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The map label for this gene is NtpE

Identifier: 20094450

GI number: 20094450

Start: 977572

End: 978174

Strand: Direct

Name: NtpE

Synonym: MK1014

Alternate gene names: 20094450

Gene position: 977572-978174 (Clockwise)

Preceding gene: 20094449

Following gene: 20094451

Centisome position: 57.67

GC content: 62.19

Gene sequence:

>603_bases
ATGGGCGTAGAGGAGCTCGAGCGTAAGATCCTGGAGGATGCCGAGAAGGAGGCCGAAGAGATCCTCGAGGAGGCGAAACG
AGACGCGGAACGTATCCGTGAAAAGGCGGAGCGTGAAGCCGAGGAGGTGCGTCGAGAGATTTTGGACCGTGCTCGGCGTG
AGGCTGAGACCCGACGGAGGCGCGAGATAGCGCAGGCCAAGCTGGAGATCCGTCAGGAGAGGCTTCGGGTTAAGGAGGAG
TACATCGAGAAGGCGATCGAGCGGGCCGAGGAGAAGATCAGGGAGCTGGCGGAGGAGGGTCGGAAGGAGTACCTGGAGTT
CCTCAAGCGTTCCGCCATCGAGGCCGTGAACGCGATTTCCTCCGATGAAGTCGTGCTCCGAGCCAACGAGAACGATCTGA
TGCTGCTGGACGAGATGCTCTCGGAGATCCGCGACGAGACCGGTAAGGACGTTGAGCTGGGCGAGCCAGTGGAGGCCGTG
GGTGGTGTGATCGCGGAGAGTAAGGACGGCTCCGAGGCGTACGACAACACCGTCGATGCCCGGCTCCGTCGCCGGCGCTC
CGAGATAGTTAGACGGGTCTCGGAGACGCTCTTCGGGGGATAA

Upstream 100 bases:

>100_bases
ACTCAGGCTATCTACGGACTACTGACCGCGATCCTGATAGTGTTCGCCGCCCTCGCGGCCTCTTAACCACCATATTCTCA
GCTGAGTTGGGGTGTTACAC

Downstream 100 bases:

>100_bases
CCTTTGCTAGGACTGGCCGGCCTGCAAGATTACACCCTTCTCGCCGTCGGGATCATCGCGCTGGTCACGGTGCTCTCGAT
AATCTTGTCCATACCGATCA

Product: V-type ATP synthase subunit E

Products: ADP; phosphate; H+

Alternate protein names: V-ATPase subunit E

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MGVEELERKILEDAEKEAEEILEEAKRDAERIREKAEREAEEVRREILDRARREAETRRRREIAQAKLEIRQERLRVKEE
YIEKAIERAEEKIRELAEEGRKEYLEFLKRSAIEAVNAISSDEVVLRANENDLMLLDEMLSEIRDETGKDVELGEPVEAV
GGVIAESKDGSEAYDNTVDARLRRRRSEIVRRVSETLFGG

Sequences:

>Translated_200_residues
MGVEELERKILEDAEKEAEEILEEAKRDAERIREKAEREAEEVRREILDRARREAETRRRREIAQAKLEIRQERLRVKEE
YIEKAIERAEEKIRELAEEGRKEYLEFLKRSAIEAVNAISSDEVVLRANENDLMLLDEMLSEIRDETGKDVELGEPVEAV
GGVIAESKDGSEAYDNTVDARLRRRRSEIVRRVSETLFGG
>Mature_199_residues
GVEELERKILEDAEKEAEEILEEAKRDAERIREKAEREAEEVRREILDRARREAETRRRREIAQAKLEIRQERLRVKEEY
IEKAIERAEEKIRELAEEGRKEYLEFLKRSAIEAVNAISSDEVVLRANENDLMLLDEMLSEIRDETGKDVELGEPVEAVG
GVIAESKDGSEAYDNTVDARLRRRRSEIVRRVSETLFGG

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane

COG id: COG1390

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit E

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the V-ATPase E subunit family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): VATE_METKA (Q8TWL9)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614297.1
- ProteinModelPortal:   Q8TWL9
- SMR:   Q8TWL9
- GeneID:   1477115
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1014
- NMPDR:   fig|190192.1.peg.1010
- HOGENOM:   HBG726821
- OMA:   IDDSTLW
- ProtClustDB:   PRK03963
- BioCyc:   MKAN190192:MK1014-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_00311
- InterPro:   IPR002842

Pfam domain/function: PF01991 vATP-synt_E

EC number: 3.6.3.14

Molecular weight: Translated: 23338; Mature: 23207

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVEELERKILEDAEKEAEEILEEAKRDAERIREKAEREAEEVRREILDRARREAETRRR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REIAQAKLEIRQERLRVKEEYIEKAIERAEEKIRELAEEGRKEYLEFLKRSAIEAVNAIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SDEVVLRANENDLMLLDEMLSEIRDETGKDVELGEPVEAVGGVIAESKDGSEAYDNTVDA
CCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHH
RLRRRRSEIVRRVSETLFGG
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GVEELERKILEDAEKEAEEILEEAKRDAERIREKAEREAEEVRREILDRARREAETRRR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REIAQAKLEIRQERLRVKEEYIEKAIERAEEKIRELAEEGRKEYLEFLKRSAIEAVNAIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SDEVVLRANENDLMLLDEMLSEIRDETGKDVELGEPVEAVGGVIAESKDGSEAYDNTVDA
CCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHH
RLRRRRSEIVRRVSETLFGG
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014