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The map label for this gene is folP [H]

Identifier: 21226542

GI number: 21226542

Start: 559424

End: 560659

Strand: Reverse

Name: folP [H]

Synonym: MM_0440

Alternate gene names: 21226542

Gene position: 560659-559424 (Counterclockwise)

Preceding gene: 21226543

Following gene: 21226541

Centisome position: 13.69

GC content: 47.9

Gene sequence:

>1236_bases
TTGTCAAAAATGGTAATTAATACTGATATTTGCGGTATAAAAGTAGGAGACCAGTATCCTGCACATGTAATGGGTATTAT
TAATCTGAGCCCTGAGTCTTTTTACAATGGTTCAATTATAAGTCCTGACTCTACACTTGAGACCGCCCAAAAAATGGTTG
AAGACGGAGCAACTTTCCTGGACATAGGTGCCCGGTCAACATGGCGCTTTTCAGAACCTATTAGCAGAAAAGAAGAACTT
GACCGCTTACTTCCCGTGCTTGAAGCTCTGGAAGGCAATGTGGACGCTGTGGTCTCAGTTGATACCATGTTTTCCGAAAT
AGCAGAGGAAGTTCTTAAAAGAGGGGCACAGGTCATAAACGATGTTTCCGGCTTTACGGCGGATCCCAGGATGATGGAAG
TGGTGGCAGACAACGGCTGTCCGGCTGTGGTTATGGCTTCCAAAAAAGCCCCCGGAGACCTCCTGGGCATGGATGCCATT
ATTGAAGCCCTTGATTCCATTATACAGGCTGCTGAGTCCAGGGGCATAGCGTCTGAAAGCCTCATCCTTGACCCTGCGAT
AGGAAGATGGATGGACGAGAAGCAGCCCATGTACGACTTTGAGACTTTGGACGATTTCGAGCGCCTTAAGATCTTTGAAA
AACCTCTGCTTGCAGCCCTTTCAAGAAAATCCTTCATAGGTGAAGTCCTTGGAAAGCCGGCAGATGAAAGGCTCTATGGC
AGCCTGGCTGCAGCGGCGATTGCTGTCTATAAAGGCGCACATATTATCCGTACACACGATGTACCTGCAACTTCTGACGT
TGTCAGGCTTTCAGGAGCCCTGAGGAGCCGCACAAGTGTTGTAAAGGAAGGCAGGTATGAAGTTTCGGTGCTTGAAGTGA
AAACCCCGCAGGACGCGGGCATTGCAATGAGAAATATCGGAGCCACAAGAGTCGGTTCACAGGTTATGCAGGGAAAAAGC
GTTCATCTTGTTTTAAAAATAAGGAACCTTACAACCACGGAAGCTCTGATAATTAAACAGGAGATGCTTGCAAGGGGAGG
AGATGCAGCCCTCGCCAGGGATGCTGTTTCCCATGAAACGGAAGCTACCGATGTTCTTGTTATGGGAACCCTGCTGCAAT
TTGAGCGTCTTGCACGTAAACTGGATGGGCAGGCCCGTTCTTTGCCGCTTATCGCCGAGATGATTCGCGAATGCATATCT
AATCGGACTAACCTGGAATACAGATATTTGAGGTAA

Upstream 100 bases:

>100_bases
TCAGATGGCGGAGTGGAAGGCTTTCAGCAATATCCACGGACGAGTATTGTCATATTTATCAGCGCTGTTGCGCTACTGAT
TTAGTATCTATATAACCTGG

Downstream 100 bases:

>100_bases
TTATGATCATAACTTCAGCAAAACCCTTTGAAGAAATCCTGGACATGTTAAAAGACGAAGATAATATTTTTATTGTCGGA
TGCAACGTGTGCGCTGCAAA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MSKMVINTDICGIKVGDQYPAHVMGIINLSPESFYNGSIISPDSTLETAQKMVEDGATFLDIGARSTWRFSEPISRKEEL
DRLLPVLEALEGNVDAVVSVDTMFSEIAEEVLKRGAQVINDVSGFTADPRMMEVVADNGCPAVVMASKKAPGDLLGMDAI
IEALDSIIQAAESRGIASESLILDPAIGRWMDEKQPMYDFETLDDFERLKIFEKPLLAALSRKSFIGEVLGKPADERLYG
SLAAAAIAVYKGAHIIRTHDVPATSDVVRLSGALRSRTSVVKEGRYEVSVLEVKTPQDAGIAMRNIGATRVGSQVMQGKS
VHLVLKIRNLTTTEALIIKQEMLARGGDAALARDAVSHETEATDVLVMGTLLQFERLARKLDGQARSLPLIAEMIRECIS
NRTNLEYRYLR

Sequences:

>Translated_411_residues
MSKMVINTDICGIKVGDQYPAHVMGIINLSPESFYNGSIISPDSTLETAQKMVEDGATFLDIGARSTWRFSEPISRKEEL
DRLLPVLEALEGNVDAVVSVDTMFSEIAEEVLKRGAQVINDVSGFTADPRMMEVVADNGCPAVVMASKKAPGDLLGMDAI
IEALDSIIQAAESRGIASESLILDPAIGRWMDEKQPMYDFETLDDFERLKIFEKPLLAALSRKSFIGEVLGKPADERLYG
SLAAAAIAVYKGAHIIRTHDVPATSDVVRLSGALRSRTSVVKEGRYEVSVLEVKTPQDAGIAMRNIGATRVGSQVMQGKS
VHLVLKIRNLTTTEALIIKQEMLARGGDAALARDAVSHETEATDVLVMGTLLQFERLARKLDGQARSLPLIAEMIRECIS
NRTNLEYRYLR
>Mature_410_residues
SKMVINTDICGIKVGDQYPAHVMGIINLSPESFYNGSIISPDSTLETAQKMVEDGATFLDIGARSTWRFSEPISRKEELD
RLLPVLEALEGNVDAVVSVDTMFSEIAEEVLKRGAQVINDVSGFTADPRMMEVVADNGCPAVVMASKKAPGDLLGMDAII
EALDSIIQAAESRGIASESLILDPAIGRWMDEKQPMYDFETLDDFERLKIFEKPLLAALSRKSFIGEVLGKPADERLYGS
LAAAAIAVYKGAHIIRTHDVPATSDVVRLSGALRSRTSVVKEGRYEVSVLEVKTPQDAGIAMRNIGATRVGSQVMQGKSV
HLVLKIRNLTTTEALIIKQEMLARGGDAALARDAVSHETEATDVLVMGTLLQFERLARKLDGQARSLPLIAEMIRECISN
RTNLEYRYLR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=274, Percent_Identity=36.1313868613139, Blast_Score=152, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324073, Length=320, Percent_Identity=24.0625, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 44911; Mature: 44780

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKMVINTDICGIKVGDQYPAHVMGIINLSPESFYNGSIISPDSTLETAQKMVEDGATFL
CCCEEEECCCCEEEECCCCCCEEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHCCCCEE
DIGARSTWRFSEPISRKEELDRLLPVLEALEGNVDAVVSVDTMFSEIAEEVLKRGAQVIN
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
DVSGFTADPRMMEVVADNGCPAVVMASKKAPGDLLGMDAIIEALDSIIQAAESRGIASES
HHCCCCCCCHHHHEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LILDPAIGRWMDEKQPMYDFETLDDFERLKIFEKPLLAALSRKSFIGEVLGKPADERLYG
EEECHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SLAAAAIAVYKGAHIIRTHDVPATSDVVRLSGALRSRTSVVKEGRYEVSVLEVKTPQDAG
HHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCC
IAMRNIGATRVGSQVMQGKSVHLVLKIRNLTTTEALIIKQEMLARGGDAALARDAVSHET
CHHHHCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCC
EATDVLVMGTLLQFERLARKLDGQARSLPLIAEMIRECISNRTNLEYRYLR
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure 
SKMVINTDICGIKVGDQYPAHVMGIINLSPESFYNGSIISPDSTLETAQKMVEDGATFL
CCEEEECCCCEEEECCCCCCEEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHCCCCEE
DIGARSTWRFSEPISRKEELDRLLPVLEALEGNVDAVVSVDTMFSEIAEEVLKRGAQVIN
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
DVSGFTADPRMMEVVADNGCPAVVMASKKAPGDLLGMDAIIEALDSIIQAAESRGIASES
HHCCCCCCCHHHHEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LILDPAIGRWMDEKQPMYDFETLDDFERLKIFEKPLLAALSRKSFIGEVLGKPADERLYG
EEECHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SLAAAAIAVYKGAHIIRTHDVPATSDVVRLSGALRSRTSVVKEGRYEVSVLEVKTPQDAG
HHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCC
IAMRNIGATRVGSQVMQGKSVHLVLKIRNLTTTEALIIKQEMLARGGDAALARDAVSHET
CHHHHCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCC
EATDVLVMGTLLQFERLARKLDGQARSLPLIAEMIRECISNRTNLEYRYLR
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]