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The map label for this gene is lepW [H]

Identifier: 18311277

GI number: 18311277

Start: 2639141

End: 2639641

Strand: Reverse

Name: lepW [H]

Synonym: CPE2295

Alternate gene names: 18311277

Gene position: 2639641-2639141 (Counterclockwise)

Preceding gene: 18311278

Following gene: 18311276

Centisome position: 87.08

GC content: 26.75

Gene sequence:

>501_bases
ATGAATAGTAAAAAGATTGTTAATACTATATATTACATAGTTATTTCTATGTTAGTTATAATATTAGTAAATAATTTTAT
GAGTAAGTCAGATTCAATATTTAAAGCTGTTGGATTTAGAACATATTCAATATTAAGTGGAAGTATGGAACCAGAGATTA
ATACTGGAGATTTAGCTATTGTTAAGAGTATTGATGCTGATGATGTTAAAGTTGGAGATATAATAACATTTAAATATGAG
GGGAAAGTAGTTACCCATAGAGTTGTTGAAAAAAATGAAGAGGGATTTATAACAAAGGGTGATAATAATAATGCTAATGA
TACTGAAATAGTTAGAGGAGAAGACTTAATAGGAAAAGTTTTATTTCATATGCCTTTCTTAGGATATGTTACAGTATTTT
TATCAAAGCCAATAGTAATATCAGGACTTATGGTCCTAATTGCAATAAGCATACTTTGGGATACTTTTAAAGTTGATAAG
AAAAAAACAATAAAGGCTTAG

Upstream 100 bases:

>100_bases
TTTTAGTACAGTTTTTATTTTTATATAGGAATACTTTACATAATCTTTGAATATACATATAATAGGAGAATTATATTTTA
TATTTAGCAAGGGTGAATTT

Downstream 100 bases:

>100_bases
CTTAATAACATGGAGGGTGATTCGAAAGAACACCTATCCGTGTTTTTTTCTTTTTATATTATATAAAAACACTATTTATT
AATAACTTTTATTAGTATAA

Product: signal peptidase type I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MNSKKIVNTIYYIVISMLVIILVNNFMSKSDSIFKAVGFRTYSILSGSMEPEINTGDLAIVKSIDADDVKVGDIITFKYE
GKVVTHRVVEKNEEGFITKGDNNNANDTEIVRGEDLIGKVLFHMPFLGYVTVFLSKPIVISGLMVLIAISILWDTFKVDK
KKTIKA

Sequences:

>Translated_166_residues
MNSKKIVNTIYYIVISMLVIILVNNFMSKSDSIFKAVGFRTYSILSGSMEPEINTGDLAIVKSIDADDVKVGDIITFKYE
GKVVTHRVVEKNEEGFITKGDNNNANDTEIVRGEDLIGKVLFHMPFLGYVTVFLSKPIVISGLMVLIAISILWDTFKVDK
KKTIKA
>Mature_166_residues
MNSKKIVNTIYYIVISMLVIILVNNFMSKSDSIFKAVGFRTYSILSGSMEPEINTGDLAIVKSIDADDVKVGDIITFKYE
GKVVTHRVVEKNEEGFITKGDNNNANDTEIVRGEDLIGKVLFHMPFLGYVTVFLSKPIVISGLMVLIAISILWDTFKVDK
KKTIKA

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26B family [H]

Homologues:

Organism=Homo sapiens, GI15150809, Length=106, Percent_Identity=33.0188679245283, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI7657609, Length=106, Percent_Identity=33.0188679245283, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510347, Length=106, Percent_Identity=34.9056603773585, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322213, Length=108, Percent_Identity=31.4814814814815, Blast_Score=62, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21358147, Length=124, Percent_Identity=33.8709677419355, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR001733 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 18513; Mature: 18513

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKKIVNTIYYIVISMLVIILVNNFMSKSDSIFKAVGFRTYSILSGSMEPEINTGDLAI
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHEEHHCCCCCCCCCCCCEEE
VKSIDADDVKVGDIITFKYEGKVVTHRVVEKNEEGFITKGDNNNANDTEIVRGEDLIGKV
EEECCCCCEEECCEEEEEECCEEEEHHHHHCCCCCCEECCCCCCCCCCEEECCHHHHHHH
LFHMPFLGYVTVFLSKPIVISGLMVLIAISILWDTFKVDKKKTIKA
HHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure
MNSKKIVNTIYYIVISMLVIILVNNFMSKSDSIFKAVGFRTYSILSGSMEPEINTGDLAI
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHEEHHCCCCCCCCCCCCEEE
VKSIDADDVKVGDIITFKYEGKVVTHRVVEKNEEGFITKGDNNNANDTEIVRGEDLIGKV
EEECCCCCEEECCEEEEEECCEEEEHHHHHCCCCCCEECCCCCCCCCCEEECCHHHHHHH
LFHMPFLGYVTVFLSKPIVISGLMVLIAISILWDTFKVDKKKTIKA
HHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 9823656 [H]