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The map label for this gene is rnr [H]

Identifier: 21226646

GI number: 21226646

Start: 672401

End: 674218

Strand: Direct

Name: rnr [H]

Synonym: MM_0544

Alternate gene names: 21226646

Gene position: 672401-674218 (Clockwise)

Preceding gene: 21226644

Following gene: 21226647

Centisome position: 16.41

GC content: 50.66

Gene sequence:

>1818_bases
TTGCACCTAAGTGGTATTATGCTGGATATGCTCAGAGGTATTACGATTGATGACGTGACAACACGGGACATGGATGATGC
AATCTGGGTGGAAGTCACGGAAAATGGGGGCTGGCACGTCGTGGTCATGATTGCGGACGTCGCAAAGGTCGTTCCGAAAA
ATTCAGAGCTTGATAGATTTGCGATGTCTCGGGTCGAGACCAGGTATTATGCAAACGGCAACAGCCCGATGTTACCCAGG
CGGCTCGCAGACGGGAAGCTATCCCTATGGCCGGGAGAGGAGAAGTATGTCCTTGCCGTGGATATTATCCTCAATAGAGA
TTTGTCGATCCTCGAAACAGGGCTTTTACGGACTATAATGACAAGCGAAGCCCGGCTAGCATTCTCTGACGTCCCCCGTA
TTCTCTCTGATAGAGAGCACCCACAGCATGCTCTCATCAAGCTCATAAGCCAGCTCACAAGCGGCCTTTTAATGCAACGC
CGCAGCCATGGAGCGCTCGCATTCTACGACCTGGGGAGGGGGCTGGTGACGAGTGAAGAAGGGTCGGTGCGGCAGTTGAG
ATGCAGAGGGGATACCATAGGCTACGTTATCATCCAGGAGCTGATGATTCTCGCTAACATGGCCATAGCAGAGTATGCGG
TCAGAAATGACATCCCTATTCTTTTCCGTAACCATACAGCCCGGAGTGCCACCCCTGAGCGGGAGAACTTGCTGAAGTTG
CTCGAAAGCATGGCTTTTATCCCTGAGGTAAACATAGCTGCCGTCAGGCATACCACGTACATGATGCTCAATAGAGCGGA
ATACGGCCCCGTAATCATGGGCCATTTCGGACTGAACCTCGGAGCGTATACACACTTCACCTCACCCATCCGAAGGTATG
CTGATCTCGTGAATCACCAGCAGATCCGTGCATACATCCGAAAAGAGCCCTTGCCCCATTCTAAAGAAGAGATTCAGGCA
ATTGCATCGCATATCAACATGAGGCACATCGAAAACGACAGGGCTAAAAGCGAATACATGAAGGAAAAGGCATATAAAGA
AGCTGAGTTGGCTATCCGGGGTAATCGGATCGAAGATGCAAACGATACAGACTTCGAGCGCATCACCAAAGTACTGATCC
GGGAGGGTAAAGACTGCCCCGAGGCTTATTTCGATGCCTTCCTGAAACGCCTTGCCAAGCTGCCGGTTATCTGCGCAGGG
CTGGTACTCCTGCAAGCTCCTGATGGCGAAAAATGGACTGAGCTTAAAATAGCGCTGCTGGAGGATATCGCAACCGCGCC
TCAGAAAGCCGTCTCGGTCTTCGACATCGCACAACATATATCGGGCTGGCAGATGCCAGTATACGAAGTGACAGAAACTA
CGCGAAGCAACCTGCCTGCATTCACCGCCATAAGTGCAATTAGAATCGGTGACAGAGAGTACCGGTCCGCTGCATACGAA
GACCTGACAAAAAAAGGTGCCATGCAGCAAGCGTCCGCAGGCCTTCTAGCAACTATTCTGGGCTTACCTGCTCCGAACTT
GAAGATCAGGATAGAAGATTCGCCAGCCAGTCAGGAAGAAATAACAATTAATGCGTCAAAAGACCCAACAATTAACACGT
CAAAAGACCCGATCTTTGCCCTGCAAGAATATTGTCAGGCAAAAAAACTTCCCTTGCCAGCTTATTCCTTTGAGATGGAA
GGCGCAACCAACAGGCCAATCTTCACCTGTACCTGTACTTTTGGCTCCTCGACCAGCACCGGCCAGGCAGGAAAAAAGCA
AAGGGCCAAAAGGCTAGCAGCCAGAGCAATGATATACACTTTAGTGACAGGAAGTTGA

Upstream 100 bases:

>100_bases
TAAATATGAGCAAAATCTGTGAAACAATTTTTCATAAAAATAAGAACCCCTTACCACTTTTTTACCTACCAATATACATA
TAAGGAAAGCATACCAAATT

Downstream 100 bases:

>100_bases
TGCCGGTTTCGAGGTTGTAGTGAAAACTGCCATGGTTTTTTAGTTTCAATCCTTGTTTTAGTGGATCTTGCTCGCGAATA
AAAAGTCTTAGCAGTTTGTA

Product: exoribonuclease II

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MHLSGIMLDMLRGITIDDVTTRDMDDAIWVEVTENGGWHVVVMIADVAKVVPKNSELDRFAMSRVETRYYANGNSPMLPR
RLADGKLSLWPGEEKYVLAVDIILNRDLSILETGLLRTIMTSEARLAFSDVPRILSDREHPQHALIKLISQLTSGLLMQR
RSHGALAFYDLGRGLVTSEEGSVRQLRCRGDTIGYVIIQELMILANMAIAEYAVRNDIPILFRNHTARSATPERENLLKL
LESMAFIPEVNIAAVRHTTYMMLNRAEYGPVIMGHFGLNLGAYTHFTSPIRRYADLVNHQQIRAYIRKEPLPHSKEEIQA
IASHINMRHIENDRAKSEYMKEKAYKEAELAIRGNRIEDANDTDFERITKVLIREGKDCPEAYFDAFLKRLAKLPVICAG
LVLLQAPDGEKWTELKIALLEDIATAPQKAVSVFDIAQHISGWQMPVYEVTETTRSNLPAFTAISAIRIGDREYRSAAYE
DLTKKGAMQQASAGLLATILGLPAPNLKIRIEDSPASQEEITINASKDPTINTSKDPIFALQEYCQAKKLPLPAYSFEME
GATNRPIFTCTCTFGSSTSTGQAGKKQRAKRLAARAMIYTLVTGS

Sequences:

>Translated_605_residues
MHLSGIMLDMLRGITIDDVTTRDMDDAIWVEVTENGGWHVVVMIADVAKVVPKNSELDRFAMSRVETRYYANGNSPMLPR
RLADGKLSLWPGEEKYVLAVDIILNRDLSILETGLLRTIMTSEARLAFSDVPRILSDREHPQHALIKLISQLTSGLLMQR
RSHGALAFYDLGRGLVTSEEGSVRQLRCRGDTIGYVIIQELMILANMAIAEYAVRNDIPILFRNHTARSATPERENLLKL
LESMAFIPEVNIAAVRHTTYMMLNRAEYGPVIMGHFGLNLGAYTHFTSPIRRYADLVNHQQIRAYIRKEPLPHSKEEIQA
IASHINMRHIENDRAKSEYMKEKAYKEAELAIRGNRIEDANDTDFERITKVLIREGKDCPEAYFDAFLKRLAKLPVICAG
LVLLQAPDGEKWTELKIALLEDIATAPQKAVSVFDIAQHISGWQMPVYEVTETTRSNLPAFTAISAIRIGDREYRSAAYE
DLTKKGAMQQASAGLLATILGLPAPNLKIRIEDSPASQEEITINASKDPTINTSKDPIFALQEYCQAKKLPLPAYSFEME
GATNRPIFTCTCTFGSSTSTGQAGKKQRAKRLAARAMIYTLVTGS
>Mature_605_residues
MHLSGIMLDMLRGITIDDVTTRDMDDAIWVEVTENGGWHVVVMIADVAKVVPKNSELDRFAMSRVETRYYANGNSPMLPR
RLADGKLSLWPGEEKYVLAVDIILNRDLSILETGLLRTIMTSEARLAFSDVPRILSDREHPQHALIKLISQLTSGLLMQR
RSHGALAFYDLGRGLVTSEEGSVRQLRCRGDTIGYVIIQELMILANMAIAEYAVRNDIPILFRNHTARSATPERENLLKL
LESMAFIPEVNIAAVRHTTYMMLNRAEYGPVIMGHFGLNLGAYTHFTSPIRRYADLVNHQQIRAYIRKEPLPHSKEEIQA
IASHINMRHIENDRAKSEYMKEKAYKEAELAIRGNRIEDANDTDFERITKVLIREGKDCPEAYFDAFLKRLAKLPVICAG
LVLLQAPDGEKWTELKIALLEDIATAPQKAVSVFDIAQHISGWQMPVYEVTETTRSNLPAFTAISAIRIGDREYRSAAYE
DLTKKGAMQQASAGLLATILGLPAPNLKIRIEDSPASQEEITINASKDPTINTSKDPIFALQEYCQAKKLPLPAYSFEME
GATNRPIFTCTCTFGSSTSTGQAGKKQRAKRLAARAMIYTLVTGS

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=377, Percent_Identity=27.0557029177719, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI190014625, Length=345, Percent_Identity=25.2173913043478, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI190014623, Length=345, Percent_Identity=25.2173913043478, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI87082383, Length=360, Percent_Identity=29.1666666666667, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI1787542, Length=342, Percent_Identity=28.0701754385965, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324552, Length=349, Percent_Identity=25.5014326647564, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320499, Length=411, Percent_Identity=22.8710462287105, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24654592, Length=400, Percent_Identity=24.75, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI19922976, Length=400, Percent_Identity=24.75, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24654597, Length=400, Percent_Identity=24.75, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.13.1

Molecular weight: Translated: 67711; Mature: 67711

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS50137 DS_RBD ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLSGIMLDMLRGITIDDVTTRDMDDAIWVEVTENGGWHVVVMIADVAKVVPKNSELDRF
CCCHHHHHHHHCCCEECCCCCCCCCCEEEEEEECCCCEEEEEEEHHHHHHCCCCCCHHHH
AMSRVETRYYANGNSPMLPRRLADGKLSLWPGEEKYVLAVDIILNRDLSILETGLLRTIM
HHHHHHHHEEECCCCCCCCHHHCCCEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHH
TSEARLAFSDVPRILSDREHPQHALIKLISQLTSGLLMQRRSHGALAFYDLGRGLVTSEE
HHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEECCC
GSVRQLRCRGDTIGYVIIQELMILANMAIAEYAVRNDIPILFRNHTARSATPERENLLKL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHH
LESMAFIPEVNIAAVRHTTYMMLNRAEYGPVIMGHFGLNLGAYTHFTSPIRRYADLVNHQ
HHHHHHCCCCCHHHHHHHHHEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
QIRAYIRKEPLPHSKEEIQAIASHINMRHIENDRAKSEYMKEKAYKEAELAIRGNRIEDA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEECCCCCCC
NDTDFERITKVLIREGKDCPEAYFDAFLKRLAKLPVICAGLVLLQAPDGEKWTELKIALL
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHCEEEEECCCCCCHHHHHHHHH
EDIATAPQKAVSVFDIAQHISGWQMPVYEVTETTRSNLPAFTAISAIRIGDREYRSAAYE
HHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHEECCHHHHHHHHH
DLTKKGAMQQASAGLLATILGLPAPNLKIRIEDSPASQEEITINASKDPTINTSKDPIFA
HHHHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHH
LQEYCQAKKLPLPAYSFEMEGATNRPIFTCTCTFGSSTSTGQAGKKQRAKRLAARAMIYT
HHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHE
LVTGS
EECCC
>Mature Secondary Structure
MHLSGIMLDMLRGITIDDVTTRDMDDAIWVEVTENGGWHVVVMIADVAKVVPKNSELDRF
CCCHHHHHHHHCCCEECCCCCCCCCCEEEEEEECCCCEEEEEEEHHHHHHCCCCCCHHHH
AMSRVETRYYANGNSPMLPRRLADGKLSLWPGEEKYVLAVDIILNRDLSILETGLLRTIM
HHHHHHHHEEECCCCCCCCHHHCCCEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHH
TSEARLAFSDVPRILSDREHPQHALIKLISQLTSGLLMQRRSHGALAFYDLGRGLVTSEE
HHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEECCC
GSVRQLRCRGDTIGYVIIQELMILANMAIAEYAVRNDIPILFRNHTARSATPERENLLKL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHH
LESMAFIPEVNIAAVRHTTYMMLNRAEYGPVIMGHFGLNLGAYTHFTSPIRRYADLVNHQ
HHHHHHCCCCCHHHHHHHHHEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
QIRAYIRKEPLPHSKEEIQAIASHINMRHIENDRAKSEYMKEKAYKEAELAIRGNRIEDA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEECCCCCCC
NDTDFERITKVLIREGKDCPEAYFDAFLKRLAKLPVICAGLVLLQAPDGEKWTELKIALL
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHCEEEEECCCCCCHHHHHHHHH
EDIATAPQKAVSVFDIAQHISGWQMPVYEVTETTRSNLPAFTAISAIRIGDREYRSAAYE
HHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHEECCHHHHHHHHH
DLTKKGAMQQASAGLLATILGLPAPNLKIRIEDSPASQEEITINASKDPTINTSKDPIFA
HHHHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHH
LQEYCQAKKLPLPAYSFEMEGATNRPIFTCTCTFGSSTSTGQAGKKQRAKRLAARAMIYT
HHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHE
LVTGS
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]