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The map label for this gene is gluP [H]

Identifier: 21226784

GI number: 21226784

Start: 817854

End: 818522

Strand: Reverse

Name: gluP [H]

Synonym: MM_0682

Alternate gene names: 21226784

Gene position: 818522-817854 (Counterclockwise)

Preceding gene: 21226785

Following gene: 21226783

Centisome position: 19.98

GC content: 45.89

Gene sequence:

>669_bases
ATGTTTAGCCGTGATACACCATATGAGCCCGGAGGCGGAACGAGCGACAGGATCAAAAGTTCTATTTCTGCAAGCCCGTC
GATGGCGATTATTTTTCTCTGTATAGTTTCTTTCTTTCTGGAAATGGTCCCTGGCATAGGATCTCTCTATATAGACACCT
TTCAGTTTAATCCCAGCTCTATTTTGACAAGGCCCTGGACTCTTGTCACGTATATTTTCCTGCACGCCGGATTGGGGCAT
CTTTTTTTCAATATGATTGTCCTGTATTTCTTCGGGACTGCTCTCGAGCGAAAGGTGGGGAATAAGCAGCTCCTCGGAAT
CTTCTTTACGGCAGGAATTCTGTCCGCTATAGGGTATACTTTCTTAAGCAGGCCCATTTTCGACATCTATCCCGGTCCTA
TGGTAGGTGCAAGCGGAGCTATTTACGGGGTTTTTGCAGCTCTAACCGTACTTGAACCAAATCTGAGGGTGTATGTTTAT
TTTGTCCCCATGCGTCTGAAGCATGCCCTGTTGCTTTTTGCCGTTTTTGACTTTCTGATGGTAAATTCAACGGACATGAT
AGCCCACACTGCCCACTTAAGCGGGCTCTTTGTCGGGCTTTACATGGGTTACCGTATAAAGAGAATGCATGATAAATACA
TTAGAACGAGGTTTGCCGGCAGGTGGTGA

Upstream 100 bases:

>100_bases
TTTAAGGGCATTATAAAATCGCTTATTATTATACTGCCCCATTAATCAGTAATTTTAATCCAACAATTTTATACTGGAAT
TAAATAGAGAGCAATCAAAC

Downstream 100 bases:

>100_bases
GGCTGGATGAAGAGGCTTTTTCTCAGGACAGGTACTATCATCCCAGACCTGGTCCAGGGGAAAAAGTTCCTGTTCAGATC
TTAAATTTCACCCGTGTCTT

Product: integral membrane protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MFSRDTPYEPGGGTSDRIKSSISASPSMAIIFLCIVSFFLEMVPGIGSLYIDTFQFNPSSILTRPWTLVTYIFLHAGLGH
LFFNMIVLYFFGTALERKVGNKQLLGIFFTAGILSAIGYTFLSRPIFDIYPGPMVGASGAIYGVFAALTVLEPNLRVYVY
FVPMRLKHALLLFAVFDFLMVNSTDMIAHTAHLSGLFVGLYMGYRIKRMHDKYIRTRFAGRW

Sequences:

>Translated_222_residues
MFSRDTPYEPGGGTSDRIKSSISASPSMAIIFLCIVSFFLEMVPGIGSLYIDTFQFNPSSILTRPWTLVTYIFLHAGLGH
LFFNMIVLYFFGTALERKVGNKQLLGIFFTAGILSAIGYTFLSRPIFDIYPGPMVGASGAIYGVFAALTVLEPNLRVYVY
FVPMRLKHALLLFAVFDFLMVNSTDMIAHTAHLSGLFVGLYMGYRIKRMHDKYIRTRFAGRW
>Mature_222_residues
MFSRDTPYEPGGGTSDRIKSSISASPSMAIIFLCIVSFFLEMVPGIGSLYIDTFQFNPSSILTRPWTLVTYIFLHAGLGH
LFFNMIVLYFFGTALERKVGNKQLLGIFFTAGILSAIGYTFLSRPIFDIYPGPMVGASGAIYGVFAALTVLEPNLRVYVY
FVPMRLKHALLLFAVFDFLMVNSTDMIAHTAHLSGLFVGLYMGYRIKRMHDKYIRTRFAGRW

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI20127652, Length=178, Percent_Identity=31.4606741573034, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 24967; Mature: 24967

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSRDTPYEPGGGTSDRIKSSISASPSMAIIFLCIVSFFLEMVPGIGSLYIDTFQFNPSS
CCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHH
ILTRPWTLVTYIFLHAGLGHLFFNMIVLYFFGTALERKVGNKQLLGIFFTAGILSAIGYT
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
FLSRPIFDIYPGPMVGASGAIYGVFAALTVLEPNLRVYVYFVPMRLKHALLLFAVFDFLM
HHHCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHH
VNSTDMIAHTAHLSGLFVGLYMGYRIKRMHDKYIRTRFAGRW
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFSRDTPYEPGGGTSDRIKSSISASPSMAIIFLCIVSFFLEMVPGIGSLYIDTFQFNPSS
CCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHH
ILTRPWTLVTYIFLHAGLGHLFFNMIVLYFFGTALERKVGNKQLLGIFFTAGILSAIGYT
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
FLSRPIFDIYPGPMVGASGAIYGVFAALTVLEPNLRVYVYFVPMRLKHALLLFAVFDFLM
HHHCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHH
VNSTDMIAHTAHLSGLFVGLYMGYRIKRMHDKYIRTRFAGRW
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]