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The map label for this gene is mtbA [H]

Identifier: 21226607

GI number: 21226607

Start: 629118

End: 630155

Strand: Direct

Name: mtbA [H]

Synonym: MM_0505

Alternate gene names: 21226607

Gene position: 629118-630155 (Clockwise)

Preceding gene: 21226606

Following gene: 21226623

Centisome position: 15.36

GC content: 47.78

Gene sequence:

>1038_bases
ATGGAAAAAAGCCTCAGGAAAAACTTTCTTAACGCCCTTCACGGAAATCCTGTTAACAGGATCCCTGCCCTTTCTGTTAC
CCAGACCGGAACCGTAGAGCTTATGGACATGACCGGAGCAGCCTGGCCGGAAGCCCACTCAGACCCTGAAAAGATGGCAA
AACTGGCAATTGCATGGCACGAAATAGCAGGCTTTGAAGCTGTCCACTATCCTTACTGCCTGACCGTTCTCGCTGAAACC
ATGGGCTGTGATGTAAGAATGGGTACAAAAGACATTCAGCCCTCGGTTCTGTCTCACCCTTTCTCAAAAGGGCCCGAGAA
TCTAGGGATTCCTGAAAACCTGCTCGAAAAAGGAAGGATCCCGGCTGTCCTCAAAGCAACTGAAATTCTGGTAGATATGA
TTGAAAACAAAAAAGGAAGGAAAATTCCCCTGATTGCAGGCATGGAAGGTCCTCTGACAGTTTTTACTCACATTGCCGAA
ATTAAAAACTGCCTTATCTGGGCACTAAAAAAGCCAGACTATTTTAATACATTTATGGAAACTTGCACCGAACTCTGTAT
TGAGTATGCAAGCACACTTTTCGACCACGGAGCAGATGCCCTCTGTATGCCCGACGGCGGAATAGTGGGATCAAGAATGA
TGCCACCTTCAGTCCTTGAAGATTCGGTAAAACCTTTCTACAAACGCCTTTGCAGAAAAGTAAATGGTCCCGTGATACTG
CACATCTGCGGCGATGCTGGAGATTCCCTGAGAACTCTTTCGGAATGCGGTTTCGAAGCTATCAGCATAGAAGAAAAAGT
GAGCTTGAAAGCTGCAAAAGAGGCTATTGGCGACAGGGCAAGGTTAATCGGAAATGTTTCTCCCTCAAGAACTCTGCTTT
TCGGAACCCCGGATGCCGTGAAGGCAGAAGCAAAACAATGCCTTTCAGCAGGTGTGGATATTCTTGCGCCGGGATGCGGG
ATCGCACCAGGGACTCCGCTTTCTAATATAAGGGCGCTTGTGGAGGCAAGGGACGAGTGGTATGTGGAGAAAGGTTGA

Upstream 100 bases:

>100_bases
TAAAAATCAATTTAAAAATGTTCCTTTGAAAAAAGTACTTCTTTGGAAAAGGTATTCCTTCGAAAAGGGTACTCATTTGA
ACAGTACCGGAGCCAGAAAA

Downstream 100 bases:

>100_bases
AAATTACGATGGACAGGTGTAAAAATGACAAAAGAAGAAAACCACTGATCATTTCATCAATTCCGTATCCTCATGCGAAT
ACGCCGGCGCACAGCAGCAG

Product: methylcobalamin:coenzyme M methyltransferase

Products: NA

Alternate protein names: MT2-A; Methylcobamide:CoM methyltransferase II isozyme A [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MEKSLRKNFLNALHGNPVNRIPALSVTQTGTVELMDMTGAAWPEAHSDPEKMAKLAIAWHEIAGFEAVHYPYCLTVLAET
MGCDVRMGTKDIQPSVLSHPFSKGPENLGIPENLLEKGRIPAVLKATEILVDMIENKKGRKIPLIAGMEGPLTVFTHIAE
IKNCLIWALKKPDYFNTFMETCTELCIEYASTLFDHGADALCMPDGGIVGSRMMPPSVLEDSVKPFYKRLCRKVNGPVIL
HICGDAGDSLRTLSECGFEAISIEEKVSLKAAKEAIGDRARLIGNVSPSRTLLFGTPDAVKAEAKQCLSAGVDILAPGCG
IAPGTPLSNIRALVEARDEWYVEKG

Sequences:

>Translated_345_residues
MEKSLRKNFLNALHGNPVNRIPALSVTQTGTVELMDMTGAAWPEAHSDPEKMAKLAIAWHEIAGFEAVHYPYCLTVLAET
MGCDVRMGTKDIQPSVLSHPFSKGPENLGIPENLLEKGRIPAVLKATEILVDMIENKKGRKIPLIAGMEGPLTVFTHIAE
IKNCLIWALKKPDYFNTFMETCTELCIEYASTLFDHGADALCMPDGGIVGSRMMPPSVLEDSVKPFYKRLCRKVNGPVIL
HICGDAGDSLRTLSECGFEAISIEEKVSLKAAKEAIGDRARLIGNVSPSRTLLFGTPDAVKAEAKQCLSAGVDILAPGCG
IAPGTPLSNIRALVEARDEWYVEKG
>Mature_345_residues
MEKSLRKNFLNALHGNPVNRIPALSVTQTGTVELMDMTGAAWPEAHSDPEKMAKLAIAWHEIAGFEAVHYPYCLTVLAET
MGCDVRMGTKDIQPSVLSHPFSKGPENLGIPENLLEKGRIPAVLKATEILVDMIENKKGRKIPLIAGMEGPLTVFTHIAE
IKNCLIWALKKPDYFNTFMETCTELCIEYASTLFDHGADALCMPDGGIVGSRMMPPSVLEDSVKPFYKRLCRKVNGPVIL
HICGDAGDSLRTLSECGFEAISIEEKVSLKAAKEAIGDRARLIGNVSPSRTLLFGTPDAVKAEAKQCLSAGVDILAPGCG
IAPGTPLSNIRALVEARDEWYVEKG

Specific function: Catalyzes the transfer of the methyl group from the methylated corrinoid cofactor of mtmC, mtbC and mttC to coenzyme M [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family. MtbA/mtaA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006360
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: NA

Molecular weight: Translated: 37445; Mature: 37445

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKSLRKNFLNALHGNPVNRIPALSVTQTGTVELMDMTGAAWPEAHSDPEKMAKLAIAWH
CCHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHH
EIAGFEAVHYPYCLTVLAETMGCDVRMGTKDIQPSVLSHPFSKGPENLGIPENLLEKGRI
HHHCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHCCCCCCCCCCCCCHHHHHCCCC
PAVLKATEILVDMIENKKGRKIPLIAGMEGPLTVFTHIAEIKNCLIWALKKPDYFNTFME
CHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHEEEECCCHHHHHHHH
TCTELCIEYASTLFDHGADALCMPDGGIVGSRMMPPSVLEDSVKPFYKRLCRKVNGPVIL
HHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEE
HICGDAGDSLRTLSECGFEAISIEEKVSLKAAKEAIGDRARLIGNVSPSRTLLFGTPDAV
EEECCCCHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHH
KAEAKQCLSAGVDILAPGCGIAPGTPLSNIRALVEARDEWYVEKG
HHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHEECCC
>Mature Secondary Structure
MEKSLRKNFLNALHGNPVNRIPALSVTQTGTVELMDMTGAAWPEAHSDPEKMAKLAIAWH
CCHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHH
EIAGFEAVHYPYCLTVLAETMGCDVRMGTKDIQPSVLSHPFSKGPENLGIPENLLEKGRI
HHHCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHCCCCCCCCCCCCCHHHHHCCCC
PAVLKATEILVDMIENKKGRKIPLIAGMEGPLTVFTHIAEIKNCLIWALKKPDYFNTFME
CHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHEEEECCCHHHHHHHH
TCTELCIEYASTLFDHGADALCMPDGGIVGSRMMPPSVLEDSVKPFYKRLCRKVNGPVIL
HHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEE
HICGDAGDSLRTLSECGFEAISIEEKVSLKAAKEAIGDRARLIGNVSPSRTLLFGTPDAV
EEECCCCHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHH
KAEAKQCLSAGVDILAPGCGIAPGTPLSNIRALVEARDEWYVEKG
HHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]