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The map label for this gene is MCM2_2 [H]

Identifier: 20094556

GI number: 20094556

Start: 1092364

End: 1093884

Strand: Reverse

Name: MCM2_2 [H]

Synonym: MK1120

Alternate gene names: 20094556

Gene position: 1093884-1092364 (Counterclockwise)

Preceding gene: 20094559

Following gene: 20094555

Centisome position: 64.54

GC content: 64.23

Gene sequence:

>1521_bases
GTGTTCCGATTGGGCACCACACCCCGAGCCACGACCTATGATCCGGACGCTAGGATTGGGGAAGTCGCGAGTAGGTTCGG
CCTCCCTACCCGGGTTCTAATCGAAATAGTTCGAACCGAGTCGTTCCAGCGCTCGCTGAGGCGCGTCACCTCCGGTAAGC
CGGTAGTGTTAGACCTCCGCGAGCTGGACTCCGATCTAGCATCCTGGATTGCGACCCATGCCAGGCTGGTCGAACCGGCG
CTCCGCGAGCTCGTCAGAACGGTGGCCCCGGATGTCGAACCACGCGTGAGGTTCCGAGGTCTCCCCCATCGGTTCCGGAG
GGTAGAGAGAATACGGCCCATGGACGGAGCCCTCATCTCGATCGAGGGGGTAGTCCGCGAGGTCCGAGGTGCCGAGAGGT
TGGAACATGCGATCGTCGACACGGGCTCGGAGCTGGTGGCCGTGCGGCTCCACGGCCACCGCCTCGGACCCGGACTCCGG
GTCGAGATCCTCGGGATAGTTCGATCGGCGACGTTGGACGCGCTGGAAGTTCACAAGAAGGACCCCATCCCGGAGGTACA
CCCCGACCCCGCGGAGCTGGAGGAGTTCCGCGAGCTCGCGGATAAAGACCCGCTAACGACGTTCGCCCGTGCGATCGCCC
CGCTTCCAGGGGCCGAGGAAGTCGGTAAGATGCTCGCCCTCCAGCTCTTCTCATGCGTCGGAAAGAACAGCGAGCGTCTG
CACGTACTGCTCGCGGGTTACCCGGTCGTGTGCTCCGAGATCCTACACCACGTTCTGGATCACCTCGCACCCCGGGGTGT
GTACGTAGACCTCCGACGCACGGAGCTCACGGACCTGACCGCGGTCCTGAAGGAGGACAGGGGTTGGGCCCTTAGAGCCG
GTGCGGCCGTGCTCGCGGACGGCGGTATCCTAGCGGTGGACCACCTCGAAGGGGCCCCGGAGCCCCATCGGTGGGCCCTC
ATGGAGGCCATGGACAAGGGTACGGTAACCGTCGACGGGATCGCGCTGAACGCCCGATGCGCCGTCCTAGCCGCCATCAA
CCCTGGTGAGCAGTGGCCGAGTGATCCTCCGATCGCCCGGATCGACCTGGACCAGGACTTCCTCTCCCACTTCGACCTCA
TCGCCTTCCTCGGGGTCGATCCACGACCCGGGGAGCCGGAGGAGCAAGACACCGAAGTACCGAGCTACACGCTGCTCCGG
AGGTATCTCCTCTACGCGATCCGCGAGCATCCGAAGCCCGAGCTCACAGAGGAAGCGAGGAAGCGCTTAGAGCACTGGTA
CGAGACCCGACGCGAGGAAGTCGAGGAGCGCCTCGGGATGGGTCTCCCGACGCTCCCCGTGACTAGGAGACAGCTCGAGT
CCGTAGAAAGACTCGCGAAGGCTCACGCTCGCATGCGTCTCTCCGACGATGTCGAGCCCGAAGACGTGGACATTGCGGCC
GAGCTCGTGGATTGGTATCTCGAGACTGCTATGCAGATACCGGGAGGGGATGAGATCAGGATCTCGTCGCTCAAACCCTG
A

Upstream 100 bases:

>100_bases
GTGCTGTTAGCTGTGAGAATGGGAATACCGGGGATCGGAAAGCGTATACGGCTAACGTGTGTCGGATACGTGGGCGCAAT
CCCGAGGACGTTCTGAGGGT

Downstream 100 bases:

>100_bases
GTCTCGGGCCGGCTCCGACTTCATACCCTCATTTTCTATGCTCTCTGTATTCATATTATGATATTATACGAGCAGGAAGA
CGCGCCGGAGAGCCTTACCC

Product: ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MFRLGTTPRATTYDPDARIGEVASRFGLPTRVLIEIVRTESFQRSLRRVTSGKPVVLDLRELDSDLASWIATHARLVEPA
LRELVRTVAPDVEPRVRFRGLPHRFRRVERIRPMDGALISIEGVVREVRGAERLEHAIVDTGSELVAVRLHGHRLGPGLR
VEILGIVRSATLDALEVHKKDPIPEVHPDPAELEEFRELADKDPLTTFARAIAPLPGAEEVGKMLALQLFSCVGKNSERL
HVLLAGYPVVCSEILHHVLDHLAPRGVYVDLRRTELTDLTAVLKEDRGWALRAGAAVLADGGILAVDHLEGAPEPHRWAL
MEAMDKGTVTVDGIALNARCAVLAAINPGEQWPSDPPIARIDLDQDFLSHFDLIAFLGVDPRPGEPEEQDTEVPSYTLLR
RYLLYAIREHPKPELTEEARKRLEHWYETRREEVEERLGMGLPTLPVTRRQLESVERLAKAHARMRLSDDVEPEDVDIAA
ELVDWYLETAMQIPGGDEIRISSLKP

Sequences:

>Translated_506_residues
MFRLGTTPRATTYDPDARIGEVASRFGLPTRVLIEIVRTESFQRSLRRVTSGKPVVLDLRELDSDLASWIATHARLVEPA
LRELVRTVAPDVEPRVRFRGLPHRFRRVERIRPMDGALISIEGVVREVRGAERLEHAIVDTGSELVAVRLHGHRLGPGLR
VEILGIVRSATLDALEVHKKDPIPEVHPDPAELEEFRELADKDPLTTFARAIAPLPGAEEVGKMLALQLFSCVGKNSERL
HVLLAGYPVVCSEILHHVLDHLAPRGVYVDLRRTELTDLTAVLKEDRGWALRAGAAVLADGGILAVDHLEGAPEPHRWAL
MEAMDKGTVTVDGIALNARCAVLAAINPGEQWPSDPPIARIDLDQDFLSHFDLIAFLGVDPRPGEPEEQDTEVPSYTLLR
RYLLYAIREHPKPELTEEARKRLEHWYETRREEVEERLGMGLPTLPVTRRQLESVERLAKAHARMRLSDDVEPEDVDIAA
ELVDWYLETAMQIPGGDEIRISSLKP
>Mature_506_residues
MFRLGTTPRATTYDPDARIGEVASRFGLPTRVLIEIVRTESFQRSLRRVTSGKPVVLDLRELDSDLASWIATHARLVEPA
LRELVRTVAPDVEPRVRFRGLPHRFRRVERIRPMDGALISIEGVVREVRGAERLEHAIVDTGSELVAVRLHGHRLGPGLR
VEILGIVRSATLDALEVHKKDPIPEVHPDPAELEEFRELADKDPLTTFARAIAPLPGAEEVGKMLALQLFSCVGKNSERL
HVLLAGYPVVCSEILHHVLDHLAPRGVYVDLRRTELTDLTAVLKEDRGWALRAGAAVLADGGILAVDHLEGAPEPHRWAL
MEAMDKGTVTVDGIALNARCAVLAAINPGEQWPSDPPIARIDLDQDFLSHFDLIAFLGVDPRPGEPEEQDTEVPSYTLLR
RYLLYAIREHPKPELTEEARKRLEHWYETRREEVEERLGMGLPTLPVTRRQLESVERLAKAHARMRLSDDVEPEDVDIAA
ELVDWYLETAMQIPGGDEIRISSLKP

Specific function: Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein) [H]

COG id: COG1241

COG function: function code L; Predicted ATPase involved in replication control, Cdc46/Mcm family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MCM domain [H]

Homologues:

Organism=Homo sapiens, GI33469919, Length=326, Percent_Identity=34.6625766871166, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI33469917, Length=326, Percent_Identity=34.6625766871166, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI6631095, Length=425, Percent_Identity=28.4705882352941, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI33356547, Length=334, Percent_Identity=27.2455089820359, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI23510448, Length=336, Percent_Identity=29.4642857142857, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI7427519, Length=324, Percent_Identity=29.9382716049383, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI33469922, Length=367, Percent_Identity=29.9727520435967, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI33469968, Length=367, Percent_Identity=29.9727520435967, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI310115110, Length=238, Percent_Identity=30.2521008403361, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI310128402, Length=238, Percent_Identity=30.2521008403361, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI310119838, Length=238, Percent_Identity=30.2521008403361, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17508417, Length=401, Percent_Identity=30.1745635910224, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71997752, Length=389, Percent_Identity=27.2493573264781, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17562700, Length=259, Percent_Identity=33.5907335907336, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17554306, Length=407, Percent_Identity=27.027027027027, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17562702, Length=359, Percent_Identity=30.08356545961, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71997563, Length=277, Percent_Identity=28.158844765343, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71997571, Length=277, Percent_Identity=28.158844765343, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325276, Length=343, Percent_Identity=32.9446064139942, Blast_Score=126, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6321237, Length=330, Percent_Identity=30.3030303030303, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323304, Length=331, Percent_Identity=28.0966767371601, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319679, Length=279, Percent_Identity=28.673835125448, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6319448, Length=270, Percent_Identity=28.8888888888889, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320803, Length=191, Percent_Identity=33.5078534031414, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17137242, Length=332, Percent_Identity=35.5421686746988, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17137132, Length=318, Percent_Identity=28.3018867924528, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24645774, Length=346, Percent_Identity=29.1907514450867, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24639835, Length=366, Percent_Identity=30.8743169398907, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17530827, Length=323, Percent_Identity=27.8637770897833, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17647617, Length=282, Percent_Identity=29.7872340425532, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001208
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF00493 MCM [H]

EC number: NA

Molecular weight: Translated: 56696; Mature: 56696

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS50051 MCM_2 ; PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRLGTTPRATTYDPDARIGEVASRFGLPTRVLIEIVRTESFQRSLRRVTSGKPVVLDLR
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHH
ELDSDLASWIATHARLVEPALRELVRTVAPDVEPRVRFRGLPHRFRRVERIRPMDGALIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHCCCCCCCEEE
IEGVVREVRGAERLEHAIVDTGSELVAVRLHGHRLGPGLRVEILGIVRSATLDALEVHKK
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECEECCCCCEEHHHHHHHHHHHHHHHHHCC
DPIPEVHPDPAELEEFRELADKDPLTTFARAIAPLPGAEEVGKMLALQLFSCVGKNSERL
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEE
HVLLAGYPVVCSEILHHVLDHLAPRGVYVDLRRTELTDLTAVLKEDRGWALRAGAAVLAD
EEEEECCHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCCEEECCCEEEEC
GGILAVDHLEGAPEPHRWALMEAMDKGTVTVDGIALNARCAVLAAINPGEQWPSDPPIAR
CCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCCCCCCCCCCEEE
IDLDQDFLSHFDLIAFLGVDPRPGEPEEQDTEVPSYTLLRRYLLYAIREHPKPELTEEAR
EECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
KRLEHWYETRREEVEERLGMGLPTLPVTRRQLESVERLAKAHARMRLSDDVEPEDVDIAA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
ELVDWYLETAMQIPGGDEIRISSLKP
HHHHHHHHHHHCCCCCCCEEECCCCC
>Mature Secondary Structure
MFRLGTTPRATTYDPDARIGEVASRFGLPTRVLIEIVRTESFQRSLRRVTSGKPVVLDLR
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHH
ELDSDLASWIATHARLVEPALRELVRTVAPDVEPRVRFRGLPHRFRRVERIRPMDGALIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHCCCCCCCEEE
IEGVVREVRGAERLEHAIVDTGSELVAVRLHGHRLGPGLRVEILGIVRSATLDALEVHKK
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECEECCCCCEEHHHHHHHHHHHHHHHHHCC
DPIPEVHPDPAELEEFRELADKDPLTTFARAIAPLPGAEEVGKMLALQLFSCVGKNSERL
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEE
HVLLAGYPVVCSEILHHVLDHLAPRGVYVDLRRTELTDLTAVLKEDRGWALRAGAAVLAD
EEEEECCHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCCEEECCCEEEEC
GGILAVDHLEGAPEPHRWALMEAMDKGTVTVDGIALNARCAVLAAINPGEQWPSDPPIAR
CCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCCCCCCCCCCEEE
IDLDQDFLSHFDLIAFLGVDPRPGEPEEQDTEVPSYTLLRRYLLYAIREHPKPELTEEAR
EECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
KRLEHWYETRREEVEERLGMGLPTLPVTRRQLESVERLAKAHARMRLSDDVEPEDVDIAA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
ELVDWYLETAMQIPGGDEIRISSLKP
HHHHHHHHHHHCCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]