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The map label for this gene is srrA [H]

Identifier: 18311222

GI number: 18311222

Start: 2563369

End: 2563836

Strand: Reverse

Name: srrA [H]

Synonym: CPE2240

Alternate gene names: 18311222

Gene position: 2563836-2563369 (Counterclockwise)

Preceding gene: 18311223

Following gene: 18311221

Centisome position: 84.58

GC content: 28.63

Gene sequence:

>468_bases
ATGGGAATAATAATGTTAACTGCTAAAGGTGAAGATATGGATAAAATCATGGGGCTTCAGTTTGGAGCAGATGATTATGT
TTTAAAACCATTTAATCCACTAGAGATAACTTTAAGAGTAAAAGCATTAATAAGAAGGTTAGAAGGAATAAATGAAGAAA
ATAATAGTGATTGCATAGAAGTAGATAATTTTAAATTAGATTTATATTCTCAAAGTTTATATAAAGAAAATGTAGAAATA
GATGTAACACCTAAAGAGTTTTTACTAATGAAAATATTCATGCAAAACCCAGGAAAGGCCTTTACTAGAGATGAATTGTT
GAATTTAGTATGGGGAATAGACTTTTTTGGAGATCCAAAGATAGTTGATGTTAATATAAGGAGATTAAGATCTAAAATAG
AAGAAAACTCTTCAAAACCTAAATACATAGAAACTGTATGGGGAACAGGATATAGGTGGAAGAGATAA

Upstream 100 bases:

>100_bases
GCTTTAATAGAAAAGCCTAGATATAGCAATACTTGATGTTATGTTACCTGGCATGAATGGGTTTGAAGTATGTCAAAAGT
TAAGAGAAAGTTTTCCTAGA

Downstream 100 bases:

>100_bases
ATCTGTTTTTGTGAAAATCCTAAAACATTATGATTAGAATAGGATTTAGATGGAAAGGATAAATCTATATATTACAGTAT
TCATAGGAATTTTATAAAGA

Product: two-component response regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 155; Mature: 154

Protein sequence:

>155_residues
MGIIMLTAKGEDMDKIMGLQFGADDYVLKPFNPLEITLRVKALIRRLEGINEENNSDCIEVDNFKLDLYSQSLYKENVEI
DVTPKEFLLMKIFMQNPGKAFTRDELLNLVWGIDFFGDPKIVDVNIRRLRSKIEENSSKPKYIETVWGTGYRWKR

Sequences:

>Translated_155_residues
MGIIMLTAKGEDMDKIMGLQFGADDYVLKPFNPLEITLRVKALIRRLEGINEENNSDCIEVDNFKLDLYSQSLYKENVEI
DVTPKEFLLMKIFMQNPGKAFTRDELLNLVWGIDFFGDPKIVDVNIRRLRSKIEENSSKPKYIETVWGTGYRWKR
>Mature_154_residues
GIIMLTAKGEDMDKIMGLQFGADDYVLKPFNPLEITLRVKALIRRLEGINEENNSDCIEVDNFKLDLYSQSLYKENVEID
VTPKEFLLMKIFMQNPGKAFTRDELLNLVWGIDFFGDPKIVDVNIRRLRSKIEENSSKPKYIETVWGTGYRWKR

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=155, Percent_Identity=41.2903225806452, Blast_Score=135, Evalue=9e-34,
Organism=Escherichia coli, GI1786599, Length=152, Percent_Identity=39.4736842105263, Blast_Score=127, Evalue=3e-31,
Organism=Escherichia coli, GI1788394, Length=157, Percent_Identity=35.031847133758, Blast_Score=109, Evalue=7e-26,
Organism=Escherichia coli, GI1790863, Length=158, Percent_Identity=38.6075949367089, Blast_Score=107, Evalue=3e-25,
Organism=Escherichia coli, GI1786784, Length=151, Percent_Identity=37.0860927152318, Blast_Score=105, Evalue=1e-24,
Organism=Escherichia coli, GI1786911, Length=151, Percent_Identity=31.7880794701987, Blast_Score=100, Evalue=4e-23,
Organism=Escherichia coli, GI87082012, Length=149, Percent_Identity=35.5704697986577, Blast_Score=100, Evalue=5e-23,
Organism=Escherichia coli, GI1790860, Length=151, Percent_Identity=33.112582781457, Blast_Score=98, Evalue=2e-22,
Organism=Escherichia coli, GI2367329, Length=153, Percent_Identity=32.6797385620915, Blast_Score=95, Evalue=2e-21,
Organism=Escherichia coli, GI1787229, Length=155, Percent_Identity=31.6129032258064, Blast_Score=83, Evalue=9e-18,
Organism=Escherichia coli, GI1787375, Length=151, Percent_Identity=33.7748344370861, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI1790552, Length=149, Percent_Identity=34.8993288590604, Blast_Score=78, Evalue=3e-16,
Organism=Escherichia coli, GI1789402, Length=149, Percent_Identity=30.2013422818792, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI145693140, Length=157, Percent_Identity=29.9363057324841, Blast_Score=67, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 18099; Mature: 17968

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIIMLTAKGEDMDKIMGLQFGADDYVLKPFNPLEITLRVKALIRRLEGINEENNSDCIE
CCEEEEEECCCCHHHHHCEEECCCCEEECCCCCEEEEHHHHHHHHHHHCCCCCCCCCCEE
VDNFKLDLYSQSLYKENVEIDVTPKEFLLMKIFMQNPGKAFTRDELLNLVWGIDFFGDPK
ECCEEEEEEHHHHHHCCCEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCE
IVDVNIRRLRSKIEENSSKPKYIETVWGTGYRWKR
EEEHHHHHHHHHHHHCCCCCCEEEEECCCCEEECC
>Mature Secondary Structure 
GIIMLTAKGEDMDKIMGLQFGADDYVLKPFNPLEITLRVKALIRRLEGINEENNSDCIE
CEEEEEECCCCHHHHHCEEECCCCEEECCCCCEEEEHHHHHHHHHHHCCCCCCCCCCEE
VDNFKLDLYSQSLYKENVEIDVTPKEFLLMKIFMQNPGKAFTRDELLNLVWGIDFFGDPK
ECCEEEEEEHHHHHHCCCEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCE
IVDVNIRRLRSKIEENSSKPKYIETVWGTGYRWKR
EEEHHHHHHHHHHHHCCCCCCEEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA