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The map label for this gene is vanR [H]

Identifier: 18311346

GI number: 18311346

Start: 2727062

End: 2727760

Strand: Reverse

Name: vanR [H]

Synonym: CPE2364

Alternate gene names: 18311346

Gene position: 2727760-2727062 (Counterclockwise)

Preceding gene: 18311349

Following gene: 18311345

Centisome position: 89.98

GC content: 28.04

Gene sequence:

>699_bases
ATGGAAAAAGAAAAGTTTAATGTTTTAGTTGTAGATGATGAAAAAGAAATAAGAGATGCAATAGATATATATTTAAGAGG
AGAAGGAATAAATGTAATAAAGGCTGGAGATGGATTTGAGGCCTTAGAGATTTTAGATAAGGAAGACATACATCTAGTGG
TTTTAGATATAATGATGCCTAAGTTAGATGGAATGAGAACTTGTTTAAAAATAAGAGAAAGTAGAAATATACCAATAATA
TTACTATCAGCAAAATCAGAAGATAGTGATAAGATATTAGGTTTAAACATAGGGGCAGATGATTACGTTACAAAACCTTT
TAATCACTTAGAACTTGTTGCAAGAGTAAAATCTCAATTAAGAAGGTATGATTATCCTTTAAATAGGGAAAATACTCAAG
ATTTAATAGTAATAAAAGATTTAACTATAGATACTGTAAATAAGCAGGTTTCTTTAAGAGGAGAAAATATAAAATTAACT
GCAACAGAGTATAAGATATTAACACTTTTAGCATCACATCCAGGAAGAATATTTTCAATTAAGGAAATTTATGAAAGAGT
TTGGGAAGAACCTTTTTATAAAAGTGAAAATACAGTAACAGTTCATATAAGAAGAATGAGAGAAAAAATAGAAATAAATT
CGAAAGAACCTGAGTATATAAAGGTGGTGTGGGGACTTGGGTATAAAATTGACAAATAG

Upstream 100 bases:

>100_bases
AGAAGGTATATCTTAAGAAAATCGTAATAAATAAATAGGTTAATTTTAATTTTCCTCCTTTACTATTTAGAGGAGGCATA
AGTTTAAGGAGTGCTTTATT

Downstream 100 bases:

>100_bases
TTTTTCAAGATGGTGGAAAAACTATAGCCTTTCAGTAAGAAGCATAGAAAATATGTTTATAGTAATATTTGCTGTGTTTA
TACCTGTTTTATATATTATC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MEKEKFNVLVVDDEKEIRDAIDIYLRGEGINVIKAGDGFEALEILDKEDIHLVVLDIMMPKLDGMRTCLKIRESRNIPII
LLSAKSEDSDKILGLNIGADDYVTKPFNHLELVARVKSQLRRYDYPLNRENTQDLIVIKDLTIDTVNKQVSLRGENIKLT
ATEYKILTLLASHPGRIFSIKEIYERVWEEPFYKSENTVTVHIRRMREKIEINSKEPEYIKVVWGLGYKIDK

Sequences:

>Translated_232_residues
MEKEKFNVLVVDDEKEIRDAIDIYLRGEGINVIKAGDGFEALEILDKEDIHLVVLDIMMPKLDGMRTCLKIRESRNIPII
LLSAKSEDSDKILGLNIGADDYVTKPFNHLELVARVKSQLRRYDYPLNRENTQDLIVIKDLTIDTVNKQVSLRGENIKLT
ATEYKILTLLASHPGRIFSIKEIYERVWEEPFYKSENTVTVHIRRMREKIEINSKEPEYIKVVWGLGYKIDK
>Mature_232_residues
MEKEKFNVLVVDDEKEIRDAIDIYLRGEGINVIKAGDGFEALEILDKEDIHLVVLDIMMPKLDGMRTCLKIRESRNIPII
LLSAKSEDSDKILGLNIGADDYVTKPFNHLELVARVKSQLRRYDYPLNRENTQDLIVIKDLTIDTVNKQVSLRGENIKLT
ATEYKILTLLASHPGRIFSIKEIYERVWEEPFYKSENTVTVHIRRMREKIEINSKEPEYIKVVWGLGYKIDK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=34.9344978165939, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=34.6846846846847, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=34.070796460177, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI2367329, Length=224, Percent_Identity=34.8214285714286, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=34.0807174887892, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=30.3571428571429, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=32.8888888888889, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=33.1877729257642, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790860, Length=231, Percent_Identity=31.1688311688312, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=31.6964285714286, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1787229, Length=210, Percent_Identity=33.8095238095238, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=30.3571428571429, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=28.9473684210526, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=30.1310043668122, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790299, Length=127, Percent_Identity=31.496062992126, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788550, Length=120, Percent_Identity=35, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1790437, Length=121, Percent_Identity=32.2314049586777, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787487, Length=120, Percent_Identity=29.1666666666667, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26961; Mature: 26961

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKEKFNVLVVDDEKEIRDAIDIYLRGEGINVIKAGDGFEALEILDKEDIHLVVLDIMMP
CCCCEEEEEEEECHHHHHHHEEEEEECCCEEEEECCCCCHHHHHCCCCCCEEEEEEEHHC
KLDGMRTCLKIRESRNIPIILLSAKSEDSDKILGLNIGADDYVTKPFNHLELVARVKSQL
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
RRYDYPLNRENTQDLIVIKDLTIDTVNKQVSLRGENIKLTATEYKILTLLASHPGRIFSI
HHCCCCCCCCCCCCEEEEEECEEEECCCEEEEECCEEEEEEEEEEEEEEEECCCCCEEEH
KEIYERVWEEPFYKSENTVTVHIRRMREKIEINSKEPEYIKVVWGLGYKIDK
HHHHHHHHCCCCCCCCCEEEEEEEHHHHHHCCCCCCCCEEEEEEECCEEECC
>Mature Secondary Structure
MEKEKFNVLVVDDEKEIRDAIDIYLRGEGINVIKAGDGFEALEILDKEDIHLVVLDIMMP
CCCCEEEEEEEECHHHHHHHEEEEEECCCEEEEECCCCCHHHHHCCCCCCEEEEEEEHHC
KLDGMRTCLKIRESRNIPIILLSAKSEDSDKILGLNIGADDYVTKPFNHLELVARVKSQL
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
RRYDYPLNRENTQDLIVIKDLTIDTVNKQVSLRGENIKLTATEYKILTLLASHPGRIFSI
HHCCCCCCCCCCCCEEEEEECEEEECCCEEEEECCEEEEEEEEEEEEEEEECCCCCEEEH
KEIYERVWEEPFYKSENTVTVHIRRMREKIEINSKEPEYIKVVWGLGYKIDK
HHHHHHHHCCCCCCCCCEEEEEEEHHHHHHCCCCCCCCEEEEEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]