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The map label for this gene is 20093979

Identifier: 20093979

GI number: 20093979

Start: 505144

End: 505872

Strand: Direct

Name: 20093979

Synonym: MK0541

Alternate gene names: NA

Gene position: 505144-505872 (Clockwise)

Preceding gene: 20093978

Following gene: 20093980

Centisome position: 29.8

GC content: 55.97

Gene sequence:

>729_bases
TTGACCGTCCCGACGTTCCTTCGCAAGGTGACCCTGCGTGAGATCTGTGTCATTGAGGAGTACGTGGACGTCCAATACAG
GGCTATCGAAGCGTTGATGGACACACTACCTTCGACCGACCTCGTCCGGCTGACCGTAGCCAATGCTCTCGTCAGCTATC
AGCTCTCGAGCTCTGGAGAGGATTGGTGGCGTGAGTTCTCCAGCTACTTCCGTGAACGTCGTCCGAGGGACATCGTTCGA
GAGTACGCCCGGTTCCTTCCCCGCTCTAGGGGCAATCGGAGGCTCATCCGTCAGAAGCTCCGCCGCCTCCATCGTGCTAA
GGCCTTTCTAGAGGAGTTATCCTGGCAGGACGCGAAATCGTACTACCGTGACATGAACCGGTTACGCCTTGACCTTGCTC
GGGTCCTCAACGCCGATCCCGAGTCTAAGACGATCGTGTTCACGGTCAAGATGTTCGGGTACGCACTAAGGGCGATAACG
GGTAGGTTTCGTCCTTATCCGTTCGAGATTCCGATTCCTGTGGACGCGAGGATCGAACGAATCACCCGAAGGATCACGAA
CGATGATCCACAACTGTACTGGGACTCGATCGCACGGCGGACAGGCATCCCACCACTACACCTTGACTCGATCCTATGGG
TCGGGACGAGTCGGGATCCAGAGGTAAAGAGACTGCTGGCAAAAGTCTTACCGAAGCTTATAGGGGAACTGGAGATGTTG
GGCAATTGA

Upstream 100 bases:

>100_bases
TGGGCCACATAGATTCCGACATCAAGCATGACCCAATCAAACGCGGGCGCTGCCGCGTAATCGTCAGGCCTAAGGGCACG
GACTGAAACGGGGTCTTCAA

Downstream 100 bases:

>100_bases
ACCTGGATCCTGTGCGCGGTATCGATCGGCGGACGGTTGTGCAGGATTTAACATTTAACCATAAGTGATCCGAGAGGACG
GAACGACTCGCGACGTATTG

Product: N-glycosylase/DNA lyase

Products: NA

Alternate protein names: 8-oxoguanine DNA glycosylase; AGOG; DNA-(apurinic or apyrimidinic site) lyase; AP lyase

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTVPTFLRKVTLREICVIEEYVDVQYRAIEALMDTLPSTDLVRLTVANALVSYQLSSSGEDWWREFSSYFRERRPRDIVR
EYARFLPRSRGNRRLIRQKLRRLHRAKAFLEELSWQDAKSYYRDMNRLRLDLARVLNADPESKTIVFTVKMFGYALRAIT
GRFRPYPFEIPIPVDARIERITRRITNDDPQLYWDSIARRTGIPPLHLDSILWVGTSRDPEVKRLLAKVLPKLIGELEML
GN

Sequences:

>Translated_242_residues
MTVPTFLRKVTLREICVIEEYVDVQYRAIEALMDTLPSTDLVRLTVANALVSYQLSSSGEDWWREFSSYFRERRPRDIVR
EYARFLPRSRGNRRLIRQKLRRLHRAKAFLEELSWQDAKSYYRDMNRLRLDLARVLNADPESKTIVFTVKMFGYALRAIT
GRFRPYPFEIPIPVDARIERITRRITNDDPQLYWDSIARRTGIPPLHLDSILWVGTSRDPEVKRLLAKVLPKLIGELEML
GN
>Mature_241_residues
TVPTFLRKVTLREICVIEEYVDVQYRAIEALMDTLPSTDLVRLTVANALVSYQLSSSGEDWWREFSSYFRERRPRDIVRE
YARFLPRSRGNRRLIRQKLRRLHRAKAFLEELSWQDAKSYYRDMNRLRLDLARVLNADPESKTIVFTVKMFGYALRAITG
RFRPYPFEIPIPVDARIERITRRITNDDPQLYWDSIARRTGIPPLHLDSILWVGTSRDPEVKRLLAKVLPKLIGELEMLG
N

Specific function: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates

COG id: COG4047

COG function: function code S; Uncharacterized protein conserved in archaea

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AGOG_METKA (Q8TXW8)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613826.1
- ProteinModelPortal:   Q8TXW8
- SMR:   Q8TXW8
- GeneID:   1476642
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0541
- NMPDR:   fig|190192.1.peg.539
- HOGENOM:   HBG539606
- OMA:   PLHIDSI
- ProtClustDB:   PRK13280
- BioCyc:   MKAN190192:MK0541-MONOMER
- BRENDA:   4.2.99.18
- HAMAP:   MF_01168
- InterPro:   IPR011257
- InterPro:   IPR023170
- InterPro:   IPR015254
- InterPro:   IPR016544
- Gene3D:   G3DSA:1.10.340.30
- Gene3D:   G3DSA:1.10.1670.10
- PIRSF:   PIRSF008955

Pfam domain/function: PF09171 DUF1886; SSF48150 DNA_glycsylse

EC number: =4.2.99.18

Molecular weight: Translated: 28615; Mature: 28483

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: NA

Important sites: ACT_SITE 143-143 ACT_SITE 175-175 BINDING 25-25 BINDING 52-52 BINDING 63-63 BINDING 147-147 BINDING 173-173 BINDING 209-209 BINDING 213-213

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVPTFLRKVTLREICVIEEYVDVQYRAIEALMDTLPSTDLVRLTVANALVSYQLSSSGE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCH
DWWREFSSYFRERRPRDIVREYARFLPRSRGNRRLIRQKLRRLHRAKAFLEELSWQDAKS
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHH
YYRDMNRLRLDLARVLNADPESKTIVFTVKMFGYALRAITGRFRPYPFEIPIPVDARIER
HHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
ITRRITNDDPQLYWDSIARRTGIPPLHLDSILWVGTSRDPEVKRLLAKVLPKLIGELEML
HHHHHCCCCHHHHHHHHHHHCCCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
GN
CC
>Mature Secondary Structure 
TVPTFLRKVTLREICVIEEYVDVQYRAIEALMDTLPSTDLVRLTVANALVSYQLSSSGE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCH
DWWREFSSYFRERRPRDIVREYARFLPRSRGNRRLIRQKLRRLHRAKAFLEELSWQDAKS
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHH
YYRDMNRLRLDLARVLNADPESKTIVFTVKMFGYALRAITGRFRPYPFEIPIPVDARIER
HHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
ITRRITNDDPQLYWDSIARRTGIPPLHLDSILWVGTSRDPEVKRLLAKVLPKLIGELEML
HHHHHCCCCHHHHHHHHHHHCCCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
GN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014