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The map label for this gene is HemC [H]

Identifier: 20094183

GI number: 20094183

Start: 707526

End: 708443

Strand: Direct

Name: HemC [H]

Synonym: MK0746

Alternate gene names: 20094183

Gene position: 707526-708443 (Clockwise)

Preceding gene: 20094182

Following gene: 20094184

Centisome position: 41.74

GC content: 61.98

Gene sequence:

>918_bases
GTGAAGGGGGACACCATTACCGTGTCGGAGACGATCCGAGTCGCCACTCGATCCAGCCGTCTGGCGATTATCCAGACCCG
GGAGGTAATCGAGCTGCTGGAGCGGGAATCCCCGCGTGACGTCGAGGTTGAGATCGTGAAGACGAAGTCACGTGGGGACG
TCGTTCGGGATCGACCCCTCCACAAGCTGGGTGAGAAGGGTGTGTTCGTGAAAGAGGTTGACAGGCTGGTACTCGAAGGT
AAGGCCGATATCGCCGTTCACAGCGCCAAAGACGTTCCTTCCGTCGTAGATTATCCCGTGGATGTGGCGGCTGTGCCTCC
CCGGAGGGACCCCCGAGAATGTCTGGTGTCGCGACACGGCGGACTCAAAGAACTTCCGCGGGGAGCTACCGTGGGGACCA
GCAGTCCTAGACGGCGCGCGCAGATCCTCCTAGAAAGACCTGACTTGAAGGTGGAGCCGATGCGCGGGAACGTAGACACC
AGGGTCTCCAAGGTGAGGCGGAGGGAGTACGACGCCGCCGTTCTCGCCAAAGTCGGGTTGGACCGGCTCGGGATGACATC
CGAGGTTTCCGAGGTGTACGACCCGGAAGAGTTCGTGCCGCCGGCGGGCCAAGGGGCCCTGATGATCACCTGCCGCAAGG
ACGACGATCGCGTTAAACGCCTTCTGGAAGTCGTGGACGACGAGAAGAGTCGGGTGGAAGTCGAGACGGAGAAGGCCGTC
GTGAGGGAGCTCGGAGTGGGTTGCTCGGAGCCTGTAGGAGTCCACGTGCGAGCTCGCGACGGTGATCACGTGAGGTTGGT
GCTGGGACTGTTCGAAGAAGACGGCTCTTGCGGCCACGTACTCAAGATGCGGGGCTCGCCTGAGGACGTCGTCCGTGAGG
CGGTGTCTCAGGCTAGGGAGGTGTTATCGGATGGGTGA

Upstream 100 bases:

>100_bases
CGCTCCGACTTGAAGGCATTCCCGCCGCCAACCTTCACCACGAGCTCTCTCACCTCATGGGGGACGACCTGGGCCCCAGC
GTGCTGGAGTTCGAGGTCGA

Downstream 100 bases:

>100_bases
GCTGTACCTGGTCGGAGGGGGTCTCTCCGACGTTCGAGATCTCACGCTGCGGGCCCTTGAAGTGCTAGCTAGCGTGGAGT
TGGTGCTGGTCGACACCTAC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKGDTITVSETIRVATRSSRLAIIQTREVIELLERESPRDVEVEIVKTKSRGDVVRDRPLHKLGEKGVFVKEVDRLVLEG
KADIAVHSAKDVPSVVDYPVDVAAVPPRRDPRECLVSRHGGLKELPRGATVGTSSPRRRAQILLERPDLKVEPMRGNVDT
RVSKVRRREYDAAVLAKVGLDRLGMTSEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAV
VRELGVGCSEPVGVHVRARDGDHVRLVLGLFEEDGSCGHVLKMRGSPEDVVREAVSQAREVLSDG

Sequences:

>Translated_305_residues
MKGDTITVSETIRVATRSSRLAIIQTREVIELLERESPRDVEVEIVKTKSRGDVVRDRPLHKLGEKGVFVKEVDRLVLEG
KADIAVHSAKDVPSVVDYPVDVAAVPPRRDPRECLVSRHGGLKELPRGATVGTSSPRRRAQILLERPDLKVEPMRGNVDT
RVSKVRRREYDAAVLAKVGLDRLGMTSEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAV
VRELGVGCSEPVGVHVRARDGDHVRLVLGLFEEDGSCGHVLKMRGSPEDVVREAVSQAREVLSDG
>Mature_305_residues
MKGDTITVSETIRVATRSSRLAIIQTREVIELLERESPRDVEVEIVKTKSRGDVVRDRPLHKLGEKGVFVKEVDRLVLEG
KADIAVHSAKDVPSVVDYPVDVAAVPPRRDPRECLVSRHGGLKELPRGATVGTSSPRRRAQILLERPDLKVEPMRGNVDT
RVSKVRRREYDAAVLAKVGLDRLGMTSEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAV
VRELGVGCSEPVGVHVRARDGDHVRLVLGLFEEDGSCGHVLKMRGSPEDVVREAVSQAREVLSDG

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=270, Percent_Identity=36.6666666666667, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI66933009, Length=270, Percent_Identity=36.6666666666667, Blast_Score=168, Evalue=7e-42,
Organism=Escherichia coli, GI48994974, Length=302, Percent_Identity=41.7218543046358, Blast_Score=204, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6319996, Length=261, Percent_Identity=34.0996168582375, Blast_Score=162, Evalue=8e-41,
Organism=Drosophila melanogaster, GI20130425, Length=249, Percent_Identity=36.9477911646586, Blast_Score=161, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33768; Mature: 33768

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGDTITVSETIRVATRSSRLAIIQTREVIELLERESPRDVEVEIVKTKSRGDVVRDRPL
CCCCEEEHHHHEEEEECCCCEEEEEHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCH
HKLGEKGVFVKEVDRLVLEGKADIAVHSAKDVPSVVDYPVDVAAVPPRRDPRECLVSRHG
HHHCCCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHCCCCCEEECCCCCCHHHHHHHCCC
GLKELPRGATVGTSSPRRRAQILLERPDLKVEPMRGNVDTRVSKVRRREYDAAVLAKVGL
CHHHCCCCCCCCCCCCHHHHHHEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCH
DRLGMTSEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAV
HHCCCHHHHHHHCCCHHHCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCEEEEHHHHHH
VRELGVGCSEPVGVHVRARDGDHVRLVLGLFEEDGSCGHVLKMRGSPEDVVREAVSQARE
HHHHCCCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHH
VLSDG
HHHCC
>Mature Secondary Structure
MKGDTITVSETIRVATRSSRLAIIQTREVIELLERESPRDVEVEIVKTKSRGDVVRDRPL
CCCCEEEHHHHEEEEECCCCEEEEEHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCH
HKLGEKGVFVKEVDRLVLEGKADIAVHSAKDVPSVVDYPVDVAAVPPRRDPRECLVSRHG
HHHCCCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHCCCCCEEECCCCCCHHHHHHHCCC
GLKELPRGATVGTSSPRRRAQILLERPDLKVEPMRGNVDTRVSKVRRREYDAAVLAKVGL
CHHHCCCCCCCCCCCCHHHHHHEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCH
DRLGMTSEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAV
HHCCCHHHHHHHCCCHHHCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCEEEEHHHHHH
VRELGVGCSEPVGVHVRARDGDHVRLVLGLFEEDGSCGHVLKMRGSPEDVVREAVSQARE
HHHHCCCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHH
VLSDG
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]