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The map label for this gene is hisE

Identifier: 20093938

GI number: 20093938

Start: 461906

End: 462208

Strand: Direct

Name: hisE

Synonym: MK0500

Alternate gene names: 20093938

Gene position: 461906-462208 (Clockwise)

Preceding gene: 20093930

Following gene: 20093939

Centisome position: 27.25

GC content: 53.8

Gene sequence:

>303_bases
ATGGGAGACCCCGAGGTTCTCCTCGAGGTCTACGAAGTGATCCGTAACCGTATCGAGGAGCGTCCGGAGGGATCTTACGT
CGCGGAGCTCACTGAGGACGACGACACTAAACCGGCTATCAACAAGATCTGCGAGAAGATCATCGAGGAGTCGGGAGAGC
TCATCCTCGCGGCTAAGGATGGGGACCGGGAAGGTGTAGTTTATGAATCCACCGACCTTATCTTCCACGTGTTGGTCTTA
CTCGCGTACTTAGGGATAGAGATAGGGGAAGTGTTCGATGAGTTCGAGCGGAGAAGGAAATGA

Upstream 100 bases:

>100_bases
ATGAACCCGTGATCCAGGCAGATCTTGGTGAGCGCCGTCGAGTATATACCACGTATCCTGACCTTACAGGGCACCCAGAG
CACCCCCCCGGGGGAAGCGG

Downstream 100 bases:

>100_bases
GCTGCCAGATCCCCCGGTGCCTGAGGATTGCAAGTACGTCTACTACGTGGTCCTGTTTCAGAACCCCGAGGACAAAAACT
GGGATCTTTTCGCCGTGATC

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 100; Mature: 99

Protein sequence:

>100_residues
MGDPEVLLEVYEVIRNRIEERPEGSYVAELTEDDDTKPAINKICEKIIEESGELILAAKDGDREGVVYESTDLIFHVLVL
LAYLGIEIGEVFDEFERRRK

Sequences:

>Translated_100_residues
MGDPEVLLEVYEVIRNRIEERPEGSYVAELTEDDDTKPAINKICEKIIEESGELILAAKDGDREGVVYESTDLIFHVLVL
LAYLGIEIGEVFDEFERRRK
>Mature_99_residues
GDPEVLLEVYEVIRNRIEERPEGSYVAELTEDDDTKPAINKICEKIIEESGELILAAKDGDREGVVYESTDLIFHVLVLL
AYLGIEIGEVFDEFERRRK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_METKA (P58835)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613785.1
- ProteinModelPortal:   P58835
- SMR:   P58835
- GeneID:   1476601
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0500
- NMPDR:   fig|190192.1.peg.498
- HOGENOM:   HBG646527
- OMA:   INKICEK
- ProtClustDB:   PRK00400
- BioCyc:   MKAN190192:MK0500-MONOMER
- BRENDA:   3.6.1.31
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11457; Mature: 11326

Theoretical pI: Translated: 4.06; Mature: 4.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDPEVLLEVYEVIRNRIEERPEGSYVAELTEDDDTKPAINKICEKIIEESGELILAAKD
CCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECC
GDREGVVYESTDLIFHVLVLLAYLGIEIGEVFDEFERRRK
CCCCCCEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
GDPEVLLEVYEVIRNRIEERPEGSYVAELTEDDDTKPAINKICEKIIEESGELILAAKD
CCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECC
GDREGVVYESTDLIFHVLVLLAYLGIEIGEVFDEFERRRK
CCCCCCEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014