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The map label for this gene is ilvC [H]

Identifier: 21226770

GI number: 21226770

Start: 801128

End: 802135

Strand: Reverse

Name: ilvC [H]

Synonym: MM_0668

Alternate gene names: 21226770

Gene position: 802135-801128 (Counterclockwise)

Preceding gene: 21226771

Following gene: 21226769

Centisome position: 19.58

GC content: 51.49

Gene sequence:

>1008_bases
ATGGCAACGATAATTTATGACGACGAAACCACTTTTGATGCACTTAAGGACAGGACCATCGCAGTAATGGGTTACGGAAG
CCAGGGGCACGCCCATGCCAGGAACCTCCACGAATCCGGGCTTAATGTTATTGTCGGGCTCAGGCAGGGAAGTTCAAGCT
GGGCAAAAGCCGAGTCTGACGGTCTTAAAGTCATGACTGTTGACGACGCCTCCAGAGCTGCGGATGTTATCATGATCCTC
CTCCCTGACGAAAAGCAGGCAGCAGTTTACTATTCTCAGATTGAGCCCAACCTGAAAGCCGGAGACGCCCTTGTTTTTGC
TCACGGCTTCAACATCCACTATAACCAGATAGTGCCTCCAAAAGATGTCGACGTCTTCATGGTTGCCCCCAAAGGTCCCG
GGCACATTGTCAGGAGGACCTACACTGAAGGCATCGGGGTTCCGGGCCTGATCGCAGTCTACCAGGACGCGACCGGAAAA
GCCAGAGACCTTGCTCTTTCTTATGCAAAGGGAATAGGCGCCACAAGGGCGGGAGTCTATGAGACCACTTTCCGTGAAGA
AACCGAAACCGATCTCTTCGGAGAACAGGTTGACCTCTGCGGAGGGCTTTCTGCACTTATCAAGACCGCTTTTGAAGTGC
TTGTAGAAGCAGGGTACCAGCCGGAAATGGCTTACTTTGAGACCTGCCACGAAGTTAAACTCATTGTTGACCTTATCTAC
GAAGGCGGGCTTGAGAGAATGTGGCACTCAGTTTCCAATACTGCCGAATATGGTGGCATGACAGTTGGTCCCAGGGTCAT
CAACGAGTATTCCCGTGAAGCCATGTACGAGGCACTTGAGAGGATCCAGAACGGAGAGTTCGCAAAAGAGTTCGTACTCG
AAGGCATGGTCAACCACCCTGTTCTTAAAGCCATGGAACGCCAGGAAAAGGAACACCAGCTTGAGGTTGTCGGAAAACAG
ATCCGTGCAAACATCCCCTGGCTCAACAAGAAGATTGATGACGACTGA

Upstream 100 bases:

>100_bases
TAATTCTAAAATTAAATTCTATAATTCAATTTTAAAATTAAGGAATTAAAGGAAAGGAATTAAAGAATAATCAGTTAAAA
ATCAATCAGGAGAATCGAGA

Downstream 100 bases:

>100_bases
ACGTGAAATTGCTCTTTCTCATTTCTAGCCAGGTCAGTTATATGGCCTGGCAGGCTCATTTTTTATGAAACATTTCCTTG
ATGGTTCATTTTTCTCGTTG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MATIIYDDETTFDALKDRTIAVMGYGSQGHAHARNLHESGLNVIVGLRQGSSSWAKAESDGLKVMTVDDASRAADVIMIL
LPDEKQAAVYYSQIEPNLKAGDALVFAHGFNIHYNQIVPPKDVDVFMVAPKGPGHIVRRTYTEGIGVPGLIAVYQDATGK
ARDLALSYAKGIGATRAGVYETTFREETETDLFGEQVDLCGGLSALIKTAFEVLVEAGYQPEMAYFETCHEVKLIVDLIY
EGGLERMWHSVSNTAEYGGMTVGPRVINEYSREAMYEALERIQNGEFAKEFVLEGMVNHPVLKAMERQEKEHQLEVVGKQ
IRANIPWLNKKIDDD

Sequences:

>Translated_335_residues
MATIIYDDETTFDALKDRTIAVMGYGSQGHAHARNLHESGLNVIVGLRQGSSSWAKAESDGLKVMTVDDASRAADVIMIL
LPDEKQAAVYYSQIEPNLKAGDALVFAHGFNIHYNQIVPPKDVDVFMVAPKGPGHIVRRTYTEGIGVPGLIAVYQDATGK
ARDLALSYAKGIGATRAGVYETTFREETETDLFGEQVDLCGGLSALIKTAFEVLVEAGYQPEMAYFETCHEVKLIVDLIY
EGGLERMWHSVSNTAEYGGMTVGPRVINEYSREAMYEALERIQNGEFAKEFVLEGMVNHPVLKAMERQEKEHQLEVVGKQ
IRANIPWLNKKIDDD
>Mature_334_residues
ATIIYDDETTFDALKDRTIAVMGYGSQGHAHARNLHESGLNVIVGLRQGSSSWAKAESDGLKVMTVDDASRAADVIMILL
PDEKQAAVYYSQIEPNLKAGDALVFAHGFNIHYNQIVPPKDVDVFMVAPKGPGHIVRRTYTEGIGVPGLIAVYQDATGKA
RDLALSYAKGIGATRAGVYETTFREETETDLFGEQVDLCGGLSALIKTAFEVLVEAGYQPEMAYFETCHEVKLIVDLIYE
GGLERMWHSVSNTAEYGGMTVGPRVINEYSREAMYEALERIQNGEFAKEFVLEGMVNHPVLKAMERQEKEHQLEVVGKQI
RANIPWLNKKIDDD

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=283, Percent_Identity=34.982332155477, Blast_Score=143, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323387, Length=335, Percent_Identity=35.5223880597015, Blast_Score=162, Evalue=8e-41,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 37063; Mature: 36932

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIIYDDETTFDALKDRTIAVMGYGSQGHAHARNLHESGLNVIVGLRQGSSSWAKAESD
CEEEEECCCCHHHHHCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCC
GLKVMTVDDASRAADVIMILLPDEKQAAVYYSQIEPNLKAGDALVFAHGFNIHYNQIVPP
CEEEEEECCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCEEEEEECCCEEECCCCCC
KDVDVFMVAPKGPGHIVRRTYTEGIGVPGLIAVYQDATGKARDLALSYAKGIGATRAGVY
CCCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCC
ETTFREETETDLFGEQVDLCGGLSALIKTAFEVLVEAGYQPEMAYFETCHEVKLIVDLIY
HHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLERMWHSVSNTAEYGGMTVGPRVINEYSREAMYEALERIQNGEFAKEFVLEGMVNHP
HCCHHHHHHHHHCHHHHCCEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCH
VLKAMERQEKEHQLEVVGKQIRANIPWLNKKIDDD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
ATIIYDDETTFDALKDRTIAVMGYGSQGHAHARNLHESGLNVIVGLRQGSSSWAKAESD
EEEEECCCCHHHHHCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCC
GLKVMTVDDASRAADVIMILLPDEKQAAVYYSQIEPNLKAGDALVFAHGFNIHYNQIVPP
CEEEEEECCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCEEEEEECCCEEECCCCCC
KDVDVFMVAPKGPGHIVRRTYTEGIGVPGLIAVYQDATGKARDLALSYAKGIGATRAGVY
CCCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCC
ETTFREETETDLFGEQVDLCGGLSALIKTAFEVLVEAGYQPEMAYFETCHEVKLIVDLIY
HHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLERMWHSVSNTAEYGGMTVGPRVINEYSREAMYEALERIQNGEFAKEFVLEGMVNHP
HCCHHHHHHHHHCHHHHCCEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCH
VLKAMERQEKEHQLEVVGKQIRANIPWLNKKIDDD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]