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The map label for this gene is TyrA_2 [C]

Identifier: 20094235

GI number: 20094235

Start: 759053

End: 760315

Strand: Direct

Name: TyrA_2 [C]

Synonym: MK0798

Alternate gene names: 20094235

Gene position: 759053-760315 (Clockwise)

Preceding gene: 20094234

Following gene: 20094237

Centisome position: 44.78

GC content: 61.76

Gene sequence:

>1263_bases
ATGAGGATCGCGATACTCGGCGGTACCGGCGCCATGGGCCGTCTTATCGCCCGCGAGCTCCGTGACGACGGTCATGAGGT
AGTTATCACTGGTTCTAACCCTCACACCGCCGAACGCGTCGCCCGCGAGCTCGACGTCGAGGCTGCTCCGACCAACGTCG
ATGCCGCCAAAGATGCCGACGTTGTGGTGGTTTCCGTCCCCATCTCCGTGACTGAAGACGTCATCCGTGAGGTCGCACCA
CACGTTCCTGAGGGTTCCCTCCTCACCGACGTGACCTCCGTCAAGGTTCGTCCCGTTCGCGCTATGCTCGAGCACGCTCC
CGAGGATGTGTACGTCCTCGGAACTCACCCCCTCTTCGGCCCCACGGTCCCCAGTCTCCGCGGTCAGACCGTCATCCTCA
CGCCCACGGAGCGTAGTGGTCCCTGGACTCGCCGCGTTCGTCGTTATCTCGAGCGGAAAGGCGCTCGAGTCGTTGAGACC
ACCCCGGAGGAACACGATCGCACTATGGCCGTCGTTCAGTGCCTCACCCATGCTGTCCTCCTCGCTGCAGGCGCCGCCAT
AGGCCGTTTCCTCCCAAGTCTCGAGCTCGACATCGAAGAGGTCGCCAGCCCCGTGTATCGCCTACTCATGGACGTCGTGG
GTCGTATCGCCGGGCAGGATCCACGTCTTTACGCCGAGATCCAAGCCTTCAACCCCTACGGTGACGAAGCCCGTGAAGAG
CTCCTCCGCGCCCTCAGACGCTTCCACGAGCACGCCCACGACCATAACGCCCTTACCGAGTACATAGCGGAGAGCCGGGA
GAGACTCGGCCGAGAGCTCGATCTCGAAGCCTGTCAGCGTCGTACCGACAAACTCCTGTCGTACCTGGCCGACGAACTCA
GGATCCTACAGGAGGGAATCGAGGCCATCCTCCTCGACGTGTACACGAACGAGGCCCTTGAGGGTGAGGTTACGGGTGAT
CGGGATACAATCCGATTAGACGGCCGTGAACTACCCCGAGACCGTTACAAGATCCTCCCAAGGTGTCCCAAAGAGCTTGC
ACACTTCGACGGTGAAGTTACAGTTCTAGAGTTGCGTACAGGTGCGGATCCCGGGGACGTCGCGGCCGTAGTGGACGCTC
TCGGCCGTAACTTGCGTGCACTACGGGCCGAGCGTCGGGGCGAACGTGTACGCGTTGAAGTCGAATACACCGGCAAGGAA
TCGCTCGAGGGATTACTCCGAAAGCTACGCGCCCTGGGACTGGAAGTGCGGGTTGCTCGATGA

Upstream 100 bases:

>100_bases
CGGACGACGTGTTTCACGAGGCCCTCCACAACATTCGCGAGGACGAGCGCAAGGTTCTCCGGATAACCCGGTTCCTACGC
GGTGCCCAGGGGTGTACCGG

Downstream 100 bases:

>100_bases
TAGGCACACGTCGGACTCCGGGTTTCAACTGGACTTTAAAAAAGTGTTTATTGGGAGAGGACCCGCCGGATCGCCTCTGT
GAACTGTCGAAGTCCGTGTT

Product: prephenate dehydrogenase

Products: 4-hydroxyphenylpyruvate; CO2; NADH

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MRIAILGGTGAMGRLIARELRDDGHEVVITGSNPHTAERVARELDVEAAPTNVDAAKDADVVVVSVPISVTEDVIREVAP
HVPEGSLLTDVTSVKVRPVRAMLEHAPEDVYVLGTHPLFGPTVPSLRGQTVILTPTERSGPWTRRVRRYLERKGARVVET
TPEEHDRTMAVVQCLTHAVLLAAGAAIGRFLPSLELDIEEVASPVYRLLMDVVGRIAGQDPRLYAEIQAFNPYGDEAREE
LLRALRRFHEHAHDHNALTEYIAESRERLGRELDLEACQRRTDKLLSYLADELRILQEGIEAILLDVYTNEALEGEVTGD
RDTIRLDGRELPRDRYKILPRCPKELAHFDGEVTVLELRTGADPGDVAAVVDALGRNLRALRAERRGERVRVEVEYTGKE
SLEGLLRKLRALGLEVRVAR

Sequences:

>Translated_420_residues
MRIAILGGTGAMGRLIARELRDDGHEVVITGSNPHTAERVARELDVEAAPTNVDAAKDADVVVVSVPISVTEDVIREVAP
HVPEGSLLTDVTSVKVRPVRAMLEHAPEDVYVLGTHPLFGPTVPSLRGQTVILTPTERSGPWTRRVRRYLERKGARVVET
TPEEHDRTMAVVQCLTHAVLLAAGAAIGRFLPSLELDIEEVASPVYRLLMDVVGRIAGQDPRLYAEIQAFNPYGDEAREE
LLRALRRFHEHAHDHNALTEYIAESRERLGRELDLEACQRRTDKLLSYLADELRILQEGIEAILLDVYTNEALEGEVTGD
RDTIRLDGRELPRDRYKILPRCPKELAHFDGEVTVLELRTGADPGDVAAVVDALGRNLRALRAERRGERVRVEVEYTGKE
SLEGLLRKLRALGLEVRVAR
>Mature_420_residues
MRIAILGGTGAMGRLIARELRDDGHEVVITGSNPHTAERVARELDVEAAPTNVDAAKDADVVVVSVPISVTEDVIREVAP
HVPEGSLLTDVTSVKVRPVRAMLEHAPEDVYVLGTHPLFGPTVPSLRGQTVILTPTERSGPWTRRVRRYLERKGARVVET
TPEEHDRTMAVVQCLTHAVLLAAGAAIGRFLPSLELDIEEVASPVYRLLMDVVGRIAGQDPRLYAEIQAFNPYGDEAREE
LLRALRRFHEHAHDHNALTEYIAESRERLGRELDLEACQRRTDKLLSYLADELRILQEGIEAILLDVYTNEALEGEVTGD
RDTIRLDGRELPRDRYKILPRCPKELAHFDGEVTVLELRTGADPGDVAAVVDALGRNLRALRAERRGERVRVEVEYTGKE
SLEGLLRKLRALGLEVRVAR

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=225, Percent_Identity=36.8888888888889, Blast_Score=125, Evalue=5e-30,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR005121
- InterPro:   IPR008299
- InterPro:   IPR003099 [H]

Pfam domain/function: PF03147 FDX-ACB; PF02153 PDH [H]

EC number: 1.3.1.12

Molecular weight: Translated: 46755; Mature: 46755

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS01034 GLYCOSYL_HYDROL_F16

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAILGGTGAMGRLIARELRDDGHEVVITGSNPHTAERVARELDVEAAPTNVDAAKDAD
CEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
VVVVSVPISVTEDVIREVAPHVPEGSLLTDVTSVKVRPVRAMLEHAPEDVYVLGTHPLFG
EEEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
PTVPSLRGQTVILTPTERSGPWTRRVRRYLERKGARVVETTPEEHDRTMAVVQCLTHAVL
CCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHH
LAAGAAIGRFLPSLELDIEEVASPVYRLLMDVVGRIAGQDPRLYAEIQAFNPYGDEAREE
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHH
LLRALRRFHEHAHDHNALTEYIAESRERLGRELDLEACQRRTDKLLSYLADELRILQEGI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EAILLDVYTNEALEGEVTGDRDTIRLDGRELPRDRYKILPRCPKELAHFDGEVTVLELRT
HHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCHHHHHHCCCCEEEEEEEC
GADPGDVAAVVDALGRNLRALRAERRGERVRVEVEYTGKESLEGLLRKLRALGLEVRVAR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure
MRIAILGGTGAMGRLIARELRDDGHEVVITGSNPHTAERVARELDVEAAPTNVDAAKDAD
CEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
VVVVSVPISVTEDVIREVAPHVPEGSLLTDVTSVKVRPVRAMLEHAPEDVYVLGTHPLFG
EEEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
PTVPSLRGQTVILTPTERSGPWTRRVRRYLERKGARVVETTPEEHDRTMAVVQCLTHAVL
CCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHH
LAAGAAIGRFLPSLELDIEEVASPVYRLLMDVVGRIAGQDPRLYAEIQAFNPYGDEAREE
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHH
LLRALRRFHEHAHDHNALTEYIAESRERLGRELDLEACQRRTDKLLSYLADELRILQEGI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EAILLDVYTNEALEGEVTGDRDTIRLDGRELPRDRYKILPRCPKELAHFDGEVTVLELRT
HHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCHHHHHHCCCCEEEEEEEC
GADPGDVAAVVDALGRNLRALRAERRGERVRVEVEYTGKESLEGLLRKLRALGLEVRVAR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: prephenate; NAD+

Specific reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]