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The map label for this gene is glmU [H]

Identifier: 21226404

GI number: 21226404

Start: 404174

End: 405367

Strand: Direct

Name: glmU [H]

Synonym: MM_0302

Alternate gene names: 21226404

Gene position: 404174-405367 (Clockwise)

Preceding gene: 21226403

Following gene: 21226406

Centisome position: 9.87

GC content: 46.31

Gene sequence:

>1194_bases
ATGAAAGCTGTTGTCCTTGTGGCAGGAAAAGGCACAAGGATGGAACCTCTTACTTCCGACTGCCCGAAGGTGATGCTTCA
GGTAGCAAACAAACCCGTACTCGAACATATCCTTGATTCGGCTGTTGAAGCAGGCATTGAAGGTTTTGTCTTCATTACAG
GATACCTGGAAGATCAGATAAAAACTCACTTCGGGGACGGAAGCAGATGGGGAGTGAGCATTGAGTACGTGCAGCAGAAA
GAGCAGCTAGGGACTGCAAATGCCATAGGCTATGCCAGAGGGCACGTTGAAGGAGCATTCCTTGTGCTTAACGGAGACAT
GCTCATAGAAAAATCTGATTTACAATCCCTGCTTGAAAGAAAAGAGGAAGCTGTTATCTGCGTAAAAGAGGTAGAAAATC
CCTCGGATTTCGGAGTGCTTGAAACTGAAGGAGAGAGAGTAATCAGGATAATTGAAAAGCCAAAAAACCCCCCAACAAAG
CTTGCAAACGCCGGAATTTATCTCTTCCGGGAGTCAATTTTTGGCTTTATTGACAGGACAGAGCTTTCTGTAAGAAAAGA
ACTTGAAATAACAGACTCCATCCAGATGCTGATCGACAGTGGAGCGCCTGCAGGTTACAGCCTTCTCGGAGACAGCTGGA
TTGACATAGGTTACCCCTGGGACCTCCTGAAAGCAAACGAGCACCTCTTAAAAACCCTGAAAGGATACTGCCGGGGTAAT
GTTGAACCAAACGTTACTTTAAGAGGGGAGGTCGCTATAGGAAAAGGCTCACTTATCCGGAGCGGGGCTTATATCGAAGG
ACCTGTGGTAATAGGAGATTACTGCGATATAGGGCCTAACTGCTTTATCCGCCCATCAACAGCAATAGGCAACAAAGTAA
GGATAGGGAATGCCGTTGAGGTAAAAAATACAATTGTTATGGAAGGCACTCATATTGGTCACCTGAGTTATGTGGGTGAT
AGTGTTATAGGGCGCCGCTGTAATTTTGGAGCCGGCACGAAAGTTGCAAACCTCCGCCACGACGGAAAGAACATAAAAGT
AATGCTGAAAGGAAGGATTATAGATTCGGGCAGGCGAAAACTCGGTGTGATAATGGGGGATGATGTGCATACAGGCATCA
ATACAAGCATAAATATTGGGGTCGTAATGGGAAAAGGGAGAGCCACAGTTCCCGGAGAAGTGGTCAAGCACTGA

Upstream 100 bases:

>100_bases
CTTCAGGCACGGAAGCAAAAGTCAGGATTACTGCAGAAGCCCGGGAAAACGTGGATGGGATCTATGAGATGGCAGAAAAA
ATAGTGAAGGAGGCGCTTAA

Downstream 100 bases:

>100_bases
GAATCCGATAAAAAGATATAAAAAAGGAGTTTCGAAAACTCCCTCCTTTTCTCTTACAGGTTAAGGAGGGAAATTTCCTG
TATTAATTTTTGAAGTTTAT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKAVVLVAGKGTRMEPLTSDCPKVMLQVANKPVLEHILDSAVEAGIEGFVFITGYLEDQIKTHFGDGSRWGVSIEYVQQK
EQLGTANAIGYARGHVEGAFLVLNGDMLIEKSDLQSLLERKEEAVICVKEVENPSDFGVLETEGERVIRIIEKPKNPPTK
LANAGIYLFRESIFGFIDRTELSVRKELEITDSIQMLIDSGAPAGYSLLGDSWIDIGYPWDLLKANEHLLKTLKGYCRGN
VEPNVTLRGEVAIGKGSLIRSGAYIEGPVVIGDYCDIGPNCFIRPSTAIGNKVRIGNAVEVKNTIVMEGTHIGHLSYVGD
SVIGRRCNFGAGTKVANLRHDGKNIKVMLKGRIIDSGRRKLGVIMGDDVHTGINTSINIGVVMGKGRATVPGEVVKH

Sequences:

>Translated_397_residues
MKAVVLVAGKGTRMEPLTSDCPKVMLQVANKPVLEHILDSAVEAGIEGFVFITGYLEDQIKTHFGDGSRWGVSIEYVQQK
EQLGTANAIGYARGHVEGAFLVLNGDMLIEKSDLQSLLERKEEAVICVKEVENPSDFGVLETEGERVIRIIEKPKNPPTK
LANAGIYLFRESIFGFIDRTELSVRKELEITDSIQMLIDSGAPAGYSLLGDSWIDIGYPWDLLKANEHLLKTLKGYCRGN
VEPNVTLRGEVAIGKGSLIRSGAYIEGPVVIGDYCDIGPNCFIRPSTAIGNKVRIGNAVEVKNTIVMEGTHIGHLSYVGD
SVIGRRCNFGAGTKVANLRHDGKNIKVMLKGRIIDSGRRKLGVIMGDDVHTGINTSINIGVVMGKGRATVPGEVVKH
>Mature_397_residues
MKAVVLVAGKGTRMEPLTSDCPKVMLQVANKPVLEHILDSAVEAGIEGFVFITGYLEDQIKTHFGDGSRWGVSIEYVQQK
EQLGTANAIGYARGHVEGAFLVLNGDMLIEKSDLQSLLERKEEAVICVKEVENPSDFGVLETEGERVIRIIEKPKNPPTK
LANAGIYLFRESIFGFIDRTELSVRKELEITDSIQMLIDSGAPAGYSLLGDSWIDIGYPWDLLKANEHLLKTLKGYCRGN
VEPNVTLRGEVAIGKGSLIRSGAYIEGPVVIGDYCDIGPNCFIRPSTAIGNKVRIGNAVEVKNTIVMEGTHIGHLSYVGD
SVIGRRCNFGAGTKVANLRHDGKNIKVMLKGRIIDSGRRKLGVIMGDDVHTGINTSINIGVVMGKGRATVPGEVVKH

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=356, Percent_Identity=27.247191011236, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI11761619, Length=339, Percent_Identity=27.7286135693215, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI31881779, Length=366, Percent_Identity=22.6775956284153, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI45447090, Length=366, Percent_Identity=22.6775956284153, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1790168, Length=449, Percent_Identity=28.7305122494432, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1790224, Length=239, Percent_Identity=31.7991631799163, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1788351, Length=237, Percent_Identity=28.6919831223629, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788355, Length=258, Percent_Identity=26.3565891472868, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787488, Length=254, Percent_Identity=26.3779527559055, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI133931050, Length=355, Percent_Identity=30.7042253521127, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17509979, Length=403, Percent_Identity=27.2952853598015, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17509981, Length=392, Percent_Identity=26.0204081632653, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=340, Percent_Identity=26.1764705882353, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI21355443, Length=357, Percent_Identity=28.2913165266106, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24644084, Length=357, Percent_Identity=28.2913165266106, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24653912, Length=400, Percent_Identity=25.75, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 43122; Mature: 43122

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVLVAGKGTRMEPLTSDCPKVMLQVANKPVLEHILDSAVEAGIEGFVFITGYLEDQI
CCEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEEEEHHHH
KTHFGDGSRWGVSIEYVQQKEQLGTANAIGYARGHVEGAFLVLNGDMLIEKSDLQSLLER
HHHCCCCCEECEEEHHHHHHHHCCCCCCCCEECCCCCEEEEEEECCEEEEHHHHHHHHHC
KEEAVICVKEVENPSDFGVLETEGERVIRIIEKPKNPPTKLANAGIYLFRESIFGFIDRT
CHHEEEEEEECCCCCCCCEEECCCHHEEHEECCCCCCHHHHHCCCHHEEHHHHHHHHCCC
ELSVRKELEITDSIQMLIDSGAPAGYSLLGDSWIDIGYPWDLLKANEHLLKTLKGYCRGN
CHHHHHHCCHHHHHHHHHHCCCCCCEEECCCCEEECCCCHHHHHCCHHHHHHHHHHHCCC
VEPNVTLRGEVAIGKGSLIRSGAYIEGPVVIGDYCDIGPNCFIRPSTAIGNKVRIGNAVE
CCCCEEEEEEEEECCCCEEECCCEEECCEEEECCCCCCCCCEECCCCCCCCEEEECCEEE
VKNTIVMEGTHIGHLSYVGDSVIGRRCNFGAGTKVANLRHDGKNIKVMLKGRIIDSGRRK
ECCEEEEECCCEEEHHHHCCHHHCCCCCCCCCCEEEEEEECCCCEEEEEEEEEEECCCCE
LGVIMGDDVHTGINTSINIGVVMGKGRATVPGEVVKH
EEEEECCCCCCCCCCEEEEEEEECCCCCCCCHHHHCC
>Mature Secondary Structure
MKAVVLVAGKGTRMEPLTSDCPKVMLQVANKPVLEHILDSAVEAGIEGFVFITGYLEDQI
CCEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEEEEHHHH
KTHFGDGSRWGVSIEYVQQKEQLGTANAIGYARGHVEGAFLVLNGDMLIEKSDLQSLLER
HHHCCCCCEECEEEHHHHHHHHCCCCCCCCEECCCCCEEEEEEECCEEEEHHHHHHHHHC
KEEAVICVKEVENPSDFGVLETEGERVIRIIEKPKNPPTKLANAGIYLFRESIFGFIDRT
CHHEEEEEEECCCCCCCCEEECCCHHEEHEECCCCCCHHHHHCCCHHEEHHHHHHHHCCC
ELSVRKELEITDSIQMLIDSGAPAGYSLLGDSWIDIGYPWDLLKANEHLLKTLKGYCRGN
CHHHHHHCCHHHHHHHHHHCCCCCCEEECCCCEEECCCCHHHHHCCHHHHHHHHHHHCCC
VEPNVTLRGEVAIGKGSLIRSGAYIEGPVVIGDYCDIGPNCFIRPSTAIGNKVRIGNAVE
CCCCEEEEEEEEECCCCEEECCCEEECCEEEECCCCCCCCCEECCCCCCCCEEEECCEEE
VKNTIVMEGTHIGHLSYVGDSVIGRRCNFGAGTKVANLRHDGKNIKVMLKGRIIDSGRRK
ECCEEEEECCCEEEHHHHCCHHHCCCCCCCCCCEEEEEEECCCCEEEEEEEEEEECCCCE
LGVIMGDDVHTGINTSINIGVVMGKGRATVPGEVVKH
EEEEECCCCCCCCCCEEEEEEEECCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]