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The map label for this gene is yrbG [C]

Identifier: 21226332

GI number: 21226332

Start: 309343

End: 310392

Strand: Direct

Name: yrbG [C]

Synonym: MM_0230

Alternate gene names: 21226332

Gene position: 309343-310392 (Clockwise)

Preceding gene: 21226328

Following gene: 21226334

Centisome position: 7.55

GC content: 41.33

Gene sequence:

>1050_bases
ATGGTCATAACAAATTTTCTCATTCTTTTGCTTGGCCTGGTTTTTCTGGTCAAGGGGTCAGACTATTTCGTTAAGTCTGC
ATCATCGATTGCAAAGAAGCTTGGAATTTCGGAATTTATTATAGGGCTGACCCTTGTGGCAGTCGGTACATCGATTCCCG
AACTTGCTTCTTCGATGGCTGCTTCTATCCAGCAGGCAAGTGGTATAGTAATAGGAAATGTTGTAGGTTCAAACATTGCA
AACATAGGTTTGATTGTTGGAATTGCTGCATTTCTTTCTCCAATGAAAACCGAAGTTGAGATGCTAAGGAGAGACGGCTA
TATAATGCTCTTTGCAGCTTTACTTTTCTTTGCCTTTGCACTCAACGGGGAATTATCGAAAATCGAAGCCGGCCTGTTCT
TACTGCTGTATATAGCTTACACATTTTTCCTGTTTGAAGAAACAGACAAACATGAAGGTAAGCTCTATTTCAAAGAATTC
ATAAAATATTTCGTTAAGTTCCAGTATATAAACAGTGCAAGACAGAAAATCAATGGCATAAATAACGGTGTTAGCCGCAC
TAACGGAGATTCAGGCAACAAAAACTGCCAGCCAAAAAATAGCTTTTCAAAAGATATCCTTGCCCTGATATTGAGCTGTG
CAGCCATTATAATAGGAGCAAAGTATTTCGTCAGTGAGTCAATATTTTTTGCAGAGCTCCTCGGAATTCCGGACACCATC
ATAGGCACTACTCTGGTTGCAATAGGGACCTCCCTTCCCGAACTTGCGGTAACGGTATCCGCAGCAAGGCAGGGTTACGG
AAATATTGCACTTGGGAATATAATAGGCTCGAATATCACAAATATACTTATGATCCTTGGAGTTTCCGGTCTCCTCTTTC
CGATCGCCGTTGCAGAGATAAGCCTCGTCTTTACAGCTCCTGTAATGATATTCATAAGCGTGGTCCTGCTTATATTCATC
AGCACAGGCTGGGAAATAAAAAGATGGGAAGGAGCTGCATTGATGTCTCTATATGCAGCTTTCCTGTTTGTACTCTTCAG
AATCAGCTAA

Upstream 100 bases:

>100_bases
TAATTTCTTTTTTAACTGAAAACCTTTAATAAGAGTTCTGCAGATTAAGGTCCAGATCAAGAACTAGAGTAAACAGAAAA
AATCGATCCGACGTTATTTT

Downstream 100 bases:

>100_bases
AGTACCTGAAAAATTGACAGGACATTCGGAAAAAAGGACATTCGGAAAAAAATATTTGCAGGAAAGGCCGGATAACAGGC
GGCAAGCTTAAAAAATGCAT

Product: sodium-calcium exchanger

Products: Na (I) [Cytoplasm]; Ca (II) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MVITNFLILLLGLVFLVKGSDYFVKSASSIAKKLGISEFIIGLTLVAVGTSIPELASSMAASIQQASGIVIGNVVGSNIA
NIGLIVGIAAFLSPMKTEVEMLRRDGYIMLFAALLFFAFALNGELSKIEAGLFLLLYIAYTFFLFEETDKHEGKLYFKEF
IKYFVKFQYINSARQKINGINNGVSRTNGDSGNKNCQPKNSFSKDILALILSCAAIIIGAKYFVSESIFFAELLGIPDTI
IGTTLVAIGTSLPELAVTVSAARQGYGNIALGNIIGSNITNILMILGVSGLLFPIAVAEISLVFTAPVMIFISVVLLIFI
STGWEIKRWEGAALMSLYAAFLFVLFRIS

Sequences:

>Translated_349_residues
MVITNFLILLLGLVFLVKGSDYFVKSASSIAKKLGISEFIIGLTLVAVGTSIPELASSMAASIQQASGIVIGNVVGSNIA
NIGLIVGIAAFLSPMKTEVEMLRRDGYIMLFAALLFFAFALNGELSKIEAGLFLLLYIAYTFFLFEETDKHEGKLYFKEF
IKYFVKFQYINSARQKINGINNGVSRTNGDSGNKNCQPKNSFSKDILALILSCAAIIIGAKYFVSESIFFAELLGIPDTI
IGTTLVAIGTSLPELAVTVSAARQGYGNIALGNIIGSNITNILMILGVSGLLFPIAVAEISLVFTAPVMIFISVVLLIFI
STGWEIKRWEGAALMSLYAAFLFVLFRIS
>Mature_349_residues
MVITNFLILLLGLVFLVKGSDYFVKSASSIAKKLGISEFIIGLTLVAVGTSIPELASSMAASIQQASGIVIGNVVGSNIA
NIGLIVGIAAFLSPMKTEVEMLRRDGYIMLFAALLFFAFALNGELSKIEAGLFLLLYIAYTFFLFEETDKHEGKLYFKEF
IKYFVKFQYINSARQKINGINNGVSRTNGDSGNKNCQPKNSFSKDILALILSCAAIIIGAKYFVSESIFFAELLGIPDTI
IGTTLVAIGTSLPELAVTVSAARQGYGNIALGNIIGSNITNILMILGVSGLLFPIAVAEISLVFTAPVMIFISVVLLIFI
STGWEIKRWEGAALMSLYAAFLFVLFRIS

Specific function: Unknown

COG id: COG0530

COG function: function code P; Ca2+/Na+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Homo sapiens, GI31563526, Length=118, Percent_Identity=36.4406779661017, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1789587, Length=296, Percent_Identity=29.3918918918919, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004481
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 37661; Mature: 37661

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVITNFLILLLGLVFLVKGSDYFVKSASSIAKKLGISEFIIGLTLVAVGTSIPELASSMA
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHH
ASIQQASGIVIGNVVGSNIANIGLIVGIAAFLSPMKTEVEMLRRDGYIMLFAALLFFAFA
HHHHHHCCEEEECHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LNGELSKIEAGLFLLLYIAYTFFLFEETDKHEGKLYFKEFIKYFVKFQYINSARQKINGI
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NNGVSRTNGDSGNKNCQPKNSFSKDILALILSCAAIIIGAKYFVSESIFFAELLGIPDTI
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
IGTTLVAIGTSLPELAVTVSAARQGYGNIALGNIIGSNITNILMILGVSGLLFPIAVAEI
HHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLVFTAPVMIFISVVLLIFISTGWEIKRWEGAALMSLYAAFLFVLFRIS
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVITNFLILLLGLVFLVKGSDYFVKSASSIAKKLGISEFIIGLTLVAVGTSIPELASSMA
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHH
ASIQQASGIVIGNVVGSNIANIGLIVGIAAFLSPMKTEVEMLRRDGYIMLFAALLFFAFA
HHHHHHCCEEEECHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LNGELSKIEAGLFLLLYIAYTFFLFEETDKHEGKLYFKEFIKYFVKFQYINSARQKINGI
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NNGVSRTNGDSGNKNCQPKNSFSKDILALILSCAAIIIGAKYFVSESIFFAELLGIPDTI
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
IGTTLVAIGTSLPELAVTVSAARQGYGNIALGNIIGSNITNILMILGVSGLLFPIAVAEI
HHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLVFTAPVMIFISVVLLIFISTGWEIKRWEGAALMSLYAAFLFVLFRIS
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; Ca (II) [Cytoplasm] [C]

Specific reaction: Na (I) [Periplasm] + Ca (II) [Cytoplasm] = Na (I) [Cytoplasm] + Ca (II) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]