEEDKWKVYDARNGQEMPIPPAPEFLLTTAETWQEAIPMMAKACIRPSDNSM
GRAIKLTHWMELHKKYLGGSEPEDWWKFVRNEADLPLANREALLKKLEAERGWEIDWKKKKIISGPKIKFDVSAQPTNLK
RLCKEA

Specific function: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy

COG id: COG1152

COG function: function code C; CO dehydrogenase/acetyl-CoA synthase alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDA2_METMA (Q49163)

Other databases:

- EMBL:   L26486
- EMBL:   AE008384
- RefSeq:   NP_632708.1
- ProteinModelPortal:   Q49163
- SMR:   Q49163
- GeneID:   1479026
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0684
- NMPDR:   fig|192952.1.peg.684
- HOGENOM:   HBG539676
- OMA:   ICCTAID
- ProtClustDB:   PRK00941
- BioCyc:   MMAZ192952:MM0684-MONOMER
- BRENDA:   1.2.99.2
- GO:   GO:0005737
- GO:   GO:0015948
- HAMAP:   MF_01137
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR004460
- InterPro:   IPR016101
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004137
- InterPro:   IPR011254
- InterPro:   IPR016099
- Gene3D:   G3DSA:1.20.1270.30
- Gene3D:   G3DSA:1.10.1060.10
- Gene3D:   G3DSA:3.40.50.2030
- TIGRFAMs:   TIGR00314

Pfam domain/function: PF03063 Prismane; SSF46548 Helical_ferredxn; SSF56821 Prismane_like

EC number: =1.2.99.2

Molecular weight: Translated: 88509; Mature: 88378

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLTTGSFSIEDLESVQITINNIVGAAKEAAEEKAKELVKAGPTLFPGLESYRDDWNFK
CCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEE
LLDRYEPVVTPMCDQCCYCTYGPCDLSGNKRGACGIDMMGHNGREFFLRVITGTACHAAH
EECCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHH
GRHLLDHLIETFGEDLPLNLGQSNVLTPNITISTGLSPKNLGEVKPAMEFVEEQLTQLLA
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
TVHAGQESAEIDYDSKALFSGSLDHVGMEISDVVQVAAYDFPKADPEAPLIEIGMGTIDK
HHHCCCCCCCCCCCCHHHHCCCHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCC
SKPFLCVIGHNVGGVTYMMDYMEENNLTDKMEIAGLCCTAIDLTRYKEADRRPPYAKVIG
CCCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SMAKELKVIRSGMPDVIVVDEQCVRGDIVPEAQKLKIPVIASNAKIMFGLPNRTDADVNE
HHHHHHHHHHCCCCCEEEECCHHHCCCCCCCHHHEEEEEEECCCEEEEECCCCCCCCHHH
TIEELKSGAIPGCVMLDYEKLGELCIRLTMEMAPIRDASGITAIPTDEELANWVAKCADC
HHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHCC
GACLIACPEELDIPEAMGFAKEGDYSYLEGLHDICIGCRRCEQVCKKEIPILNIIEKVSQ
CEEEEECCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KQIAEEKGWMRAGRGQVSDAEIRAEGLNLVMGTTPGIIAIIGCPNYAEGTKDVYYIAEEF
HHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHH
LKRNFIVVTTGCGAMDIGMFKDDDGKTLYERYPGGFQCGGLVNIGSCVSNAHITGAAEKV
HHCCEEEEEECCCCEECCCEECCCCCCHHHHCCCCCCCCCCEEHHHHHCCCCCCCHHHHH
AAIFAQRTLEGNLAEIADYILNRVGACGLAWGAFSQKASSIGTGCNILGIPAVLGPHSSK
HHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHH
YRRALIAKTYEEDKWKVYDARNGQEMPIPPAPEFLLTTAETWQEAIPMMAKACIRPSDNS
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHEEECHHHHHHHHHHHHHHHCCCCCCC
MGRAIKLTHWMELHKKYLGGSEPEDWWKFVRNEADLPLANREALLKKLEAERGWEIDWKK
CCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCH
KKIISGPKIKFDVSAQPTNLKRLCKEA
HHHCCCCCEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure 
SKLTTGSFSIEDLESVQITINNIVGAAKEAAEEKAKELVKAGPTLFPGLESYRDDWNFK
CCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEE
LLDRYEPVVTPMCDQCCYCTYGPCDLSGNKRGACGIDMMGHNGREFFLRVITGTACHAAH
EECCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHH
GRHLLDHLIETFGEDLPLNLGQSNVLTPNITISTGLSPKNLGEVKPAMEFVEEQLTQLLA
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
TVHAGQESAEIDYDSKALFSGSLDHVGMEISDVVQVAAYDFPKADPEAPLIEIGMGTIDK
HHHCCCCCCCCCCCCHHHHCCCHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCC
SKPFLCVIGHNVGGVTYMMDYMEENNLTDKMEIAGLCCTAIDLTRYKEADRRPPYAKVIG
CCCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SMAKELKVIRSGMPDVIVVDEQCVRGDIVPEAQKLKIPVIASNAKIMFGLPNRTDADVNE
HHHHHHHHHHCCCCCEEEECCHHHCCCCCCCHHHEEEEEEECCCEEEEECCCCCCCCHHH
TIEELKSGAIPGCVMLDYEKLGELCIRLTMEMAPIRDASGITAIPTDEELANWVAKCADC
HHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHCC
GACLIACPEELDIPEAMGFAKEGDYSYLEGLHDICIGCRRCEQVCKKEIPILNIIEKVSQ
CEEEEECCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KQIAEEKGWMRAGRGQVSDAEIRAEGLNLVMGTTPGIIAIIGCPNYAEGTKDVYYIAEEF
HHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHH
LKRNFIVVTTGCGAMDIGMFKDDDGKTLYERYPGGFQCGGLVNIGSCVSNAHITGAAEKV
HHCCEEEEEECCCCEECCCEECCCCCCHHHHCCCCCCCCCCEEHHHHHCCCCCCCHHHHH
AAIFAQRTLEGNLAEIADYILNRVGACGLAWGAFSQKASSIGTGCNILGIPAVLGPHSSK
HHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHH
YRRALIAKTYEEDKWKVYDARNGQEMPIPPAPEFLLTTAETWQEAIPMMAKACIRPSDNS
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHEEECHHHHHHHHHHHHHHHCCCCCCC
MGRAIKLTHWMELHKKYLGGSEPEDWWKFVRNEADLPLANREALLKKLEAERGWEIDWKK
CCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCH
KKIISGPKIKFDVSAQPTNLKRLCKEA
HHHCCCCCEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8662887; 12125824