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The map label for this gene is appB [H]

Identifier: 18311254

GI number: 18311254

Start: 2609987

End: 2610952

Strand: Reverse

Name: appB [H]

Synonym: CPE2272

Alternate gene names: 18311254

Gene position: 2610952-2609987 (Counterclockwise)

Preceding gene: 18311255

Following gene: 18311253

Centisome position: 86.13

GC content: 31.68

Gene sequence:

>966_bases
ATGCTACAGTATATCACTAGAAGAATACTATTAATAATACCGACTATTGTTGGTGTATCATTAGTACTTTTCTTCATATT
TGCTATGGCTCCAGGAGATGCTATTACAGCAAATATGGATCCAAATATGAGTGTAGAAACAAAACAAGCAATAAGAGAAA
AATATCATTTAGATGAGCCAAAAACAACACAGTACATGTATTGGTTAAAAGGCGTTGTAACAGAAGGGTCTTTAGGAGAA
TCTTTTTACTATAAAAGACCAGTTTCAGAAGTAATGAAAGACTTTATACCAAATTCCTTTATTTTAGGAGCGGCATCACT
AATTTTGGGGCTTATAATTGCGGTGCCAATAGGTATAGTTTCAGCAACAAAGCAATATTCATTTTTTGATAAATTTTTTA
CGGTATTTGCCCTTATGGGAATATCAATGCCATCATTTTTCTTTGGACTTATATTAATTAAATATTTAGGAGTTCAACTT
AATTTATTTCCAATATCGGGTATGACTACTCCAGGAAGTGCATATACAGGAATGCAATATGTTCTAGATGTATTAAAACA
TATGATTTTACCACTTATAGTTTTAACTCTTGGAAGTGTAGGTGGATGGATGAGATACACAAGATCAAGTATGCTTGAGG
TAGTTAGACAAGATTATATAAGAACTGCTAGAGCAAAAGGATTAAAAGAGAAGGTAGTTATATATAAACATGCTTTAAGA
AATGCACTTATACCAGTTGTAACACTATTAGGAATGTCAATTCCAGGATTATTCTCAGGTGCTACATTAACAGAAAAAAT
ATTTAACTGGCCAGGAATAGGTCCAGTACAGTTAAGTGCAGTTAATAACAGAGATTATTATCTACTTATGGGTATAAACC
TTACTTTGGCTATATTAGTTTTAATAGGAAACTTACTTGCTGATATTATATATGCATTAGTAGATCCAAGAATAAGGCTT
AAGTAG

Upstream 100 bases:

>100_bases
AACTTGAATTAGATAACAATAAATAAAATTTAAAATAAATTAAGAAATTAGCCTGGACAAAAAATCCAGGCTAATTTTGA
AAAATGGGGGGAACAGCAAT

Downstream 100 bases:

>100_bases
GAGGTGCTTTTTATATGCAAACAGAATTAAATAAAGAAGTTAAAGTTAAAAAAGAGAAAATAGAAAGCCCTTGGACTGTA
GCTTTTAAAAGATTGAAAAA

Product: oligopeptide ABC transporter

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MLQYITRRILLIIPTIVGVSLVLFFIFAMAPGDAITANMDPNMSVETKQAIREKYHLDEPKTTQYMYWLKGVVTEGSLGE
SFYYKRPVSEVMKDFIPNSFILGAASLILGLIIAVPIGIVSATKQYSFFDKFFTVFALMGISMPSFFFGLILIKYLGVQL
NLFPISGMTTPGSAYTGMQYVLDVLKHMILPLIVLTLGSVGGWMRYTRSSMLEVVRQDYIRTARAKGLKEKVVIYKHALR
NALIPVVTLLGMSIPGLFSGATLTEKIFNWPGIGPVQLSAVNNRDYYLLMGINLTLAILVLIGNLLADIIYALVDPRIRL
K

Sequences:

>Translated_321_residues
MLQYITRRILLIIPTIVGVSLVLFFIFAMAPGDAITANMDPNMSVETKQAIREKYHLDEPKTTQYMYWLKGVVTEGSLGE
SFYYKRPVSEVMKDFIPNSFILGAASLILGLIIAVPIGIVSATKQYSFFDKFFTVFALMGISMPSFFFGLILIKYLGVQL
NLFPISGMTTPGSAYTGMQYVLDVLKHMILPLIVLTLGSVGGWMRYTRSSMLEVVRQDYIRTARAKGLKEKVVIYKHALR
NALIPVVTLLGMSIPGLFSGATLTEKIFNWPGIGPVQLSAVNNRDYYLLMGINLTLAILVLIGNLLADIIYALVDPRIRL
K
>Mature_321_residues
MLQYITRRILLIIPTIVGVSLVLFFIFAMAPGDAITANMDPNMSVETKQAIREKYHLDEPKTTQYMYWLKGVVTEGSLGE
SFYYKRPVSEVMKDFIPNSFILGAASLILGLIIAVPIGIVSATKQYSFFDKFFTVFALMGISMPSFFFGLILIKYLGVQL
NLFPISGMTTPGSAYTGMQYVLDVLKHMILPLIVLTLGSVGGWMRYTRSSMLEVVRQDYIRTARAKGLKEKVVIYKHALR
NALIPVVTLLGMSIPGLFSGATLTEKIFNWPGIGPVQLSAVNNRDYYLLMGINLTLAILVLIGNLLADIIYALVDPRIRL
K

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG0601

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789965, Length=342, Percent_Identity=39.4736842105263, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1787053, Length=322, Percent_Identity=33.8509316770186, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1787497, Length=320, Percent_Identity=35.3125, Blast_Score=194, Evalue=5e-51,
Organism=Escherichia coli, GI1789888, Length=324, Percent_Identity=33.9506172839506, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1787761, Length=330, Percent_Identity=33.030303030303, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1788504, Length=370, Percent_Identity=30.2702702702703, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1787550, Length=269, Percent_Identity=26.7657992565056, Blast_Score=135, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 35784; Mature: 35784

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQYITRRILLIIPTIVGVSLVLFFIFAMAPGDAITANMDPNMSVETKQAIREKYHLDEP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCC
KTTQYMYWLKGVVTEGSLGESFYYKRPVSEVMKDFIPNSFILGAASLILGLIIAVPIGIV
CHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SATKQYSFFDKFFTVFALMGISMPSFFFGLILIKYLGVQLNLFPISGMTTPGSAYTGMQY
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHH
VLDVLKHMILPLIVLTLGSVGGWMRYTRSSMLEVVRQDYIRTARAKGLKEKVVIYKHALR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
NALIPVVTLLGMSIPGLFSGATLTEKIFNWPGIGPVQLSAVNNRDYYLLMGINLTLAILV
HHHHHHHHHHHCCCCCHHCCCHHHHHHHCCCCCCCEEEEEECCCCEEEEECHHHHHHHHH
LIGNLLADIIYALVDPRIRLK
HHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLQYITRRILLIIPTIVGVSLVLFFIFAMAPGDAITANMDPNMSVETKQAIREKYHLDEP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCC
KTTQYMYWLKGVVTEGSLGESFYYKRPVSEVMKDFIPNSFILGAASLILGLIIAVPIGIV
CHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SATKQYSFFDKFFTVFALMGISMPSFFFGLILIKYLGVQLNLFPISGMTTPGSAYTGMQY
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHH
VLDVLKHMILPLIVLTLGSVGGWMRYTRSSMLEVVRQDYIRTARAKGLKEKVVIYKHALR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
NALIPVVTLLGMSIPGLFSGATLTEKIFNWPGIGPVQLSAVNNRDYYLLMGINLTLAILV
HHHHHHHHHHHCCCCCHHCCCHHHHHHHCCCCCCCEEEEEECCCCEEEEECHHHHHHHHH
LIGNLLADIIYALVDPRIRLK
HHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]