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The map label for this gene is coaD

Identifier: 21226560

GI number: 21226560

Start: 579716

End: 580180

Strand: Direct

Name: coaD

Synonym: MM_0458

Alternate gene names: 21226560

Gene position: 579716-580180 (Clockwise)

Preceding gene: 21226557

Following gene: 21226561

Centisome position: 14.15

GC content: 44.52

Gene sequence:

>465_bases
ATGCCAAAGGTCGCCGTAGGCGGTACGTTTCAGTATCTTCATGACGGACACGCCAGATTAATTGAAAAAGCGTTTGAGAT
AGCAGGCAGTGGAAAAGTCTACATAGGGCTTACTTCGGACGAGATGCTGCAAAAAAACCACAGCGTCGAGAGCTATAAAA
TCCGAAGGTCACGCCTGCTTGAGTATATAAAAAAAATGGGGGTTCCGGAAGAGAAATACGAAGTTACAAGGCTGAACGAT
CCCTGCGGCCCAACTATTGAAGAGGACTTCGACCACATAATTGTCTCCCCTGAGACCTATCCGGTTGCCCTGAAAATTAA
CACTATAAGGGAGAAAAAAGGAAAGAAACCTCTGGAAATTGTATATGTTGAGTACGTGATGGCTGAAGACGGGATACCGA
TTTCTTCTACCAGGATTTCAAAAGGAGAAATAGACAGGCACGGCAGGTTAAAAAAAGAAGCTTGA

Upstream 100 bases:

>100_bases
TTGTAAAAGAAAAGAGGAAAAGAGAGAAAAAAATATAGAAAGCCTTCAAAAAACCGAGAAAAACCAAAACTTCTTTTTAC
TTAGCAGATTATCACCAATC

Downstream 100 bases:

>100_bases
AAAAAAGGTTTGAAATCCTGAACTCCTTTTTTTGTAAATTCTCCCTGCAACAGATATAATCGGGCATCAGATATAATCGG
ACAACAGATATAACCGGCCT

Product: phosphopantetheine adenylyltransferase

Products: NA

Alternate protein names: Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MPKVAVGGTFQYLHDGHARLIEKAFEIAGSGKVYIGLTSDEMLQKNHSVESYKIRRSRLLEYIKKMGVPEEKYEVTRLND
PCGPTIEEDFDHIIVSPETYPVALKINTIREKKGKKPLEIVYVEYVMAEDGIPISSTRISKGEIDRHGRLKKEA

Sequences:

>Translated_154_residues
MPKVAVGGTFQYLHDGHARLIEKAFEIAGSGKVYIGLTSDEMLQKNHSVESYKIRRSRLLEYIKKMGVPEEKYEVTRLND
PCGPTIEEDFDHIIVSPETYPVALKINTIREKKGKKPLEIVYVEYVMAEDGIPISSTRISKGEIDRHGRLKKEA
>Mature_153_residues
PKVAVGGTFQYLHDGHARLIEKAFEIAGSGKVYIGLTSDEMLQKNHSVESYKIRRSRLLEYIKKMGVPEEKYEVTRLNDP
CGPTIEEDFDHIIVSPETYPVALKINTIREKKGKKPLEIVYVEYVMAEDGIPISSTRISKGEIDRHGRLKKEA

Specific function: Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate

COG id: COG1019

COG function: function code R; Predicted nucleotidyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eukaryotic CoaD family

Homologues:

Organism=Caenorhabditis elegans, GI25143409, Length=141, Percent_Identity=31.9148936170213, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321716, Length=149, Percent_Identity=35.5704697986577, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAD_METMA (Q8PZN4)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_632482.1
- ProteinModelPortal:   Q8PZN4
- SMR:   Q8PZN4
- GeneID:   1478800
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0458
- NMPDR:   fig|192952.1.peg.458
- HOGENOM:   HBG593121
- OMA:   ISTTRIR
- ProtClustDB:   PRK00777
- BioCyc:   MMAZ192952:MM0458-MONOMER
- BRENDA:   2.7.7.3
- GO:   GO:0005737
- HAMAP:   MF_00647
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00125

Pfam domain/function: PF01467 CTP_transf_2

EC number: =2.7.7.3

Molecular weight: Translated: 17504; Mature: 17373

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVAVGGTFQYLHDGHARLIEKAFEIAGSGKVYIGLTSDEMLQKNHSVESYKIRRSRLL
CCCEECCCCHHHHHCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHCCCCHHHHHHHHHHH
EYIKKMGVPEEKYEVTRLNDPCGPTIEEDFDHIIVSPETYPVALKINTIREKKGKKPLEI
HHHHHCCCCHHHEEEEECCCCCCCCCCCCCCEEEECCCCEEEEEEEEEEHHHCCCCCEEE
VYVEYVMAEDGIPISSTRISKGEIDRHGRLKKEA
EEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PKVAVGGTFQYLHDGHARLIEKAFEIAGSGKVYIGLTSDEMLQKNHSVESYKIRRSRLL
CCEECCCCHHHHHCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHCCCCHHHHHHHHHHH
EYIKKMGVPEEKYEVTRLNDPCGPTIEEDFDHIIVSPETYPVALKINTIREKKGKKPLEI
HHHHHCCCCHHHEEEEECCCCCCCCCCCCCCEEEECCCCEEEEEEEEEEHHHCCCCCEEE
VYVEYVMAEDGIPISSTRISKGEIDRHGRLKKEA
EEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824