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The map label for this gene is ERG12 [H]

Identifier: 20094429

GI number: 20094429

Start: 952778

End: 953764

Strand: Reverse

Name: ERG12 [H]

Synonym: MK0993

Alternate gene names: 20094429

Gene position: 953764-952778 (Counterclockwise)

Preceding gene: 20094435

Following gene: 20094427

Centisome position: 56.27

GC content: 61.9

Gene sequence:

>987_bases
TTGCGTATTTCCGTCAAGGCTCCACTGAAGGCTATCCTGGCGGGCGAGCACGCCGTCGTTTACGGGTATCCGGCGGTCGC
AGTGGCATTAGATACCTATGTTAGGGTCACGGCGGAACCCGGAGACGACAGCTTCAGGGTGGAAACCGAGCTGAGCTGCG
AGGGGAACGTAAGGGCTGAGATCACACGTGACGGAAATGTAAAGGGCTTCCGATCCGAGAGCTTGCACGAGGAACTGACG
TACGTGGCTACGGCGGTGCGAAAGGCATCGGAGGAGTTCGACGCTCCTCCCTCTAACCTGAGGATTCTGTCGGAAGCTCC
CCCGGCGAGTGGTCTAGGCACATCGGCTGCGGTCACGGCGGCAGTGCTACTCGGACTAGCCGAGGTATCGGGTGTAAACG
TCTCCAGGGAAGAGATACGGAGACTTGTCCGTGAGGTGGAGCTCGAGGTGCAGGGGAAGGCGAGTTGGACCGACGCCACG
GTGGTCACGTACGGCGGGTTCGTGAGGGTTTCAGGGCGGGAGTTCGAGCTGATTGAACCGGAGCGTAACCCCGTGCTGGT
CGTGGCGCACTCCCAGGAACCCAGTCGTACGGGTGAGATGGTGCGCCGGGTGGCCGAACTCCGCGAGAGGTTGGACATCG
TCGACGGGGTCATGGAGCTGATAGGGGAGCTCGTCGATGACCTCGAGGCGGCTCTGCGTGATGGGGACTTAAGGACCGTA
GGGGAGCTCATGAACGCCAACCACGGGCTGTTGGCGGCCCTGAACGTCTCCACGCGTGCCCTGGAGGAGATCGTACACGT
ATTCAGGAGCGCGGGCGCCTTAGGGGCGAAGGTTACCGGCGCCGGAGGAGGAGGATGCGCGGTCGCGTTATTCGAGAGGG
AGGAGGATGCGAAACGTGCCGTCGAAACGCTAAGCGCCTTAGGTTACGAGGCGTTCGTCACTCGTCCGAGCCCTTGCGGT
GTGAAAACCGAGGACTCGGGATCTTAG

Upstream 100 bases:

>100_bases
TCAGGTCCGCCAGCTCTTCGAGACTCTCAACGTACTTATCCTCCACCACGGGCTTAAGGGTCTTCGGCAACATCAAGCTC
GGTCACCCGGGGGACTATGG

Downstream 100 bases:

>100_bases
CCAACAACGCTTTCATCTTCTTGAACGCGACCTCGGCGATCATCGTTCCGGTCACACGGACGGCATCGATGCCGTCCTCC
TTCAGCCGTCGGATAAGATA

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MRISVKAPLKAILAGEHAVVYGYPAVAVALDTYVRVTAEPGDDSFRVETELSCEGNVRAEITRDGNVKGFRSESLHEELT
YVATAVRKASEEFDAPPSNLRILSEAPPASGLGTSAAVTAAVLLGLAEVSGVNVSREEIRRLVREVELEVQGKASWTDAT
VVTYGGFVRVSGREFELIEPERNPVLVVAHSQEPSRTGEMVRRVAELRERLDIVDGVMELIGELVDDLEAALRDGDLRTV
GELMNANHGLLAALNVSTRALEEIVHVFRSAGALGAKVTGAGGGGCAVALFEREEDAKRAVETLSALGYEAFVTRPSPCG
VKTEDSGS

Sequences:

>Translated_328_residues
MRISVKAPLKAILAGEHAVVYGYPAVAVALDTYVRVTAEPGDDSFRVETELSCEGNVRAEITRDGNVKGFRSESLHEELT
YVATAVRKASEEFDAPPSNLRILSEAPPASGLGTSAAVTAAVLLGLAEVSGVNVSREEIRRLVREVELEVQGKASWTDAT
VVTYGGFVRVSGREFELIEPERNPVLVVAHSQEPSRTGEMVRRVAELRERLDIVDGVMELIGELVDDLEAALRDGDLRTV
GELMNANHGLLAALNVSTRALEEIVHVFRSAGALGAKVTGAGGGGCAVALFEREEDAKRAVETLSALGYEAFVTRPSPCG
VKTEDSGS
>Mature_328_residues
MRISVKAPLKAILAGEHAVVYGYPAVAVALDTYVRVTAEPGDDSFRVETELSCEGNVRAEITRDGNVKGFRSESLHEELT
YVATAVRKASEEFDAPPSNLRILSEAPPASGLGTSAAVTAAVLLGLAEVSGVNVSREEIRRLVREVELEVQGKASWTDAT
VVTYGGFVRVSGREFELIEPERNPVLVVAHSQEPSRTGEMVRRVAELRERLDIVDGVMELIGELVDDLEAALRDGDLRTV
GELMNANHGLLAALNVSTRALEEIVHVFRSAGALGAKVTGAGGGGCAVALFEREEDAKRAVETLSALGYEAFVTRPSPCG
VKTEDSGS

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323864, Length=389, Percent_Identity=23.3933161953728, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 34970; Mature: 34970

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISVKAPLKAILAGEHAVVYGYPAVAVALDTYVRVTAEPGDDSFRVETELSCEGNVRAE
CEEECCCCHHHHHCCCCEEEEECCHHHHEEEEEEEEEECCCCCCEEEEEEECCCCCEEEE
ITRDGNVKGFRSESLHEELTYVATAVRKASEEFDAPPSNLRILSEAPPASGLGTSAAVTA
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHH
AVLLGLAEVSGVNVSREEIRRLVREVELEVQGKASWTDATVVTYGGFVRVSGREFELIEP
HHHHHHHHHCCCCCCHHHHHHHHHHHCEEECCCCCCCCCEEEEECCEEEECCCEEEEECC
ERNPVLVVAHSQEPSRTGEMVRRVAELRERLDIVDGVMELIGELVDDLEAALRDGDLRTV
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GELMNANHGLLAALNVSTRALEEIVHVFRSAGALGAKVTGAGGGGCAVALFEREEDAKRA
HHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEEEECCHHHHHH
VETLSALGYEAFVTRPSPCGVKTEDSGS
HHHHHHCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MRISVKAPLKAILAGEHAVVYGYPAVAVALDTYVRVTAEPGDDSFRVETELSCEGNVRAE
CEEECCCCHHHHHCCCCEEEEECCHHHHEEEEEEEEEECCCCCCEEEEEEECCCCCEEEE
ITRDGNVKGFRSESLHEELTYVATAVRKASEEFDAPPSNLRILSEAPPASGLGTSAAVTA
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHH
AVLLGLAEVSGVNVSREEIRRLVREVELEVQGKASWTDATVVTYGGFVRVSGREFELIEP
HHHHHHHHHCCCCCCHHHHHHHHHHHCEEECCCCCCCCCEEEEECCEEEECCCEEEEECC
ERNPVLVVAHSQEPSRTGEMVRRVAELRERLDIVDGVMELIGELVDDLEAALRDGDLRTV
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GELMNANHGLLAALNVSTRALEEIVHVFRSAGALGAKVTGAGGGGCAVALFEREEDAKRA
HHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEEEECCHHHHHH
VETLSALGYEAFVTRPSPCGVKTEDSGS
HHHHHHCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]