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The map label for this gene is CDC9

Identifier: 20094435

GI number: 20094435

Start: 958234

End: 959913

Strand: Reverse

Name: CDC9

Synonym: MK0999

Alternate gene names: 20094435

Gene position: 959913-958234 (Counterclockwise)

Preceding gene: 20094439

Following gene: 20094429

Centisome position: 56.63

GC content: 62.14

Gene sequence:

>1680_bases
GTGTACTACTCGTCCCTGGCGGAGGCCTTCGAGAGGCTGGAGCGGATCAGTTCCAGGAAGGCCAAGATAAGCCTGATCGC
CCAGTTCCTACGGCAGTGTCCGGAGGACGTCGTCGACACCGTCGCACTGTTCCTGGCCAATCAGGTGTTCCCCGGATGGG
ATCCGAGGGACCTCGGCATCGGGTCCAAGCTGATGCGGAAGGTGATCGCGACTGCCACGGGGTCTACCGACTCCGAGGTC
ACGGAGCTGTTCAAGCGGCTCGGCGATCTCGGACTCACCGCCGAGGAGCTGCTGAAGCGTCGGAAGACGTCGACGCTGCT
CGATTCGCGACCCCTCATGGTGGGCGAAGTCAGGGAAACCTTCGAGAAGATAGCGGAAGTCGAGGGTGAGGGAGCCGTCA
AGCGGAAGATGAGGCTGATGATGGGGTTGCTCGCCAGGGCGAAGCCGAAGGAGGCCCGCTACCTGGTTCGGCAGGCGCTG
AGTGAGCTGCGGACGGGCGTACGGGAGAGCACCGTGGAGGAGGCCATCGCCCAGGCCTTCGGTGTGAGCAGGAAGTTGGT
CGAGAGGGCCCACATGCTGTCGAACGACCTAGGACTGGTGGCCAAAGTGGCGATGACGAAGGGCGAGGAAGGTCTCCGCG
AGATCGACCTGAGACCCATGCGACCGATCAAGCCGATGCTGGCGCAAGCAGCGAGGAACGTGAAGGAGGCGCTCGCCGAG
GTCGGAGGGAAGGGCGCGGTGGAGATCAAGCTGGACGGCGCCCGCGTGCAGGTACACTCGGACGGAGAGGAAGTGCGCGT
GTACACCAGGAGGATCGAGGACGTGACCCACGCGCTCCCCGATATCGTGGAGGCCGTGAAGGACTGCGTGGACGCGGACG
AGTTCATCCTGGAGGGCGAGGCCGTGGCCATCAACCCCGAGACGGGCAAACCGAGACCGTTCCAGGAGCTGCTCCATAGG
ATCAAGCGGAAGTACGATATCGAGGAGGTGCGCAAGGAGATCCCGGTGGAGCTGCACCTCTTCGACTGCTTGTACGTGGA
CGGCGAGTCGTTGGTCGACACCCCGTTCCGAGAGCGTCGACGTCGACTCGAGGAGATAGTGCGCGAGCGCGAGGGAGAGG
TGATGCTCGTCGAGCAGGTGATCACGGACGATCCCAAGGAGGCTGCCGAGATGTTCCATCGAGCCCTAGAGATGGGCCAC
GAAGGGGTCATGGTGAAGGACCTGGACGCGAACTACACTCCGGGCGTCCGCGGCAAGAAGATGCTGAAGGTCAAGCCGGT
ACTCGAGACGCTGGATTGTGTGGTCATCGGCGGTATTTGGGGTAAGGGCAAGCGGAAGGGACTCATCGGTTCCTACCTGC
TGGCCGTCTGGGACGAGAACAAGGAGAACCTGCTTGAGGTGGGTAAGGTCGGAACGGGCATGGACGACGAGACACTCGAG
CGATTGACCAAGATGTTCGAGGACTTGATAGTGGAGGAGTCGGGACGTGAGGTTAGGTTCAAGCCTGAGGTGGTTTTCGA
GGTGGAGTTCGAGGATATCCAGAAGAGCCCGAAGTACTCGTCCGGATTCGCCCTTCGGTTCCCGAGACTGGTGCGCGTGC
GCGACGATCTGGGTCCGGAAGACGCGGACACGATCGAGAAGGTTCGGAGGATCTACGAGGAAGTACTGCAGAAGCACTAG

Upstream 100 bases:

>100_bases
GGAGCGTAAGAGAGCTCGTAAGGAGGAGCGGGAGAGGGAGCCCACCAAAGCGGTCGGTCCCAGTGGAGCCGAGTTCAAGG
TCAAAACGACGGACGACGAC

Downstream 100 bases:

>100_bases
ACTATCAACTCCACCAGCCCGGTGAGCGTATCCCAGAAGACCAAAGGTCCTTGGGTACAGACCGTGTAGCTCTTGACCCC
AGGTGTGTAGAGCTCAGTGC

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP]

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MYYSSLAEAFERLERISSRKAKISLIAQFLRQCPEDVVDTVALFLANQVFPGWDPRDLGIGSKLMRKVIATATGSTDSEV
TELFKRLGDLGLTAEELLKRRKTSTLLDSRPLMVGEVRETFEKIAEVEGEGAVKRKMRLMMGLLARAKPKEARYLVRQAL
SELRTGVRESTVEEAIAQAFGVSRKLVERAHMLSNDLGLVAKVAMTKGEEGLREIDLRPMRPIKPMLAQAARNVKEALAE
VGGKGAVEIKLDGARVQVHSDGEEVRVYTRRIEDVTHALPDIVEAVKDCVDADEFILEGEAVAINPETGKPRPFQELLHR
IKRKYDIEEVRKEIPVELHLFDCLYVDGESLVDTPFRERRRRLEEIVREREGEVMLVEQVITDDPKEAAEMFHRALEMGH
EGVMVKDLDANYTPGVRGKKMLKVKPVLETLDCVVIGGIWGKGKRKGLIGSYLLAVWDENKENLLEVGKVGTGMDDETLE
RLTKMFEDLIVEESGREVRFKPEVVFEVEFEDIQKSPKYSSGFALRFPRLVRVRDDLGPEDADTIEKVRRIYEEVLQKH

Sequences:

>Translated_559_residues
MYYSSLAEAFERLERISSRKAKISLIAQFLRQCPEDVVDTVALFLANQVFPGWDPRDLGIGSKLMRKVIATATGSTDSEV
TELFKRLGDLGLTAEELLKRRKTSTLLDSRPLMVGEVRETFEKIAEVEGEGAVKRKMRLMMGLLARAKPKEARYLVRQAL
SELRTGVRESTVEEAIAQAFGVSRKLVERAHMLSNDLGLVAKVAMTKGEEGLREIDLRPMRPIKPMLAQAARNVKEALAE
VGGKGAVEIKLDGARVQVHSDGEEVRVYTRRIEDVTHALPDIVEAVKDCVDADEFILEGEAVAINPETGKPRPFQELLHR
IKRKYDIEEVRKEIPVELHLFDCLYVDGESLVDTPFRERRRRLEEIVREREGEVMLVEQVITDDPKEAAEMFHRALEMGH
EGVMVKDLDANYTPGVRGKKMLKVKPVLETLDCVVIGGIWGKGKRKGLIGSYLLAVWDENKENLLEVGKVGTGMDDETLE
RLTKMFEDLIVEESGREVRFKPEVVFEVEFEDIQKSPKYSSGFALRFPRLVRVRDDLGPEDADTIEKVRRIYEEVLQKH
>Mature_559_residues
MYYSSLAEAFERLERISSRKAKISLIAQFLRQCPEDVVDTVALFLANQVFPGWDPRDLGIGSKLMRKVIATATGSTDSEV
TELFKRLGDLGLTAEELLKRRKTSTLLDSRPLMVGEVRETFEKIAEVEGEGAVKRKMRLMMGLLARAKPKEARYLVRQAL
SELRTGVRESTVEEAIAQAFGVSRKLVERAHMLSNDLGLVAKVAMTKGEEGLREIDLRPMRPIKPMLAQAARNVKEALAE
VGGKGAVEIKLDGARVQVHSDGEEVRVYTRRIEDVTHALPDIVEAVKDCVDADEFILEGEAVAINPETGKPRPFQELLHR
IKRKYDIEEVRKEIPVELHLFDCLYVDGESLVDTPFRERRRRLEEIVREREGEVMLVEQVITDDPKEAAEMFHRALEMGH
EGVMVKDLDANYTPGVRGKKMLKVKPVLETLDCVVIGGIWGKGKRKGLIGSYLLAVWDENKENLLEVGKVGTGMDDETLE
RLTKMFEDLIVEESGREVRFKPEVVFEVEFEDIQKSPKYSSGFALRFPRLVRVRDDLGPEDADTIEKVRRIYEEVLQKH

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family

Homologues:

Organism=Homo sapiens, GI4557719, Length=619, Percent_Identity=32.6332794830372, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI73747829, Length=547, Percent_Identity=26.3254113345521, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI73747844, Length=547, Percent_Identity=26.3254113345521, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI46255052, Length=490, Percent_Identity=26.1224489795918, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI23199993, Length=490, Percent_Identity=26.1224489795918, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI148539894, Length=490, Percent_Identity=26.1224489795918, Blast_Score=145, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI71985269, Length=607, Percent_Identity=32.2899505766063, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI71985278, Length=186, Percent_Identity=30.1075268817204, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320038, Length=613, Percent_Identity=30.6688417618271, Blast_Score=250, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6324578, Length=219, Percent_Identity=28.310502283105, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24762424, Length=610, Percent_Identity=29.016393442623, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI85815841, Length=508, Percent_Identity=26.3779527559055, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24641829, Length=488, Percent_Identity=22.3360655737705, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNLI_METKA (Q8TWN3)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614282.1
- ProteinModelPortal:   Q8TWN3
- SMR:   Q8TWN3
- GeneID:   1477100
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0999
- NMPDR:   fig|190192.1.peg.995
- HOGENOM:   HBG570821
- OMA:   GRPRPFQ
- BioCyc:   MKAN190192:MK0999-MONOMER
- BRENDA:   6.5.1.1
- HAMAP:   MF_00407
- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027
- Gene3D:   G3DSA:2.40.50.140
- TIGRFAMs:   TIGR00574

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N; SSF50249 Nucleic_acid_OB

EC number: =6.5.1.1

Molecular weight: Translated: 63338; Mature: 63338

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00697 DNA_LIGASE_A1; PS00333 DNA_LIGASE_A2; PS50160 DNA_LIGASE_A3

Important sites: ACT_SITE 250-250 BINDING 248-248 BINDING 255-255 BINDING 270-270 BINDING 300-300 BINDING 341-341 BINDING 417-417 BINDING 423-423

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYYSSLAEAFERLERISSRKAKISLIAQFLRQCPEDVVDTVALFLANQVFPGWDPRDLGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCC
GSKLMRKVIATATGSTDSEVTELFKRLGDLGLTAEELLKRRKTSTLLDSRPLMVGEVRET
CHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
FEKIAEVEGEGAVKRKMRLMMGLLARAKPKEARYLVRQALSELRTGVRESTVEEAIAQAF
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVSRKLVERAHMLSNDLGLVAKVAMTKGEEGLREIDLRPMRPIKPMLAQAARNVKEALAE
HHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
VGGKGAVEIKLDGARVQVHSDGEEVRVYTRRIEDVTHALPDIVEAVKDCVDADEFILEGE
CCCCCEEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEECCC
AVAINPETGKPRPFQELLHRIKRKYDIEEVRKEIPVELHLFDCLYVDGESLVDTPFRERR
EEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEEEEECCCHHHCCCHHHHH
RRLEEIVREREGEVMLVEQVITDDPKEAAEMFHRALEMGHEGVMVKDLDANYTPGVRGKK
HHHHHHHHHCCCCEEEEHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCH
MLKVKPVLETLDCVVIGGIWGKGKRKGLIGSYLLAVWDENKENLLEVGKVGTGMDDETLE
HEEHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHH
RLTKMFEDLIVEESGREVRFKPEVVFEVEFEDIQKSPKYSSGFALRFPRLVRVRDDLGPE
HHHHHHHHHHHCCCCCCEEECCCEEEEEEHHHHHCCCCCCCCCEEECHHHHHHHHCCCCC
DADTIEKVRRIYEEVLQKH
CHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYYSSLAEAFERLERISSRKAKISLIAQFLRQCPEDVVDTVALFLANQVFPGWDPRDLGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCC
GSKLMRKVIATATGSTDSEVTELFKRLGDLGLTAEELLKRRKTSTLLDSRPLMVGEVRET
CHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
FEKIAEVEGEGAVKRKMRLMMGLLARAKPKEARYLVRQALSELRTGVRESTVEEAIAQAF
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVSRKLVERAHMLSNDLGLVAKVAMTKGEEGLREIDLRPMRPIKPMLAQAARNVKEALAE
HHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
VGGKGAVEIKLDGARVQVHSDGEEVRVYTRRIEDVTHALPDIVEAVKDCVDADEFILEGE
CCCCCEEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEECCC
AVAINPETGKPRPFQELLHRIKRKYDIEEVRKEIPVELHLFDCLYVDGESLVDTPFRERR
EEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEEEEECCCHHHCCCHHHHH
RRLEEIVREREGEVMLVEQVITDDPKEAAEMFHRALEMGHEGVMVKDLDANYTPGVRGKK
HHHHHHHHHCCCCEEEEHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCH
MLKVKPVLETLDCVVIGGIWGKGKRKGLIGSYLLAVWDENKENLLEVGKVGTGMDDETLE
HEEHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHH
RLTKMFEDLIVEESGREVRFKPEVVFEVEFEDIQKSPKYSSGFALRFPRLVRVRDDLGPE
HHHHHHHHHHHCCCCCCEEECCCEEEEEEHHHHHCCCCCCCCCEEECHHHHHHHHCCCCC
DADTIEKVRRIYEEVLQKH
CHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014