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The map label for this gene is ECM27_2 [C]

Identifier: 20094387

GI number: 20094387

Start: 912898

End: 913887

Strand: Direct

Name: ECM27_2 [C]

Synonym: MK0951

Alternate gene names: 20094387

Gene position: 912898-913887 (Clockwise)

Preceding gene: 20094385

Following gene: 20094388

Centisome position: 53.86

GC content: 68.48

Gene sequence:

>990_bases
GTGAACGGCCTTAAACCGTGTTCGGTCCGCGCGCTCCCCGTCCGGGGGAGTGATCGGGTGGATCCTTGGTCGGCGTTGGC
CGTCATGATGGGGTGCTTCGTCGGGTTCCACTTCCTCTCGGAACTGCTCGTGGACGCCACGGTCGGCCTCGCCCGGAAAT
ACGGTCTCTCGGAGTCGGTCGCCGGGGCCACCCTCGCGGCGATCGGGACCAGCGCACCCGAGTTCGGCTCCTCGCTGAGC
TCGATCCTGCTCGAACACCCGAACGTGGGTGTGGGTACCATCCTCGGATCGGCCGTGTACAACGTCACCGTCATACCCGG
GCTCGCGGCGCTCGCCGCGGGCGGTCTGACCCTCGAGCGTGCCGTGTACCGTCGAGACGTCCTCTTCTACCTCCTCGCGC
TCGTGGTCGTGCTCGTCAGTCTCTGGGACCGGGTGGTCCTCCGCGTCGAGGCGCTCGCGTGGGTGGCGTTGTACGGGCTC
TACGTCCTCCTCATGAGACGGACCGACGAGAGTACCATCGGGGCCGAGGGCGACACCGGCGAGGCCTCGCTGCGGAGCCT
CGTCGTCCGGGTATCGGTGGCCGTGGTCGGGATCGCGGCGCTCTCCGACCTGATGGTCCGGGCGACCGTCGACTTCTGCG
AGGGGTTCGGTCTGTCCGAGTCGAGGGTGAGCCTGCTCCTGAACGCCGCGGGCACGTCGGTGCCCGACACCCTGGCCTCG
GTGCACGCGGCCCGTCGGGGTTTCGGGAGCCTGGCGGTCTCGAACGCCGTCGGGAGCAACACGTTCGACCTCCTCGTCTG
TTTGGGGGTTCCACTGTCGCTCGTGTCCCGGACACCGGTCCACGGGGAGTTGGGGGCGACGGTGCTGGCGCTGGTCGGCT
GCGTGGTGCTCCTGTACCTGGTCACGGTGGACGGGAAGCTTCGCAACGTGGAGGCGCTGGCGCTGCTGGGGGCGTACGCC
GCGTTCGTGGCGTGCTTACTGGTATTATAA

Upstream 100 bases:

>100_bases
GGGGACGGCCTCGACCGGTGTGACCGGGCTACCGACGGGCCGGATCACCGGGGGCGGCGGGGGAGGCCGCCCGATCCTGA
CCGGCCGTACTCCCGAACCG

Downstream 100 bases:

>100_bases
GAGAGGAACCTTCGACGTACCCGGGCACTTGAAGACTCCCGGTCCCTAGTAGGCCCACCGGAACCGCGCACCCCTGAGGG
TCGGTGCTAACTAATACCCC

Product: Ca2+/Na+ antiporter

Products: Na (I) [Cytoplasm]; Ca (II) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MNGLKPCSVRALPVRGSDRVDPWSALAVMMGCFVGFHFLSELLVDATVGLARKYGLSESVAGATLAAIGTSAPEFGSSLS
SILLEHPNVGVGTILGSAVYNVTVIPGLAALAAGGLTLERAVYRRDVLFYLLALVVVLVSLWDRVVLRVEALAWVALYGL
YVLLMRRTDESTIGAEGDTGEASLRSLVVRVSVAVVGIAALSDLMVRATVDFCEGFGLSESRVSLLLNAAGTSVPDTLAS
VHAARRGFGSLAVSNAVGSNTFDLLVCLGVPLSLVSRTPVHGELGATVLALVGCVVLLYLVTVDGKLRNVEALALLGAYA
AFVACLLVL

Sequences:

>Translated_329_residues
MNGLKPCSVRALPVRGSDRVDPWSALAVMMGCFVGFHFLSELLVDATVGLARKYGLSESVAGATLAAIGTSAPEFGSSLS
SILLEHPNVGVGTILGSAVYNVTVIPGLAALAAGGLTLERAVYRRDVLFYLLALVVVLVSLWDRVVLRVEALAWVALYGL
YVLLMRRTDESTIGAEGDTGEASLRSLVVRVSVAVVGIAALSDLMVRATVDFCEGFGLSESRVSLLLNAAGTSVPDTLAS
VHAARRGFGSLAVSNAVGSNTFDLLVCLGVPLSLVSRTPVHGELGATVLALVGCVVLLYLVTVDGKLRNVEALALLGAYA
AFVACLLVL
>Mature_329_residues
MNGLKPCSVRALPVRGSDRVDPWSALAVMMGCFVGFHFLSELLVDATVGLARKYGLSESVAGATLAAIGTSAPEFGSSLS
SILLEHPNVGVGTILGSAVYNVTVIPGLAALAAGGLTLERAVYRRDVLFYLLALVVVLVSLWDRVVLRVEALAWVALYGL
YVLLMRRTDESTIGAEGDTGEASLRSLVVRVSVAVVGIAALSDLMVRATVDFCEGFGLSESRVSLLLNAAGTSVPDTLAS
VHAARRGFGSLAVSNAVGSNTFDLLVCLGVPLSLVSRTPVHGELGATVLALVGCVVLLYLVTVDGKLRNVEALALLGAYA
AFVACLLVL

Specific function: Unknown

COG id: COG0530

COG function: function code P; Ca2+/Na+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Homo sapiens, GI300796347, Length=154, Percent_Identity=35.0649350649351, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI9966787, Length=154, Percent_Identity=35.0649350649351, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4759128, Length=153, Percent_Identity=37.2549019607843, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI300797299, Length=128, Percent_Identity=35.9375, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI29788987, Length=128, Percent_Identity=35.9375, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI300797277, Length=128, Percent_Identity=35.9375, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI31563526, Length=128, Percent_Identity=35.9375, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI45504369, Length=339, Percent_Identity=25.0737463126844, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1789587, Length=246, Percent_Identity=27.6422764227642, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532296, Length=147, Percent_Identity=35.3741496598639, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193208990, Length=96, Percent_Identity=42.7083333333333, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583109, Length=128, Percent_Identity=35.15625, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24583111, Length=128, Percent_Identity=35.15625, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24643941, Length=118, Percent_Identity=36.4406779661017, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45550690, Length=118, Percent_Identity=36.4406779661017, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004481
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 34143; Mature: 34143

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGLKPCSVRALPVRGSDRVDPWSALAVMMGCFVGFHFLSELLVDATVGLARKYGLSESV
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AGATLAAIGTSAPEFGSSLSSILLEHPNVGVGTILGSAVYNVTVIPGLAALAAGGLTLER
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AVYRRDVLFYLLALVVVLVSLWDRVVLRVEALAWVALYGLYVLLMRRTDESTIGAEGDTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
EASLRSLVVRVSVAVVGIAALSDLMVRATVDFCEGFGLSESRVSLLLNAAGTSVPDTLAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHH
VHAARRGFGSLAVSNAVGSNTFDLLVCLGVPLSLVSRTPVHGELGATVLALVGCVVLLYL
HHHHHHCHHHHHHHHHCCCCHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
VTVDGKLRNVEALALLGAYAAFVACLLVL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNGLKPCSVRALPVRGSDRVDPWSALAVMMGCFVGFHFLSELLVDATVGLARKYGLSESV
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AGATLAAIGTSAPEFGSSLSSILLEHPNVGVGTILGSAVYNVTVIPGLAALAAGGLTLER
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AVYRRDVLFYLLALVVVLVSLWDRVVLRVEALAWVALYGLYVLLMRRTDESTIGAEGDTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
EASLRSLVVRVSVAVVGIAALSDLMVRATVDFCEGFGLSESRVSLLLNAAGTSVPDTLAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHH
VHAARRGFGSLAVSNAVGSNTFDLLVCLGVPLSLVSRTPVHGELGATVLALVGCVVLLYL
HHHHHHCHHHHHHHHHCCCCHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
VTVDGKLRNVEALALLGAYAAFVACLLVL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; Ca (II) [Cytoplasm] [C]

Specific reaction: Na (I) [Periplasm] + Ca (II) [Cytoplasm] = Na (I) [Cytoplasm] + Ca (II) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]