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The map label for this gene is nrdA [H]

Identifier: 18311343

GI number: 18311343

Start: 2722215

End: 2724446

Strand: Reverse

Name: nrdA [H]

Synonym: CPE2361

Alternate gene names: 18311343

Gene position: 2724446-2722215 (Counterclockwise)

Preceding gene: 18311344

Following gene: 18311342

Centisome position: 89.87

GC content: 31.45

Gene sequence:

>2232_bases
ATGACACTATTAGAGAGATATTGTGCATGGTCTATAGAAGAACTGAATGATGAAACAGGATTATATACTGAAGAAAAGTT
AATGGTTGCTTTAGATAATATAGTTACATCAAAAATGGGAGAAAAAGAGATAATAAAATCTTTCATACAAGTTTCGTTAG
AGTTAACTTCTCAAGTAGAACCAAGATGGCAGGAAATTGCGGCGAAGTTATATGTTAAAAATTTATATGAAGAAGTAAGA
GTAAATAGAGGACTAGAAGAAGGGGCAAATCCATATGATAATTTCTATGGTTTTATAAAGGAACTTACTGATAAAGGATT
ATACGGAAAATATATTTTAGATAATTACTCTAAGGAAGATATAGAAGAATTAGAAAAAGAAATAAAAAGAGAGAGAGACT
TTTTATTTACATACAGTGGAATAAATTTATTAGCAAAAAGATATTTAGTTCAAGATTTTAATAGATTACCATTAGAACTT
CCTCAACAAATGTTTATGGGAATTGCTATGCACCTTGCTATCCCTGAGAAGAAGGAAAAAAGACTTTATTGGGCAAAAAG
ATTTTATGATGTTTTAAGTTCAATAAAGGCTACAATGGCTACTCCAACTATGTCTAATGCTAGAAAGCCATTTTACCAAT
TAAGTTCATGTTTTATAGATACTGTAGATGATAGTTTAGCTGGTATATATAAATCATTAGATAATTTCTCAAAGGTTTCT
AAGTTTGGTGGAGGAATGGGAATCTATATGGGTAAGGTAAGAGCCTTAGGCTCAGCCATAAGAGGTTTTAAAGGTGCATC
AGGTGGAATTATACCTTGGATAAAATTATTCAATGATACAGCCATAGCTGTTGACCAATTAGGAGTTAGAAACGGATCAG
TTGCTATTTGGTTAGATGCATGGCATAAAGATTTACCAGAGTTTCTTCAAATAAGAACAAACAACGGAGACGATAGAAAG
AAAGCTCATGATATATTCCCAGGGATTTGTTATCCAGATTTATTCTGGAAGTTAGCAGAAAATGATATAGATGCTAACTG
GTATATGATGTGTCCTCATGAAATAAAAACTGTTAAAGGATATTCTTTAGAAGATTTCTATGGGGAAGAATGGGAAAAGA
AATATTATGAGTGTGTAGAAGATGATAGAATAGAAAAGAGAGTTATGAGTGTTAAGGATATTGTAAGACTTATCATAAAA
AGTGCTGCAGAAACAGGAACACCATTTGCTTTCTATAGAGATACAGTAAATAAATTTAACCCTAATAAACACAAAGGAAT
GATATATTCATCAAATCTTTGTACTGAAATAATGCAAAACATGAGTGCTATGGAGATAGAACAAACAGAAATTAAGGATG
AAAATGGTGATGTAGTAGTTATTGAAAAAACTAAGCCAGGAGACTTTGTTGTTTGTAACCTTTCTTCAGTGGTATTAGGA
AATGTTGATGTTACATCAGATGAAGAAGTGGAATACGTTGTTGAAACTCAAATAAGAGCTATGGACAATGTAATAGACTT
AAATTATTATTCAGTTCCATTTGCTGAAATAACAAACAAGAAATATAGAGCTGTTGGATTAGGAACATCAGGATACCATC
ATATGCTTGTAAATAATAAGATTGTATGGGATTCAGAGGAACACTTAAACTTTGTAGATAAAGTTTATGAGAGAATAAAC
TTCTATGCTATAAAAGCTAGTTTAAACATAGCAAAAGAAAAAGGAAGCTATCCATTATTTGAAGGATCAGATTGGAGTAA
TGGTGATTATTTTGAACTAAGAGAATATAATTCACCACAGTGGAAAGAACTAAAAGAAGAGATTGCTAAATATGGTATGA
GAAATGGATACCTATTTGCAGTAGCTCCAAATGGTTCAACTGCCACTTTAGCTGGAACTTCAGAGGGAGTAGATCCTGTT
ATGAATAGATTCTGGTTAGAAGAGAAAAAAGGAAGCATAACTCCAAAGGTAGCACCTGGATTATGTCAAGAAAATTTCTG
GTACTATGTTTCAGCTTACAATGTAAATCAAGAATTTACAGTTAGAGCAAACGGAGTAAGACAAAGACATATAGACCAAG
GACAATCATTTAACCTTTATATAACTACAGATTATACTATGAGACAAATAATGAATCTTTATATTTCAGCTTGTAAAAAT
GGAGTTAAAAGTATTTATTATGTAAGAAGTAAATCTCTAAGTGTTGACGAATGTGAGAGTTGTTCAGCTTAG

Upstream 100 bases:

>100_bases
AATCTGAGTTTTACAAAACAACTTTAAATTATTATAATAAATTGTCAAGATATTGTGCGAAATTTAAAAATAATTACTAT
ATATTGTGGAGGGCTAGTTG

Downstream 100 bases:

>100_bases
AATATAAATTAAGAATTTTAAAGATACTCATCTAGGCTTAGGTGAGTATCTATTAATTATAGATAGAGAAATAAAGAGAT
GAAAGGTGACGTAAAATGGA

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 743; Mature: 742

Protein sequence:

>743_residues
MTLLERYCAWSIEELNDETGLYTEEKLMVALDNIVTSKMGEKEIIKSFIQVSLELTSQVEPRWQEIAAKLYVKNLYEEVR
VNRGLEEGANPYDNFYGFIKELTDKGLYGKYILDNYSKEDIEELEKEIKRERDFLFTYSGINLLAKRYLVQDFNRLPLEL
PQQMFMGIAMHLAIPEKKEKRLYWAKRFYDVLSSIKATMATPTMSNARKPFYQLSSCFIDTVDDSLAGIYKSLDNFSKVS
KFGGGMGIYMGKVRALGSAIRGFKGASGGIIPWIKLFNDTAIAVDQLGVRNGSVAIWLDAWHKDLPEFLQIRTNNGDDRK
KAHDIFPGICYPDLFWKLAENDIDANWYMMCPHEIKTVKGYSLEDFYGEEWEKKYYECVEDDRIEKRVMSVKDIVRLIIK
SAAETGTPFAFYRDTVNKFNPNKHKGMIYSSNLCTEIMQNMSAMEIEQTEIKDENGDVVVIEKTKPGDFVVCNLSSVVLG
NVDVTSDEEVEYVVETQIRAMDNVIDLNYYSVPFAEITNKKYRAVGLGTSGYHHMLVNNKIVWDSEEHLNFVDKVYERIN
FYAIKASLNIAKEKGSYPLFEGSDWSNGDYFELREYNSPQWKELKEEIAKYGMRNGYLFAVAPNGSTATLAGTSEGVDPV
MNRFWLEEKKGSITPKVAPGLCQENFWYYVSAYNVNQEFTVRANGVRQRHIDQGQSFNLYITTDYTMRQIMNLYISACKN
GVKSIYYVRSKSLSVDECESCSA

Sequences:

>Translated_743_residues
MTLLERYCAWSIEELNDETGLYTEEKLMVALDNIVTSKMGEKEIIKSFIQVSLELTSQVEPRWQEIAAKLYVKNLYEEVR
VNRGLEEGANPYDNFYGFIKELTDKGLYGKYILDNYSKEDIEELEKEIKRERDFLFTYSGINLLAKRYLVQDFNRLPLEL
PQQMFMGIAMHLAIPEKKEKRLYWAKRFYDVLSSIKATMATPTMSNARKPFYQLSSCFIDTVDDSLAGIYKSLDNFSKVS
KFGGGMGIYMGKVRALGSAIRGFKGASGGIIPWIKLFNDTAIAVDQLGVRNGSVAIWLDAWHKDLPEFLQIRTNNGDDRK
KAHDIFPGICYPDLFWKLAENDIDANWYMMCPHEIKTVKGYSLEDFYGEEWEKKYYECVEDDRIEKRVMSVKDIVRLIIK
SAAETGTPFAFYRDTVNKFNPNKHKGMIYSSNLCTEIMQNMSAMEIEQTEIKDENGDVVVIEKTKPGDFVVCNLSSVVLG
NVDVTSDEEVEYVVETQIRAMDNVIDLNYYSVPFAEITNKKYRAVGLGTSGYHHMLVNNKIVWDSEEHLNFVDKVYERIN
FYAIKASLNIAKEKGSYPLFEGSDWSNGDYFELREYNSPQWKELKEEIAKYGMRNGYLFAVAPNGSTATLAGTSEGVDPV
MNRFWLEEKKGSITPKVAPGLCQENFWYYVSAYNVNQEFTVRANGVRQRHIDQGQSFNLYITTDYTMRQIMNLYISACKN
GVKSIYYVRSKSLSVDECESCSA
>Mature_742_residues
TLLERYCAWSIEELNDETGLYTEEKLMVALDNIVTSKMGEKEIIKSFIQVSLELTSQVEPRWQEIAAKLYVKNLYEEVRV
NRGLEEGANPYDNFYGFIKELTDKGLYGKYILDNYSKEDIEELEKEIKRERDFLFTYSGINLLAKRYLVQDFNRLPLELP
QQMFMGIAMHLAIPEKKEKRLYWAKRFYDVLSSIKATMATPTMSNARKPFYQLSSCFIDTVDDSLAGIYKSLDNFSKVSK
FGGGMGIYMGKVRALGSAIRGFKGASGGIIPWIKLFNDTAIAVDQLGVRNGSVAIWLDAWHKDLPEFLQIRTNNGDDRKK
AHDIFPGICYPDLFWKLAENDIDANWYMMCPHEIKTVKGYSLEDFYGEEWEKKYYECVEDDRIEKRVMSVKDIVRLIIKS
AAETGTPFAFYRDTVNKFNPNKHKGMIYSSNLCTEIMQNMSAMEIEQTEIKDENGDVVVIEKTKPGDFVVCNLSSVVLGN
VDVTSDEEVEYVVETQIRAMDNVIDLNYYSVPFAEITNKKYRAVGLGTSGYHHMLVNNKIVWDSEEHLNFVDKVYERINF
YAIKASLNIAKEKGSYPLFEGSDWSNGDYFELREYNSPQWKELKEEIAKYGMRNGYLFAVAPNGSTATLAGTSEGVDPVM
NRFWLEEKKGSITPKVAPGLCQENFWYYVSAYNVNQEFTVRANGVRQRHIDQGQSFNLYITTDYTMRQIMNLYISACKNG
VKSIYYVRSKSLSVDECESCSA

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=717, Percent_Identity=30.6834030683403, Blast_Score=323, Evalue=3e-88,
Organism=Escherichia coli, GI1789030, Length=685, Percent_Identity=28.029197080292, Blast_Score=264, Evalue=2e-71,
Organism=Escherichia coli, GI2367133, Length=778, Percent_Identity=26.2210796915167, Blast_Score=259, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17555242, Length=728, Percent_Identity=29.2582417582418, Blast_Score=306, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6322123, Length=731, Percent_Identity=28.4541723666211, Blast_Score=301, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6320914, Length=731, Percent_Identity=28.5909712722298, Blast_Score=300, Evalue=5e-82,
Organism=Drosophila melanogaster, GI17352481, Length=716, Percent_Identity=29.3296089385475, Blast_Score=303, Evalue=3e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 85412; Mature: 85281

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLERYCAWSIEELNDETGLYTEEKLMVALDNIVTSKMGEKEIIKSFIQVSLELTSQVE
CCHHHHHHCCCHHHCCCCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
PRWQEIAAKLYVKNLYEEVRVNRGLEEGANPYDNFYGFIKELTDKGLYGKYILDNYSKED
HHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCHHH
IEELEKEIKRERDFLFTYSGINLLAKRYLVQDFNRLPLELPQQMFMGIAMHLAIPEKKEK
HHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHH
RLYWAKRFYDVLSSIKATMATPTMSNARKPFYQLSSCFIDTVDDSLAGIYKSLDNFSKVS
HHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFGGGMGIYMGKVRALGSAIRGFKGASGGIIPWIKLFNDTAIAVDQLGVRNGSVAIWLDA
HHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEHHHCCCCCCCEEEEEEC
WHKDLPEFLQIRTNNGDDRKKAHDIFPGICYPDLFWKLAENDIDANWYMMCPHEIKTVKG
HHCCCHHHHEEECCCCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEECCHHHHHCCC
YSLEDFYGEEWEKKYYECVEDDRIEKRVMSVKDIVRLIIKSAAETGTPFAFYRDTVNKFN
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
PNKHKGMIYSSNLCTEIMQNMSAMEIEQTEIKDENGDVVVIEKTKPGDFVVCNLSSVVLG
CCCCCCEEEECHHHHHHHHCCHHHEEHHHHCCCCCCCEEEEEECCCCCEEEEECCEEEEE
NVDVTSDEEVEYVVETQIRAMDNVIDLNYYSVPFAEITNKKYRAVGLGTSGYHHMLVNNK
CCCCCCCCCHHHHHHHHHHHHHCEEECCEEECCHHHHCCCCEEEEECCCCCCEEEEECCE
IVWDSEEHLNFVDKVYERINFYAIKASLNIAKEKGSYPLFEGSDWSNGDYFELREYNSPQ
EEECCHHHHHHHHHHHHHHCEEEEEEEEEEHHCCCCCCCCCCCCCCCCCEEEEECCCCCH
WKELKEEIAKYGMRNGYLFAVAPNGSTATLAGTSEGVDPVMNRFWLEEKKGSITPKVAPG
HHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
LCQENFWYYVSAYNVNQEFTVRANGVRQRHIDQGQSFNLYITTDYTMRQIMNLYISACKN
CCCCCCEEEEEEEECCCEEEEEECCCHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHH
GVKSIYYVRSKSLSVDECESCSA
HHHHEEEECCCCCCHHHHCCCCC
>Mature Secondary Structure 
TLLERYCAWSIEELNDETGLYTEEKLMVALDNIVTSKMGEKEIIKSFIQVSLELTSQVE
CHHHHHHCCCHHHCCCCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
PRWQEIAAKLYVKNLYEEVRVNRGLEEGANPYDNFYGFIKELTDKGLYGKYILDNYSKED
HHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCHHH
IEELEKEIKRERDFLFTYSGINLLAKRYLVQDFNRLPLELPQQMFMGIAMHLAIPEKKEK
HHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHH
RLYWAKRFYDVLSSIKATMATPTMSNARKPFYQLSSCFIDTVDDSLAGIYKSLDNFSKVS
HHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFGGGMGIYMGKVRALGSAIRGFKGASGGIIPWIKLFNDTAIAVDQLGVRNGSVAIWLDA
HHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEHHHCCCCCCCEEEEEEC
WHKDLPEFLQIRTNNGDDRKKAHDIFPGICYPDLFWKLAENDIDANWYMMCPHEIKTVKG
HHCCCHHHHEEECCCCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEECCHHHHHCCC
YSLEDFYGEEWEKKYYECVEDDRIEKRVMSVKDIVRLIIKSAAETGTPFAFYRDTVNKFN
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
PNKHKGMIYSSNLCTEIMQNMSAMEIEQTEIKDENGDVVVIEKTKPGDFVVCNLSSVVLG
CCCCCCEEEECHHHHHHHHCCHHHEEHHHHCCCCCCCEEEEEECCCCCEEEEECCEEEEE
NVDVTSDEEVEYVVETQIRAMDNVIDLNYYSVPFAEITNKKYRAVGLGTSGYHHMLVNNK
CCCCCCCCCHHHHHHHHHHHHHCEEECCEEECCHHHHCCCCEEEEECCCCCCEEEEECCE
IVWDSEEHLNFVDKVYERINFYAIKASLNIAKEKGSYPLFEGSDWSNGDYFELREYNSPQ
EEECCHHHHHHHHHHHHHHCEEEEEEEEEEHHCCCCCCCCCCCCCCCCCEEEEECCCCCH
WKELKEEIAKYGMRNGYLFAVAPNGSTATLAGTSEGVDPVMNRFWLEEKKGSITPKVAPG
HHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
LCQENFWYYVSAYNVNQEFTVRANGVRQRHIDQGQSFNLYITTDYTMRQIMNLYISACKN
CCCCCCEEEEEEEECCCEEEEEECCCHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHH
GVKSIYYVRSKSLSVDECESCSA
HHHHEEEECCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]